"If Jupiter doesn’t have a surface, what does it have? "

Viewers were left stunned by ‘savage’ exit of character in first episode of new season

A dome-shaped device floating in Halifax’s Northwest Arm could easily be confused with a buoy, but it is actually a contraption meant to turn ocean water into fresh water. Two Dalhousie University researchers hope it can help with water scarcity in the real world.

The United States has a wide range of climate zones, from the subtropical to the arctic. On the low end of the thermometer, there are plenty of options for a deep winter chill. Here, we look at a couple different ways to determine the coldest state in the U.S. — and by both definitions, there's one winner.

Black Friday is right around the corner and the deals are already coming in hot. You can pick up a four-pack of Apple AirTags for just $70, as an early Black Friday promotion. This is a discount of 30 percent and represents a record low price.

Apple AirTags easily made our list of the best Bluetooth trackers, particularly for regular iPhone users. We love the vast finding network, which really helps when you misplace a tag. Just think of all of those AirTags, iPhones and other Apple devices out there helping to create this network.

Apple AirTags also offer the ability to tap into the ultra-wideband (UWB) wireless protocol. This creates a sort of game out of finding lost items, as long as the object is within 25 feet of the phone. The screen will display directional arrows and a distance meter so you can zero in on the lost item without having to ring the AirTag.

There are some caveats. These trackers only really work with iPhones, so Android users should buy something else. Also, the ringer only goes for seven seconds at a time, which isn’t always enough time to track something down. Finally, there’s no attachment point for connecting to a keychain or a related item. However, there are plenty of good AirTag accessories to solve that problem.

Check out all of the latest Black Friday and Cyber Monday deals here.

This article originally appeared on Engadget at https://www.engadget.com/deals/a-four-pack-of-apple-airtags-drops-to-a-record-low-of-70-in-this-black-friday-deal-191040686.html?src=rss

Cineplex Inc. says it will continue adding a fee to some online ticket purchases after being penalized earlier this fall for alleged deceptive marketing, but it will adjust how the charge is communicated to moviegoers.

Deputy Prime Minister Chrystia Freeland is reassuring Canadians as officials worry president-elect Donald Trump’s promise to deport millions of undocumented immigrants could send them northward.

THE stocks of cattle exporter Wellard have crashed.

The rate of unemployment stood at 4.3% in the three months to September, up from 4% the previous quarter.

Today’s guest post comes from Shabbir Ahmed, Chief Commercial Officer at CareMetx.

Shabbir explains the barriers that providers face when dealing with branded portals for multiple products. He then maintains that patients can access new therapies more quickly when the manufacturer relies on a brand-agnostic hub connected to a large network of providers and integrated with the systems those providers use daily.

To learn more, download CareMetx’s new 2024 Patient Services Report: Revealing Manufacturer Priorities: Patients Naturally Take Center Stage.

Read on for Shabbir’s insights.
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<p> <b>Abstract</b><br />CinnaGen, the largest biopharmaceutical company in the MENA region, is a leader in developing follow-on biologicals/biosimilars. Dr&nbsp;Haleh Hamedifar, Chairperson of CinnaGen, spoke to GaBI<i>&nbsp;</i>(Generics and Biosimilars Initiative) about the company’s strategic focus, which includes expanding its product portfolio, entering highly regulated global markets, and advancing affordable treatments for conditions such as multiple sclerosis and&nbsp;immunological diseases—transforming healthcare in underserved regions.</p><p><b>Keywords</b>: Biosimilars, clinical development, commercialization, MENA</p>

The General Pharmaceutical Council has said it is “double, treble, quadruple-checking” for any “flexibility” that would allow all overseas candidates to sit the March 2021 registration assessment exam in their countries of residence.

The General Pharmaceutical Council has said most candidates living in countries with a two-hour or more time difference from the UK will be able to apply to sit the registration assessment at home.

Community pharmacies able to administer up to 400 COVID-19 vaccines per week can now apply to become designated vaccination sites, NHS England has said.

The Wall Street Journal has an interesting article on the use of “Big Data” to identify and solicit potential clinical trial participants. The premise is that large consumer data aggregators like Experian can target patients with certain diseases through correlations with non-health behavior. Examples given include “a preference for jazz” being associated with arthritis and “shopping online for clothes” being an indicator of obesity.

We've seen this story before.

In this way, allegedly, clinical trial patient recruitment companies can more narrowly target their solicitations* for patients to enroll in clinical trials.

In the spirit of full disclosure, I should mention that I was interviewed by the reporter of this article, although I am not quoted. My comments generally ran along three lines, none of which really fit in with the main storyline of the article:

1. I am highly skeptical that these analyses are actually effective at locating patients
   
2. These methods aren't really new – they’re the same tactics that direct marketers have been using for years
   
3. Most importantly, the clinical trials community can – and should – be moving towards open and collaborative patient engagement. Relying on tactics like consumer data snooping and telemarketing is an enormous step backwards.

The first point is this: certainly some diseases have correlates in the real world, but these correlates tend to be pretty weak, and are therefore unreliable predictors of disease. Maybe it’s true that those struggling with obesity tend to buy more clothes online (I don’t know if it’s true or not – honestly it sounds a bit more like an association built on easy stereotypes than on hard data). But many obese people will not shop online (they will want to be sure the clothes actually fit), and vast numbers of people with low or average BMIs will shop for clothes online.  So the consumer data will tend to have very low predictive value. The claims that liking jazz and owning cats are predictive of having arthritis are even more tenuous. These correlates are going to be several times weaker than basic demographic information like age and gender. And for more complex conditions, these associations fall apart.

Marketers claim to solve this by factoring a complex web of associations through a magical black box – th WSJ article mentions that they “applied a computed algorithm” to flag patients. Having seen behind the curtain on a few of these magic algorithms, I can confidently say that they are underwhelming in their sophistication. Hand-wavy references to Big Data and Algorithms are just the tools used to impress pharma clients. (The down side to that, of course, is that you can’t help but come across as big brotherish – see this coverage from Forbes for a taste of what happens when people accept these claims uncritically.)

But the effectiveness of these data slice-n-dicing activities is perhaps beside the point. They are really just a thin cover for old-fashioned boiler room tactics: direct mail and telemarketing. When I got my first introduction to direct marketing in the 90’s, it was the exact same program – get lead lists from big companies like Experian, then aggressively mail and call until you get a response.

The limited effectiveness and old-school aggressiveness of these programs comes is nicely illustrated in the article by one person’s experience:

Larna Godsey, of Wichita, Kan., says she received a dozen phone calls about a diabetes drug study over the past year from a company that didn't identify itself. Ms. Godsey, 63, doesn't suffer from the disease, but she has researched it on the Internet and donated to diabetes-related causes. "I don't know if it's just a coincidence or if they're somehow getting my information," says Ms. Godsey, who filed a complaint with the FTC this year.

The article notes that one recruitment company, Acurian, has been the subject of over 500 FTC complaints regarding its tactics. It’s clear that Big Data is just the latest buzzword lipstick on the telemarketing pig. And that’s the real shame of it.

We have arrived at an unprecedented opportunity for patients, researchers, and private industry to come together and discuss, as equals, research priorities and goals. Online patient communities like Inspire and PatientsLikeMe have created new mechanisms to share clinical trial opportunities and even create new studies. Dedicated disease advocates have jumped right into the world of clinical research, with groups like the Cystic Fibrosis Foundation and Michael J. Fox Foundation no longer content with raising research funds, but actively leading the design and operations of new studies.

Some – not yet enough – pharmaceutical companies have embraced the opportunity to work more openly and honestly with patient groups. The scandal of stories like this is not the Wizard of Oz histrionics of secret computer algorithms, but that we as an industry continue to take the low road and resort to questionable boiler room tactics.

It’s past time for the entire patient recruitment industry to drop the sleaze and move into the 21st century. I would hope that patient groups and researchers will come together as well to vigorously oppose these kinds of tactics when they encounter them.

Learn how to take simple x/y coordinates, and create map polygons shaped like holiday images, that can be plotted using SAS/Graph's PROC GMAP.

Aug 1, 2023

Using the private journals of commission secretaries Henry Marie Brackenridge and Dr. William Baldwin, as well as Captain Sinclair, this chapter will explore the establishment of American naval identity through its diplomatic experiences in South America. It will also exhibit the role of the U.S. Navy in a proto framework of the Monroe Doctrine.

Jul 17, 2023

Apekshya Prasai, a political science doctoral candidate at the Massachusetts Institute of Technology, was recently named a 2023 Harry Frank Guggenheim Foundation Emerging Scholar.   The Emerging Scholars (nine in all) are doctoral candidates who are in the final year of writing dissertations on the nature of and responses to violence around the world.

Apr 12, 2024

The share of Russians who would like to leave Russia for permanent residence in another country has reached a record low, according to the results of a national poll conducted by Russia’s Levada Center on March 21-27, 2024.  Of the countries Russians were eager to relocate to, the U.S. topped the list (11%), followed by Germany (8%) and Italy and Turkey (6% each). China ranked 10-11 along with Canada.That seven out of the top 11 countries Russians would like to relocate to are members of the collective West, with 46% interested in moving to these countries, also shows the limits of the Kremlin’s efforts to instill anti-Western sentiments in the Russian public.

Trans-Atlantic Information Flow

Video 1 Preview Image Caption

The Thumb Loop system is designed to meet the maximum wind energy potential of Michigan�s Thumb region as well as contribute to regional system reliability and facilitate wholesale market competition.

No Blank Screens, London

Former star or ABC�s The Bachelorette Ali Fedotowsky and [ yellow tail ], America�s go-to holiday wine, team up to Spread Holiday Cheer in New York City to kick-off [yellow tail ] wine�s 12 Days of Giveaways. Starting Tuesday, Dec. 8, 2015, people can visit Facebook.com/yellowtail to find out more ways to win exciting prizes.

Oklahoma Tornado Update

Power washing is made even easier with POWERflow+ Technology by Briggs & Stratton. This pressure washer allows you to do deep cleaning, remove mold and mildew and reach second stories.

Autotrader just announced the list of 2016 Must Test Drive vehicles. NASCAR driver Brad Keselowski�s #2 racecar is not on the list�and he thinks it should be. Find out why.

Praised as the most beautiful countryside in China, the unique view of shaiqiu can only be found in Huangling village where baskets of colorful harvest bask in the sunshine.

Buy a new Clayton home and receive gift cards from Lowe�s* to build your dream backyard.

Virginia Bioinformatics Institute Video Case Study

They created their own path. Will you create yours?

Cooking Lesson

Long COVID has made the last couple of months quite difficult for me. I supposed it’s inaccurate to say that slowing down has been hard for me to do, because I haven’t been given a choice in the matter. What’s been difficult is adapting, adjusting, and ultimately accepting the slow-down.

For those just catching up on the old news, I contracted COVID back in “wave zero,” the community-spread wave in late January of 2020 when none of us thought the virus was here yet. I was the father of the bride at a wedding whose guests included a family who had guests in their home who had recently arrived from Wuhan province in China. I got better, but I never got all the way better, and I’ve been dealing with chronic fatigue ever since.

The salient point: I want to do more than I am doing. I mean, sure, I want to do more than I am *able* to do, which is a pretty common desire among humans of all stripes, but especially among those whose abilities have been, for whatever reason, reduced in scope.

So what *am* I doing? Well, today I’m writing this, and then diving back into the marginalia for Book 18, which we can’t send to the printer until it has all its marginalia. A lot of the pieces are things like this one – concept sketches which I’ve revisited digitally and cleaned up so they look nicer.

The marginalia is a necessity born of the fact that Schlock Mercenary was not originally formatted for print. Comics should be written and illustrated to the page turn, with attention given to the reveal that occurs as the reader turns the page and uncovers the art and dialog of the next spread. I say “should” be because Schlock Mercenary definitely is NOT written that way.

When we put it into print, we can fit four regular-sized strips on a single page of the book. A week of strips has nine of these rectangular collections of panels, because Sundays have three, and those last three strips in the week need to all be on the same page. Since no amount of fudging the math will make 9 cleanly divisible by 4, a week of Schlock Mercenary takes up three pages of book, and those three pages have some white space.

Hence the marginalia. Sometimes a weekday installment is extra large, sometimes there’s a footnote, and sometimes I broke the pattern in other ways, and so sure, sometimes the white space has taken care of itself, but sometimes my layout shenanigans mean an entire half-page of the book needs a new picture.

So that’s what I’m working on. I wish I could do more, or do it faster, and maybe the booster shot I got two days ago will perk me up the way previous booster shots have, but I’m not going to wait for a cure before I get back to work. I’m just going to accept that I have to slow down.

As Yellowstone Season 5 Part 2 continues, fans are eagerly tuning in to catch each new episode. With Episode 9 kicking off Part 2, viewers are curious about the Yellowstone Season 5 episode release schedule and want to know how many episodes remain. Each installment builds suspense, showcasing the Dutton family’s battle for land and […]

The post How Many Episodes of Yellowstone Season 5 Part 2 Are Left? Schedule Explained appeared first on ComingSoon.net - Movie Trailers, TV & Streaming News, and More.

Yellowstone recently started airing part 2 of its fifth season. It resumes the journey of the Dutton’s to protect their ranch triggering high-voltage drama and entertainment. However, the most shocking aspect of the season was the death of the family’s patriarch, John Dutton. So, who killed John Dutton in Yellowstone Season 5? Here is everything […]

The post Yellowstone Season 5: Who Killed John Dutton? Jamie, Sarah or Beth? appeared first on ComingSoon.net - Movie Trailers, TV & Streaming News, and More.

The American Trucking Associations (ATA) expressed what it called its “grave concerns” about media reports that the Environmental Protection Agency (EPA) may be on the verge of granting the state of California waivers to implement potentially harmful and unrealistic emissions rules on the industry. Under California rules, new Class 8 heavy truck models would be zero-emission next year. Diesel and gasoline-powered drayage trucks must retire after 18 years to guarantee that they meet a zero-emission requirement by 2035.

Golden slices of summer squash and kernels of corn are baked in a creamy sauce and topped with bread crumbs in this Southern-style vegan squash casserole. It’s the perfect summer side dish. Hi, my name is Susan, and I’m a vegan. It’s been so long since I updated this blog that I only half-humorously feel...

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The post Vegan Yellow Squash and Corn Casserole appeared first on FatFree Vegan Kitchen.

Bathe “Avalon” “Avalon” is a song about wanting to be somewhere else. You can go a few different directions with that idea – like, you could focus on conveying discomfort, dissatisfaction, a burning desire to get out of your current setting. The R&B duo Bathe opted for evoking the place they’d rather be. The music […]

Being the big fan of Netflix that I am, I jumped at the chance to watch a new series from the same people who did Orange Is the New Black. I am now requesting every single one of you go see GLOW. It is, as this T-shirt suggests, a GLORIOUS way to spend your time. And after you get done watching a few episodes, go ahead and buy this T-shirt, 'cause you're gonna want to brag to all of your friends that you're up on the awesomest show on Netflix. $22 | URL | Paypal Credit | S - 3XL ')}

Look at this glorious work of art from artist Rocky Davies. And he's seen fit to put this work of art on a T-shirt? Amazing. This amazing piece conjures a time between the '80s and '90s when Batman was happy and weird and apparently had a swimmer's body. Wrap this fantastic cloth around your torso so that you can proclaim "I remember when George Clooney was Batman!" And why wouldn't you want to proclaim that? That was a glorious time in cinematic history. $19.95 | URL | Paypal Credit | S - 2XL ')}

Unique low-profile keyboard crafted by Ben Fryc...

The post The Knob 1 low-profile keyboard first appeared on peopleofdesign.