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Rutgers Health study uncovers vulnerabilities in drug-resistant TB, offering hope for improved treatments.

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For the first time, Uber will guarantee drivers an hourly wage of $20 an hour in Los Angeles, or $26 during peak times.; Credit: David Ramos/Getty Images

To keep demand high during the slower winter months, the ridesharing service, Uber, has cut fares by 20 percent in 48 markets – including Los Angeles and Orange County.

The company says a trip from West Hollywood to downtown will now be around nine dollars, instead of $11.

When Uber lowered prices in the past to muscle out competitors like Lyft and taxi services, passengers loved it but drivers have complained it puts an unfair squeeze on them, complaining their already low take went even lower.

Uber stresses the fact cutting fares actually helps drivers because they get more business. In a blog post, the company points to data from Chicago where fares dropped 23 percent last month compared to December 2013 while drivers' income increased by 12 percent.

But drivers have been skeptical whether volume can make up for the price drop. The company's claim that New York city drivers earn a median of $90,766 a year has been refuted. Slate talked to New York UberX driver Jesus Garay in October:

“They say it doesn’t hurt the pocket of the drivers,” Garay says of the 20 percent fare cuts. “It does. Because it’s impossible with those numbers to be in business.”

The way drivers see it, ride volume can only increase so much in response to lower prices. Garay says that on average, a ride takes him 20 minutes from start to finish: five minutes to reach the pickup location, five to wait for the customer, and 10 to drive to the destination. For a trip of that length, Garay says he’ll make $10 or $11. “So if you’re busy, you’re going to make three rides in an hour,” he explains. 

Newly flush with a $40 billion valuation, Uber is now willing to put its money where its mouth is; For the first time, Uber will guarantee its partners – as it calls them -  an hourly wage of $20 an hour in Los Angeles, or $26 during peak times. (The guarantee comes with a few conditions: Drivers have to accept 90% of trips, average at least one trip per hour, and be online for 50 minutes of every hour worked)

This content is from Southern California Public Radio. View the original story at SCPR.org.

AB 2293 bans drivers from using their personal policies and mandates that drivers have to be covered from the moment they turn on their app and look for customers.; Credit: Photo by Daniel X. O'Neil via Flickr Creative Commons

Amid all the talk about cutting-edge technology, much of Uber and Lyft’s success actually owes to that fact the ride-sharing companies have been able to exploit a basic loophole: The companies foist the cost of insurance on their drivers, but the drivers' insurance companies don’t know they are underwriting cars for hire, and even if drivers wanted to be honest and get a policy that would cover ride-sharing, they couldn’t, because no such policy exists.

AB-2293, introduced by Assemblywoman Susan Bonilla (D-Concord) and signed into law Wednesday by Governor Jerry Brown, tries to close the loophole by paving the way for insurance companies to offer hybrid personal/commercial policies by next summer.

Uber once derided the bill as a backroom deal between insurance companies and trial lawyers.

"The bill does nothing to enhance safety, yet compromises the transportation choices and entrepreneurial opportunities Uber offers Californians," the company wrote in a June blog post that encouraged customers to contact their representatives opposing the bill.

However, the company backed down and supported the legislation when Bonilla insurance requirements were lowered.

AB 2293 also specifically bans drivers from using their personal policies and mandates drivers have to be covered from the moment they turn on their app and look for customers, which is a response to the tragic accident on New Year's Eve in San Francisco when an UberX driver hit and killed a six year old child.

Uber argued that because the driver was waiting for a fare he wasn't working for the company at the time, so he wasn't covered by the company's insurance.

A play celebrating the life of legendary Bermudian musician Hubert Smith — best known for being the composer and singer of Bermuda is Another World – is presently running at the Fourways Inn, where it is set to continue until October 5th. “Hubert Smith: The Play” was spearheaded by Dale Butler, and the performers include […]

Uber is enhancing its driver partner training programmes following claims from a 22-year-old Gauteng woman that one of its drivers discriminated against her because of her disability by cancelling the trip and charging her a cancellation fee.

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Nearly 40 years after making his professional debut, and 19 years after being battered into retirement, a 58-year-old Mike Tyson will climb back into the ring on Friday for a Netflix-backed bout that has drawn widespread condemnation across the boxin

The fight has received widespread condemnation owing to Tyson's age and the fear of possible injuries.

Nisha Madhulika is known for her delicious, home-style recipes. From starting as a teacher to emerging as one of India's richest female content creators on YouTube.

Sen. Tommy Tuberville, R-Ala., praised Rep. Matt Gaetz, R-Fla., after President-elect Trump tapped him for attorney general on Wednesday.

"Genius begins great works; labor alone finishes them."

Внезапно, охуеннейший прог альбом
в духе самых аутичных пассажей из группы Кэн
либо Кинг-Кримсона из 1980-х.
https://www.youtube.com/watch?v=RfUDBxwVwSg
Gunter Schickert - Uberfallig

Еще похоже на Spacemen 3 и что-то аналогичное
с лейбла 4AD, импровизационная гитара и сэмплы.
Последний трэк гитара с лупом и секвенсором,
как у Ashra.
Рецензия:

Few people outside of a small fraternity of German music
specialists probably even remember the name G"unter
Schickert, and it's no exaggeration to call his 1979 album
"Uberfallig" one of the lost treasures of late '70s
Krautrock. For me, Schickert has remained an enigma for
close to thirty years, ever since I gave up trying to
decipher the dense, illegible scrawl of notes on the back
of the LP (a pointless exercise anyway: it's all in
German).

But he was certainly a unique talent, even within such a
wildly creative music scene. Schickert's style, at least
on this one album, employed multiple guitars to do (more
or less) what KLAUS SCHULZE and EDGAR FROESE were at the
same time doing with synthesizers and sequencers: building
layers of sometimes dreamy, sometimes tense ostinato
patterns over a subtle, shifting backbeat of driving
percussion. The rhythms are often provided by a heavy
application of echo to some unusual sound sources,
transforming a single splash of water or a labored gasp of
breath into a repetitive loop of hypnotic pulses.

The effect is especially striking on the two longer tracks
here, the aptly titled album opener "Puls", and the almost
12-minute long "Apricot Brandy". The former has the
cinematic momentum of a high-speed Hollywood chase; the
latter is a psychedelic rocker accelerating from a
semi-conscious dreamscape to a hyperkinetic rush of
overlapping guitars and voices.

Relief is provided by the ballad "In Der Zeit", sung in an
ominous half-whisper over an unadorned acoustic guitar,
and in the album's haunting finale "Wanderer", a brooding
piece of music perfectly matched to the empty autobahn
pictured on the back cover.

Altogether the album is somewhat reminiscent of (ex-NEU!)
guitarist MICHAEL ROTHER's early solo work, and in fact
was originally released on the same label (the always
reliable Sky Records). Schickert shared a similar approach
to pristine guitar minimalism, but with a darker, more
malevolent edge: he might have been the turbulent yin to
Rother's more angelic yang.

It's reassuring to find that Gunter Schickert hasn't been
completely forgotten. And, by a funny coincidence, a
translation of the album's title (Uberfallig = Overdue)
perfectly describes his status as a true Krautrock legend.

Привет

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Slippery Bloggers getting their Palms Greased

"I wish to thank Bill Gates for giving me an opportunity at Microsoft catapulting me onto the blogger A-list. But above all I wish to thank my loyal suckup fans who have made this all possible. For without you I am nothing".

Todays Blog Quiz:

Absolutely nothing.

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Mycobacterium tuberculosis can reside and persist in deep tissues; latent tuberculosis can evade immune detection and has a unique mechanism to convert it into active disease through reactivation. M. tuberculosis Rv1421 (MtRv1421) is a hypothetical protein that has been proposed to be involved in nucleotide binding-related metabolism in cell-growth and cell-division processes. However, due to a lack of structural information, the detailed function of MtRv1421 remains unclear. In this study, a truncated N-terminal domain (NTD) of MtRv1421, which contains a Walker A/B-like motif, was purified and crystallized using PEG 400 as a precipitant. The crystal of MtRv1421-NTD diffracted to a resolution of 1.7 Å and was considered to belong to either the C-centered monoclinic space group C2 or the I-centered orthorhombic space group I222, with unit-cell parameters a = 124.01, b = 58.55, c = 84.87 Å, β = 133.12° or a = 58.53, b = 84.86, c = 90.52 Å, respectively. The asymmetric units of the C2 or I222 crystals contained two or one monomers, respectively. In terms of the binding ability of MtRv1421-NTD to various ligands, uridine diphosphate (UDP) and UDP-N-acetylglucosamine significantly increased the melting temperature of MtRv1421-NTD, which indicates structural stabilization through the binding of these ligands. Altogether, the results reveal that a UDP moiety may be required for the interaction of MtRv1421-NTD as a nucleotide-binding protein with its ligand.

The Mycobacterium tuberculosis trifunctional enzyme (MtTFE) is an α2β2 tetrameric enzyme in which the α-chain harbors the 2E-enoyl-CoA hydratase (ECH) and 3S-hydroxyacyl-CoA dehydrogenase (HAD) active sites, and the β-chain provides the 3-ketoacyl-CoA thiolase (KAT) active site. Linear, medium-chain and long-chain 2E-enoyl-CoA molecules are the preferred substrates of MtTFE. Previous crystallographic binding and modeling studies identified binding sites for the acyl-CoA substrates at the three active sites, as well as the NAD binding pocket at the HAD active site. These studies also identified three additional CoA binding sites on the surface of MtTFE that are different from the active sites. It has been proposed that one of these additional sites could be of functional relevance for the substrate channeling (by surface crawling) of reaction intermediates between the three active sites. Here, 226 fragments were screened in a crystallographic fragment-binding study of MtTFE crystals, resulting in the structures of 16 MtTFE–fragment complexes. Analysis of the 121 fragment-binding events shows that the ECH active site is the `binding hotspot' for the tested fragments, with 41 binding events. The mode of binding of the fragments bound at the active sites provides additional insight into how the long-chain acyl moiety of the substrates can be accommodated at their proposed binding pockets. In addition, the 20 fragment-binding events between the active sites identify potential transient binding sites of reaction intermediates relevant to the possible channeling of substrates between these active sites. These results provide a basis for further studies to understand the functional relevance of the latter binding sites and to identify substrates for which channeling is crucial.

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John Wilkes from Google talks with Charles Anderson about managing large clusters of machines. The discussion starts with Borg, Google’s internal cluster management program. John discusses what Borg does and what it provides to programmers and system administrators. He also describes Kubernetes, an open-source cluster management system recently developed by Google using lessons learned from Borg, Mesos, and Omega

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