La Procuraduría solicitó frenar los gastos de viaje de la primera dama

El exsecretario general de la Cancillería, explicó lo que ocurre con la licitación de los pasaportes.

El Dr. Andrés Vecino, profesor e investigador de la Facultad de Salud Pública de la Universidad Johns Hopkins en EEUU, advierte sobre el posible incremento de la mortalidad durante una intervención a EPS, así como los traumatismos que esta puede generar.

En mayo de 2024, el recaudo tributario bruto de la Dian fue de $30.26 billones de pesos, un aumento nominal de 17,8% y real de 11% frente a mayo de 2023.

En 6AM Hoy por Hoy, el líder estudiantil William Molina denunció haber recibido amenazas de muerte tras exigir derechos al Gobierno de Petro.

Entre la semana 12 (fin de marzo) y la semana 27 (ahora) el costo de Transporte marítimo de un contenedor de 40 pies ha subido de 1.700 a 8.200 dólares (ver gráfica).

Humberto Amín, concejal de la capital, entregó detalles en 6AM de la propuesta que le presentó al distrito con el propósito de reducir los tiempos en algunos corredores viales sin que los conductores sean sancionados con comparendos

De acuerdo con Juan Carlos Echeverry, exministro de Hacienda y expresidente de Ecopetrol, se trata de un negocio que no se daría fácilmente.

El representante a la cámara, Julián López, hizo hincapié en sobre cuáles serán los puntos clave del proyecto de ley con el que pretenden evitar el reclutamiento. 

A pesar de todos los desacuerdos, el gobierno decidió incrementar el precio del diésel.

El gobierno asegura que es necesario el incremento del ACPM, pero ¿no hay otras posibilidades?

En el programa 6AM de Caracol Radio, Martha Carvajalino, la ministra de Agricultura, hizo hincapié en cuáles son los departamentos más afectados con incrementos en el precio de alimentos 

En 6AM Hoy por Hoy de Caracol Radio estuvo Jorge Emilio Rey, gobernador de Cundinamarca, para hablar sobre qué información tienen sobre grupos y actividades ilegales en esta parte del departamento y las acciones que adelantan para esto.

En Caracol Radio estuvo Cielo Rusinque, superintendente de Industria y Comercio, explicando las medidas de la entidad.

Armando Novoa, jefe del equipo negociador del Gobierno nacional con la Segunda Marquetalia de ‘Iván Márquez’, estuvo en 6AM para abordar las especulaciones sobre la muerte del guerrillero disidente.

NPR's Ayesha Rascoe talks with A.B. Stoddard, columnist at The Bulwark, about the election results and if it means there has been a durable political realignment.

Exact services vary depending on the community each project targets, but supportive housing generally includes on-site case managers, often with some health care or job training classes available in the building.

Donald Trump has said he would increase tariffs even more if he wins the election. It's not clear what approach Kamala Harris would take.

The highest number of pedestrian crashes that led to serious injury or death were reported in Adams, Pueblo, Douglas, Jefferson and Boulder counties, according to the Colorado State Patrol.

BELCO advised that beginning October 1st, 2023 there will be an increase in the Fuel Adjustment Rate [FAR]. A spokesperson said, “With the approval of the Bermuda Regulatory Authority, the FAR will increase from the existing rate of 16.513 cents per kilowatt-hour [kWh] to 24.517 cents per kWh. The FAR is comprised of 20.09 cents per […]

Since announcing there would be an increase in the Fuel Adjustment Rate [FAR] “there have been several misconceptions and incorrect information circulating,” the BELCO President said, adding that “customers’ bills are not increasing by 48%, only a portion of the bill will increase, the base rate and other charges will remain the same.” BELCO President […]

[Opinion column written by OBA Shadow Minister for Legal & Home Affairs Scott Pearman] In his speech made the day he became Opposition Leader, Jarion Richardson observed that “blame is not a solution”. Friday’s press conference by Deputy Premier Walter Roban on the impending increases in our electricity costs, was sadly short on meaningful solutions. Instead […]

The Regulatory Authority of Bermuda [RA] has approved an adjustment to the Feed-In-Tariff [FIT], increasing it from 0.131 $/kWh to 0.1915 $/kWh. A spokesperson said, “This decision is a calculated response to the dynamic shifts unfolding in both the energy and economic landscapes. “The rationale behind this move is grounded in a commitment to maintaining […]

The Ministry of Health says that there has been an increase in reported cases of fever and respiratory symptoms on the island. A Government spokesperson said, “The Epidemiology and Surveillance Unit [ESU] at the Ministry of Health is alerting the public to an increase in reported cases of fever and respiratory symptoms, including Covid-19, the […]

The police said there has been an increase in the number of motorcycles reported stolen, with 20 motorcycles reported stolen in the last week. A police spokesperson said, “In recent times, the Bermuda Police Service [BPS] has observed an increase in the number of motorcycles reported stolen. Last week, 20 motorcycles were reported stolen from various locations around […]

BermudAir announced that they are increasing flights on its recently launched service between Bermuda and Halifax to twice a week; the airline is adding a flight on Wednesdays to its schedule starting on July 10th 2024, along with flights on Saturdays. “We’re delighted to be increasing our Halifax flights after launching service in May,” said Adam […]

The COVID-19 pandemic has changed the nature of work as we know it. Between flexible work arrangements, part-time contracts, and side gigs, it’s been difficult to gauge just how many people are working from home as a result. But according to Stanford’s research, 42% of the U.S. labor force was working from home full time […]

The post How employers can address increased gender inequality due to Working From Home appeared first on DiversityJobs.com.

More to come......

Our Blogging Delay Update First off, if anyone who is a subscriber has been wondering why the news letter has been the same for about two months now, it has been because of being extremely busy. There has been an extensive amount of work being completed elsewhere for another company over the last few months. […]

Current prices are now a deal, get them while you can or cancel your subscription in protest. Many vendors have already increased prices.

https://www.forbes.com/sites/erikkain/2023/08/31/time-to-cancel-playstation-plus-as-sony-quietly-raises-prices-through-the-roof/?sh=e43dfc0c9ac6

By Jesse Published: November 11th, 2024

The ways buildings are constructed has to change. It has become something else instead, something more sustainable, something newer. And it doesn't get much more modern than buildings that can actually move and adapt at will.[...]

The film is being scripted by 'Terminator 3: Rise of Machines' and 'Rugrats' writer Michael Ferris.

Improving organic traffic can sometimes be challenging, but if you apply the correct SEO strategies, the hard work will eventually pay off. Search engine traffic is great because it’s relevant and targeted. For most websites, organic traffic converts much better than traffic from social media or other sources. Another great advantage is that visits from […]

The post 10 Smart Ways To Increase Organic Traffic To A Website appeared first on RSSground.com.

The underlying cause of multiple sclerosis is not yet known, but Epstein-Barr virus is a possible culprit, Harvard researchers say.

Selling your services and wares online can be challenging, as today’s digital shoppers are smart and demanding. You need a customer-focused approach right from the start. The customer is the most significant pillar of modern businesses, so you need to build a genuine relationship with them if you want your online store to survive. Read […]

Police revealed Tuesday they had infiltrated and taken down an encrypted chat app called Ghost used by criminals across the world.

The molecular mechanisms of reduced frataxin (FXN) expression in Friedreich's ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, play an important role in the regulation of FXN expression and represent a novel therapeutic target. Using a human FXN–GAA–Luciferase repeat expansion genomic DNA reporter model of FRDA, we screened the Structural Genomics Consortium epigenetic probe collection. We found that pharmacological inhibition of the SUV4-20 methyltransferases by the tool compound A-196 increased the expression of FXN by ∼1.5-fold in the reporter cell line. In several FRDA cell lines and patient-derived primary peripheral blood mononuclear cells, A-196 increased FXN expression by up to 2-fold, an effect not seen in WT cells. SUV4-20 inhibition was accompanied by a reduction in H4K20me2 and H4K20me3 and an increase in H4K20me1, but only modest (1.4–7.8%) perturbation in genome-wide expression was observed. Finally, based on the structural activity relationship and crystal structure of A-196, novel small molecule A-196 analogs were synthesized and shown to give a 20-fold increase in potency for increasing FXN expression. Overall, our results suggest that histone methylation is important in the regulation of FXN expression and highlight SUV4-20 H1 as a potential novel therapeutic target for FRDA.

Environmental factors, such as viral infection, are proposed to play a role in the initiation of autoimmune diabetes. In response to encephalomyocarditis virus (EMCV) infection, resident islet macrophages release the pro-inflammatory cytokine IL-1β, to levels that are sufficient to stimulate inducible nitric oxide synthase (iNOS) expression and production of micromolar levels of the free radical nitric oxide in neighboring β-cells. We have recently shown that nitric oxide inhibits EMCV replication and EMCV-mediated β-cell lysis and that this protection is associated with an inhibition of mitochondrial oxidative metabolism. Here we show that the protective actions of nitric oxide against EMCV infection are selective for β-cells and associated with the metabolic coupling of glycolysis and mitochondrial oxidation that is necessary for insulin secretion. Inhibitors of mitochondrial respiration attenuate EMCV replication in β-cells, and this inhibition is associated with a decrease in ATP levels. In mouse embryonic fibroblasts (MEFs), inhibition of mitochondrial metabolism does not modify EMCV replication or decrease ATP levels. Like most cell types, MEFs have the capacity to uncouple the glycolytic utilization of glucose from mitochondrial respiration, allowing for the maintenance of ATP levels under conditions of impaired mitochondrial respiration. It is only when MEFs are forced to use mitochondrial oxidative metabolism for ATP generation that mitochondrial inhibitors attenuate viral replication. In a β-cell selective manner, these findings indicate that nitric oxide targets the same metabolic pathways necessary for glucose stimulated insulin secretion for protection from viral lysis.

Colin T. McDowell
Nov 24, 2020; 0:RA120.002256v1-mcp.RA120.002256
Research

Large regions in tumor tissues, particularly pancreatic cancer, are hypoxic and nutrient-deprived because of unregulated cell growth and insufficient vascular supply. Certain cancer cells, such as those inside a tumor, can tolerate these severe conditions and survive for prolonged periods. We hypothesized that small molecular agents, which can preferentially reduce cancer cell survival under nutrient-deprived conditions, could function as anticancer drugs. In this study, we constructed a high-throughput screening system to identify such small molecules and screened chemical libraries and microbial culture extracts. We were able to determine that some small molecular compounds, such as penicillic acid, papyracillic acid, and auranofin, exhibit preferential cytotoxicity to human pancreatic cancer cells under nutrient-deprived compared with nutrient-sufficient conditions. Further analysis revealed that these compounds target to redox systems such as GSH and thioredoxin and induce accumulation of reactive oxygen species in nutrient-deprived cancer cells, potentially contributing to apoptosis under nutrient-deprived conditions. Nutrient-deficient cancer cells are often deficient in GSH; thus, they are susceptible to redox system inhibitors. Targeting redox systems might be an attractive therapeutic strategy under nutrient-deprived conditions of the tumor microenvironment.

Postoperative recurrence from microscopic residual disease must be prevented to cure intractable cancers, including pancreatic cancer. Key to this goal is the elimination of cancer stem cells (CSCs) endowed with tumor-initiating capacity and drug resistance. However, current therapeutic strategies capable of accomplishing this are insufficient. Using in vitro models of CSCs and in vivo models of tumor initiation in which CSCs give rise to xenograft tumors, we show that dexamethasone induces expression of MKP-1, a MAPK phosphatase, via glucocorticoid receptor activation, thereby inactivating JNK, which is required for self-renewal and tumor initiation by pancreatic CSCs as well as for their expression of survivin, an anti-apoptotic protein implicated in multidrug resistance. We also demonstrate that systemic administration of clinically relevant doses of dexamethasone together with gemcitabine prevents tumor formation by CSCs in a pancreatic cancer xenograft model. Our study thus provides preclinical evidence for the efficacy of dexamethasone as an adjuvant therapy to prevent postoperative recurrence in patients with pancreatic cancer.