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A Practical Guide to Understanding Anxiety and Managing It Effectively

Anxiety is something most of us are familiar with in one way or another. It can feel like a storm inside your mind, making even simple things feel overwhelming. Anxiety disorders are more common than ever, and while they can feel insurmountable, the right understanding and tools can make all the difference. In this article, ... Read more

The post A Practical Guide to Understanding Anxiety and Managing It Effectively appeared first on LifeHack.




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The Ultimate Guide to Questions to Ask a Guy: From Flirty to Deep

Having the right questions can make all the difference when getting to know a guy, whether you’re building a friendship or exploring a romantic connection. Conversations are more than just words; they’re opportunities to spark curiosity, foster understanding, and build meaningful bonds. This guide provides questions that help you move beyond small talk and create ... Read more

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Cultivating Mutual Respect: A Guide to Healthy Relationships

How do you build mutual respect, a quality that everyone values but few know how to cultivate consistently? We know it’s important—whether it’s in our personal relationships or at work—but actually developing and maintaining it can be challenging. This article is here to help you understand what mutual respect really means, why it matters, and ... Read more

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A Guide to Self-Love: From Overcoming Doubt to System-Based Growth

Self-love is a topic we hear about often, but putting it into practice can feel elusive, like trying to hold onto something that keeps slipping away. You know it’s there, but it’s hard to hold on to. The concept of self-love involves valuing oneself and letting go of toxic influences. It’s about stepping back from ... Read more

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How to Get Over Someone: A Step-by-Step Guide to Moving On with Your Life

Breaking up with someone is often one of the most difficult experiences we face. It can feel as though your entire world has shifted, leaving you disoriented and unsure of what comes next. But even amid the pain, a breakup can also be a profound opportunity for growth. This journey—one of rediscovering who you are, ... Read more

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Mastering Stress Management: A Guide to Thriving, Not Just Surviving

Stress is a common experience that can either drive us toward success or hinder our progress if not managed effectively. What if you could understand stress better and turn it into something you can handle and even benefit from? This article will guide you through practical strategies for managing stress by blending effective techniques with ... Read more

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10 Ways to Take Stunning Portraits (Portrait Photography Guide)

The post 10 Ways to Take Stunning Portraits (Portrait Photography Guide) appeared first on Digital Photography School. It was authored by Darren Rowse.

How do you do portrait photography that has the wow factor? Capturing stunning portraits often seems difficult, but it’s actually pretty easy once you know a few tips and tricks. Below, I share my 10 absolute favorite techniques for shooting portraits, including tips for lighting, composition, perspective, and much more. I’ve also included plenty of […]

The post 10 Ways to Take Stunning Portraits (Portrait Photography Guide) appeared first on Digital Photography School. It was authored by Darren Rowse.




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The Essential Guide to Low-Light Landscape Photography

The post The Essential Guide to Low-Light Landscape Photography appeared first on Digital Photography School. It was authored by Natalie Denton (nee Johnson).

Low-light landscape photography offers a unique challenge for photographers. On the one hand, a landscape lit by softer, subtler light can result in the kind of magical shots that go beyond more conventional photos. On the other hand, capturing these scenes requires a careful approach and a keen understanding of camera settings. But don’t fret! […]

The post The Essential Guide to Low-Light Landscape Photography appeared first on Digital Photography School. It was authored by Natalie Denton (nee Johnson).




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Smartphone Photography: The Essential Guide (+ 15 Tips)

The post Smartphone Photography: The Essential Guide (+ 15 Tips) appeared first on Digital Photography School. It was authored by Karthika Gupta.

These days, you don’t need professional photography equipment to take stunning photos. The smartphone in your pocket has the power to capture the kind of high-quality shots you can find in magazines – and it’s extremely easy to use, too! That said, smartphone photography involves more than grabbing that iPhone or Google Pixel, turning on […]

The post Smartphone Photography: The Essential Guide (+ 15 Tips) appeared first on Digital Photography School. It was authored by Karthika Gupta.




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Depth of Field: The Essential Guide (+ Tips)

The post Depth of Field: The Essential Guide (+ Tips) appeared first on Digital Photography School. It was authored by Bruce Wunderlich.

You may have heard the term depth of field (DoF), but what actually is it, and why does it matter for photographers? Regardless of your skill level or the type of camera you possess, comprehending depth of field is essential to expanding your photographic horizons. It applies to every aspect of photography, from macro close-ups […]

The post Depth of Field: The Essential Guide (+ Tips) appeared first on Digital Photography School. It was authored by Bruce Wunderlich.




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Can I be Your Guide?




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A Hacker's Guide to Password Cracking

Defending your organization’s security is like fortifying a castle—you need to understand where attackers will strike and how they’ll try to breach your walls. And hackers are always searching for weaknesses, whether it’s a lax password policy or a forgotten backdoor. To build a stronger defense, you must think like a hacker and anticipate their moves. Read on to learn more about hackers'




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Guided tour of "Monsters and Machines: Caricature, Visual Satire, and the Twentieth-Century Bestiary"

A 30-minute guided tour of the latest exhibition in the Milberg Gallery in Firestone Library at Princeton University. Tours meet in the lobby of Firestone Library. The exhibition is open Monday to Friday from 10 a.m. to 6 p.m., and 11 a.m. to 6 p.m. on Saturday and Sunday in the Milberg Gallery, Firestone Library. Open to the public. “Monsters and Machines: Caricature, Visual Satire, and the Twentieth-Century Bestiary” will focus on the use of bestiary – animal or zoological motifs – in visual satire during the period between World War I and the end of the Cold War. Drawing from PUL’s rich collections of 20th-century posters, illustrated periodicals, and ephemera from North America, Europe, Asia, Eurasia, and the Middle East, the exhibition will look at works of weaponized visual humor created by and aimed at exponents of different national cultures and ideologies. The exhibition will run from September 12 to December 8, 2024.




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Musician’s Guide to TikTok: 6 Tips for Growing Your Fanbase

With TikTok going viral, it has become the perfect platform for musicians to showcase their talent and reach new audiences. No matter what genre you specialize in, this blog will provide you with all the tips and tricks to get noticed on TikTok and grow your fanbase. So, what are you waiting for? Let’s get ... Read more

The post Musician’s Guide to TikTok: 6 Tips for Growing Your Fanbase appeared first on Star Two.




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Beginner’s Guide to Electronic Music Production: Tips and Tricks for Starting Out

The beginner’s guide to electronic music production is a comprehensive resource offering a thorough introduction to the fundamentals of electronic music production. Tailored for beginners, the guide covers essential concepts, techniques, and tools in the field, spanning from basic sound design to the application of effects plugins and mixing strategies. Electronic music production is a ... Read more

The post Beginner’s Guide to Electronic Music Production: Tips and Tricks for Starting Out appeared first on Star Two.






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An expert guide to Val Thorens, ‘the world's best ski resort’






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The Pinkbike Holiday Gift Guide: Top Gifts for All the MTBers in Your Life



We've pulled together an eclectic mix of mountain bike-related gift ideas for all the riders on your list.
( Photos: 12, Comments: 49 )




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How to Measure Your Child’s Ring Size: A Simple Guide for Parents

When our loved ones are young they get showered with plenty of gifts. Usually, we’re talking about toys and that’s nice. Once they get a little bit older, the types of gifts we present to them change. In no time, your toddler is old enough to be wearing a ring. Rings are nice presents. Valuable ... Read more

The post How to Measure Your Child’s Ring Size: A Simple Guide for Parents appeared first on Star Two.




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Guide to Buying a Lab Grown Diamond Engagement Ring

The decision to purchase an engagement ring is a momentous occasion in one’s life, and with the growing popularity of lab grown diamonds, individuals now have an alternative to traditional mined diamonds. Lab grown diamonds offer a stunning option for those seeking a beautiful symbol of commitment. In this comprehensive guide, we will explore key ... Read more

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An Adventure Lover’s Guide For a Trip to The Smokies

For those who seek the thrill of adventure and the rush of adrenaline, the Smoky Mountains present a vast playground of untamed wilderness and exhilarating activities. This majestic region is not just for the serene soul seeking peace in nature but also for the adventure lovers who crave excitement and challenge. From the rugged trails to the rapid waters, the Smokies offer a diverse array of experiences that cater to every kind of thrill-seeker. Let’s delve into ten thrilling activities that promise to ignite your adventurous spirit in the heart of the Smokies. 1. Hiking to Alum Cave Bluffs The journey to Alum Cave Bluffs is one of the most rewarding adventures the Smokies have to offer. This 4.6-mile hike is not just a physical challenge; it’s a passage through the varying moods of the mountains. As you ascend through the dense forest, you’ll encounter unique geological features, like Arch Rock, and the sweeping views from Inspiration Point. The trail culminates at Alum Cave Bluff, offering spectacular vistas. It’s an immersive experience that combines physical exertion with the tranquil beauty of the natural surroundings. 2. Jeep Ride Adventures For those who prefer their adventures on wheels, a Jeep ride through the Smoky Mountains provides an exhilarating way to explore the rugged landscapes. The winding mountain roads and off-road trails offer a thrilling ride with panoramic views that are simply unmatched. For Jeep owners, the experience can be further enhanced by customizing their vehicles with accessories from local outfitters like Smoky Mountain Off-Road Outfitters. Adding specialized Jeep badges not only personalizes your ride but also commemorates your adventure in the Smokies, making each journey as unique as the trails you choose to explore. 3. Whitewater Rafting on the Pigeon River Whitewater rafting on the Pigeon River is an adrenaline-packed activity that draws adventure-seekers from all over. The river features sections suitable for all levels, from the gentle flows ideal for beginners to the challenging Class III and IV rapids that test even the most experienced rafters. This exhilarating experience not only offers a thrilling ride through the rapids but also provides a unique perspective of the Smokies’ natural beauty, all from the heart of the river. 4. Ziplining Through the Canopy Ziplining offers a bird’s-eye view of the Smokies’ breathtaking landscapes, making it a must-try for anyone seeking adventure. Gliding through the canopy, adventurers can experience the forest in a way that’s impossible to do so from the ground. The sensation of flying above the trees, with the wind in your face and the valley below, is both exhilarating and serene. Zipline tours in the Smokies cater to a range of ages and thrill levels, ensuring that everyone can enjoy the rush of soaring through the air. 5. Mountain Biking on the Trails Mountain biking in the Smokies offers an off-road adventure that combines physical challenge with the natural beauty of the mountains. The region boasts a variety of trails, from gentle forest paths to rugged mountain tracks that require skill and endurance. Biking through these landscapes offers a unique way to explore the wilderness, with the added thrill of navigating the terrain at speed. It’s an activity that appeals to both seasoned bikers and those looking to try something new and exciting. 6. Rock Climbing and Bouldering The rugged terrain of the Smoky Mountains offers prime spots for rock climbing and bouldering, providing both beginners and seasoned climbers with the perfect setting to test their skills. The region’s natural rock formations offer a variety of climbs, from short, challenging boulders to towering cliff faces that demand endurance and technique. Climbing in the Smokies is not just about getting an adrenaline rush; it’s an opportunity to connect with the raw beauty of the mountains, offering a sense of achievement and exhilaration that is unmatched. 7. Horseback Riding Through the Forest Horseback riding through the Smoky Mountains offers a unique blend of adventure and tranquility. It’s an opportunity to explore the dense forests and rolling hills at a leisurely pace, allowing for a deeper connection with the natural surroundings. Riding trails meander through the heart of the Smokies, offering riders stunning views and the chance to encounter wildlife in their natural habitat. Whether you’re an experienced rider or trying it for the first time, horseback riding is a wonderful way to experience the Smokies’ serene beauty. 8. Fishing in Mountain Streams Fishing in the pristine mountain streams of the Smokies is an adventure that combines the thrill of the catch with the peace of being surrounded by nature. The clear, cool waters are home to a variety of fish, including trout, providing both challenge and reward for anglers. Fishing in the Smokies is not just about the sport; it’s an immersive experience that allows you to slow down and appreciate the subtle beauty of the mountain landscapes. Whether you’re fly fishing or using traditional methods, the streams of the Smokies offer a serene yet adventurous escape. 9. Exploring Caves and Caverns Delving into the caves and caverns of the Smoky Mountains is an adventure that takes you beneath the surface of the earth into a world of ancient rock formations, hidden chambers, and underground streams. Cave exploration in the Smokies allows adventurers to experience the thrill of discovery and the awe of natural wonders that have formed over millions of years. The cool, dark environments of these caves provide a stark contrast to the lush, vibrant landscapes above, offering a unique and thrilling exploration experience. 10. Camping Under the Stars Camping in the Smoky Mountains is the ultimate adventure for those who wish to immerse themselves fully in the natural beauty of the region. Whether you’re setting up camp in a designated campground or venturing into the backcountry, camping allows you to connect with the wilderness in a profound way. Sleeping under the stars, waking up to the sounds of nature, and living off the land are experiences that not only challenge but also rejuvenate the spirit. Camping here offers a blend of adventure, tranquility, and a deep connection with the natural world. Conclusion: More Than A Rush! The Smoky Mountains are a treasure trove of adventures, offering a plethora of activities for those who seek the thrill of the outdoors. The best part is that these adventures not only provide an adrenaline rush but also allow you to connect with nature in an intimate and memorable way. Whether you’re a seasoned adventurer or looking to step out of your comfort zone, the Smokies invite you to explore, challenge yourself, and create unforgettable memories amidst their majestic landscapes.

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Top 10 Must-Visit Ibiza Nightclubs: Your Ultimate Guide to the Island’s Hottest Spots

Ibiza, a stunning island in the Mediterranean Sea, is globally renowned for its electric nightlife and vibrant party scene. This picturesque island has become the epitome of summer party destinations. It attracts visitors from all corners of the world with its beautiful beaches, mesmerizing sunsets, and, most notably, its unparalleled nightlife. Clubs in Ibiza are not just venues; they are the beating heart of the island’s culture as they showcase world-class DJs, groundbreaking music, and unforgettable experiences to define the essence of a perfect summer getaway. The purpose of this article is to guide you through the exhilarating nightlife of Ibiza. Whether you’re a seasoned club-goer or a first-time visitor, this comprehensive guide to the top 10 must-visit nightclubs will ensure you hit the hottest spots and make the most of your nights in Ibiza. From iconic institutions to cutting-edge clubs, we’ve curated a list that captures the diversity and vibrancy of Ibiza’s nightlife. These places promise unforgettable nights filled with music, dance, and celebration. Why Ibiza? Ibiza stands as a beacon for nightlife enthusiasts from around the globe. It’s celebrated for its unmatched party scene and vibrant atmosphere. But what exactly catapults this Balearic Island into the spotlight as a world-renowned destination for nightlife? Diverse Music Scene: Ibiza’s music landscape is as varied as it is electrifying. From techno and house to EDM and indie rock, the island offers something for every taste, hosted across an array of clubs and venues. Vibrant Atmosphere: There’s an infectious energy that permeates Ibiza’s nightlife. Whether you’re dancing under the stars at an outdoor beach club or losing yourself in the immersive environment of an underground venue, the atmosphere is always charged with excitement. Stunning Venues: Ibiza’s nightclubs are more than just places to dance; they’re architectural wonders and sensory experiences. From clubs with breathtaking views of the Mediterranean to venues that push the boundaries of interior design, Ibiza offers stunning settings that elevate the party experience to new heights. Criteria for Selection When it comes to pinpointing the top 10 nightclubs in Ibiza, our selection is driven by a carefully considered set of criteria. We aim to showcase venues that not only dominate the nightlife scene but also offer unique experiences that leave a lasting impression. The following factors play a crucial role in our selection: Music Genres: A club’s musical offerings are pivotal. We look for diversity and quality, favoring venues that host world-renowned DJs to suit a wide range of musical tastes. Atmosphere: The vibe of a nightclub is its soul. We seek out places that offer more than just a dance floor. In fact, we prioritize those who create an immersive experience through their energy, design, and crowd.  Reputation: A club’s reputation is built on years of delivering exceptional nights out. We consider the esteem in which venues are held by both locals and international visitors, as well as their recognition within the global nightlife community. Overall Experience: Finally, we factor in the overall experience, including the quality of sound and lighting systems, the presence of unique features (like outdoor terraces or poolside dance floors), and the level of service provided. A club that offers an unforgettable night out, from entry to exit, makes our list.  Club 1: Amnesia Ibiza Location San Rafael, Ibiza Music Genres Techno House EDM Atmosphere Amnesia Ibiza stands out for its high-energy ambiance which makes it a sanctuary for dance music enthusiasts. The club’s iconic terrace offers an immersive experience that draws partygoers into a world of euphoric beats and rhythms. Notable Features Famous Foam Parties: These unique and wildly entertaining parties are a signature Amnesia experience. State-of-the-Art Sound System: Delivers crystal-clear audio that enhances the musical journey. Spectacular Light Shows: Visually stunning displays complement the sonic experience, creating unforgettable moments.  Highlights Legends of the electronic music scene, such as Carl Cox and Marco Carola, are regulars here, guaranteeing an unmatched lineup of performances. Club 2: Pacha Ibiza Location Ibiza Town, Ibiza Music Genres House Techno EDM Atmosphere Pacha Ibiza exudes a glamorous and chic vibe and offers a luxurious nightclub experience. Its atmosphere attracts a stylish crowd to dance the night away in one of the island’s most iconic settings. Notable Features Iconic Cherry Logo: A symbol of the club’s heritage and prestige. VIP Sections: For those seeking a more exclusive experience, with stunning views of Ibiza Town. Elegant Decor: Pacha’s interior design combines style with comfort, creating a uniquely sophisticated environment. Highlights Hosting world-renowned DJs like David Guetta and Martin Solveig, Pacha remains at the forefront of Ibiza’s nightlife scene. Club 3: DC-10 Location Sant Josep de sa Talaia, Ibiza Music Genres Techno House Atmosphere DC-10 is celebrated for its raw and underground atmosphere. This club offers an intimate setting where the focus is squarely on the music and the communal experience of dance. Notable Features Open-Air Terrace: Provides a unique outdoor clubbing experience. Industrial Vibe: The club’s minimalist, warehouse-style setup enhances its gritty, authentic feel. Immersive Experiences: DC-10’s events are designed to create a deep connection between the DJs and the crowd. Highlights Home to the legendary Circoloco parties, DC-10 attracts top DJs such as Seth Troxler and The Martinez Brothers to ensure an unparalleled lineup and vibe. Club 4: Ushuaïa Ibiza Beach Club Location Playa d’en Bossa, Ibiza Music Genres EDM House Atmosphere Ushuaïa Ibiza Beach Club is the epitome of an extravagant outdoor party experience. With its poolside setting, it invites guests to dance under the sun and stars in one of the most breathtaking venues on the island. Notable Features Massive Stage: Hosts some of the biggest names in the music industry. Stunning Visuals: Offers a sensory feast with its impressive light shows and stage productions. Celebrity Appearances: A hotspot for celebrities, adding to the club’s allure. Highlights Iconic pool parties featuring world-class performances by artists like Calvin Harris and Avicii are the heart of Ushuaïa’s appeal. Club 5: Hï Ibiza Location Playa d’en Bossa, Ibiza Music Genres Techno House EDM Atmosphere Hï Ibiza offers a sophisticated and futuristic nightclub experience. Its immersive atmosphere is crafted through cutting-edge sound and stunning visuals that make every night a journey into the future of nightlife. Notable Features Cutting-Edge Sound System: Delivers unparalleled audio quality. Immersive Production: Engages all senses for a complete clubbing experience. Stunning Visuals: The club’s design and lighting create a mesmerizing environment. Highlights Glitterbox parties at Hï Ibiza shine with disco and house music vibes, featuring top DJs and a vibrant, inclusive atmosphere. Club 6: Privilege Ibiza Location San Rafael, Ibiza Music Genres House Techno EDM Atmosphere Privilege Ibiza is recognized for its massive scale and extravagant atmosphere. Holding the Guinness World Record for the world’s largest club, it offers an immersive experience with panoramic views of Ibiza. Notable Features World’s Largest Club: A title that adds to its legendary status. Panoramic Views: The club’s location and design provide breathtaking views of the island. Highlights Resistance parties at Privilege are a highlight, featuring top techno and house DJs like Adam Beyer and Charlotte de Witte to create unforgettable nights. Club 7: Eden Ibiza Location San Antonio, Ibiza Music Genres House Techno EDM Atmosphere Eden Ibiza strikes a perfect balance between lively and intimate as it creates an energetic atmosphere for music lovers to enjoy themselves up close with the performers. Notable Features Renovated Venue: A recent makeover has injected new life into Eden, enhancing its appeal. Impressive LED Screens: Add to the visual experience, complementing the beats with captivating displays. Intimate Dance Floor: Despite its size, Eden maintains an intimate feel, making every night more personal. Highlights Toolroom parties at Eden are a standout, with house music legends like Mark Knight behind the decks. Club 8: Heart Ibiza Location Ibiza Town, Ibiza Music Genres Eclectic Avant-garde Live performances Atmosphere Heart Ibiza offers an artistic and immersive experience with a blend of music, art, and gastronomy into a unique nightlife adventure to tantalize all senses. Notable Features Fusion of Music, Art, and Gastronomy: A unique concept that stands out in Ibiza’s nightlife. Stunning Interior Design: Adds to the immersive experience with its beauty and creativity. Highlights Heart Factory events are particularly notable for their live performances and DJ sets by international artists, making each night a unique journey. Club 9: Ibiza Rocks Hotel Location San Antonio, Ibiza Music Genres Indie Rock EDM Atmosphere Ibiza Rocks Hotel is known for its lively and vibrant environment, where the poolside setting adds a refreshing twist to the traditional nightclub experience. Notable Features Outdoor Stage: Offers a unique venue for live music under the Ibiza sun and stars. Pool Parties: Bring an energetic and fun atmosphere, perfect for daytime reveling. Live Music Events: Unlike many other clubs focusing solely on DJs, Ibiza Rocks hosts live bands and performances. Highlights The Ibiza Rocks Pool Party series is a summer highlight, featuring an eclectic mix of live performances by indie bands and DJs. It offers something different from the typical club scene. Club 10: Octan Ibiza Location Playa d’en Bossa, Ibiza Music Genres Techno House Atmosphere Octan Ibiza brings a raw and underground vibe to the forefront of Ibiza’s nightlife. Its intimate setting allows for an immersive clubbing experience that’s both intense and personal. Notable Features Intimate Dance Floors: Designed to create a close connection between the DJs and the crowd. Immersive Experiences: Focused on delivering cutting-edge underground parties. Legacy: Carrying the torch from the famed Sankeys Ibiza, Octan continues to push the boundaries of the electronic music scene. Highlights The club is a haven for enthusiasts of techno and house music, and it hosts cutting-edge underground parties with leading DJs in the genre. Frequently Asked Questions (FAQ) What is the legal drinking age in Ibiza? The legal drinking age in Ibiza is 18 years old. Is there a dress code for Ibiza nightclubs? Dress codes can vary. While some clubs are more relaxed, others might require a more upscale attire. It’s best to check the specific club’s policy before going. How much does it cost to enter Ibiza nightclubs? Entrance fees can range widely from club to club and depending on the event or DJ playing. Prices can vary from €20 to over €50. VIP services and tables will cost significantly more. Are there any age restrictions for entry into nightclubs? Yes, most nightclubs in Ibiza have an age restriction of 18 years and above. Is it necessary to book tickets in advance for Ibiza nightclubs? It’s highly recommended to book tickets in advance, especially for popular events, to ensure entry and often at a lower price. What are the typical opening hours for Ibiza nightclubs? Nightclubs usually open around midnight and can go on till dawn, with peak hours from 1 AM to 4 AM. Are there any safety tips for clubbing in Ibiza? Stay hydrated, especially if dancing for long periods. Keep an eye on your belongings. Never accept drinks from strangers. Stick with your friends and plan how to get back to your accommodation safely. Conclusion We’ve explored the top 10 must-visit nightclubs in Ibiza, and each offers its unique vibe. From the extravagant and glamorous to the raw and underground, Ibiza’s nightlife is unparalleled. Its diverse music scenes and world-renowned DJs provide an unforgettable experience for every partygoer. Whether you’re drawn to the legendary foam parties of Amnesia, the sophisticated atmosphere of Hï Ibiza, or the intimate underground vibes of Octan, the island caters to all. We encourage you to dive into the vibrant energy of Ibiza’s nightlife scene and experience the magic of these iconic clubs firsthand.  

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Exploring the Enchantment of Zhangjiajie National Park: A Comprehensive Guide

Imagine stepping into a world where towering columns of rock stretch towards the sky, each shrouded in a veil of greenery and mist. This is not the realm of fantasy. This is Zhangjiajie National Forest Park in China, a place where nature’s artistry is on grand display. With landscapes so surreal, it’s no wonder that this park became a source of inspiration for the visually stunning world of Pandora in the movie “Avatar.” Zhangjiajie’s unique landscape is more than just a feast for the eyes; it’s a gateway to an adventure that promises to be as enchanting as it is exhilarating. From the ethereal beauty of its towering sandstone pillars to the deep, serene forests that blanket their bases, the park offers a tapestry of natural wonders waiting to be explored. This article is designed to be your comprehensive guide to navigating the spellbinding beauty of Zhangjiajie National Park. Whether you’re planning a visit or just dreaming of a journey to this otherworldly destination, we’ll take you through the heart of its magic, offering insights and tips to ensure your experience is as unforgettable as the landscape itself. Welcome to the gateway of a real-life Pandora, where the wonders of Zhangjiajie await. Is Zhangjiajie Worth Visiting? Address the central question directly Absolutely. Zhangjiajie Forest Park in China is a marvel of natural beauty that captivates all who visit. Its ethereal landscape is not just a visual treat but a soul-enriching experience. Highlight the park’s most distinctive features Quartzite Pillars: These towering, slender columns are the park’s signature feature. They rise dramatically from the ground, creating a surreal landscape that inspired the floating mountains in the movie “Avatar.” Diverse Flora and Fauna: Home to a rich biodiversity, the park shelters various species of plants and animals, some of which are rare and endemic to the region. Unique Karst Formations: The area showcases a fascinating range of karst phenomena, from deep ravines and gorges to natural bridges and caves, sculpted over millions of years. Briefly mention outdoor activities available Hiking: Trails wind through the park, offering routes for all abilities. They lead through dense forests, past serene streams, and up to breathtaking viewpoints. Cable Car Rides: For those who wish to take in the scenery without the hike, cable cars provide a stunning aerial view of the park. Sightseeing: Designated platforms and bridges offer spectacular vistas of the pillars, especially enchanting at sunrise or sunset. Planning Your Trip to Zhangjiajie Seasons Ideal Time to Visit: The best times to visit are spring (April to June) and fall (September to November). These seasons offer comfortable weather and the beauty of the park in full bloom or in the midst of autumnal colors. Peak vs. Shoulder Seasons: Summer (July and August) is peak tourist season, making the park more crowded. Winter sees fewer visitors, offering a quieter experience, albeit with cooler temperatures. Getting There Major Airports Nearby: The closest airport is Zhangjiajie Hehua International Airport, with connections to major Chinese cities. Transportation from Surrounding Cities: Buses and trains from cities like Changsha provide access to Zhangjiajie, making it reachable from various parts of China. Getting Around Shuttles: The park operates shuttle buses that connect different areas, making it easy to explore without excessive walking. Cable Cars and Elevators: To navigate the steep terrain, cable cars and the famous Bailong Elevator offer convenient and scenic rides. Walking Paths: For those who prefer to explore on foot, well-marked paths lead through the stunning scenery, allowing for an immersive experience. Must-See Sights in Zhangjiajie National Park Zhangjiajie National Park, a UNESCO World Heritage site, offers an array of natural wonders and cultural insights. Below are some of the must-see attractions within the park. Zhangjiajie National Forest The heart of Zhangjiajie’s magic lies in its iconic quartzite pillars, rising majestically from the earth. These formations are so unique that they inspired the floating “Hallelujah Mountains” in the blockbuster movie “Avatar.” The Avatar Hallelujah Mountain scenic area within the park pays homage to this connection, allowing visitors to step into a world that feels straight out of a science fiction fantasy. Tianzi Mountain Tianzi Mountain offers sweeping panoramic views that are unparalleled in their beauty. The area is renowned for its: Unique rock formations: The mountain’s landscape is dotted with towering pillars, each shaped by the forces of nature over millions of years. Points of interest: Notable spots include the Emperor Sightseeing Platform and Tianzi Pavilion, from where visitors can gaze out over an ocean of mist-enshrouded peaks. Huangshi Village (Yellow Lion Village) This traditional village offers a glimpse into the culture of the Tujia minority, showcasing their customs, architecture, and way of life. Huangshi Village is also celebrated for its: Cultural significance: The village is a living museum of Tujia traditions. Sunrise views: The location provides spectacular sunrise vistas, making it a favorite spot for early risers and photographers alike. Bailong Elevator The Bailong Elevator holds the record as the world’s highest outdoor elevator, whisking visitors up the side of a cliff face for an exhilarating ride. Highlights include: Breathtaking views: As you ascend, panoramic views of the surrounding landscape unfold, offering a unique perspective on the park’s natural beauty. Activities in Zhangjiajie National Park Zhangjiajie National Park is a playground for nature lovers, offering a plethora of activities that allow visitors to immerse themselves in its breathtaking landscapes. From challenging hikes to scenic cable car rides, there’s something for everyone in this majestic park. Hiking Hiking is undoubtedly one of the best ways to experience the natural beauty of Zhangjiajie National Park. The park boasts a range of trails that cater to various fitness levels, offering everyone the chance to explore its unique terrain. Golden Whip Stream: This trail is perfect for those who prefer a leisurely hike. It meanders alongside a crystal-clear stream, flanked by towering sandstone pillars. Bailong Elevator Path: For a more challenging adventure, the path leading from the base to the top of the Bailong Elevator allows hikers to experience the park’s verticality. This trail offers stunning views and a vigorous workout. Cable Car Rides For those who wish to take in the scenery without the physical exertion of hiking, cable car rides provide a spectacular alternative. Scenic Views: Cable cars glide over the park, offering panoramic views of the verdant landscapes and quartzite pillars that make Zhangjiajie so famous. Accessibility: This mode of transportation makes the park’s breathtaking beauty accessible to all, including those who may find hiking challenging. Photography Zhangjiajie National Park is a paradise for photographers, boasting an array of photogenic spots that capture the essence of its natural wonders. Photogenic Spots: Iconic locations like the Avatar Hallelujah Mountain and Tianzi Mountain offer unforgettable scenes for photography enthusiasts. Photography Tips: To capture the park’s landscapes at their best, aim for the golden hours of sunrise and sunset when the light casts a magical glow over the pillars and valleys. Essential Tips for Visitors to Zhangjiajie National Park Planning a trip to Zhangjiajie National Park can be an exciting adventure. To ensure a smooth and enjoyable experience, consider these essential tips covering accommodation, budget, weather, and other considerations. Accommodation Zhangjiajie offers a range of accommodation options to suit different preferences and budgets: Inside the Park: For a fully immersive experience, several hotels and guesthouses are located within the park itself. Staying here allows you to start exploring early in the morning before the crowds arrive. Outside the Park: The city of Zhangjiajie and nearby Wulingyuan offer more accommodation choices, from budget hostels to luxury hotels. These areas provide easy park access and additional dining options. Budget Understanding the costs associated with your visit can help you plan effectively: Park Entrance Fees: Entrance fees to the park vary by season, generally ranging from 225 to 245 RMB. Transportation: Costs will vary depending on your mode of travel within and to the park. Local buses and shuttle services are economical options. Food: Dining costs can vary widely, but budget-friendly options are available, especially in the city and at food stalls near the park. Accommodation: Prices range significantly based on location and comfort level. Budget accommodations start from around 100 RMB per night, while luxury options can exceed 1000 RMB. Weather and Clothing Zhangjiajie experiences distinct seasons, which can influence what you pack: Spring/Fall: These mild seasons require light layers that can be adjusted throughout the day. Summer: The weather can be hot and humid. Lightweight, breathable clothing and rain gear are advisable. Winter: Cold temperatures demand warm clothing and layers. Additional Considerations To enhance your trip, keep these tips in mind: Currency Exchange: It’s advisable to exchange some currency into RMB (Chinese Yuan) before arriving, especially for purchases in smaller shops and rural areas. Language Barriers: While Mandarin Chinese is the primary language, having a translation app or phrasebook can be invaluable. Some tourism workers speak basic English. Etiquette: Respect local customs and etiquette. For example, queue politely, speak respectfully, and ask permission before taking photos of locals. Conclusion Zhangjiajie National Park stands as a testament to nature’s artistry, offering a unique blend of breathtaking landscapes and rich cultural heritage. From the towering quartzite pillars that inspired the landscapes of “Avatar” to the serene beauty of its vast forests, the park provides an unparalleled adventure for nature lovers and adventurers alike. The diverse range of activities, from hiking the rugged trails to peaceful cable car rides, ensures that every visitor can find their own way to connect with this extraordinary place. We encourage you to plan your trip to Zhangjiajie and experience its magic firsthand. Witnessing the park’s majestic beauty and immersing yourself in its enchanting atmosphere is an adventure that promises to be unforgettable. FAQ How much time do I need to spend in Zhangjiajie? To truly appreciate the main highlights of Zhangjiajie National Park, we recommend spending a minimum of 2-3 days. This allows ample time to explore the iconic landscapes, take part in various activities, and soak in the natural beauty of the park. Is Zhangjiajie safe to visit? Yes, Zhangjiajie is safe for visitors. Like any travel destination, it’s wise to take basic precautions, stay on marked paths, and follow park guidelines to ensure a safe and enjoyable visit. What language is spoken in Zhangjiajie? The primary language spoken in Zhangjiajie is Mandarin Chinese. While some tourism resources and staff might be available in English, learning a few basic Mandarin phrases can enhance your experience. Are there any festivals or events held in Zhangjiajie? Zhangjiajie hosts various festivals and events throughout the year, celebrating the rich cultural traditions of the region. These can include traditional Tujia festivals, which are a fantastic way to experience local customs and entertainment. What are some local delicacies I should try? Zhangjiajie offers a variety of local delicacies that reflect its rich culinary tradition. Some must-try dishes include Tujia sour fish soup and flavorful stews, which are sure to provide a memorable dining experience.

The post Exploring the Enchantment of Zhangjiajie National Park: A Comprehensive Guide appeared first on Geeky Traveller.





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The Role of Word-, Sentence-, and Text-Level Variables in Predicting Guided Reading Levels of Kindergarten and First-Grade Texts

Texts classified according to guided reading levels (GRL) are ubiquitous in U.S. beginning reading classrooms. This study examined features of texts across three grade bands (kindergarten, early first grade, final first grade) and the 10 GRLs within these bands. The 510 texts came from three programs with different functions in beginning reading instruction: core, intervention, and content areas.




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Visiting Locorotondo, Italy – A Guide to the Trulli Town

Have you heard of Locorotondo, Italy? Locorotondo is one of Southern Italy’s most beautiful villages, in my opinion, but it isn’t yet overwhelmed with tourist crowds. A true hidden gem, Locorotondo is just a 12-minute drive from busy Alberobello in the Puglia region, but feels like a world away. Planning your trip to Locorotondo last […]

The post Visiting Locorotondo, Italy – A Guide to the Trulli Town appeared first on Adventurous Kate.




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Cavtat, Croatia Guide: A Quiet Alternative to Dubrovnik

Cavtat, Croatia, might be the biggest surprise of your trip! This peaceful seaside town in the far south of Croatia is so close to Dubrovnik, and yet a world away. If you want to visit Dubrovnik but would rather stay somewhere with a quiet, more relaxing atmosphere — oh, and cheaper, too! — Cavtat (pronounced […]

The post Cavtat, Croatia Guide: A Quiet Alternative to Dubrovnik appeared first on Adventurous Kate.




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Guide to the 5 Towns of Cinque Terre, Italy

Cinque Terre is one of the most picturesque regions in Italy. These steep, colorful fishing villages perched on seaside cliffs of the Italian Riviera will take your breath away! There are 5 towns of Cinque Terre: Monterosso al Mare, Vernazza, Corniglia, Manarola, and Riomaggiore. Here you’ll find my recommendations for all five towns, plus the […]

The post Guide to the 5 Towns of Cinque Terre, Italy appeared first on Adventurous Kate.




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A guide to the Chinese Communist Party's National Congress

A guide to the Chinese Communist Party's National Congress The World Today rescobales.drupal 21 September 2022

In the first of a three-part series examining the global importance of the CCP’s 20th National Congress, Yu Jie explains how it makes its big decisions.

Why does the CCP National Congress matter?

The world’s most populous country and its smallest state have little in common with one exception: how they select their leader. Like the Vatican, the Chinese Communist Party (CCP) shrouds its leadership selection process in secrecy.

Every five years, a week-long conclave – the Party Congress – is held and at its end a new cohort of leaders is presented that will steer the world’s second largest economy for the next five years.

October’s Congress will reveal the depth and breadth of Xi Jinping’s power

The congress is the most important date in China’s political calendar. It not only selects China’s leadership team but acts as a signpost indicating the direction the country will be heading in the near future, with implications for decades to come. It also reveals the breadth and depth of power held by Xi Jinping, the party’s general-secretary.

The 20th CCP National Congress, opening on October 16 and expected to last a week, is taking place during unsettling times. While Xi Jinping is expected to embark on his third term as general-secretary of the party after the removal of a two-term limit in February 2018, it is hardly a crowning glory. Xi’s China is battling an economic maelstrom at home while juggling fraught foreign relations abroad.

What does the National Congress do?

Quite simply, the CCP National Congress is the gathering that defines China’s political leadership and sets the tone for its relationship with the rest of the world.

It serves to fulfil three primary functions:

First, it sets the party’s principal agenda across all policy sectors, from macroeconomics to the price of food. During the week, it draws up a consensus-based evaluation of the party’s work over the past five years, which includes a detailed examination of the party’s current situation.

Second, it introduces any revisions to the party constitution deemed necessary, for instance on changes to the criteria for leadership recruitment or amendments to the party’s ‘guiding ideology’.

Third, it selects the leadership team that will steer China for the next five years, a function that attracts the most international attention but is not the sole purpose of the congress.

How is the party leadership team chosen?

The congress comprises 2,300 delegates representing all levels of the party hierarchy across 34 provinces and regions – from the governors of towns and cities, to Olympic champions, astronauts, and even the odd stand-up comedian to mark the ‘inclusiveness’ of the party.

The votes that decide the next cohort of party leaders come from three committees only: the Central Commission for Discipline Inspection, with 205 members and 171 alternate members (alternate members are simply substitutes to replace a member if they die, retire or are dismissed); the Central Committee, with 204 members; and the Politburo, with 25 members, only one of whom is a woman.

Unlike multiparty elections in liberal democracies, neither the full 25 members of the Politburo nor the seven members of its Standing Committee are nominated by or directly voted for by constituents.

A procedure known as ‘democratic recommendation’ is essentially a straw poll that includes all congress participants. They are then given a ballot listing the names of around 200 Politburo candidates in stroke order – the Chinese equivalent to alphabetical order. This short-listing process is completed in the run-up to the congress. Some pundits asserted that this process was put on hold after 2017, yet this has not been formally confirmed within the party constitution.

A few senior delegates may express their preferences to their colleagues anonymously during this process. All the shortlisted candidates must meet the criteria for Politburo membership, which means serving at either a ministerial rank or above or in the People’s Liberation Army at military region level or above and being younger than 62.

Based on the result of this straw poll, and more importantly on the preferences of current Politburo members, the incumbent Politburo and its Standing Committee will approve the nominees, conclude the Seventh Plenum of the 19th Party Congress and call for the 20th Congress. The delegates at the Party Congress then ceremonially cast their votes for the Politburo at the Party Congress although the result is pre-agreed, a procedure somewhat similar to the US Electoral College.

What are the rules for choosing Politburo members?

The Politburo Standing Committee (PSC) consists of between five and nine members, with seven selected at the 19th Congress. It is the supreme decision-making body of the Communist Party as well as the People’s Republic of China.

If the 20th Congress follows convention, there are three de-facto rules to be followed:

First, Politburo and Standing Committee members must retire at 68. This age limit is known as ‘Eight down, Seven up’.

Second, new appointments to the PSC are drawn exclusively from regular Politburo members. The only exceptions to this rule have been Xi Jinping and Li Keqiang, who were appointed at the 17th Party Congress in 2007.

Standing Committee members must retire at 68, but it is highly unlikely that 69-year-old Xi Jinping will stand down

This exception follows the third convention, under which PSC appointees are among the youngest senior party leaders eligible. Potentially three vacancies could arise in 2022, as Xi himself is 69 but it is highly unlikely that he would step down. That would be a radical departure from past precedents.

The extent to which past procedure is applied could act as a signal as to whether Xi Jinping is consolidating his power, while the size of the standing committee will be scrutinized to assess how much power Xi wields.

If the procedure for leadership appointments at the 20th Congress deviates from these conventions, it could indicate two things. First, the CCP faces a new set of challenges and requires the introduction of new rules to shape the top leadership. Or, second, Xi has gained substantial personal power that allows him to bypass the collective leadership system endorsed by Deng Xiaoping and choose appointees to suit his own taste. There has thus far been little evidence from the official media to reflect on any changes.

Changes in party institutional constraints, however, raise the danger of undermining governance at home and China’s relations abroad.

Read the two further articles in this series: the second discusses the key domestic policy themes that Xi Jinping is expected to outline at this year’s congress; the third analyses the foreign policy issues likely to be discussed at the congress.   

 




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Book preview: Guide to Chinese Climate Policy 2022

Book preview: Guide to Chinese Climate Policy 2022 20 October 2022 — 10:00AM TO 11:15AM Anonymous (not verified) 28 September 2022 Chatham House and Online

Join authors David Sandalow and Michal Meidan to discuss their upcoming book.

China is the world’s largest emitter of greenhouse gases and a key player in tackling the global climate crisis. Its stated climate policies, namely its high-level targets to peak emissions by 2030 and to achieve carbon neutrality by 2060, are significant.

But while national-level ministries, local governments and businesses are setting climate roadmaps, implementation is challenging at times. In the current context of the global energy market and geopolitical turmoil, China’s need to maintain energy security can seem at odds with its climate pledges.

The authors will present the book, which examines Chinese emissions, the impacts of climate change in China, as well as China’s domestic and international climate change policies and the main implementation challenges these policies face.




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International relations: The ‘how not to’ guide

International relations: The ‘how not to’ guide Expert comment NCapeling 11 October 2022

A centenary special issue of International Affairs explores past foreign policy failures to help policymakers avoid future catastrophes.

Policy decisions in international relations frequently have a long-lasting effect on the world order, shaping the lives of millions. Often acting under pressure and severe time constraints, decision-makers must rely on their own experience and the best expertise available. And so, despite many striving for a more peaceful and prosperous world, policy failures are all too common.

The second of International Affairs’ centenary special issues – devised and guest-edited by Amrita Narlikar and Daniel W. Drezner – is a ‘how not to guide’ for international relations. Focusing on historic failures, 14 experts examine what went wrong, and how policy practitioners and researchers can get it right together.

Between theory and outcome fall two ‘shadows’: one of decision-makers not taking advantage of sound academic policy advice – in some cases ignoring it because they think they already know best – and a second of bias in academic analyses and researchers simply erring, or erring on the side of their own self-importance. Between these two, there lies a joint path toward better policies.

The special issue provides policymakers with cautionary lessons, transforming well-known cases into a guide of what not to do in international politics. Building on that, the collection also suggests ways forward, including borrowing the medical Hippocratic Oath of ‘do no harm’, which in international relations serves as a cautionary warning against action merely for action’s sake, and then going decidedly beyond this minimum requirement.

A series of comics also accompanies the articles, produced in collaboration with Sequential Potential comics.

In their introduction, Drezner and Narlikar draw out four overarching factors which increase the likelihood of foreign policy failure – these are a focus on short-term successes, underestimating the power of narratives, hubris, and technocratic bubbles. If academics and policymakers can work together with these careful considerations, perhaps mistakes can avoid being repeated.

Richard Toye examines three pivotal moments in the UK’s history – the Munich crisis of 1938, the Suez crisis and war of 1956, and the Iraq war of 2003. He finds that in these cases the failures were over-determined, a consequence of Britain’s relative decline rather than its cause.

Daniel W. Drezner reviews two high profile failures of sanction use – United Nations (UN) sanctions on Iraq during the two Gulf wars, and the US re-imposition of sanctions on Iran in 2018. In both cases the main goals were not achieved and the costs were great. Drezner highlights ten ‘do’s and don’ts’ for sanctions as a result.

Amrita Narlikar shows how the World Trade Organization (WTO) has become an almost perfect example of how not to negotiate, even when taking into account recent limited successes. She identifies three broad categories of bargaining failures and explores the impact of narratives on the course of events, giving a clear list of do’s and don’ts for international negotiation.

Harold James also looks at three historic moments, the financial crises in 1931, 1997, and 2008. While responses to the crises initially looked successful, ironically in each case the drive to avoid past mistakes opened the door for the next crisis.

Cecilia Emma Sottilotta considers recent disasters in the European Union (EU) – the eurozone crisis and COVID-19 pandemic – and recommends for policymakers to find a middle ground between supranationalism and intergovernmentalism in crisis situations.

The growth of Chinese influence is a key issue in international relations today. Various articles in the special issue explain how not to deal with a rising China, coming from different angles. Exploring the US-China relationship, Janice Gross Stein is critical of the narrative around US decline and Chinese growth. The world should look beyond GDP as an indicator of a country’s growth and pay attention to strategic choices made by leaders in both states.

Joseph S. Nye Jr also provides a US perspective, arguing that while some historic analogies are misleading, the US should contemplate the cautionary narrative of sleepwalking into World War One when thinking about its relationship with China.

Amitabh Mattoo gives a south Asian view, asserting there is a need to understand Chinese policies in the region. Through examining China’s relations with India, Pakistan, and Sri Lanka he concludes that because China is adopting aggressive policies in the region, states must start cooperating with like-minded allies.

Yuen Foong Khong answers two questions in his paper tackling which ‘how not to’s’ are relevant when learning from history, and whether policymakers are aware of them. His research points to four things to avoid, which he then applies to how the Cold War analogy is used to understand contemporary US-China relations.

On the theme of foreign interference, Igor Istomin looks at the Soviet support for Mao Zedong’s Communist Party in the 1920s to 1940s. He argues strongly against interfering with major powers, as short-term gains cannot last.

From Iraq and Afghanistan to Somalia and the Balkans, there have been many failed interventions by the West since the end of the Cold War. Stephanie Carvin asserts the overreliance on automated weaponry has allowed supposedly ‘easy wars’ to turn into ‘forever wars’ – and this is not likely to stop.




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Pattern of Failure in Patients with Biochemical Recurrence After PSMA Radioguided Surgery

Visual Abstract




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Theranostics for Meningioma on the Rise: New EANM/EANO/RANO/SNMMI Guidelines Pave the Way to Improved Patient Outcomes Using Radiolabeled Somatostatin Receptor Ligands




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SNMMI Procedure Standard/EANM Practice Guideline for Brain [18F]FDG PET Imaging, Version 2.0

PREAMBLE

The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and professional organization founded in 1954 to promote the science, technology, and practical application of nuclear medicine. The European Association of Nuclear Medicine (EANM) is a professional nonprofit medical association that facilitates communication worldwide between individuals pursuing clinical and research excellence in nuclear medicine. The EANM was founded in 1985. The EANM was founded in 1985. SNMMI and EANM members are physicians, technologists, and scientists specializing in the research and practice of nuclear medicine.

The SNMMI and EANM will periodically define new guidelines for nuclear medicine practice to help advance the science of nuclear medicine and to improve the quality of service to patients throughout the world. Existing practice guidelines will be reviewed for revision or renewal, as appropriate, on their fifth anniversary or sooner, if indicated.

Each practice guideline, representing a policy statement by the SNMMI/EANM, has undergone a thorough consensus process in which it has been subjected to extensive review. The SNMMI and EANM recognize that the safe and effective use of diagnostic nuclear medicine imaging requires specific training, skills, and techniques, as described in each document. Reproduction or modification of the published practice guideline by those entities not providing these services is not authorized.

These guidelines are an educational tool designed to assist practitioners in providing appropriate care for patients. They are not inflexible rules or requirements of practice and are not intended, nor should they be used, to establish a legal standard of care. For these reasons and those set forth below, both the SNMMI and the EANM caution against the use of these guidelines in litigation in which the clinical decisions of a practitioner are called into question.

The ultimate judgment regarding the propriety of any specific procedure or course of action must be made by the physician or medical physicist in light of all the circumstances presented. Thus, there is no implication that an approach differing from the guidelines, standing alone, is below the standard of care. To the contrary, a conscientious practitioner may responsibly adopt a course of action different from that set forth in the guidelines when, in the reasonable judgment of the practitioner, such course of action is indicated by the condition of the patient, limitations of available resources, or advances in knowledge or technology subsequent to publication of the guidelines.

The practice of medicine includes both the art and the science of the prevention, diagnosis, alleviation, and treatment of disease. The variety and complexity of human conditions make it impossible to always reach the most appropriate diagnosis or to predict with certainty a particular response to treatment.

Therefore, it should be recognized that adherence to these guidelines will not ensure an accurate diagnosis or a successful outcome. All that should be expected is that the practitioner will follow a reasonable course of action based on current knowledge, available resources, and the needs of the patient to deliver effective and safe medical care. The sole purpose of these guidelines is to assist practitioners in achieving this objective.




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Analytical Guidelines for co-fractionation Mass Spectrometry Obtained through Global Profiling of Gold Standard Saccharomyces cerevisiae Protein Complexes [Research]

Co-fractionation MS (CF-MS) is a technique with potential to characterize endogenous and unmanipulated protein complexes on an unprecedented scale. However this potential has been offset by a lack of guidelines for best-practice CF-MS data collection and analysis. To obtain such guidelines, this study thoroughly evaluates novel and published Saccharomyces cerevisiae CF-MS data sets using very high proteome coverage libraries of yeast gold standard complexes. A new method for identifying gold standard complexes in CF-MS data, Reference Complex Profiling, and the Extending 'Guilt-by-Association' by Degree (EGAD) R package are used for these evaluations, which are verified with concurrent analyses of published human data. By evaluating data collection designs, which involve fractionation of cell lysates, it is found that near-maximum recall of complexes can be achieved with fewer samples than published studies. Distributing sample collection across orthogonal fractionation methods, rather than a single high resolution data set, leads to particularly efficient recall. By evaluating 17 different similarity scoring metrics, which are central to CF-MS data analysis, it is found that two metrics rarely used in past CF-MS studies – Spearman and Kendall correlations – and the recently introduced Co-apex metric frequently maximize recall, whereas a popular metric—Euclidean distance—delivers poor recall. The common practice of integrating external genomic data into CF-MS data analysis is also evaluated, revealing that this practice may improve the precision and recall of known complexes but is generally unsuitable for predicting novel complexes in model organisms. If studying nonmodel organisms using orthologous genomic data, it is found that particular subsets of fractionation profiles (e.g. the lowest abundance quartile) should be excluded to minimize false discovery. These assessments are summarized in a series of universally applicable guidelines for precise, sensitive and efficient CF-MS studies of known complexes, and effective predictions of novel complexes for orthogonal experimental validation.




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A Pragmatic Guide to Enrichment Strategies for Mass Spectrometry-based Glycoproteomics [Review]

Glycosylation is a prevalent, yet heterogeneous modification with a broad range of implications in molecular biology. This heterogeneity precludes enrichment strategies that can be universally beneficial for all glycan classes. Thus, choice of enrichment strategy has profound implications on experimental outcomes. Here we review common enrichment strategies used in modern mass spectrometry (MS)-based glycoproteomic experiments, including lectins and other affinity chromatographies, hydrophilic interaction chromatography (HILIC) and its derivatives, porous graphitic carbon (PGC), reversible and irreversible chemical coupling strategies, and chemical biology tools that often leverage bioorthogonal handles. Interest in glycoproteomics continues to surge as MS instrumentation and software improve, so this review aims to help equip researchers with necessary information to choose appropriate enrichment strategies that best complement these efforts.




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Here's your guide to Angels Spring Training

It's almost time for Spring Training yet again, as Angels pitchers and catchers report to their Spring Training complex in Tempe, Ariz. on Feb. 12.




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Ausmus eager to guide Halos as camp opens

Spring Training is officially here for the Angels, with pitchers and catchers reporting to Tempe Diablo Stadium on Tuesday. And there's a new face at manager, with Brad Ausmus replacing longtime skipper Mike Scioscia this offseason.




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The Rise of Molecular Image-Guided Robotic Surgery

Following early acceptance by urologists, the use of surgical robotic platforms is rapidly spreading to other surgical fields. This empowerment of surgical perception via robotic advances occurs in parallel to developments in intraoperative molecular imaging. Convergence of these efforts creates a logical incentive to advance the decades-old image-guided robotics paradigm. This yields new radioguided surgery strategies set to optimally exploit the symbiosis between the growing clinical translation of robotics and molecular imaging. These strategies intend to advance surgical precision by increasing dexterity and optimizing surgical decision-making. In this state-of-the-art review, topic-related developments in chemistry (tracer development) and engineering (medical device development) are discussed, and future scientific robotic growth markets for molecular imaging are presented.




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USS Frank E. Petersen Jr. guided-missile destroyer completes acceptance trials

The USS Frank E. Petersen Jr. cleared another hurdle toward joining the Navy's fleet after it completed acceptance trials on Thursday.




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How To Change Negative Core Beliefs: A Straightforward Guide to Cognitive Behavioral Therapy (CBT)

The core beliefs that cause the most common problems fall into the following 3 categories. These core beliefs commonly underlie depression and anxiety. Helpless Core Beliefs such as: “I’m incompetent” “I’m needy” “I’m weak” “I’m defective, I don’t measure up” “I’m a failure” Unlovable Core Beliefs such as: “I’m unlovable” “I’m different” “I’m bound to […]

The post How To Change Negative Core Beliefs: A Straightforward Guide to Cognitive Behavioral Therapy (CBT) appeared first on Dr Alice Boyes.




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Thousands of Teachers. 4 States. Your Guide to the Protests Sweeping the Nation

As Oklahoma teachers prepare for day four of their statewide walkout, here's a guide to the larger picture of teacher protests.




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This Captivating Guide Uncovers the History and Mystery of Dinosaurs in 50 Fossils

A paleontologist at the Natural History Museum in London chronicles the age of the famous and fascinating massive reptiles




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An action-oriented guide for decision makers

A valuable tool has been produced for decision makers responsible for integrating the Sustainable Development Goals into national policies and programmes. This publication, Transforming food and agriculture to achieve [...]




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The Ultimate Skywatching Guide for Every Season

Whether you're a passionate astronomer or a beginner eager to explore the cosmos, join us as we deep-dive into seasonal skywatching. Gain valuable insights into identifying meteors, stars, and fascinating deep-sky objects that grace the night sky. Interested in learning more? Check out this piece from Smithsonian Magazine on the celestial events to watch in 2024: https://www.smithsonianmag.com/science-nature/nine-dazzling-celestial-events-to-watch-in-2024-180983505/ And don't forget to subscribe to our channel for more exciting videos exploring the wonders of the natural world. --- Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Video Editor: Sierra Theobald




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Anus-Breathing Animals and Pigeon-Guided Missiles: Ig Nobel Prizes Reward Unusual but Valuable Science

The annual award ceremony featured costumes, songs and paper airplanes as scientists recognized comedic research across ten disciplines