BACKGROUND:Pulmonary function tests (PFTs) have historically used race-specific prediction equations. The recent American Thoracic Society guidelines recommend the use of a race-neutral approach in prediction equations. There are limited studies centering the opinions of practicing pulmonologists on the use of race in spirometry. Provider opinion will impact adoption of the new guideline. The aim of this study was to ascertain the beliefs of academic pulmonary and critical care providers regarding the use of race as a variable in spirometry prediction equations.METHODS:We report data from 151 open-ended responses from a voluntary, nationwide survey (distributed by the Association of Pulmonary Critical Care Medicine Program Directors) of academic pulmonary and critical care providers regarding the use of race in PFT prediction equations. Responses were coded using inductive and deductive methods, and a thematic content analysis was conducted.RESULTS:There was a balanced distribution of opinions among respondents supporting, opposing, or being unsure about the incorporation of race in spirometry prediction equations. Responses demonstrated a wide array of understanding related to the concept and definition of race and its relationship to physiology.CONCLUSIONS:There was no consensus among providers regarding the use of race in spirometry prediction equations. Concepts of race having biologic implications persist among pulmonary providers and will likely affect the uptake of the Global Lung Function Initiative per the American Thoracic Society guidelines.

Introduction

Exacerbation of COPD complicated by respiratory acidaemia is the commonest indication for noninvasive ventilation (NIV). The NIV outcomes (NIVO) score offers the best estimate of survival for those ventilated. Unfortunately, two-thirds of cases of COPD are unrecognised, and patients may present without COPD having been confirmed by spirometry.

ABSTRACTIntroduction:Health risks associated with short interpregnancy intervals, coupled with women’s desires to avoid pregnancy following childbirth, underscore the need for effective postpartum family planning programs. The antenatal period provides an opportunity to intervene; however, evidence is limited on the effectiveness of interventions aimed at reaching women in the antenatal period to increase voluntary postpartum family planning in low- and middle-income countries (LMICs). This systematic review aimed to identify and describe interventions in LMICs that attempted to increase postpartum contraceptive use via contacts with pregnant women in the antenatal period.Methods:Studies published from January 2012 to July 2022 were considered if they were conducted in LMICs, evaluated an intervention delivered during the antenatal period, were designed to affect postpartum contraceptive use, were experimental or quasi-experimental, and were published in French or English. The main outcome of interest was postpartum contraceptive use within 1 year after birth, defined as the use of any method of contraception at the time of data collection. We searched EMBASE, Global Health, and Medline and manually searched the reference lists from studies included in the full-text screening.Results:We double-screened 771 records and included 34 reports on 31 unique interventions in the review. Twenty-three studies were published from 2018 on, with 21 studies conducted in sub-Saharan Africa. Approximately half of the study designs (n=16) were randomized controlled trials, and half (n=15) were quasi-experimental. Interventions were heterogeneous. Among the 24 studies that reported on the main outcome of interest, 18 reported a positive intervention effect, with intervention recipients having greater contraceptive use in the first year postpartum.Conclusion:While the studies in this systematic review were heterogeneous, the findings suggest that interventions that included a multifaceted package of initiatives appeared to be most likely to have a positive effect.

Low-efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics with improved safety relative to high-efficacy opioids. This study used a recently validated assay of pain-depressed behavior in mice to evaluate a novel series of MOR-selective C9-substituted phenylmorphan opioids with graded MOR efficacies. Intraperitoneal injection of dilute lactic acid (IP acid) served as a noxious stimulus to depress locomotor activity by mice in an activity chamber composed of two compartments connected by an obstructed door. Behavioral measures included (1) crosses between compartments (vertical activity over the obstruction) and (2) movement counts quantified as photobeam breaks summed across compartments (horizontal activity). Each drug was tested alone and as a pretreatment to IP acid. A charcoal-meal test and whole-body-plethysmography assessment of breathing in 5% CO₂ were also used to assess gastrointestinal (GI) inhibition and respiratory depression, respectively. IP acid produced a concentration-dependent depression in crosses and movement that was optimally alleviated by intermediate- to low-efficacy phenylmorphans with sufficient efficacy to produce analgesia with minimal locomotor disruption. Follow-up studies with two low-efficacy phenylmorphans (JL-2-39 and DC-1-76.1) indicated that both drugs produced naltrexone-reversible antinociception with a rapid onset and a duration of ~1 h. Potency of both drugs increased when behavior was depressed by a lower IP-acid concentration, and neither drug alleviated behavioral depression by a non-pain stimulus (IP lithium chloride). Both drugs produced weaker GI inhibition and respiratory depression than fentanyl and attenuated fentanyl-induced GI inhibition and respiratory depression. Results support further consideration of selective, low-efficacy MOR agonists as candidate analgesics.

BACKGROUND AND PURPOSE:

Low-field 64 mT portable brain MRI has recently shown diagnostic promise for MS. This study aimed to evaluate the utility of portable MRI (pMRI) in assessing dissemination in space (DIS) in patients presenting with optic neuritis and determine whether deploying pMRI in the MS clinic can shorten the time from symptom onset to MRI.

BACKGROUND AND PURPOSE:

Percutaneous cement augmentation has been reported as an effective salvage procedure for frail patients with spinal instrumentation failure, such as screw loosening, hardware breakage, cage subsidence, and fractures within or adjacent to stabilized segments. Favorable results were reported during a median follow-up period of 16 months in a retrospective analysis of 31 consecutive procedures performed in 29 patients. In the present study, the long-term effectiveness of this treatment in avoiding or postponing revision surgery is reported.

BACKGROUND AND PURPOSE:

Neuronal ceroid lipofuscinoses are a group of neurodegenerative disorders. Recently, enzyme replacement therapy (ERT) was approved for neuronal ceroid lipofuscinosis type 2 (CLN2), a subtype of neuronal ceroid lipofuscinoses. The aim of this study was to quantify brain volume loss in CLN2 disease in patients on ERT in comparison with a natural history cohort using MRI.

BACKGROUND AND PURPOSE:

Gadolinium-based contrast agents are widely used for meningioma imaging; however, concerns exist regarding their side effects, cost, and environmental impact. At the standard gadolinium dose, most meningiomas show avid contrast enhancement, suggesting that administering a smaller dose may be feasible. The purpose of this study was to evaluate the impact of a lower gadolinium dose on the differentiation between meningiomas and adjacent intracranial tissues.

BACKGROUND AND PURPOSE:

Prediction of aneurysm instability is crucial to guide treatment decisions and to select appropriate patients with unruptured intracranial aneurysms (IAs) for preventive treatment. High-resolution 4D MR flow imaging and 3D quantification of aneurysm morphology could offer insights and new imaging markers for aneurysm instability. In this cross-sectional study, we aim to identify 4D MR flow imaging markers for aneurysm instability by relating hemodynamics in the aneurysm sac to 3D morphologic proxy parameters for aneurysm instability.

Pilocytic astrocytomas are the most common pediatric brain tumors, typically presenting as low-grade neoplasms. We report two cases of pilocytic astrocytoma with atypical tumor progression. Case 1 involves a 12-yr-old boy with an unresectable suprasellar tumor, negative for BRAF rearrangement but harboring a BRAF p.V600E mutation. He experienced tumor size reduction and stable disease following dabrafenib treatment. Case 2 describes a 6-yr-old boy with a thalamic tumor that underwent multiple resections, with no actionable driver detected using targeted next-generation sequencing. Whole-genome and RNA-seq analysis identified an internal tandem duplication in FGFR1 and RAS pathway activation. Future management options include FGFR1 inhibitors. These cases demonstrate the importance of escalating molecular diagnostics for pediatric brain cancer, advocating for early reflexing to integrative whole-genome sequencing and transcriptomic profiling when targeted panels are uninformative. Identifying molecular drivers can significantly impact treatment decisions and improve patient outcomes.

A nudibranch from the midnight zone has fingers on its tail, collects food with a hood, and glows.

The City of Vancouver council has reneged on a previous commitment to a living wage for its employees.

The post City of Vancouver to lowest paid workers: Let them eat cuts! appeared first on rabble.ca.

Ministers must follow the UK Government and extend rates relief for businesses in Scotland, Anas Sarwar has said.

Emergency services were called to the Glebe Place area of the town

It's just the core trio this week, as Chris tosses a coin to his hunting horn partner Kelley, and Anna Marie rolls her eyes as Chris cracks terrible jokes about what the Vita really means. We all consider MiHoYo's bottom line, as well as whether we're classified as normies.

The post RPG Cast – Episode 580: “Marshmallow Is Canon” appeared first on RPGamer.

I've spent quite a lot of today trying to figure out why, exactly, some of the monsters in the Monster Hunter Wilds beta looked like bundles of copulating pyramids slathered in crocodile gravy. Nic clued me in on this reddit thread earlier, which cites unnamed Chinese players who've allegedly data-mined the beta's monster models, and learned that they are extremely large, encompassing hundreds of thousands of polygons.

If every monster in Monster Hunter Wilds were that fancy all of the time, your computer would become a volcano. As such, the game resorts to loading-on-demand systems to ensure that you only see those gorgeous details when the monsters are close by and, as the case may be, angrily sitting on you. When they're further afield, the flourishes fall away to free up memory and processing power. The popular Redditor explanation for the presence of monsters that look like Henry Moore sculpture is basically that the LOD systems are being forgetful, and neglecting to load the additional polygons at proximity.

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A DWP employee who has been working in the welfare system for 42 years has shared some key advice for new claims for the likes of PIP and Attendance Allowance

The long-standing mystery of how supermassive black holes grew so huge so quickly could be solved by decaying dark matter

A Spot robot equipped with a blowtorch can locate weeds on farms and precisely heat them up to stop them growing, offering a possible alternative to herbicides

A newly identified smartphone vulnerability can reveal the floor plans of where you are and what you are doing - and it is possible that companies or intelligence agencies are already making use of it

Autonomous taxis are already operating on US streets, while Elon Musk has spent years promising a self-driving car and failing to deliver. The newly announced Tesla Cybercab is unlikely to change that

Gary is up to his usual schtick with Dani. Will he or the new stews ever learn? (Don’t answer that.)

Maryland's new education chief, Carey Wright, an old-school champion of rigorous standards, is pushing back against efforts in other states to boost test scores by essentially lowering their exp

Scientists say geoengineering, or doing things like intentionally increasing Earth’s reflectivity or blocking the sun, is a “really big deal” in slowing down climate change. Here are the ideas they are proposing.

Two large grizzly bears followed 13 hikers down a trail in Banff National Park for 20 minutes — with one even making a few quick runs at the group.

A new Government Accountability Office report says that the Justice Department kept FBI employees in the dark for seven years after Congress updated whistleblower protections for bureau personnel in 2016.

A coronal mass ejection could strike the Earth's magnetosphere this week and cause a geomagnetic storm due to conditions caused by the autumnal equinox.

The spy writing star, whose series has become a huge television hit starring Gary Oldman, is to chair the Theakston Old Peculier Crime Writing Festival 2025

An accurate description of low-density nuclear matter is crucial for explaining the physics of neutron star crusts, according to a team of theoretical physicists led by Argonne National Laboratory’s Dr. Alessandro Lovato.

The post Physicists Find Evidence for Superfluidity in Low-Density Neutron Matter appeared first on Sci.News: Breaking Science News.

Despite the limitations of Alzheimer's drugs like lecanemab, this new class of treatments and a group of experimental vaccines are paving the way to a world without dementia

Medical clowns, who play with children in hospitals, may help them be discharged sooner by reducing their heart rates

While the 20th century saw rapid rises in average life expectancy at birth, more recent years have seen a slowdown, suggesting we may be reaching the limit of human lifespan

Popular weight-loss medications including Ozempic and Wegovy contain a drug that seems to decrease cravings for food and drugs – and now there’s evidence that it might make exercise less rewarding, too

Filters on commercial flights seem to stop peanut particles from circulating around aircraft, making the risk of a serious allergic reaction from inhaling the allergens very low

The Canadian women's soccer team was implicated in a drone scandal this past summer. But, an investigation determined drone use against opponents, predated the Paris Olympics.

Research expeditions conducted at sea using a rotating gravity machine and microscope found that the Earth’s oceans may not be absorbing as much carbon as researchers have long thought.

Oceans are believed to absorb roughly 26 percent of global carbon dioxide emissions by drawing down CO₂ from the atmosphere and locking it away. In this system, CO₂ enters the ocean, where phytoplankton and other organisms consume about 70 percent of it. When these organisms eventually die, their soft, small structures sink to the bottom of the ocean in what looks like an underwater snowfall.

This “marine snow” pulls carbon away from the surface of the ocean and sequesters it in the depths for millennia, which enables the surface waters to draw down more CO₂ from the air. It’s one of Earth’s best natural carbon-removal systems. It’s so effective at keeping atmospheric CO₂ levels in check that many research groups are trying to enhance the process with geoengineering techniques.

But the new study, published on 11 October in Science, found that the sinking particles don’t fall to the ocean floor as quickly as researchers thought. Using a custom gravity machine that simulated marine snow’s native environment, the study’s authors observed that the particles produce mucus tails that act like parachutes, putting the brakes on their descent—sometimes even bringing them to a standstill.

The physical drag leaves carbon lingering in the upper hydrosphere, rather than being safely sequestered in deeper waters. Living organisms can then consume the marine snow particles and respire their carbon back into the sea. Ultimately, this impedes the rate at which the ocean draws down and sequesters additional CO₂ from the air.

The implications are grim: Scientists’ best estimates of how much CO₂ the Earth’s oceans sequester could be way off. “We’re talking roughly hundreds of gigatonnes of discrepancy if you don’t include these marine snow tails,” says Manu Prakash, a bioengineer at Stanford University and one of the paper’s authors. The work was conducted by researchers at Stanford, Rutgers University in New Jersey, and Woods Hole Oceanographic Institution in Massachusetts.

Oceans Absorb Less CO₂ Than Expected

Researchers for years have been developing numerical models to estimate marine carbon sequestration. Those models will need to be adjusted for the slower sinking speed of marine snow, Prakash says.

The findings also have implications for startups in the fledgling marine carbon geoengineering field. These companies use techniques such as ocean alkalinity enhancement to augment the ocean’s ability to sequester carbon. Their success depends, in part, on using numerical models to prove to investors and the public that their techniques work. But their estimates are only as good as the models they use, and the scientific community’s confidence in them.

“We’re talking roughly hundreds of gigatonnes of discrepancy if you don’t include these marine snow tails.” —Manu Prakash, Stanford University

The Stanford researchers made the discovery on an expedition off the coast of Maine. There, they collected marine samples by hanging traps from their boat 80 meters deep. After pulling up a sample, the researchers quickly analyzed the contents while still on board the ship using their wheel-shaped machine and microscope.

The researchers built a microscope with a spinning wheel that simulates marine snow falling through sea water over longer distances than would otherwise be practical.Prakash Lab/Stanford

The device simulates the organisms’ vertical travel over long distances. Samples go into a wheel about the size of a vintage film reel. The wheel spins constantly, allowing suspended marine-snow particles to sink while a camera captures their every move.

The apparatus adjusts for temperature, light, and pressure to emulate marine conditions. Computational tools assess flow around the sinking particles and custom software removes noise in the data from the ship’s vibrations. To accommodate for the tilt and roll of the ship, the researchers mounted the device on a two-axis gimbal.

Slower Marine Snow Reduces Carbon Sequestration

With this setup, the team observed that sinking marine snow generates an invisible halo-shaped comet tail made of viscoelastic transparent exopolymer—a mucus-like parachute. They discovered the invisible tail by adding small beads to the seawater sample in the wheel, and analyzing the way they flowed around the marine snow. “We found that the beads were stuck in something invisible trailing behind the sinking particles,” says Rahul Chajwa, a bioengineering postdoctoral fellow at Stanford.

The tail introduces drag and buoyancy, doubling the amount of time marine snow spends in the upper 100 meters of the ocean, the researchers concluded. “This is the sedimentation law we should be following,” says Prakash, who hopes to get the results into climate models.

The study will likely help models project carbon export—the process of transporting CO₂ from the atmosphere to the deep ocean, says Lennart Bach, a marine biochemist at the University of Tasmania in Australia, who was not involved with the research. “The methodology they developed is very exciting and it’s great to see new methods coming into this research field,” he says.

But Bach cautions against extrapolating the results too far. “I don’t think the study will change the numbers on carbon export as we know them right now,” because these numbers are derived from empirical methods that would have unknowingly included the effects of the mucus tail, he says.

Marine snow may be slowed by “parachutes” of mucus while sinking, potentially lowering the rate at which the global ocean can sequester carbon in the depths.Prakash Lab/Stanford

Prakash and his team came up with the idea for the microscope while conducting research on a human parasite that can travel dozens of meters. “We would make 5- to 10-meter-tall microscopes, and one day, while packing for a trip to Madagascar, I had this ‘aha’ moment,” says Prakash. “I was like: Why are we packing all these tubes? What if the two ends of these tubes were connected?”

The group turned their linear tube into a closed circular channel—a hamster wheel approach to observing microscopic particles. Over five expeditions at sea, the team further refined the microscope’s design and fluid mechanics to accommodate marine samples, often tackling the engineering while on the boat and adjusting for flooding and high seas.

In addition to the sedimentation physics of marine snow, the team also studies other plankton that may affect climate and carbon-cycle models. On a recent expedition off the coast of Northern California, the group discovered a cell with silica ballast that makes marine snow sink like a rock, Prakash says.

The crafty gravity machine is one of Prakash’s many frugal inventions, which include an origami-inspired paper microscope, or “foldscope,” that can be attached to a smartphone, and a paper-and-string biomedical centrifuge dubbed a “paperfuge.”

In physical books, yellowing pages are usually a sign of age. But brand-new users of Amazon’s Kindle Colorsofts, the tech giant’s first color e-reader, are already noticing yellow hues appearing at the bottoms of their displays.

Since the complaints began the trickle in, Amazon has reportedly suspended shipments and announced that it is working to fix the issue. (As of publication of this article, the US $280 Kindle had an average 2.6 star rating on Amazon.) It’s not yet clear what is causing the discoloration. But while the issue is new—and unexpected—the technology is not, says Jason Heikenfeld, an IEEE Fellow and engineering professor at the University of Cincinnati. The Kindle Colorsoft, which became available on 30 October, uses “a very old approach,” says Heikenfeld, who previously worked to develop the ultimate e-paper technology. “It was the first approach everybody tried.”

Amazon’s e-reader uses reflective display technology developed by E Ink, a company that started in the 1990s as an MIT Media Lab spin off before developing its now-dominant electronic paper displays. E Ink is used in Kindles, as well as top e-readers from Kobo, reMarkable, Onyx, and more. E Ink first introduced Kaleido—the basis of the Colorsoft’s display—five years ago, though the road to full-color e-paper started well before.

How E-Readers Work

Monochromatic Kindles work by applying voltages to electrodes in the screen that bring black or white pigment to the top of each pixel. Those pixels then reflect ambient light, creating a paper-like display. To create a full-color display, companies like E Ink added an array of filters just above the ink. This approach didn’t work well at first because the filters lost too much light, making the displays dark and low resolution. But with a few adjustments, Kaleido was ready for consumer products in 2019. (Other approaches—like adding colored pigments to the ink—have been developed, but these come with their own drawbacks, including a higher price tag.)

Given this design, it initially seemed to Heikenfeld that the issue would have stemmed from the software, which determines the voltages applied to each electrode. This aligned with reports from some users that the issue appeared after a software update.

But industry analyst Ming-Chi Kuo suggested in a post on X that the issue is due to the e-reader’s hardware. Amazon switched the optically clear adhesive (OCA) used in the Colorsoft to a material that may not be so optically clear. In its announcement of the Colorsoft, the company boasted “custom formulated coatings” that would enhance the color display as one of the new e-reader’s innovations.

In terms of resolving the issue, Kuo’s post also stated that “While component suppliers have developed several hardware solutions, Amazon seems to be leaning toward a software-based fix.” Heikenfeld is not sure how a software fix would work, apart from blacking out the bottom of the screen.

Amazon did not reply to IEEE Spectrum’s request for comment. In an email to IEEE Spectrum, E Ink stated, “While we cannot comment on any individual partner or product, we are committed to supporting our partners in understanding and addressing any issues that arise.”

The Future of E-Readers

It took a long time for color Kindles to arrive, and the future of reflective e-reader displays isn’t likely to improve much, according to Heikenfeld. “I used to work a lot in this field, and it just really slowed down at some point, because it’s a tough nut to crack,” Heikenfeld says.

There are inherent limitations and inefficiencies to working with filter-based color displays that rely on ambient light, and there’s no Moore’s Law for these displays. Instead, their improvement is asymptotic—and we may already be close to the limit. Meanwhile, displays that emit light, like LCD and OLED, continue to improve. “An iPad does a pretty damn good job with battery life now,” says Heikenfeld.

At the same time, he believes there will always be a place for reflective displays, which remain a more natural experience for our eyes. “We live in a world of reflective color,” Heikenfeld says.

This is story was updated on 12 November 2024 to correct that Jason Heikenfeld is an IEEE Fellow.

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Kelly Clarkson filled in for Cowell as he recuperates from back surgery.

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Imagine walking into your yard with a coffee in one hand, no lawn mower in sight, and the kind of lush greenery that looks effortlessly perfect. No frantic trimming or sweating under the summer sun. Sounds too good to be true? It’s possible when you pick the right low-maintenance grass. Let’s walk through some game-changing […]

The post Looking for Low-Maintenance Grasses? Discover the Best Choices for Busy Gardeners appeared first on Chart Attack.

On “The Alex Marlow Show” on Tuesday, Breitbart Editor-in-Chief and host Alex Marlow mocked Ivy League schools like Yale for degrading themselves with things like Yale’s Beyoncé course. Marlow said, “Yale University’s going to offer a Beyoncé makes history course in 2025. So, that’s what they’re doing. We’re just kicking butt and taking names and then they’re — they’ve got a new Beyoncé course over at Yale. Do the Ivy Leagues know that they degrade themselves and debase themselves? I love it. Because, as people have been pointing out, there’s no surer sign of people moving to the left than…when they go to college. That’s where it’s at. That is the fountain of leftism in our society…the universities. … And, not to mention, they infect our cities.” “The Alex Marlow Show,” hosted by Breitbart Editor-in-Chief Alex Marlow, is a weekday podcast produced by Breitbart News and Salem Podcast Network. You can subscribe to the podcast on YouTube, Rumble, Apple Podcasts, and Spotify. Follow Breitbart.tv on Twitter @BreitbartVideo

The post Alex Marlow: Yale Embarrasses Itself with Woke ‘Beyonce Makes History’ Course appeared first on Breitbart.

Significant visual and comfort compromises make last year's Quest 3 a better VR investment.

About two and a half years ago we were treated to a lovely gaming experience titled Dungeons of Dreadrock from …

Continue reading "‘Dungeons of Dreadrock 2’ Announced, Launching on Nintendo Switch in November with Mobile and PC Versions to Follow"

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Continue reading "The Huge ‘Peglin’ 1.0 Update Is Now Live on iOS, Android, and Steam Following Switch Launch Yesterday"