Jeremy Jung talks with David Calavera about zero-downtime migrations and rollbacks with Kubernetes. In this episode we define migrations, rollbacks, and discuss how Netlify was able to migrate to Kubernetes and roll back off of it multiple times without impacting their users. David explains how developers can run old and new systems simultaneously, the importance of defining errors in your system, and when to apply fixes vs rolling back. We also discuss their decision to move to Kubernetes, and the benefits they received.

Bert Hubert, author of the open source PowerDNS nameserver discusses DNS security and all aspects of the Domain Name System with its flaws and history.

Nigel Poulton, author of The Kubernetes Book and Docker Deep Dive, discusses Kubernetes fundamentals, why Kubernetes is gaining so much momentum, deploying an example app, and why Kubernetes is considered "the" Cloud OS.

Bastian Gruber, author of the book Rust Web Development, speaks with host Philip Winston about creating server-based web applications with Rust. They explore Rust language features, tooling, and web frameworks such as Warp and Tokio. From there, they examine the steps to build a simple web server and a RESTful API, as well as modules, logging and tracing, and other aspects of web development with Rust.

Andy Suderman, CTO of Fairwinds, joins host Robert Blumen to talk about standing up a kubernetes cluster. Their discussion covers build-your-own versus managed clusters provided by cloud services, and how to determine the number of kubernetes clusters an organization needs. Andy describes best practices for automating cluster provisioning, and offers recommendations about customizations and opinionation of cloud service providers, choice of container registry, and whether you should run complementary services such as CI and monitoring on the same cluster. The episode also examines the day 0/day 1/day 2 lifecycle, cluster auto-scaling at the cloud service level, integrating stateful services and other cloud services into your cluster, and kubernetes secrets and alternatives. Finally, they consider the container-network interface (CNI), ingress and load balancers, and provisioning external DNS and TLS certificates for cluster services.

Yeckezkel Rabinovich, CTO of Groundcover, speaks with host Philip Winston about observability and eBPF as it applies to Kubernetes. Rabinovich was previously the chief architect at the healthcare security company CyberMDX and spent eight years in the cyber security division of the Israeli Prime Minister’s Office. This episode explores the three pillars of observability, extending the Linux Kernel with eBPF, the basics of Kubernetes, and how Groundcover uses eBPF as the basis for its observability platform.

William Morgan, founder of the Linkerd service mesh and CEO of Bouyant, joins SE Radio’s Robert Blumen for a discussion of sidecars, service mesh, and a forthcoming enhancement to kubernetes to support sidecars natively. The conversation explores the origin of sidecars, sidecars and service mesh, and migrating service mesh to kubernetes. They take a deep dive into some aspects of running service mesh on kubernetes, the difficulties in running a sidecar container in a pod, and Kubernetes Enhancement Proposal (KEP) 753, which is intended to provide better native support for sidecar containers. William also gives some thoughts on the continuing relevance of service mesh.

Infrastructure engineer and Kubernetes ingress-Nginx maintainer James Strong joins host Robert Blumen to discuss the Kubernetes networking layer. The discussion draws on content from Strong’s book on the topic and covers a lot of ground, including: the Kubernetes network's use of different IP ranges than the host network; overlay network with its own IP ranges compared to using expanded portions of the host network ranges; adding routes with kernel extension points; programming kernel extension points with IP tables compared to eBPF; how routes are updated as the host network gains or loses nodes, the use of the Linux network namespace to isolate each pod; routing between pods on the same host; routing between pods across the host network; the container-network interface (CNI); the CNI ecosystem; differences between CNIs; choosing a CNI when running on a public cloud service; the Kubernetes service abstraction with a cluster-wide IP address; monitoring and telemetry of the Kubernetes network; and troubleshooting the Kubernetes network.

Brought to you by IEEE Software magazine and IEEE Computer Society.

Jim Bugwadia, CEO of Nirmata and a committer to the Kyverno projects, joins host Robert Blumen for a discussion of policy-as-code and the open source Kyverno project. The discussion covers the nature of policies; policies and security; policies and compliance to standards; security scans that generate reports compared to tools that allow or deny operations at run time; Kyverno as a kubernetes service; the Kyverno helm charts; the components of Kyverno; bootstrapping a kubernetes cluster with Kyverno; installing policies; implementing policies; customizing policies; packaging and installing policies; kubernetes dynamic admission controllers; the Kyverno admission controller; securing Kyverno itself; observability of Kyverno; types of reports and messages available to cluster users.

This episode is sponsored by QA Wolf.

With the inauguration of a modern training centre in Crailsheim, packaging machine manufacturer Schubert is laying the foundation for the expansion and relaunch of its training concept. 

Schubert has developed a new, compact solution to automate the infeed of carton blanks to the packaging machine.

Room 30, Parliament Buildings

Kelsey Hightower is a developer advocate, an open source aficionado, and a widely recognized expert on Kubernetes. He is the creator of the open source tutorial Kubernetes The Hard Way, available on Github, and he is a co-author of Kubernetes: Up and Running: Dive Into the Future of Infrastructure, the second edition of which is now available from O’Reilly Media. In this program his conversation with Oracle's Karthik Gaekwad encompasses Kubernetes, Open Source, cloud computing, developer advocacy and a lot more. Listen!

See the complete show notes.

WASHINGTON: Uber on Tuesday selected Melbourne, Australia, as the first non-US city for its aerial ridesharing service that is expected to launch in 2023, as it unveiled new partners for the ambitious initiative.

GAF's new membranes combine cool roof initiatives with the durability of modified bitumen and the aesthetics of a solar reflective bright white surfaced roof.

Las escritoras chilena y barcelonesa comparten el galardón en su 42ª edición Leer

Su labor, sin formar parte del Ejecutivo, deberá concluir a más tardar el 4 de julio de 2026, en el 250 aniversario de la fundación de EEUU Leer

El popular youtuber lanzó un reto que provocó varios casos de ahogamientos fingidos en las playas del Postiguet y San Juan Leer

Library - Art Library, Location - LIB, Call number - N7153.T33 A4 2016

The autonomous vehicle company Cruise, which lost its California operating license last year after one of its cars struck a pedestrian, announced a partnership this week with the ride-hail service Uber.

The Supreme Court refuses to shield Uber and Lyft from California state labor lawsuits that seek back pay for tens of thousands of drivers.

Sen. Tommy Tuberville (R-AL) signaled Thursday he may be ready to drop his nearly 10-month blockade of military promotions as soon as next week as many Senate Republicans have attempted to find an off-ramp for months, and patience is wearing thin.

Why are Washingtonians using the Empower ride-sharing app?

KinectAir, an on-demand private air travel company, is now booking budget-friendly private planes.

La tuberculosis aún existe y debemos cuidarnos.

En 6AM Hoy por Hoy, Juan Fernando Cristo, exministro del Interior, analiza viabilidad de constituyente en Colombia.

YouTuber Jake Paul and boxing heavyweight legend Mike Tyson are finally set to battle in their much-anticipated match at AT&T Stadium in Dallas on Friday night.

The post ‘I’m a Natural-Born Killer’: Mike Tyson Highlights the Difference Between Him and YouTuber Jake Paul appeared first on Breitbart.

[Written by Don Burgess] Did you know that one of Bermuda’s first great Olympic hopes is a former world record holder in the International Swimming Hall of Fame? And how he came to represent Bermuda is controversial, and that process will never happen again. Hubert Leonard Spence represented Bermuda at the 1936 Olympic Games in […]

[Written by Patrick Bean] The advantage available to Wesley and George Bryan as trick shot artists on video are staged scenes that allow for multiple takes to be edited into a single, flawlessly constructed final image of perfection. However, there’s a reason why those prone to attempting crazy stunts belying convention rarely make it to […]

Ubersoca Cruise [USC] was awarded “Best Cruise Event of the Year” at the Caribbean Music Awards held recently at the Kings Theater in Brooklyn. A spokesperson said, “Ubersoca Cruise [USC], the world’s premier Caribbean music festival at sea, was awarded ‘Best Cruise Event of the Year’ at the Caribbean Music Awards held recently at the […]

Роже Бенуа, журналист швейцарской газеты Blick, погостил на бразильской ферме семьи Экклстоунов, где был свидетелем и участником весьма любопытных разговоров...

На прошлой неделе в Sauber подтвердили состав на следующий сезон, подписав контракт с Габриэлем Бортолето, который станет напарником Нико Хюлкенберга. Однако по ходу сезона команда интересовалась кандидатурой Кевина Магнуссена, о чём рассказал сам датчанин.

I wrote this in the newsletter about this one… It’s an especially horrible issue, but one I’m intensely proud of. It’s one of those rare books that I think may actually be unique for its genre, and the logical end point of the line of thinking that’s run through all my work in superheroes. Namely, […]

One book out today, being Uber Invasion 3, which is probably the most classically Uber issue I’ve dropped, being primarily focused on a single battle engagement.  Available from your local shop, or Comixology.

Gabriel Bortoleto, 20, will make his Formula One debut for the Audi-owned Sauber next season.

Uber Safari is launching this week, offering riders in Cape Town the opportunity to go on a one-day game drive to a private reserve for $200.

Chorismate mutase (CM), an essential enzyme at the branch-point of the shikimate pathway, is required for the biosynthesis of phenylalanine and tyrosine in bacteria, archaea, plants, and fungi. MtCM, the CM from Mycobacterium tuberculosis, has less than 1% of the catalytic efficiency of a typical natural CM and requires complex formation with 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase for high activity. To explore the full potential of MtCM for catalyzing its native reaction, we applied diverse iterative cycles of mutagenesis and selection, thereby raising kcat/Km 270-fold to 5 × 105 m−1s−1, which is even higher than for the complex. Moreover, the evolutionarily optimized autonomous MtCM, which had 11 of its 90 amino acids exchanged, was stabilized compared with its progenitor, as indicated by a 9 °C increase in melting temperature. The 1.5 Å crystal structure of the top-evolved MtCM variant reveals the molecular underpinnings of this activity boost. Some acquired residues (e.g. Pro52 and Asp55) are conserved in naturally efficient CMs, but most of them lie beyond the active site. Our evolutionary trajectories reached a plateau at the level of the best natural enzymes, suggesting that we have exhausted the potential of MtCM. Taken together, these findings show that the scaffold of MtCM, which naturally evolved for mediocrity to enable inter-enzyme allosteric regulation of the shikimate pathway, is inherently capable of high activity.

Tuberculosis (TB), caused by the infection of Mycobacterium tuberculosis (MTB), is one of the leading causes of death worldwide, especially in children. However, the mechanisms by which MTB infects its cellular host, activates an immune response, and triggers inflammation remain unknown. Mitochondria play important roles in the initiation and activation of the nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) inflammasome, where mitochondria-associated endoplasmic reticulum membranes (MAMs) may serve as the platform for inflammasome assembly and activation. Additionally, mitofusin 2 (MFN2) is implicated in the formation of MAMs, but, the roles of mitochondria and MFN2 in MTB infection have not been elucidated. Using mircroarry profiling of TB patients and in vitro MTB stimulation of macrophages, we observed an up-regulation of MFN2 in the peripheral blood mononuclear cells of active TB patients. Furthermore, we found that MTB stimulation by MTB-specific antigen ESAT-6 or lysate of MTB promoted MFN2 interaction with NLRP3 inflammasomes, resulting in the assembly and activation of the inflammasome and, subsequently, IL-1β secretion. These findings suggest that MFN2 and mitochondria play important role in the pathogen-host interaction during MTB infection.

Natalie Bruiners
Dec 1, 2020; 61:1617-1628
Research Articles

The rise of drug-resistant tuberculosis poses a major risk to public health. Statins, which inhibit both cholesterol biosynthesis and protein prenylation branches of the mevalonate pathway, increase anti-tubercular antibiotic efficacy in animal models. However, the underlying molecular mechanisms are unknown. In this study, we used an in vitro macrophage infection model to investigate simvastatin’s anti-tubercular activity by systematically inhibiting each branch of the mevalonate pathway and evaluating the effects of the branch-specific inhibitors on mycobacterial growth. The anti-tubercular activity of simvastatin used at clinically relevant doses specifically targeted the cholesterol biosynthetic branch rather than the prenylation branches of the mevalonate pathway. Using Western blot analysis and AMP/ATP measurements, we found that simvastatin treatment blocked activation of mechanistic target of rapamycin complex 1 (mTORC1), activated AMP-activated protein kinase (AMPK) through increased intracellular AMP:ATP ratios, and favored nuclear translocation of transcription factor EB (TFEB). These mechanisms all induce autophagy, which is anti-mycobacterial. The biological effects of simvastatin on the AMPK-mTORC1-TFEB-autophagy axis were reversed by adding exogenous cholesterol to the cells. Our data demonstrate that the anti-tubercular activity of simvastatin requires inhibiting cholesterol biosynthesis, reveal novel links between cholesterol homeostasis, the AMPK-mTORC1-TFEB axis, and Mycobacterium tuberculosis infection control, and uncover new anti-tubercular therapy targets.

WALLISELLEN, Switzerland, Nov. 15, 2023 — Hewlett Packard Enterprise (HPE) today announced that Sauber Motorsport AG is partnering with HPE to advance aerodynamics of its Formula One race cars. The […]

The post HPE Unveils Advanced Computational Fluid Dynamics Solutions for Sauber Motorsport appeared first on HPCwire.