Dispensaries and cultivations reported 10 burglaries in the first two weeks of April, Denver police said. That's up from eight burglaries reported during the whole month of April 2019.

“We’re just really scared and there's no protections and there's no testing, and we’re just continually exposed.”

He shared the near-death experience during a FaceTime.

Cyclists and noncyclists have a wide range of perceptions of on-street bicycling facility designs — including sharrows, bike lanes, and buffered bike lanes — along a variety of roadway types, with and without curbside automobile parking. The TRB National Cooperative Highway Research Program's NCHRP Research Report 941: Bicyclist Facility Preferences and Effects on Increasing Bicycle Trips provides insights from communities where on-road cycling for transportation is less common, particularly in the South...

Self-consolidating concrete (SCC) is a highly flowable, nonsegregating concrete that is placed without any mechanical consolidation. TRB will conduct a webinar on Thursday, June 11, 2020, from 1:00 PM to 3:00 PM Eastern to discuss how SCC may be used to fill heavily congested or irregularly shaped members in bridge applications more easily while providing improved in-place quality and surface finish.The use of SCC may also decrease construction costs due to the reduced labor requirements during construct...

Rubber Content of Crumb Rubber Modified Bitumen: Soxhlet Method , released by Austroads

Фото из архива Сильвии Видаль.

Первопрохождение. Соло. Сильвия Видаль. Не восхищаться этой "Чудо-женщиной" в мире альпинизма и её восхождениями невозможно! На этот раз она отправилась в долину Чилино в Патагонии, чтобы соло проложить новый маршрут по северной стене Сьеро-Чилино-Гранде.

One of the key points we've been making concerning Attorney General William Barr and his DOJ's eager support for the terrible EARN-IT Act, is that much of it really seems to be to cover up the DOJ's own failings in fighting child porn and child exploitation. The premise behind the EARN IT Act is that there's a lot of child exploitation/child abuse material found on social media... and that social media companies should do more to block that content. Of course, if you step back and think about it, you'd quickly realize that this is a form of sweeping the problem under the rug. Rather than actually tracking down and arresting those exploiting and abusing children, it's demanding private companies just hide the evidence of those horrific acts.

And why might the DOJ and others be so supportive of sweeping evidence under the rug and hiding it? Perhaps because the DOJ and Congress have literally failed to live up to their mandates under existing laws to actually fight child exploitation. Barr's DOJ has been required under law to produce reports showing data about internet crimes against children, and come up with goals to fight those crimes. It has produced only two out of the six reports that were mandated over a decade ago. At the same time, Congress has only allocated a very small budget to state and local law enforcement for fighting internet child abuse. While the laws Congress passed say that Congress should give $60 million to local law enforcement, it has actually allocated only about half of that. Oh, and Homeland Security took nearly half of its "cybercrimes" budget and diverted it to immigration enforcement, rather than fighting internet crimes such as child exploitation.

So... maybe we should recognize that the problem isn't social media platforms, but the fact that Congress and law enforcement -- from local and state up to the DOJ -- have literally failed to do their job.

At least some elected officials have decided to call the DOJ's bluff on why we need the EARN IT Act. Led by Senator Ron Wyden (of course), Senators Kirsten Gillbrand, Bob Casey, Sherrod Brown and Rep. Anna Eshoo have introduced a new bill to actually fight child sex abuse online. Called the Invest in Child Safety Act, it would basically make law enforcement do its job regarding this stuff.

The Invest in Child Safety Act would direct $5 billion in mandatory funding to investigate and target the pedophiles and abusers who create and share child sexual abuse material online. And it would create a new White House office to coordinate efforts across federal agencies, after DOJ refused to comply with a 2008 law requiring coordination and reporting of those efforts. It also directs substantial new funding for community-based efforts to prevent children from becoming victims in the first place.

Basically, the bill would do a bunch of things to make sure that law enforcement is actually dealing with the very real problem of child exploitation, rather than demanding that internet companies (1) sweep evidence under the rug, and (2) break encryption:

• Quadruple the number of prosecutors and agents in DOJ’s Child Exploitation and Obscenity Section from 30 FTEs to 120 FTEs;
• Add 100 new agents and investigators for the Federal Bureau of Investigation’s Innocent Images National Initiative, Crimes Against Children Unit, Child Abduction Rapid Deployment Teams, and Child Exploitation and Human Trafficking Task Forces;
• Fund 65 new NCMEC analysts, engineers, and mental health counselors, as well as a major upgrade to NCMEC’s technology platform to enable the organization to more effectively evaluate and process CSAM reports from tech companies;
• Double funding for the state Internet Crimes Against Children (ICAC) Task Forces;
• Double funding for the National Criminal Justice Training Center, to administer crucial Internet Crimes Against Children and Missing and Exploited Children training programs;
• Increase funding for evidence-based programs, local governments and non-federal entities to detect, prevent and support victims of child sexual abuse, including school-based mental health services and prevention programs like the Children’s Advocacy Centers and the HHS’ Street Outreach Program;
• Require tech companies to increase the time that they hold evidence of CSAM, in a secure database, to enable law enforcement agencies to prosecute older cases;
• Establish an Office to Enforce and Protect Against Child Sexual Exploitation, within the Executive Office of the President, to direct and streamline the federal government’s efforts to prevent, investigate and prosecute the scourge of child exploitation;
• Require the Office to develop an enforcement and protection strategy, in coordination with HHS and GAO; and
• Require the Office to submit annual monitoring reports, subject to mandatory Congressional testimony to ensure timely execution.

If you listen closely, you can hear how the creatures' full-throated call increases in volume when you are on holiday

On Call Friday is here! How is your weekend looking? Same as the last one, and the one before that? Never mind – before breaking into the lockdown lagers, join us for another entry in The Register's tales of those brave souls who are On Call.…

Chronic pancreatitis (CP) is considered an irreversible fibroinflammatory pancreatic disease. Despite numerous animal model studies, questions remain about local immune characteristics in human CP. We profiled pancreatic immune cell characteristics in control organ donors and CP patients including those with hereditary and idiopathic CP undergoing total pancreatectomy with islet autotransplantation. Flow cytometric analysis revealed a significant increase in the frequency of CD68+ macrophages in idiopathic CP. In contrast, hereditary CP samples showed a significant increase in CD3+ T cell frequency, which prompted us to investigate the T cell receptor β (TCRβ) repertoire in the CP and control groups. TCRβ sequencing revealed a significant increase in TCRβ repertoire diversity and reduced clonality in both CP groups versus controls. Interestingly, we observed differences in Vβ-Jβ gene family usage between hereditary and idiopathic CP and a positive correlation of TCRβ rearrangements with disease severity scores. Immunophenotyping analyses in hereditary and idiopathic CP pancreases indicate differences in innate and adaptive immune responses, which highlights differences in immunopathogenic mechanisms of disease among subtypes of CP. TCR repertoire analysis further suggests a role for specific T cell responses in hereditary versus idiopathic CP pathogenesis, providing insights into immune responses associated with human CP.

Alterations in calcium signaling in pancreatic acinar cells can result in pancreatitis. Although pressure changes in the pancreas can elevate cytosolic calcium (Ca2+) levels, it is not known how transient pressure-activated elevations in calcium can cause prolonged calcium changes and consequent pancreatitis. In this issue of the JCI, Swain et al. describe roles for the mechanically activated plasma membrane calcium channels Piezo1 and transient receptor potential vanilloid subfamily 4 (TRPV4) in acinar cells. The authors used genetic deletion models and cell culture systems to investigate calcium signaling. Notably, activation of the Piezo1-dependent TRPV4 pathway was independent of the cholecystokinin (CCK) stimulation pathway. These results elegantly resolve an apparent discrepancy in calcium signaling and the pathogenesis of pancreatitis in pancreatic acinar cells.

Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography, and gallstones. In the pancreas, excessive intracellular calcium causes mitochondrial dysfunction, premature zymogen activation, and necrosis, ultimately leading to pancreatitis. Although stimulation of the mechanically activated, calcium-permeable ion channel Piezo1 in the pancreatic acinar cell is the initial step in pressure-induced pancreatitis, activation of Piezo1 produces only transient elevation in intracellular calcium that is insufficient to cause pancreatitis. Therefore, how pressure produces a prolonged calcium elevation necessary to induce pancreatitis is unknown. We demonstrate that Piezo1 activation in pancreatic acinar cells caused a prolonged elevation in intracellular calcium levels, mitochondrial depolarization, intracellular trypsin activation, and cell death. Notably, these effects were dependent on the degree and duration of force applied to the cell. Low or transient force was insufficient to activate these pathological changes, whereas higher and prolonged application of force triggered sustained elevation in intracellular calcium, leading to enzyme activation and cell death. All of these pathological events were rescued in acinar cells treated with a Piezo1 antagonist and in acinar cells from mice with genetic deletion of Piezo1. We discovered that Piezo1 stimulation triggered transient receptor potential vanilloid subfamily 4 (TRPV4) channel opening, which was responsible for the sustained elevation in intracellular calcium that caused intracellular organelle dysfunction. Moreover, TRPV4 gene–KO mice were protected from Piezo1 agonist– and pressure-induced pancreatitis. These studies unveil a calcium signaling pathway in which a Piezo1-induced TRPV4 channel opening causes pancreatitis.

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. The primary endpoint was the change in BAT metabolic activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT. Secondary endpoints included resting energy expenditure (REE), plasma metabolites, and glucose and insulin metabolism as assessed by a frequently sampled intravenous glucose tolerance test.RESULTS Chronic mirabegron therapy increased BAT metabolic activity. Whole-body REE was higher, without changes in body weight or composition. Additionally, there were elevations in plasma levels of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids. Adiponectin, a WAT-derived hormone that has antidiabetic and antiinflammatory capabilities, increased with acute treatment and was 35% higher upon completion of the study. Finally, an intravenous glucose tolerance test revealed higher insulin sensitivity, glucose effectiveness, and insulin secretion.CONCLUSION These findings indicate that human BAT metabolic activity can be increased after chronic pharmacological stimulation with mirabegron and support the investigation of β3-AR agonists as a treatment for metabolic disease.TRIAL REGISTRATION Clinicaltrials.gov NCT03049462.FUNDING This work was supported by grants from the Intramural Research Program of the NIDDK, NIH (DK075112, DK075116, DK071013, and DK071014).

Digital video consumption is viral and, according to a new study released today by IBM and International Broadcasting Convention (IBC), more than half of the 21,000 consumers surveyed are using mobiles every day to watch streaming videos, and that number is expected to grow 45 percent in the next three years.

IBM (NYSE: IBM) announced today it will upgrade the University of Canterbury’s BlueFern High Performance Computing (HPC) facility, enhancing its ability to deliver quality science and technology outcomes and significantly increasing New Zealand’s research capacity.

La empresa se afianza como líder de Proveedores Autorizados de Certificación (PAC) y logra procesar grandes volúmenes de transacciones de manera sencilla

When it comes to ways you can increase traffic to your website there are dozens if not hundreds of ways to get more traffic. Depending on your website, the content or products you’re trying to get viewed, and the amount of time you can invest each day on your site, not all of those hundreds or ways are going to be as effective. You also want to avoid anything that could be considered “Black Hat SEO” as these types of tricks to increase your traffic may work in the short term, but get your website kicked out of search engine rankings.

Alexa site rank like Google’s page rank is a measure to determine how popular a particular website or blog is. And while Alexa isn’t an accurate representation since it’s only limited to those who use their toolbar it can still be an important factor when it comes to generating traffic, getting others to link to you, and advertising on your site. If you’re not familiar with how Alexa page ranking works it essentially works like this..................

Designer Andrey Rudenko was able to use a 3D concrete printer to make layer after layer of this little castle. His next goal? A complete two-story house.

The new ‘national living wage’ has seen the sector’s pay bill rise by 6.9%, and further promised increases will add a total £2.3bn to wage costs

As there have been countless cases of Zoombombing in the recent weeks, the security in the video conferencing platform Zoom has been doubted by its users. In response to this, Zoom finally announced on Thursday that they will be implementing and offering end-to-end encryption.

With the acquisition of Keybase, a New York-based startup specializing in encrypted messaging and cloud services, Zoom will finally be able to make good on its claims of offering end-to-end encryption.

“We are excited to integrate Keybase’s team into the Zoom family to help us build end-to-end encryption that can reach current Zoom scalability,” CEO Eric Yuan said in a Zoom blog post on Thursday.

Unfortunately, not all Zoom users will benefit from the company’s new move, as the end-to-end encryption feature will only be available to users who have paid plans (which start at $14.99/month, by the way) on the video conferencing platform.

If a meeting’s host has enabled this feature, participants will be barred from joining by phone and cloud-based recording will be disabled. In Thursday’s blog post, Yuan emphasized that the feature will not store the encryption key on Zoom’s servers, so the company will not be able to see any part of the call.

What are your thoughts about this one?

(Image Credit: Zoom/ Wikimedia Commons)

If you want to create some highly targeted leads for your home based MLM business opportunity, I recommend writing Articles. This strategy allows you to make a connection with your reader by providing valuable content to help their business.

Unless you have been hiding in a cave for the last few years you can't help but to notice the online video revolution taking place. The online video industry leader YouTube is now one of the most visited websites in the world. You can take advantage of this popularity and use it to increase your home based MLM business opportunity leads. This article will give you 5 tips to do just that.

How to increase my blog subscribers? I am going to show you how to do this and you will be happily blogging to the bank in 2010!

Sumo deadlifts against increasing tension. It is Jan 2 and the gym is not yet full of new year’s resolutioneers. https://ift.tt/37wIcUa

One of my visitors wanted to know how to change the distance between paragraphs on a web page. This article addresses that question. It also deals with what to do when you change the spacing between lines (eg to double-space it), and the gap between paragraphs becomes too wide.

Hello everyone I hope you are all well and enjoyed the half term break. Since I last wrote I have been busy exploring more of New Zealand so let me fill you in on what we have been up to whilst visiting the South Island. Mount CookWe spent a n

After hearing horror stories about driving down the coast in a big rig we decided to head through central Oregon south to California. We camped at Cascade Meadows RPI because Bend Thousand Trails has no sewers and our new motorcoach is a primadona with a

Tako kot gre turisticni slogan Incredible India ...Ugotovila sem da lahko zacnem razvijati nov adrenalinski sport lov na vzlet letala Po tem ko smo za dve uri neplansko obticali na avstrijski cesti zatadi prometne nesrece kamiona nalozenega z 22 ti

While the COVID-19 pandemic keeps New Yorkers separated by face masks and social distancing and self-quarantine, a growing number of city residents are connecting through local mutual aid groups now sprouting across the shuttered boroughs.

The Angels failed to land a standout starter, or even Ross Stripling, during the offseason, but manager Joe Maddon expressed confidence in second-year starters.

C’mon folks. You’re getting to your destinations faster than ever with less than half the traffic on the road so why speed? Yet many of you (not my readers, of course, so pass this onto your friends and acquaintances) are doing so putting all of us at risk.

University of California regents will not vote on a tuition increase as scheduled this week because the coronavirus crisis has created too much uncertainty, officials said Wednesday.

The survey, conducted by college affordability group Rise, found that 75% of students who responded were more anxious, depressed or stressed amid the coronavirus outbreak.

On Tuesday, Simon & Schuster announced it will publish Alex Trebek's memoir, "The Answer Is…: Reflections on My Life," on July 21.

'We want to help Britain return to what we knew as normal before the pandemic,' says head of train drivers' union

NASA’s Goddard Institute for Space Studies (GISS) monitors global surface temperatures on an ongoing basis. Their analysis shows temperatures around the globe in 2011 compared to the average global temperature from the mid-20th century. The comparison shows how Earth continues to experience warmer temperatures than several decades ago.

Global temperatures have warmed significantly since 1880, the beginning of what scientists call the “modern record.” At this time, the coverage provided by weather stations allowed for essentially global temperature data. As greenhouse gas emissions from energy production, industry and vehicles have increased, temperatures have climbed, most notably since the late 1970s. In this animation of temperature data from 1880-2011, reds indicate temperatures higher than the average during a baseline period of 1951-1980, while blues indicate lower temperatures than the baseline average.

Click on the image to see the video:

Read full article: Global Temperature Anomaly, 1880 - 2011

The latest data covering global arms sales shows that sale of arms in 2011 increased to around $85 billion, 84% of which went to developing countries. This was almost double the arms sales compared to 2010 which was the lowest since 2004.

One major factor for the increase was the US sales of arms to Saudi Arabia. Most other major arms sellers otherwise saw a decrease in sales and the trend in recent years had been declining sales.

The global financial crisis has affected many countries, and many developing countries started to see a decrease in purchases in the last few years. However, just 10 developing countries account for some 85% of all sales to developing countries in the period 2004 to 2011, which the data covers. Saudi Arabia tops that list followed by India and the United Arab Emirates. (As well as concerns about some of the regimes in the top buyers, some of this spending is also said to be due to modernizing efforts.)

Updated graphs and charts on arms sales data are provided here.

The arms trade is big business. The 5 permanent members of the UN Security Council (US, Russia, France, United Kingdom and China), together with Germany and Italy, account for approximately 85% of all arms sold between 2004 and 2011.

Some of the arms sold go to regimes where human rights violations will occur. Corruption often accompanies arms sales due to the large sums of money involved.

Read full article: The Arms Trade Is Big Business

A recent study found that coral reefs will face severe challenges even if average global warming temperature rise is restricted to 2 degrees Celsius. This is a rise that most countries are struggling to negotiate and meet. But reefs are very sensitive to temperature changes, experts fear the window of opportunity to prevent massive reef loss is very small.

Read full article: Nature and Animal Conservation

KATE MIDDLETON AND Prince William have carried out a brilliant and selfless gesture behind the scenes to help Britain stop the spread of coronavirus - by sending their own staff to Whitehall in the battle against the pandemic.

ADELE was wowed with a new image updating fans on her 2020 weight loss. The singer looked fabulous. What diet has she followed?

KATE MIDDLETON AND Prince William have carried out a brilliant and selfless gesture behind the scenes to help Britain stop the spread of coronavirus - by sending their own staff to Whitehall in the battle against the pandemic.

Mobility data released by Apple suggests enormous declines in personal transportation since COVID-19 began its spread in Canada, but experts warn that post-pandemic there could be an increase of car use and a loss of transit routes.

Jihadists linked to al-Qaida and the Islamic State organization have been overrunning gold mines, forcing the miners to sell them the gold exclusively, which is then smuggled and sold across the border in places like Benin, Ghana or Togo.

GIN-LOVERS rejoice as Express.co.uk has two very simple gimlet recipes for you to try at home.