Two chance encounters propelled remote direct memory access from a good but obscure idea for fast networks into the jet fuel for the world’s more powerful supercomputers. The lucky breaks launched the fortunes of an Israel-based startup that staked its fortunes on InfiniBand, a network based on RDMA. Later, that startup, Mellanox Technologies, helped steer Read article >

The post How RDMA Became the Fuel for Fast Networks appeared first on The Official NVIDIA Blog.

President Moon Jae-in said on August 17, "The denuclearization bid by the current government is not so radical. It will take more than 60 years for us to reach that goal." In an interview in celebration of the 100th day since taking power, President Moon said, "The design life of nuclear reactors that were launched recently or under construction is 60 years. We plan to close reactors one by one as soon as their design life expires." His remarks are in reponse to criticism that his government'...

Highlights Period for comments from stakeholders under the consultation ended on 24 January 2020, comments from industry stakeholders may lead to a second consultation Pilot project aims to open auction for up to 230MW in aggregate of nominal capac...

Patna: Tales of humanity and brotherhood have brought much-needed comfort to the people in distress as they battle the coronavirus pandemic, locking themselves in homes for the past 40 days. Two such incidents in four days stand out. A man from the Indian state of Bihar broke his fast to donate blood in a bid to save the life of a little girl admitted to a government hospital. The...

Reports from Israel last week indicated that some believe Iran is reducing its role.

Prague Daily Monitor

According to data released by the Ministry of Interior, the number of British citizens living in the Czech Republic has increased about 35% since the Brexit referendum, and Brits with their permanent residence in the Czech Republic have risen almost 55% since 2016.

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A combination of three drugs suppressed the coronavirus within seven days when used on patients in Hong Kong, nearly twice as fast as a single medicine did, in a result seen as a leading hope in the fight against the pandemic, a study has found.The findings of the research, led by University of Hong Kong academics and published in The Lancet on Saturday, could signal progress in the search for a standard form of therapy for Sars-CoV-2, the virus that causes the Covid-19 disease.It discovered…

It is about 7pm when Muslim community leader Raheel Ahmed, 57, gathers with his wife, two sons and daughter for a home-made meal of dates, rice and spicy curried chicken, salad, fresh fruit and juice.For this Hong Kong family of Pakistani origin, it is their first meal after fasting for more than 12 hours, as this is the Islamic holy month of Ramadan.The world’s 1.8 billion Muslims mark the month by abstaining from food or drink from sunrise to sunset, and gathering as a community in mosques to…

There’s one big element missing before we can create a truly transparent, seamless and open international trading framework.

Japan has fast-tracked the approval of the anti-viral drug remdesivir to be used to treat COVID-19 patients in that country.Speaking to reporters Friday in Tokyo, Japanese Chief Cabinet Secretary Yoshihide Suga confirmed the rare fast-track, four-day approval of remdesivir by the Ministry of Health,...

New PIC® MCU Family Moves Software Tasks to Hardware for Faster System Response

FAST TALK speaks to Henk Ovink, Special Envoy for International Water Affairs for the Kingdom of the Netherlands, about scaling up financing for water security, enhanced resilience and sustainable growth for the region.

With the Narendra Modi government taking charge on Tuesday, real estate players hope the sector will get due priority, which will help bring the economy back to 8-9 percent growth. “The new government will pave way for realty reforms and take concrete steps to implement its promise given in the BJP manifesto to ensure housing for all in eight years,” Confederation of Real Estate Developers’ Associations of India (Credai) Lalit Kumar Jain said. The merger of Housing and Urban Development Department will ensure coordination and proper control, he said. “The new government will bring in a positive change to developers and buyers in the otherwise dark era that has been […]

We’re thrilled to announce that HARMAN’s QLED Auto solution has been recognized in the User Experience category in Fast Company’s 2019 Innovation by Design Awards.

Jason Statham’s new film The Meg looks gloriously silly and good luck to it, but it got us thinking about what its giant prehistoric shark was really like and why it died out

Japan's Nintendo Co Ltd said on Thursday its fourth-quarter profit soared 200% due to surging demand for its Switch games console, and that title Animal Crossing: New Horizons shifted a record 13.4 million units in its first six weeks.

Title: Big Breakfast May Be the Most Slimming Meal of the Day
Category: Health News
Created: 2/26/2020 12:00:00 AM
Last Editorial Review: 2/26/2020 12:00:00 AM

Title: Arteries Age Twice as Fast in Smokers
Category: Health News
Created: 4/26/2010 6:10:00 PM
Last Editorial Review: 4/27/2010 12:00:00 AM

Title: Scientists Find Way to Heal Broken Bones Faster
Category: Health News
Created: 4/28/2010 2:10:00 PM
Last Editorial Review: 4/29/2010 12:00:00 AM

Title: Health Tip: Make Time for Breakfast
Category: Health News
Created: 4/30/2014 7:35:00 AM
Last Editorial Review: 4/30/2014 12:00:00 AM

Title: Could Fasting Every Other Day Help You Lose More Weight?
Category: Health News
Created: 5/1/2017 12:00:00 AM
Last Editorial Review: 5/2/2017 12:00:00 AM

Age-at-onset is one of the critical traits in cohort studies of age-related diseases. Large-scale genome-wide association studies (GWAS) of age-at-onset traits can provide more insights into genetic effects on disease progression and transitions between stages. Moreover, proportional hazards (or Cox) regression models can achieve higher statistical power in a cohort study than a case-control trait using logistic regression. Although mixed-effects models are widely used in GWAS to correct for sample dependence, application of Cox mixed-effects models (CMEMs) to large-scale GWAS is so far hindered by intractable computational cost. In this work, we propose COXMEG, an efficient R package for conducting GWAS of age-at-onset traits using CMEMs. COXMEG introduces fast estimation algorithms for general sparse relatedness matrices including, but not limited to, block-diagonal pedigree-based matrices. COXMEG also introduces a fast and powerful score test for dense relatedness matrices, accounting for both population stratification and family structure. In addition, COXMEG generalizes existing algorithms to support positive semidefinite relatedness matrices, which are common in twin and family studies. Our simulation studies suggest that COXMEG, depending on the structure of the relatedness matrix, is orders of magnitude computationally more efficient than coxme and coxph with frailty for GWAS. We found that using sparse approximation of relatedness matrices yielded highly comparable results in controlling false-positive rate and retaining statistical power for an ethnically homogeneous family-based sample. By applying COXMEG to a study of Alzheimer’s disease (AD) with a Late-Onset Alzheimer’s Disease Family Study from the National Institute on Aging sample comprising 3456 non-Hispanic whites and 287 African Americans, we identified the APOE 4 variant with strong statistical power (P = 1e–101), far more significant than that reported in a previous study using a transformed variable and a marginal Cox model. Furthermore, we identified novel SNP rs36051450 (P = 2e–9) near GRAMD1B, the minor allele of which significantly reduced the hazards of AD in both genders. These results demonstrated that COXMEG greatly facilitates the application of CMEMs in GWAS of age-at-onset traits.

Qingxiang Guo, Yang Liu, Yanhua Zhai, and Zemao Gu

Disassembling the parasitic spores and acquiring the main subunits is a prerequisite for deep understanding of the basic biology of parasites. Herein we present a fast and efficient method to dissect the myxospores in a few steps, which mainly involved sonication, sucrose density gradient and Percoll density gradient. We tested our method on three myxozoans species and demonstrated this method allows the dismembering of myxospores, isolation of intact and clean nematocysts and shell valves within 2h by low-cost. This new tool will facilitate subsequent analyses and enable a better understanding of the ecological and evolutionary significance of parasitic spores.

In recent years, there have been intensive debates on whether healthy adults acquire new word knowledge through fast mapping (FM) by a different mechanism from explicit encoding (EE). In this study, we focused on this issue and investigated to what extent retention interval, prior knowledge (PK), and lure type modulated memory after FM and EE. Healthy young participants were asked to learn novel word-picture associations through both FM and EE. Half of the pictures were from familiar categories (i.e., high PK) and the other half were from unfamiliar categories (i.e., low PK). After 10 min and 1 wk, the participants were tested by forced-choice (FC) tasks, with lures from different categories (Experiment 1) or from the same categories of the target pictures (Experiment 2). Pseudowords were used to denote names of the novel pictures and baseline performance was controlled for each task. The results showed that in both Experiments 1 and 2, memory performance remained stable after FM, while it declined after EE from 10 min to 1 wk. Moreover, the effect of PK appeared at 10 min after FM while at 1 wk after EE in Experiment 2. PK enhanced memory of word-picture associations when the lures were from the same categories (Experiment 2), rather than from different categories (Experiment 1). These results were largely confirmed in Experiment 3 when encoding condition was manipulated as a between-subjects factor, while lure type as a within-subjects factor. The findings suggest that different from EE, FM facilitates rapid acquisition and consolidation of word-picture knowledge, and highlight that PK plays an important role in this process by enhancing access to detailed information.

Glucagon is classically described as a counterregulatory hormone that plays an essential role in the protection against hypoglycemia. In addition to its role in the regulation of glucose metabolism, glucagon has been described to promote ketosis in the fasted state. Sodium–glucose cotransporter 2 inhibitors (SGLT2i) are a new class of glucose-lowering drugs that act primarily in the kidney, but some reports have described direct effects of SGLT2i on α-cells to stimulate glucagon secretion. Interestingly, SGLT2 inhibition also results in increased endogenous glucose production and ketone production, features common to glucagon action. Here, we directly test the ketogenic role of glucagon in mice, demonstrating that neither fasting- nor SGLT2i-induced ketosis is altered by interruption of glucagon signaling. Moreover, any effect of glucagon to stimulate ketogenesis is severely limited by its insulinotropic actions. Collectively, our data suggest that fasting-associated ketosis and the ketogenic effects of SGLT2 inhibitors occur almost entirely independent of glucagon.

PURPOSE

We aimed to evaluate the efficacy and safety of use of the Fasting Algorithm for Singaporeans with Type 2 Diabetes (FAST) during Ramadan.