Welcome to my Nov/Dec 2021 Favorites! Hello! Can you believe we are well into December already? Instead of simply doing a favorites list of last month, I’m going to combine and share my Nov/Dec 2021 favorites into one post. At this time of the year I hope you aren’t feeling stress but instead I pray ... Read More about Catching Up with Org Junkie #20 ~ Nov/Dec 2021 Favorites: Advent, Car Diffuser & Hot Chocolate

The post Catching Up with Org Junkie #20 ~ Nov/Dec 2021 Favorites: Advent, Car Diffuser & Hot Chocolate appeared first on I'm an Organizing Junkie.

The Illinois Appellate Court upheld the denial of a disability pension to a police officer who refused surgery to address his injury. Case: Shirley v. Village of Clarendon Hills Police Pension…

The Winamp Collaborative License included restrictions that rendered Winamp nonfree

The Prison Education Program recently hosted a special campus performance for participants in its innovative prison-based spoken-word course.

This is not a side issue: it’s time to adopt a more systematic, coherent approach to D&I.

“Maybe soon I’ll add ‘measured response to frustration’ to the list of things I can pass on to my children. It’s not as fun as singing ditties about teachers or toilets, but it’s arguably a more essential skill that will serve them well in their own lives.”

Hard-to-meet goals can frustrate children with ADHD. Deploy these approaches to prevent meltdowns and transform relationships.

Bell [TXT] said on Wednesday it will keep production of the fuselage for the Army’s Future Long Range Assault Aircraft (FLRAA) in Wichita, Kansas, after taking on the assembly work […]

Using a smart composite material instead of traditional aluminum, Invi Air's diffusers reduce condensation by up to 95%, leading to improved HVAC system efficiency and long-term durability.

Title: Easily Confused Words
Topic: Vocabulary
Level: Advanced
Information: Choose the correct answer.
Link: https://www.usingenglish.com/quizzes/585.html

Fruit Slabs start as a cannabis-infused fruit blend with no added sugar that is then dried into a bite-sized square. 

According to a report from Zion Market Research, the global cannabis edibles market was valued at approximately USD 2,376 million in 2018 and is expected to generate around USD 11,564 million by 2025, at a CAGR of around 25.4% between 2019 and 2025.

Government attorneys appealed a Texas judge's finding that the Navy's strict religious accommodation process violates the religious freedoms of 35 sailors who refused the vaccine.

The post Navy appeals court decision barring punishment for SEALs who refused vaccine first appeared on Federal News Network.

Learn how to create MSP marketing content that prospects will actually care about. We provide tips on speaking to clients' problems over technical jargon.

Source: Does Your MSP Content Convince or Confuse? - Technibble.com

A Jersey City councilwoman refused to step down from office Wednesday night amid outcry over an alleged hit-and-run last month.

The 'Old Town Road' hitmaker talks about dating in the public eye, insisting he will continue to date although he is worried that he might be used as a stepping stone.

The 'Old Town Road' hitmaker talks about dating in the public eye, insisting he will continue to date although he is worried that he might be used as a stepping stone.

On its listing day, brokerage firms - Macquarie and JM Financial - became the first ones to initiate coverage on the debutant but came out with polar opposite views. Macquarie's initiating coverage report gave it an underperform rating with a target price of Rs 325, which indicates downside potential of 17% from IPO issue price of Rs 390.

With a distinguished career spanning folk, jazz, and world music, award-winning singer songwriter Laura Baron has recently released her latest album, Beauty in the Broken, a stirring collection that sees her embracing her jazz roots in a new light. Featuring eight original songs along with an inspired jazz-infused take on the classic song "Dream a Little Dream," Baron’s latest work captures a journey of healing and transformation....

Sen. Bob Casey (D-PA) continued to refuse to concede the race to Senator-elect Dave McCormick (R-PA) in Pennsylvania's Senate race, despite several outlets having called the election in McCormick's favor.

The post Bob Casey Still Refuses to Concede Race to Dave McCormick: ‘Election Officials Will Finish Counting’ appeared first on Breitbart.

Fun Fact: No-So-Handy Andy was also born on the year of the Dragon.

On July 28th, Axios reporter Jonathan Swan interviewed President Donald Trump on HBO about several topics including the staggering number of COVID-19 cases in the United States. His reactions to some of Trump's remarks are priceless, and needless to say, the memes have been top-tier. You can watch the interview here and garner your own reactions. Now on with the memes!

Perhaps my favorite episode of this podcast in a long time. We talk about Thurl Ravenscroft, odd Grinch theories, like the fact that his heart may expand and shrink regularly, if the chimneys are essentially pneumatic tubes, and that the Jim Carrey Grinch film had a key party in it.

By Matt Solomon Published: November 11th, 2024

Climate change is wreaking havoc on farmers in Nigeria.

Democratic nominee Joe Biden refused to answer the question during the first presidential debate Tuesday night as to whether he would support “packing” the Supreme Court if elected President and the Senate Republicans confirms President Trump’s nominee Amy Coney Barrett. “If Senate Republicans go ahead and confirm Justice Barrett there has been talk about ending the […]

The post Biden Refuses During Presidential Debate To Answer Court-Packing Question appeared first on Hispolitica.

It's all over but the crying for a campaign that was supposed to be characterized by 'joy'. There will be no concession speech tonight. At little before 1 am, Kamala is running like a scared rabbit.

The post Cowardly Kamala Pulls A Hillary — Refuses To Concede As Trump Paints The Country Red appeared first on Clash Daily.

Visual Abstract

The work of Diné artist DY Begay, now on view at the National Museum of the American Indian, blends tradition and modernity

Two comb jellies can merge their digestive and nervous systems and even sync their bodily functions, according to new research. The discovery could have implications for human medicine

The aim of this study was to validate a previously developed deep learning model in 5 independent clinical trials. The predictive performance of this model was compared with the international prognostic index (IPI) and 2 models incorporating radiomic PET/CT features (clinical PET and PET models). Methods: In total, 1,132 diffuse large B-cell lymphoma patients were included: 296 for training and 836 for external validation. The primary outcome was 2-y time to progression. The deep learning model was trained on maximum-intensity projections from PET/CT scans. The clinical PET model included metabolic tumor volume, maximum distance from the bulkiest lesion to another lesion, SUV_peak, age, and performance status. The PET model included metabolic tumor volume, maximum distance from the bulkiest lesion to another lesion, and SUV_peak. Model performance was assessed using the area under the curve (AUC) and Kaplan–Meier curves. Results: The IPI yielded an AUC of 0.60 on all external data. The deep learning model yielded a significantly higher AUC of 0.66 (P < 0.01). For each individual clinical trial, the model was consistently better than IPI. Radiomic model AUCs remained higher for all clinical trials. The deep learning and clinical PET models showed equivalent performance (AUC, 0.69; P > 0.05). The PET model yielded the highest AUC of all models (AUC, 0.71; P < 0.05). Conclusion: The deep learning model predicted outcome in all trials with a higher performance than IPI and better survival curve separation. This model can predict treatment outcome in diffuse large B-cell lymphoma without tumor delineation but at the cost of a lower prognostic performance than with radiomics.

BACKGROUND AND PURPOSE:

World Health Organization (WHO) grade 2 and 3 diffuse gliomas account for approximately 5% of primary brain tumors. They are invasive and infiltrative tumors and have considerable morbidity, causing progressive neurologic deterioration. The mean survival time is <10 years from diagnosis. Surgical debulking represents first-line management. The extent of resection is associated with progression-free and overall survival. Radiologic assessment of the extent of resection is challenging. This can be underestimated on early postoperative MRI, meaning that accurate assessment may be achieved only on delayed follow-up imaging. We hypothesized that DWI may help facilitate more reliable estimates of the extent of resection on early postoperative MRI. This study aimed to assess the utility of DWI in early postoperative MRI to evaluate the extent of resection.

We present a unique case of a single patient presenting with two mutationally distinct, PD-L1⁺ diffuse large B-cell lymphomas (DLBCLs). One of these DLBCLs demonstrated exceptionally high mutational burden (eight disease-associated variants and 41 variants of undetermined significance) with microsatellite instability (MSI) and an acquired PMS2 mutation with loss of PMS2 protein expression, detected postchemotherapy. This report, while highlighting the extent of possible tumor heterogeneity across separate clonal expansions as well as possible syndromic B-cell neoplasia, supports the notion that, although rare, PD-L1 expression and associated states permissive of high mutational burden (such as mismatch repair gene loss of function/MSI) should be more routinely considered in DLBCLs. Appropriate testing may be predictive of outcome and inform the utility of targeted therapy in these genetically diverse and historically treatment-refractory malignancies.

Diffuse large B-cell lymphoma (DLBCL) is a heterogenous group of lymphoid malignancies. Based on gene expression profiling, it has been subdivided into germinal center (GC)-derived and activated B-cell (ABC) types. Advances in molecular methodologies have further refined the subclassification of DLBCL, based on recurrent genetic abnormalities. Here, we describe a distinct case of DLBCL that presented in leukemic form. DNA sequencing targeting 275 genes revealed pathogenically relevant mutations of CD79B, MyD88, TP53, TBL1XR1, and PIM1 genes, indicating that this lymphoma would be best classified as MCD/C5 DLBCL, an ABC subtype. Despite an initial good clinical response to BTK inhibitor ibrutinib, anti-CD20 antibody rituxan, alkylating agent bendamustine, and hematopoietic stem-cell transplant, the lymphoma relapsed, accompanied by morphologic and molecular evidence of disease progression. Specifically, the recurrent tumor developed loss of TP53 heterozygosity (LOH) and additional chromosomal changes central to ABC DLBCL pathogenesis, such as PRDM1 loss. Acquired resistance to ibrutinib and rituxan was indicated by the emergence of BTK and FOXO1 mutations, respectively, as well as apparent activation of alternative cell-activation pathways, through copy-number alterations (CNAs), detected by high-resolution chromosomal microarrays. In vitro, studies of relapsed lymphoma cells confirmed resistance to standard BTK inhibitors but sensitivity to vecabrutinib, a noncovalent inhibitor active against both wild-type as well as mutated BTK. In summary, we provide in-depth molecular characterization of a de novo leukemic DLBCL and discuss mechanisms that may have contributed to the lymphoma establishment, progression, and development of drug resistance.

Chris gives everyone horse poop. Jason extolls the virtues of Alien Ant Farm. And Alex keeps things concise, as instructed.

The post RPG Cast – Episode 665: “Chat GPT Refused to Write This Title” appeared first on RPGamer.

The Supreme Court dealt a major legal blow to former White House Chief of Staff Mark Meadows on Tuesday, refusing to move the Georgia election interference charges against him to federal court.

It is often said that medicine is both an art and a science. In an imperfect world this is both inevitable and desirable. But it is extremely important that the two should not be confused with each other. In particular, because the “science” side of the equation has achieved overwhelming prestige and authority, it is...

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