Mammographic breast density is a strong risk factor for breast cancer. We comprehensively investigated the associations of body mass index (BMI) change from ages 10, 18, and 30 to age at mammogram with mammographic breast density in postmenopausal women. We used multivariable linear regression models, adjusted for confounders, to investigate the associations of BMI change with volumetric percent density, dense volume, and nondense volume, assessed using Volpara in 367 women. At the time of mammogram, the mean age was 57.9 years. Compared with women who had a BMI gain of 0.1–5 kg/m² from age 10, women who had a BMI gain of 5.1–10 kg/m² had a 24.4% decrease [95% confidence interval (CI), 6.0%–39.2%] in volumetric percent density; women who had a BMI gain of 10.1–15 kg/m² had a 46.1% decrease (95% CI, 33.0%–56.7%) in volumetric percent density; and women who had a BMI gain of >15 kg/m² had a 56.5% decrease (95% CI, 46.0%–65.0%) in volumetric percent density. Similar, but slightly attenuated associations were observed for BMI gain from ages 18 and 30 to age at mammogram and volumetric percent density. BMI gain over the life course was positively associated with nondense volume, but not dense volume. We observed strong associations between BMI change over the life course and mammographic breast density. The inverse associations between early-life adiposity change and volumetric percent density suggest that childhood adiposity may confer long-term protection against postmenopausal breast cancer via its effect of mammographic breast density.

BACKGROUND AND PURPOSE:

Not all tandem occlusions diagnosed on traditional vascular imaging modalities, such as MRA, represent actual complete ICA occlusion. This study aimed to explore the utility of high-resolution vessel wall imaging in identifying true ICA tandem occlusions and screening patients for their suitability for endovascular recanalization.

BACKGROUND AND PURPOSE:

Computed tomography angiography offers a non-invasive alternative to DSA for the assessment of cerebral vasospasm following subarachnoid hemorrhage but there is limited evidence regarding its reliability. Our aim was to perform a systematic review (Part I) and to assess (Part II) the inter- and intraobserver reliability of CTA in the diagnosis of cerebral vasospasm.

BACKGROUND AND PURPOSE:

It is currently not completely clear how well radiologists perform in evaluating large-vessel occlusion on CTA in acute ischemic stroke. The purpose of this study was to investigate potential factors associated with diagnostic error.

Nắm rõ và tuân theo những nguyên tắc thiết kế nội thất dưới đây sẽ giúp bạn tránh được những sai lầm không đáng có trong quá trình lập kế hoạch và triển khai dự án thiết kế nội thất.

Infographic dưới đây giới thiệu một số nguyên tắc cơ bản trong thiết kế nhà bếp hiện đại, góp phần mang tới sự tiện nghi và cảm giác thoải mái cho người nội trợ.

Hào hứng khi mua nhà lần đầu tiên nhưng vì thiếu kinh nghiệm, chủ quan nên nhiều người đã mắc phải sai lầm đáng tiếc. Để việc mua nhà không gây hối tiếc trong tương lai, hãy đảm bảo bạn không mắc phải 9 sai lầm dưới đây:

Giao dịch bất động sản là quá trình phức tạp, trải qua nhiều công đoạn. Nếu nhà đầu tư không cẩn trọng, rất có thể bị mất sạch vốn do vướng phải những giao dịch bất chính, chụp giật.

Khi mua bán bất động sản, khách hàng cần yêu cầu bên bán cung cấp đầy đủ các giấy tờ để chứng minh pháp lý của bất động sản giao dịch. Các giấy tờ đó là gì? Các bước thực hiện giao dịch ra sao?... sẽ được Batdongsan.com.vn trả lời cụ thể qua infographic dưới đây:

Căn hộ chung cư là loại hình nhà ở nằm trong một dự án gồm nhiều căn hộ, quá trình mua bán, chất lượng bàn giao và việc hoàn thiện đều được thực hiện theo hợp đồng ký với chủ đầu tư. Để giúp người mua chung cư lần đầu không bỡ ngỡ, Batdongsan.com.vn tổng hợp những thông tin chính mà người mua cần tìm hiểu trước khi thực hiện giao dịch như sau:

Không phải ai cũng có đủ điều kiện để mua một ngôi nhà mới nên nhiều người chọn mua nhà cũ để tiết kiệm chi phí. Nếu chưa có kinh nghiệm chọn mua nhà cũ, bạn hãy xem 6 lưu ý dưới đây để chọn được ngôi nhà ưng ý:

Tự làm vườn không chỉ tiết kiệm túi tiền mà còn góp phần bảo vệ hành tinh xanh. Hãy thử tái chế những món đồ bỏ đi ở quanh nhà và tạo nên một khu vườn nhỏ gọn, phong cách, phù hợp với mọi không gian.

The Law on Housing of Vietnam allows foreigners to purchase Vietnam property but with strict conditions and procedures as listed in the following infographic.

Generative visuals and eerie sound design based on height maps of glaciers, canyons and estuaries. London-based motion graphic designer Sophie Marschner transforms real-world data into a delicate digital topography in Monolith. By using the height maps of various large-scale landmarks, including glaciers, canyons and estuaries, Marschner maps the outside world into a more intimate, digital […]

The post Sophie Marschner turns real-world data into a digital topography in Monolith appeared first on FACT Magazine.

Tara Reade has claimed in a new interview that Joe Biden used graphic language to proposition her for sex when he allegedly assaulted her in 1993.

Marine biologist Cristina Mittermeier discovered that visual storytelling, rather than data sets, allowed her to be a better advocate for the ocean

Prince Louis has shown his support for the NHS by making a rainbow poster for a series of photographs to mark his second birthday.

Princess Charlotte's fifth birthday has been marked by the release of photographs showing the young royal helping to load a van with food and delivering meals for those in need.

A new biography of Harry and Meghan will "go beyond the headlines" and "reveal unknown details" of the couple's life together.

The Duchess of Cambridge has launched a landmark photographic project to capture the "spirit of the nation" during the coronavirus outbreak.

The mundanity of coronavirus lockdown life is being celebrated in a photography exhibition to raise money for frontline workers.

'We worked very hard to make it feel like it was a real, accurate and truthful representation of sex amongst young people today,' said the actor

As authors from Chaucer to Hollinghurst have shown, sex reveals our emotions, instincts and morals. The question is not why write about sex, claims author Garth Greenwell, it’s why write about anything else?

There is a widely held belief, among English-language writers, that sex is impossible to write about well – or at least much harder to write about well than anything else. I once heard a wonderful writer, addressing students at the Iowa Writers’ Workshop, say that her ideal of a sex scene would be the sentence: “They sat down on the sofa …” followed by white space. This is a prejudice I can’t understand. One of the glories of being a writer in English is that two of our earliest geniuses, Chaucer and Shakespeare, wrote of the sexual body so exuberantly, claiming it for literature and bringing its vocabulary – including all those wonderful four-letter words – into the texture of our literary language. This is a gift not all languages have received; a translator once complained to me that in her language there was only the diction of the doctor’s office or of pornography, neither of which felt native to poetry.

More than this, surely it is absurd to claim that a central activity of human life, a territory of feeling and drama, is off-limits to art. Sex is a uniquely useful tool for a writer, a powerful means not just of revealing character or exploring relationships, but of asking the largest questions about human beings.

Is Australia flattening the curve? We bring together all the latest Covid-19 confirmed cases, maps, stats and graphs from NSW, Victoria, Queensland, SA, WA, Tasmania, ACT and NT to get a broad picture of the Australian outbreak and track the impact of government response.

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Due to the difference in reporting times between states, territories and the federal government, it can be difficult to get a current picture of how many confirmed cases of coronavirus there are in Australia.

Here, we’ve brought together all the figures in one place, along with comparisons with other countries.

The overall winner will be announced in June

With permission, of course

"All of my work has been cancelled [because of the crisis] and I was just missing shooting people and thought it would be a nice way for the community to come together and have a memory of this time.

The German Society for Nature Photography (GDT) has selected its Nature Photographer of the Year 2020.

The winning image is part of a series of photographs taken in Dortmund’s north by Peter Lindel. Compared with many international nature photography hot spots, this region has little to offer. Lindel spent a lot of time and blood, sweat and tears working on this project on his doorstep. It is a beautiful statement about the long-term exploration of a single species and region.

A $2.9 million payout is being challenged in court today after it was found Nationwide News defamed actor Geoffrey Rush in a high-profile case earlier this year.

Acer is joining a flurry of PC makers in adopting the next wave of NVIDIA and Intel chips inside its laptops. It's updating its 15.6-inch Predator Triton 500 (above) and Nitro 5 (below) gaming portables to use NVIDIA's new GeForce RTX Super laptop GPUs as well as Intel's 10th-generation Core H-series processors. As you might guess, the premium Predator series is the highlight. It comes with up to a GeForce RTX 2080 Super Max-Q to deliver speedier and more efficient graphics, and mates that with a 300Hz, 3ms response IPS display and per-key RGB keyboard lighting.

Lenovo is leaping quickly on the latest NVIDIA and Intel technology for its gaming laptops. It's introducing Legion 5i and Legion 7i portables (successors to the Y540 and Y740 respectively) that, most notably, are among the first to use NVIDIA's Advanced Optimus graphics switching. The tech both lowers power consumption in less-intensive moments and ramps up performance in GPU-heavy situations, theoretically giving you added battery life and higher frame rates in the same package. The Legion 7i also touts the option of new GeForce RTX 2080 Super Max-Q graphics if you insist on the best possible visuals.

"It was a very special honor."

The Duchess of Cambridge has teamed up with the National Portrait Gallery to launch the Hold Still project.

In this week's Royal Rota, our team discuss the Duchess of Cambridge's latest volunteer work and Princess Charlotte birthday celebrations.

An ANU demographer is "concerned" the coronavirus pandemic will result in an accelerated reduced birthrate and a decline in future taxpayers, affecting Australia's socioeconomic future.

Veteran Times journalist Jim Newton's graceful "Man of Tomorrow: The Relentless Life of Jerry Brown" doubles as a history of postwar California.

By: Stacy Ehrlich and Justine E. Johnson On March 18, 2020, the Food and Drug Administration (FDA) published a final rule (21 C.F.R. Part 1141) requiring textual and graphic health warnings to be included on all cigarette packages and advertisements.[1]  FDA simultaneously published two related guidance documents: (1) Required Warnings for Cigarette Packages and Advertisements,

The post FDA ISSUES FINAL RULE ON GRAPHIC WARNINGS FOR CIGARETTE PACKAGES AND ADVERTISEMENTS appeared first on Kleinfeld Kaplan & Becker LLP.

By: Daniel Dwyer and Daniel Logan On March 27, 2020, the President signed into law the Coronavirus Aid, Relief, and Economic Security Act, or “CARES” Act (Pub. Law 116-136), which includes a comprehensive revision of the rules governing over-the-counter (OTC) drugs currently marketed under monographs published by the Food and Drug Administration (FDA).  This law

The post New Opportunities for OTC Monograph Drugs under the CARES Act appeared first on Kleinfeld Kaplan & Becker LLP.

Novartis has revealed that the European Commission has moved to approve Cosentyx (secukinumab) for the treatment of active non-radiographic axial spondyloarthritis (nr-axSpA) in adult patients.

Theodore Allan, 54, of Glendale, Ariz., was sentenced today to five years in prison for distribution of child pornography. Allan was indicted on charges of distribution, receipt and possession of child pornography on March 6, 2007.

Terry Brian Dobbs, an Oklahoma businessman, was sentenced today to 11 years in prison for receiving images of child pornography. Dobbs, 51, was also sentenced to lifetime supervised release following his term in prison by U.S. District Judge Gregory Frizzel, and was ordered to pay an $8,000 fine.

Harris Taubman, of Hyannis, Mass., pleaded guilty today in U.S. District Court in Boston to receiving and possessing child pornography. Taubman, 48, pleaded before U.S. District Judge William G. Young to three counts of receipt of child pornography and one count of possession of child pornography. He was indicted on those charges on Feb. 6, 2008.

Timothy Christenbury, of Charlotte, N.C., pleaded guilty today to possessing child pornography. Christenbury, 46, pleaded guilty before U.S. Magistrate Judge Carl Horn III to one count of possession of child pornography. He was indicted on those charges on Dec. 16, 2008. According to the indictment, Christenbury possessed computer files containing child pornography from on or about Sept. 2 to Sept. 4, 2007.

Jack A. Taylor, 68, a resident of Rolling Springs, Ky., pleaded guilty today to producing child pornography and was sentenced to 20 years in prison. Taylor, appearing before U.S. District Court Judge David F. Hamilton in Indianapolis, was also ordered to serve a lifetime of supervised release following completion of his prison term, forfeit all items seized during the investigation that were used to commit his offense, and to pay $4,000 in restitution to his victim.

“John Doe 17,” a white male with curly brown hair weighing approximately 210-250 pounds, has been indicted by a federal grand jury for transporting child pornography via the Internet on or about May 5, 2007. This is the seventeenth such case to be investigated and the twelfth prosecuted through the Endangered Child Alert Program (ECAP), which was initiated by the Criminal Division’s Child Exploitation and Obscenity Section (CEOS) and the FBI in 2004. The program uses national and international media exposure of unknown adult perpetrators featured in child pornography in an effort to identify, locate, apprehend and prosecute such offenders and to rescue abused children.

Carl Courtright III, of Granite City, Ill., was convicted today on child pornography and bank fraud charges in the Southern District of Illinois following a five-day jury trial. The federal jury convicted Courtright of one count of production of child pornography, two counts of possession of child pornography, one count of receipt of child pornography, as well as one count of bank fraud.

Charles Brown, 54, of Mesa, Ariz., pleaded guilty today to one count of receiving child pornography. During the plea hearing before U.S. District Judge Paul G. Rosenblatt, Brown admitted to receiving child pornography.