Sleep is a fundamental feature of life for virtually all multicellular animals, but many questions remain about how sleep is regulated by circadian rhythms, homeostatic sleep drive that builds up with wakefulness, and modifying factors such as hunger or social interactions, as well as about the biological functions of sleep. Substantial headway has been made in the study of both circadian rhythms and sleep in the fruit fly Drosophila melanogaster, much of it through studies of individual fly activity using Drosophila activity monitors (DAMs). Here, we describe approaches for the activation of specific neurons of interest using optogenetics (involving genetic modifications that allow for light-based neuronal activation) and thermogenetics (involving genetic modifications that allow for temperature-based neuronal activation) so that researchers can evaluate the roles of those neurons in controlling rest and activity behavior. In this protocol, we describe how to set up a rig for simultaneous optogenetic or thermogenetic stimulation and activity monitoring for analysis of sleep and circadian rhythms in Drosophila, how to raise appropriate flies, and how to perform the experiment. This protocol will allow researchers to assess the causative role in the regulation of sleep and activity rhythms of any genetically tractable subset of cells.

BackgroundDuring the COVID-19 pandemic, global trends of reduced healthcare-seeking behaviour were observed. This raises concerns about the consequences of healthcare avoidance for population health.AimTo determine the association between healthcare avoidance during the early stages of the COVID-19 pandemic and all-cause mortality.Design and settingThis was a 32-month follow-up within the population-based Rotterdam Study, after sending a COVID-19 questionnaire at the onset of the pandemic in April 2020 to all communty dwelling participants (n = 6241/8732, response rate 71.5%).MethodCox proportional hazards models assessed the risk of all-cause mortality among respondents who avoided health care because of the COVID-19 pandemic. Mortality status was collected through municipality registries and medical records.ResultsOf 5656 respondents, one-fifth avoided health care because of the COVID-19 pandemic (n = 1143). Compared with non-avoiders, those who avoided health care more often reported symptoms of depression (n = 357, 31.2% versus n = 554, 12.3%) and anxiety (n = 340, 29.7% versus n = 549, 12.2%), and more often rated their health as poor to fair (n = 336, 29.4% versus n = 457, 10.1%) . Those who avoided health care had an increased adjusted risk of all-cause mortality (hazard ratio [HR] 1.30, 95% confidence interval [CI] = 1.01 to 1.67), which remained nearly identical after adjustment for history of any non-communicable disease (HR 1.20, 95% CI = 0.93 to 1.54). However, this association attenuated after additional adjustment for mental and physical self-perceived health factors (HR 0.93, 95% CI = 0.71 to 1.20).ConclusionThis study found an increased risk of all-cause mortality among individuals who avoided health care during COVID-19. These individuals were characterised by poor mental and physical self-perceived health. Therefore, interventions should be targeted to these vulnerable individuals to safeguard their access to primary and specialist care to limit health disparities, inside and beyond healthcare crises.

Pitched as a mix of ‘Blade Runner’ and ‘Jurassic Park,’ Neom is the world’s biggest construction project. Twenty-one thousand people have died so far to make it happen.

REVERB features 17 audiovisual installations including new works by Es Devlin and Theaster Gates, plus Devon Turnbull's Listening Room.

The post The Vinyl Factory celebrates art and sound with immersive exhibition at 180 Studios appeared first on Fact Magazine.

Sega has sold Humankind and Endless developer Amplitude Studios to members of its internal team, announced the developer in a community post. This means the studio is now independent.

"Our studio is backed by strong and meaningful franchises and our team is committed to creating the best games possible," said Amplitude Studios founder Romain de Waubert de Genlis.

"With our extensive experiences in strategy game development and two exciting titles currently in progress, we are confident in our ability to deliver outstanding experience to players. This decision allows us to be more agile in our approach while continuing to shape the vision that has been ours from the very beginning, empowering us to push boundaries and be closer as ever of our community."

Sega in its own statement said: "Sega Europe has today announced the sale of Amplitude Studios following a management buyout from senior leaders and employees at the Parisian studio. The move will see Amplitude go back to its roots as an independent organisation and concludes the structural reforms that have been taking place in Sega’s European business.  

"The decision to part ways follows a period of close consultation between Sega Europe and Amplitude. As an independent studio once more, Amplitude will focus on its in-development projects and growing its own franchises, while Sega will continue to advance its strong and diverse stable of Japanese and Western IP. 

“Sega Europe acquired Amplitude in 2016, and together have released epic strategy titles like Endless Space 2 and Humankind, along with Endless Dungeon, the successor to 2014’s indie hit, Dungeon of the Endless.

"While Amplitude is no longer a part of the Sega family of studios, the two entities will continue to work together on the smooth transition of services and operations, ensuring minimum disruption for Amplitude employees and continuity of service for players of Amplitude games."

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463024/sega-sells-humankind-developer-amplitude-studios/

Tencent Games subsidiary LightSpeed Studios has announced Hideaki Itsuno, who recently left Capcom after 30 years working for the company, will be leading a new video game studio called LightSpeed Japan Studio.

LightSpeed Japan Studio will have two locations in Tokyo and Osaka and is focused on developing original AAA games.

"Joining LightSpeed Studios is an exciting new chapter for me," said Hideaki Itsuno. "With LightSpeed’s strong development capability and global network, I look forward to creating original AAA action game titles together with the amazing team and building aesthetic and innovative experiences for the global player community. We welcome all talented and passionate game creators from the world over to join our vision."

LightSpeed Studios president Jerry Chen added, "It is our great honor to have Hideaki Itsuno join LightSpeed Studios. The establishment of LightSpeed Japan Studio is a significant step in LightSpeed Studios’ expansion and demonstrates our commitment to bringing the best possible games to our players."

Itsuno directed entries in the Rival Schools, Power Stone, Capcom VS. SNK, Devil May Cry, and Dragon’s Dogma franchises.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463041/hideaki-itsuno-to-lead-new-aaa-developer-lightspeed-japan-studio/

A collective gasp echoed like a thunderclap in a valley in our Daily Beast newsroom late Wednesday afternoon at the news that singer Liam Payne, who became famous as a member of the group One Direction, died at age 31.

TMZ reports that Payne fell from a hotel balcony in Argentina, where he had reunited with bandmates at 1D-er Niall Horan’s concert. He had, according to the site, been behaving “erratically,” earlier in the day, and was spotted smashing a laptop in the hotel lobby and having to be carried back to his room. He had been in headlines on gossip blogs over tension with his ex-fiancée Maya Henry, who, TMZ says, alleged “he'd left her after asking her to get an abortion.”

In the shock of his death, fans couldn’t ignore the eerie nature that Payne had just connected with his One Direction bandmates. Dark questions emerge when a celebrity dies so young: What role did the often horrific toll of fame have on a person like Payne, who has been open about addiction and suicidal ideation? But there’s also an impulse to go back to the roots of a person’s talent, to revisit what it was that we all fell in love with—and was their passion—in the first place.

Read more at The Daily Beast.

Sega are delisting several bundles of 'classic' games from digital stores, along with "select individual" games. On Steam specifically, this adds up to over 60 games in total, including several actual classics including the original Streets Of Rage trilogy, Crazy Taxi, and Jet Set Radio.

The games will be removed on December 6th but will remain playable to those who already own them.

Read more

Amplitude Studios, developers of many a game with "Endless" in the name, have split with publisher Sega to become independent again, with ownership of the studio reverting to its original founders and "other members of the team". The developers say everyone is parting "on good terms" and that the last eight years of getting published under Sega has been "amazing". But there are other businessy reasons, of course. Namely, Sega have been trying to trim down their European studios for the past year, and Amplitude is just the latest bunch of devs affected by that.

Read more

The developers who remade Half-Life as Black Mesa are working on a new roguelite co-op shooter. It will feature no physicists celebrating Bring Your Shotgun To Work Day, but instead let up to four players tactically breach oil rigs and airports occupied by corporate-sponsored mercenaries. In Rogue Point the richest CEO on earth has croaked it, causing various megacorps to compete in a violent bum rush for control of that wealth. Which is where your team of renegade shooterists come in. They don't want to win this contest, they just want everyone else to lose.

Read more

Seven major datasets used to train audio-generating AI models are three times more likely to use the words "man" or "men" than "woman" or "women", raising fears of bias

Black Ops 6 is here, and it's Black Ops 2's anniversary, so what better time than to rank the Call of Duty Black Ops titles? Here's our ranking of every mainline version.

Human cognitive performance can be significantly influenced by the presence of audience members.

The post Study: Chimps Perform Better on Challenging Computer Tasks When They Have Audience appeared first on Sci.News: Breaking Science News.

Several trade associations have called on European policymakers to reconsider the EU-Mercosur trade deal following findings from an audit in Brazil. The EU-Mercosur deal is an agreement between the European Union and Argentina, Brazil, Paraguay and Uruguay. A recently published audit report by DG Sante revealed Brazil’s issues in meeting European food... Continue Reading

Welcome, film enthusiasts, to a captivating exploration of the diverse world of nudity in global cinema! In an era where cultural nuances shape the way we perceive art, it’s fascinating to dissect how different societies approach the depiction of the human form on the silver screen. Among different diversities like age diversity, political diversity, and […]

The post Unveiling Diversity: Nudity Across Borders in Global Cinema appeared first on Chart Attack.

Prince Turki bin Faisal al-Saud, former Saudi ambassador to the United States, has written an open letter to President-elect Donald Trump asking him to “finish what you started the last time you occupied the White House” with respect to Middle Eastern affairs.

The post Saudi Royals Ask Trump to ‘Finish What You Started’ in Middle East appeared first on Breitbart.

Santhosh Kana’s ‘A Musical Pilgramage’ containing 8 select poems combines soothing narration with Indian classical music.

Welcome to this week’s edition of the Steam Deck Weekly. I delayed publishing this because Gamescom 2024 is on right …

Continue reading "Steam Deck Weekly: Gamescom 2024 Steam Deck News, Reviews Including Bakeru and SCHiM, New Verified Games, Discounts, and More"

2024 has been a rough year for Sonos. The company’s would-be triumphant entry into the crowded headphones market was overshadowed by a disastrous app redesign. In the fallout of the botched software update, the company decided to delay products that were ready to be shipped to give itself more time to right the course. Consumer trust eroded, and people who already owned Sonos gear were living in a cycle of constant frustration.

Thanks to a number of rumors, we already knew that one of the pending product releases was the Arc Ultra ($999). A few weeks ago the company decided not to wait any longer to reveal it. While the design is mostly unchanged from the Arc that debuted in 2020, there are several key changes on the inside that make this a better all-in-one solution for people who don’t want to add more speakers to their living room setup. Sonos is promising better bass performance thanks to new speaker tech that’s debuting in the Arc Ultra, but just how good can it be?

Design

The refined design of the original Arc was a massive upgrade from that of the Playbar, and showed a progression from Sonos’ compact Beam soundbar. Honestly, the aesthetic is pretty timeless, in my opinion, and it’s a look that should age well for years to come. That said, it makes sense that Sonos would keep the design for the Arc Ultra, only making some minor changes to the exterior.

The Arc Ultra still comes in both black and white options, allowing you to choose what looks best in your living room or home theater. Sonos updated the controls to mirror what’s available on the newer Era 100 and Era 300 speakers, moving them to a top-facing bar at the back. There’s a volume slider on the right with play/pause and skip controls in the center. On the left side, Sonos gives you a microphone control so you can mute the built-in mics as needed.

And that’s really it in terms of design changes that you can see. The Arc Ultra is slightly shorter height-wise than the Arc, and it’s a little wider than its predecessor. Neither of which make a huge difference, and they won’t drastically change how you position the speaker beneath your TV.

Inside, Sonos has re-engineered the Arc Ultra to improve audio performance. The biggest piece of this overhaul is the new Sound Motion woofer that enables better bass performance before you add a standalone wireless sub. The achievement here, thanks to the acquisition of audio company Mayht, is that the new component lays flat, taking up less room than a traditional cone-shaped woofer. The Sound Motion driver also helps deliver increased clarity and depth, on top of doubling the bass output of the original Arc.

Sonos redesigned the entire acoustic architecture of the Arc Ultra during the process of adding the Sound Motion woofer. The soundbar now houses three more drivers than the arc, a list that includes seven tweeters (two of which are upfiring), six mid-range drivers (midwoofers, as Sonos calls them) and the aforementioned woofer for a total of 14. The company also employs 15 Class-D digital amplifiers along with far-field mics for tuning and voice control.

There’s still only a single HDMI (eARC) port, which allows most modern TVs the ability to control the soundbar’s volume and mute options from your TV remote. Moreover, the Arc Ultra is compatible with Wi-Fi 6 and newly-added Bluetooth 5.3 connectivity allows you to stream from any device. And of course, AirPlay 2 is still on the spec sheet. One last thing I’ll mention here is that the Arc Ultra doesn’t ship with an optical adapter if you prefer that connection. The company will sell you one for $25.

Software and features

Since the Arc Ultra is a Sonos product, there are a lot of core features that are the same as they are on the company’s other devices. You can use the soundbar as part of a multiroom setup and Trueplay tuning is here to adjust the audio to the acoustics of the room. There’s still an adjustable EQ with options for bass, treble and loudness and a Night Sound mode makes things less boomy when someone in your house may be trying to work or sleep.

While Trueplay will give you the best sound customization for the sonic characteristics of your living room, Sonos is enabling a Quick Tune feature for the first time on the Arc Ultra. Here, the soundbar will use its internal mics, as opposed to your phone, to offer a certain degree of improvement. The company says it wanted to give people the option of something quicker than Trueplay, although the full-fledged tuning process doesn’t take very long at all.

Speech Enhancement has been a handy feature on Sonos soundbars for a while, giving you the ability to improve dialog clarity as needed. Before now, it was an all-or-nothing feature, but on the Arc Ultra, the company introduced three levels of speech boost to give you more options to better suit your needs. This means the soundbar can help you hear clearly over background noise or simply follow along better by elevating dialog above the rest of the soundtrack mix.

The trademark feature of Sonos’ Ace headphones is the ability to beam the audio from a compatible soundbar to the cans for a private home theater. That TV Audio Swap tool is available on the Arc Ultra, so you can instantly send the sound to the headphones with the press of a button. In fact, Sonos bundles the Arc Ultra and Ace headphones in a $1,373 set. What’s more, the Ace supports spatial audio with dynamic head tracking, so you can count on immersive sound even when you’re employing it on an individual basis.

Despite all of the problems that Sonos has had with its app, some of which it's still working to resolve, I didn't encounter any issues during my testing. The software crashed on me once when the Trueplay tuning process completed, but everything had already run its course and I didn’t have to repeat it. Other than that, the app has worked reliably over the last week while I’ve been putting the Arc Ultra through its paces. Most importantly, the software is stable and the full suite of controls for the new soundbar is available at launch.

Sound performance

The original Arc already sounded great, so Sonos really had its work cut out for it to further improve the audio quality for the Arc Ultra. Thanks to the improved bass of the Sound Motion tech, a change that also takes up less space, the company says it had the ability to then overhaul the mid-range and high-frequency components as well. By using multiple sizes of mid-range drivers and tweeters, Sonos was able to tweak the speaker positioning inside of the soundbar for improved projection and more immersive sound.

In addition to the enhanced bass performance, the second thing that was immediately apparent on the Arc Ultra was those improvements to the dimensional sound. Whether it was a quidditch match in a Harry Potter movie or zooming F1 cars in Drive to Survive, the soundbar now has better directional, immersive sound than its predecessor. Sonos says the Arc Ultra now renders Dolby Atmos content in a 9.1.4-channel setup, versus 5.0.2 with the Arc, which further contributes to the enveloping audio. Interestingly, I haven’t seen any of the competition claim four up-firing channels from the soundbar like Sonos does here (those that do are usually accounting for up-firing drivers in the rear speakers). You can really hear the difference from the second you fire up the Arc Ultra, and the effect is consistent across content sources.

The increased bass performance makes the Arc Ultra a much better speaker for music without a separate subwoofer. You won’t get the bombastic low-end tone the newly updated Sonos Sub 4 can produce, but there’s enough from the soundbar to give Kaytranada’s Timeless, Phantogram’s Memory of a Day and Bilmuri’s American Motor Sports plenty of booming backbone when a track demands it. There’s also still the trademark Sonos clarity I’ve come to expect over the years, which means finer details like the texture of synths, layered guitars and the nuance of acoustic instruments cut through the mix cleanly.

And speaking of clarity, the company’s new Speech Enhancement settings are also a big improvement. Being able to select how much of a boost this feature offered depending on either my needs right then or based on the overall tuning of the content is really nice. It allowed me to max out the dialog when watching movies after my toddler was asleep so that speech didn’t suffer when sound effects were louder during intense scenes of The Hobbit: An Unexpected Journey.

The competition

There’s no doubt the Arc Ultra packs in deeper, more immersive sound than its predecessor, but some people will still want a more robust setup to wring every ounce of audio out of a Sonos living room setup. The high-end choice for this is what Sonos calls the Ultimate Immersive Set, which includes the Arc Ultra, two Era 300s and the Sub 4. Right now, that will cost you $2,561. For something less expensive, you can get the Arc Ultra and the new Sub 4 (normally $799) for $1,708 (Premium Entertainment Set). And therein lies the biggest problem with Sonos soundbars: expanding your living room setup to get the most immersive experience gets very pricey very quickly when the centerpiece is already $999.

If you can live without all the conveniences of Sonos products, you can get an all-in-one package from Samsung for $1,500. With the Q990D, you’ll get the soundbar, two rear speakers and a wireless subwoofer in the same box. The setup offers 11.1.4 audio for excellent Atmos sound, thanks in part to up-firing drivers in the rear speakers. Samsung offers a host of handy features, from Q-Symphony audio with TV speakers, SpaceFit Sound Pro room calibration, Adaptive Sound audio enhancement, a dedicated gaming mode and more. The Q990D remains my top pick for the best soundbars for a lot of reasons, a key one being everything you could need comes in one all-inclusive package.

Wrap-up

The Arc Ultra is an obvious improvement over the Arc in the sonic department. New technology delivers on its promise to boost bass, clarity and immersive before you start adding extra components. Expanded features like Speech Enhancements and a quick-tune option offer new tools for dialing in the sound, while the stock Sonos experience remains intact. And thankfully, that includes an app that’s more stable than it was a few months ago. The Arc Ultra is still pricey at $999, but it exhibits a lot more sonic prowess than its predecessor for only $100 more.

Les White Stripes ont abandonné leur plainte sur les droits d'auteur contre le président des États-Unis nouvellement réélu, Donald Trump.

A team at the University of Technology Sydney has developed an assistive technology for blind people and those with low vision. The system consists of glasses that can view their surroundings through an on-board camera, appraise the objects nearby using computer vision technology, and then play a sound that provides a cue for the wearer […]

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The post Provider Judi Slot Gacor Online Terbaik serta Populer di Tahun 2024 appeared first on Biosimilarnews.

The Food and Drug Administration published a concept paper in early January that describes a preliminary proposal for how the agency will ensure that companies developing antibiotics for administration to animals establish defined, evidence-based durations of use for all medically important antibiotics.

This paper begins with a look at both optimization modeling and discrete-event simulation modeling, and explores how they can most effectively work together to create additional analytic value. It then considers two examples of a combined optimization and simulation approach and discusses the resulting benefits.

European Court of Auditors

#ChangeTheNumbers - Entdecken Sie die Ergebnisse der Studie

Vivo�s New Flagship Smartphone V3 & V3Max: Faster than Faster

Turtle Beach Reveals the All-New Elite Pro

Edward James Olmos

Is a Nonsurgical Facelift a Reality and How Does it Impact Facial Aging?

Behind the scenes with Elizabeth Goodman Artis, Natalie Morales, Danielle Brooks, Padma Lakshmi and Sara Bareilles at the 2016 MORE/SHAPE Women�s Half-Marathon in Central Park on April 17.

Government of IndiaMinistry of Finance(Central Board of Indirect and Customs)Notification[No.72/2024-Customs (N.T.)]New Delhi, the 2

Download CA Intermediate Auditing and Ethics Question Papers New Course Sep 2024 in PDF. For other question papers of CA IPC May 2024, Nov 2023, May 2023, Nov 2022, May 2022, Dec 2021, Nov 2020, Nov 18, May 18, Nov 2017, May 2017, May 2016, CA IPC Nov 2015, CA IPC may 2015, CA IPC Nov 2014 check similar section. Previous years Auditing and Ethics CA Intermediate IPC question papers can also be downloaded using Search. You can also search and download may 2015 Final question papers here. We are providing ca final question papers of may 2016 for Financial Reporting FR, Advanced Financial Management AFM, Advanced Auditing and Professional Ethics, Direct Tax Laws DT, Indirect Tax Laws IDT and Inter/IPC May 2024 question papers for Advanced Accounting, Corporate and Other Laws, Taxation, Advanced Accounting , Auditing & Assurance, Information Technology & Strategic Management ITSM.

Download CA Final Advanced Auditing, Assurance And Professional Ethics Question Papers Nov 2024 in PDF. For older question papers of CA final May 2024, Nov 2024, May 2023, Nov 2022, May 2022, Dec 2021, July 2021, Jan 2021, Dec 2020, Nov 2020, Nov 19, May 2019, Nov 2018, May 18, Nov 2017, May 2017, May 16, Nov 2015, CA final may 2014, CA final Nov 2014 check similar section. Previous years CA final Advanced Auditing and Professional Ethics question papers can also be downloaded using Search. You can also search and download may 2015 IPCC & IPC question papers here. We are providing ca final question papers of may 2016 for Financial Reporting FR, Advanced Financial Management AFM, Advanced Auditing, Assurance And Professional Ethics, Direct Tax Laws DT, Indirect Tax Laws IDT, Integrated Business Solutions (Multidisciplinary Case Study with Strategic Management) and IPCC/IPC Nov 2023 question papers for Accounting , Business, Law, Ethics & Communications , Cost Accounting & Financial Management CAFM, Taxation, Advanced Accounting , Auditing & Assurance, Information Technology & Strategic Management ITSM.

Here's how we built adaptive audio in Meet, which transforms multiple laptops in close proximity into a unified audio system so you can create ad-hoc meeting spaces IRL.

Google Play announces the 10 indie games studios receiving a share of $2 million and hands-on support as a part of the Indie Games Fund 2024.

Сразу два «Хищника» выйдут в 2025 году, рассказал Стив Асбелл, глава студии 20th Century Studios. В планах у компании также продолжение фильма «Чужой: Ромул».

Один из «Хищников» — это фильм с подзаголовком «Пустоши» и Эль Фаннинг в главной роли, он выйдет 7 ноября 2025-го. Второй — пока секретный, его должны выпустить перед «Пустошами». Обе части снял Дэн Трахтенберг, режиссер «Добычи».

Над продолжением фильма «Чужой: Ромул» работает его режиссер Феде Альварес. Новое соглашение с ним пока не заключили, но у постановщика уже есть идея, каким должен быть сиквел.

Глава 20th Century Studios также не исключил, что в дальнейшем студия займется и новым «Чужим против Хищника».

The National Financial Reporting Authority (NFRA) has convened a board meeting scheduled for November 25, where it will examine and potentially set audit standards for limited liability partnerships (LLPs), according to official sources. ...

NFRA recommends revision of the Standard quality control (SCQ1) and Standard quality management (SQM1 and SQM2), on the lines of the global Standards...

Outside experts found that two studies cited in a federal case on medication abortion had serious design problems and that their authors had undisclosed conflicts of interest

A multidisciplinary studio with interesting portfolio... Check it.

Elena Seleznev is an Industrial Designer and the proud owner of Studio RDD...

Architecture studio DoBuro with their own unique style...

An analysis of thousands of cognitive tests carried out by chimpanzees finds that the number of spectators influenced their performance in different ways depending on the difficulty of the task

Seven major datasets used to train audio-generating AI models are three times more likely to use the words "man" or "men" than "woman" or "women", raising fears of bias

Shigeru Miyamoto previews games, Golden Temple ride, more in Direct video