Diarmuid McDonnell , a Lecturer in Social Sciences, University of the West of Scotland talks with host Kanchan Shringi about his experience as a social scientist on the need for computational approaches for data collection and analysis as well as the...

Jason C. McDonald, author of the book Dead Simple Python, speaks with host Samuel Taggart about leveraging quantified tasks to improve estimation, particularly across projects. They discuss the origin of the concept and its relationship with story points, and Jason offers examples to show how quantified tasks can capture nuances in software tasks that are often lost with story points. He also points to the ability to compare them across projects as a major advantage of quantified tasks. Among other topics, they consider also how to use quantified tasks to analyze the stability of a codebase. Brought to you by IEEE Computer Society and IEEE Software magazine.

International Classification of Diseases, 9th Revision, Clinical Modification, Chapter V, Mental Disorders.

JANUS® is an all-natural coating that creates a barrier to grease, water and oxygen when applied to paper for food packaging, like wrap paper, boxes, cups, utensils, K-cups, and straws.

The four-flap cups are currently available in several other international markets like Canada and Indonesia – and this month, it’s finally time for U.S. fans to try them out. 

Miami Dolphins general manager Chris Grier and coach Mike McDaniel detail operating without their first-round pick and answered other offseason questions.

Standardized digitized image set on CD-ROM - (ITU-T Recommendation T.24)
This digitized test chart set is an integral part of Recommendation T.24 and is published with it. This set of 409 Mbytes of images digitized with different resolutions includes:
- eight black and white ITU-T reference pages (the "CCITT images");
- test chart No. 4 (BW01);
- one legibility test chart;
- seven bi-level half-tone images made by processing gray-scale images with different algorithms;
- test chart No. 5 (CT01);
- two gray-scale images;
- test chart No. 6 (4CP01);
- 14 colour images with different resolutions and in different colour spaces (YUV, CMYK, RGB, CIELAB);
- low-contrast gray-scale images.
(Paper + CD-ROM)

XSTR.ibc-cd - Guidelines for identity-based cryptosystems used for cross-domain secure communications

TR.NCDP - Session-layer network coding protocol for multicast data transmission

MRSA is an antibiotic resistant superbug that causes 120,000 deaths annually.

Read more: UCD research offers potential for new ways to fight MRSA superbug

This year's grant winners represent the highest proportion of women since the scheme began.

Read more: Trinity and UCD among 57 teams to win €571m in ERC Synergy Grants

UCD's Prof Kate Robson Brown leads the development of analytical models that predict the lifetime of composites in low-Earth orbit.

Read more: UCD professor part of team developing new space materials

Led by Prof Breandán Kennedy, the research project will bring together 21 institutions from 11 countries.

Read more: UCD-led EU project aims to revolutionise biomedical research

El organismo asegura que no informó de su expulsión por la "petición" y "el deseo expreso" del elenco de la obra Leer

Christopher Skaluba, the executive director in the DoD CDAO, said the office is creating tools to provide data-driven insights on AI workforce needs.

The post DoD seeks to create ‘culture of learning’ through CDAO first appeared on Federal News Network.

Adita Karkera, the managing director of the government and public services practice at Deloitte Consulting, said having high-quality data is a must for AI.

The post Agency CDOs creating the bond between data, AI tools first appeared on Federal News Network.

Thanks to wide adoption of the Infrastructure as Code (IaC) approach, programmatic provisioning of cloud resources is slowly transforming almost every aspect of computing, with administration of web apps having emerged as a key use case. With IaC, it's possible to streamline resource management tasks, shorten time-to-market, control costs, and scale at will. The adoption of continuous integration and continuous delivery (CICD) pipelines is already making a huge difference in web app deployment and cloud resource management.

It cannot be easy to lead the agency that handles infectious diseases in the midst of an international pandemic. Still, the director of the Centers for Disease Control and Prevention should at least be able to prove she is up to the task. Dr. Rochelle Walensky has repeatedly proved herself unfit and unreliable. She needs to go.

New data show how the 50 states and the District of Columbia stack up in terms of life expectancy. Hawaii tops the list, and Mississippi is at the bottom.

The CDC plans to knock on the doors of randomly selected homes in the Tijuana River Valley later this month to ask them about how the sewage crisis has affected their wellbeing.

The Stranger's morning news round-up. by Nathalie Graham

One more for the blue: After a neck-in-neck race, Rep. Marie Gluesenkamp Perez officially won re-election to the House in the 3rd Congressional District, beating out far-right challenger Joe Kent. Her win is another step forward for Democrats as they try to take back the House and retain a shred of power in the coming administration from hell. About two dozen races nation-wide still need to be decided.

Please spare us, H5N1: The Centers for Disease Control want more testing done for bird flu after blood tests on 115 of dairy workers showed 7% had bird flu antibodies, meaning they'd already contracted the disease at some point. Previously, we only confirmed 46 cases of bird flu jumping from cows to farmworkers. This new study suggests that bird flu has infected many more people than the confirmed cases. Experts say this indicates the H5N1 viruses are a greater threat than we realized. Great! Another flu just in time for the vaccine-doubters to take office. 

Wet weekend—and then week—ahead: Friday will likely be our last dry day for a while. Get your galoshes ready. The rain starts Saturday and it'll continue at least throughout the week.

I hope you like rain this weekend! ????️

It could be wet for the State H.S. football tournament games across the Puget Sound region. #pnw pic.twitter.com/JAvPx7hegV

— Jake Whittenberg (@jwhittenbergK5) November 8, 2024

That's nice: Boeing said it will pay the employees the money they lost while being furloughed during the machinists' strike that started in September. 

Egyptian flooding: A pipe leak at the historic Egyptian Cinema on Capitol Hill shut down the 108-year-old theater for the "foreseeable future." Repairs will be expensive and take months. The universe does not want me or my people (progressives, art house movie lovers) to be happy this week. 

INBOX: The SIFF Cinema Egyptian is going to be closed for "the foreseeable future and the Fine Arts building leadership expect that it will take multiple months of building closure to assess, repair and reopen." Sad news especially during what is a big time of the year for film. pic.twitter.com/v2ItPx5Lpi

— Chase 'Hutch' Hutchinson (@EclecticHutch) November 7, 2024

Another hit while we're down: Don't forget, five light rail stops will close this weekend. Starting at 10 pm on Friday through 5 am Monday, Westlake, Symphony, Pioneer Square, International District/Chinatown, and Stadium stations will all be closed and inaccessible. Trains will run between Lynnwood and Capitol Hill and between Sodo and Angle Lake. Shuttle buses will be available to bridge gaps between open and closed stations. It’s all part of the crawling effort to connect Line 1 to the Eastside line.

Sign of the times: Margaret Atwood's The Handmaid's Tale rocketed to the top of Amazon's bestsellers list this week.  

Racist texts: In the days after the election, Black and Brown people across the country received spammy, racist texts telling them they had "been selected to pick cotton at the nearest plantation" and that the senders' "executive slave catchers" would pick them up. State attorney generals say they will root out who sent these texts. A second Donald Trump term means the masks covering the depravity in America are well and truly off. Racists are emboldened. 

Nobody panic: Forty-three monkeys escaped from a medical lab in South Carolina. "There is almost no danger to the public," a local police chief said. No danger? Isn't this how Planet of the Apes started? 

Israeli soccer fans attacked in Amsterdam: Israel’s Maccabi Tel Aviv and Dutch's Ajax faced off in a Europa League soccer game Thursday. After the game, people attacked Israelis in hit-and-run scooter attacks. Five Israeli fans went to the hospital, but have since been released. Around 20 to 30 other Israelis sustained light injuries. Police arrested 63 people, and ten are still in custody. Context, as always, is important. In the days leading up to the match, social media videos showed Maccabi fans "chanting anti-Arab slurs, praising Israeli military attacks in Gaza, and yelling 'fuck the Arabs,'" according to CNN. Ajax won the game 5-0. 

And now, something from Ashley about the cops: 

Fill’er up: The King County Jail officially lifted misdemeanor booking restrictions for the Seattle Police Department (SPD) allowing officers to finally lock up all those pesky Target shoplifters and people who tried to use the bathroom at PCC one too many times and ended up trespassed. I wrote about how SPD Deputy Chief Eric Barden told officers in a department wide email Tuesday that they should book people into jail whenever a public safety interest existed and only show additional discretion when the department neared their misdemeanor bed limit of 135 people per day. Most people charged with misdemeanors spend less than a week in jail, so could be a lot of people cycling through, which King County Department of Public Defense Interim Director Matt Sanders said will ultimately make it harder for people to hold down jobs, maintain housing, and secure behavioral health treatment, ultimately undermining public safety in the city.

Did you hear about San Francisco's new mayor? He's a centrist Democrat and he's the heir to the Levi's fortune. Daniel Lurie won the ranked-choice voting election with 56.2% of the vote. Incumbent London Breed only received 43.8%. San Franciscans made clear they are sick of seeing poverty and being confronted with crimes of desperation. Unfortunately, as we know very well in Seattle, electing a centrist may hide the problems for a bit, but it will do nothing to fix them. 

A porn gorge: North Korean soldiers deployed in Russia have unrestricted internet access for the first time in their lives and they're using it to watch mountains of porn and jerk themselves silly. Boys will be boys! 

Need something to do tonight? The world is bleak. Why not laugh a little at an improv show? The improv theater I wrote about for my column is having a battle of the star signs show tonight followed by an open-to-all improv jam. I'll be performing on the Scorpio team even though I'm not a Scorpio (don't tell anyone). 

A song for your Friday: This just feels like the sound of my psyche right now. 

Transcranial magnetic stimulation sounds like — and looks like — something you'd find in a science fiction movie, but it's a real treatment option…

A group of H1N1 swine influenza viruses have essential hallmarks of being highly adapted to infect humans and are of potential pandemic concern, health officials say. These viruses — referred to as G4 Eurasian (EA) avian-like H1N1 viruses — have been spreading in pigs in China since 2016 and are now the predominant set of genes that can be passed down from parents to offspring , according to the Centers for Disease Control and Prevention.

Panelistas comentaron que recomendaciones se acercan a elementos que estaban en la pasada reforma tributaria; creen que es necesario buen liderazgo

Este es el Personaje del día de María Alejandra Villamizar de La Luciérnaga

En 6AM Hoy por Hoy de Caracol Radio estuvo el cantautor colombiano, Billy Pontoni, quien cumple 70 años este martes 20 de febrero, para hablar sobre su carrera artística.

The sense of celebration is palpable throughout and if this indeed does turn out to be the end of the band, what an end it is.

CDOT warned that travel conditions could become “extreme to impossible” Friday and Saturday, expressing particular concern about I-70 east of Denver and I-25 south of Pueblo.

It may not feel like it when the worst stomach flu of your life has you in its grip, but often, the best thing to do when you have E. coli is to rest and keep drinking beverages with electrolytes.

The new guidance comes after blood tests for 115 farmworkers in Michigan and Colorado showed that eight workers -- or 7% — had antibodies that indicated previous infection with the virus known as Type A H5N1 influenza.

The government is expected to announce that a $100 monthly personal allowance to cover the cost of personal care items will be added for people on financial assistance and the Ministry of Transport will reduce the number of vehicle inspections required in the first five years for a new vehicle. In advance of tomorrow’s reading […]

The Bermuda Police Service said they are “aware of a social media message being circulated, reporting a firearms incident had taken place at TCD this morning” noted that it was untrue. A police spokesperson said, “The Bermuda Police Service is aware of a social media message being circulated, reporting a firearms incident had taken place at […]

REVIEW – When you live in a somewhat secluded wooded area like I do, you want to be able to monitor your property when you’re home and away from home. I’ve had multiple security cameras around my house for years, but only in the past year have I “graduated” to PoE cameras, and I love […]

Nomadland [US, Chloé Zhao, 5] When her town closes down in the wake of its gypsum mine’s closure, a self-reliant widow (Frances McDormand) moves into her van and joins the ranks of the nomad subculture, people who rove the US, taking whatever hard work they can get and living out of their vehicles. Rooted in social realist cinema, marked by a triad of transcendent qualities: poetic visual beauty, an indelible central performance and a deep love for the characters from the writer/director.

This is from Searchlight, formerly Fox Searchlight, now part of the Disney empire, so you’ll get a chance to see it. Likely as part of awards season, whatever the heck that’s gonna look like this year. Normally I don’t spend festival slots on titles with distribution but that’s out the window in the COVID-verse.

(At the moment cinemas are open, with distancing, here in Ontario but if you look at the numbers we’re in the early denial phase of a reimposition of lockdown measures. Whatever the deal is I don’t plan to be inside a theater in any foreseeable time frame.)

Her next project is a huge pivot from poetic verite dramas like this and The Rider— Marvel’s The Eternals. 

Memory House [Brazil, João Paulo Miranda Maria, 1] Racist harassment from German co-workers drives dairy worker to vengeance. Blunts the political anger of its subject matter with enervating pacing.

Another Round [Denmark, Thomas Vinterberg, 4.5] Burned out high school teacher (Mads Mikkelsen) embarks with three colleagues on an experiment to enhance their performance by maintaining a blood alcohol level of 0.5% throughout their days at work. Not only an original booze movie, but a big one, full of turns and ambiguities, and an utterly masterful performance from Mikkelsen.

Shadow in the Cloud [New Zealand, Roseanne Liang, 4] When an WWII RAF Flight Officer (Chloe Grace Moretz) boards a Samoa-bound cargo plane bearing a mysterious package, a monstrous gremlin on board is just one of the surprises. Enclosed space horror-action thriller tips an 80s-style hat to Carpenter and Cameron.

Armagh football suffers another blow as Steven McDonnell announces his retirement from the intercounty game.

The post Russian Food Trucks Replace McDonald’s in Russia appeared first on English Russia.

Come one, come all! nycdevops does its first virtual meetup! All are invited!

• Speaker: Adarsh Shah
• Topic: "Continuous Delivery for Machine Learning"
• Time: Thursday, September 17, 2020, 5-630 PM
• Link: https://www.meetup.com/nycdevops/events/272914068/

Hope to see you there!

November's nycdevops meetup speaker is John Allspaw, who will give a talk titled "Findings From the Field: 2 Years of Learning From Incidents".

The talk starts at 5pm sharp! (NY is in US/Eastern)

Please RSVP! See you there!

https://www.meetup.com/nycdevops/events/273826675/

(This is a virtual meetup. Everyone in the world is invited!)

Don't forget!

November's nycdevops meetup speaker is John Allspaw, who will give a talk titled "Findings From the Field: 2 Years of Learning From Incidents".

The talk starts at 5pm sharp! (NY is in US/Eastern)

Please RSVP! See you there!

https://www.meetup.com/nycdevops/events/273826675/

(This is a virtual meetup. Everyone in the world is invited!)

1. “Wir müssen uns von der Vorstellung lösen, dass Journalismus gleichbedeutend mit Content ist” (journalist.de, Leif Kramp & Stephan Weichert) Bei journalist.de ist ein lesenswertes Interview mit dem US-amerikanischen Journalismus-Experten Jeff Jarvis erschienen, der gleich in der ersten Antwort ziemlich direkt wird: “Während wir die US-Wahlen durchlaufen, frage ich mich, ob es Zeit ist, den […]

velocityconf: LAST DAY for #velocityconf EU call for speakers http://t.co/qShofQCDPl Share your best #WPO, #Ops, and #DevOps stories.

CD81 plays a central role in a variety of physiological and pathological processes. Recent structural analysis of CD81 indicates that it contains an intramembrane cholesterol-binding pocket and that interaction with cholesterol may regulate a conformational switch in the large extracellular domain of CD81. Therefore, CD81 possesses a potential cholesterol-sensing mechanism; however, its relevance for protein function is thus far unknown. In this study we investigate CD81 cholesterol sensing in the context of its activity as a receptor for hepatitis C virus (HCV). Structure-led mutagenesis of the cholesterol-binding pocket reduced CD81–cholesterol association but had disparate effects on HCV entry, both reducing and enhancing CD81 receptor activity. We reasoned that this could be explained by alterations in the consequences of cholesterol binding. To investigate this further we performed molecular dynamic simulations of CD81 with and without cholesterol; this identified a potential allosteric mechanism by which cholesterol binding regulates the conformation of CD81. To test this, we designed further mutations to force CD81 into either the open (cholesterol-unbound) or closed (cholesterol-bound) conformation. The open mutant of CD81 exhibited reduced HCV receptor activity, whereas the closed mutant enhanced activity. These data are consistent with cholesterol sensing switching CD81 between a receptor active and inactive state. CD81 interactome analysis also suggests that conformational switching may modulate the assembly of CD81–partner protein networks. This work furthers our understanding of the molecular mechanism of CD81 cholesterol sensing, how this relates to HCV entry, and CD81's function as a molecular scaffold; these insights are relevant to CD81's varied roles in both health and disease.

The dimeric ectonucleotidase CD73 catalyzes the hydrolysis of AMP at the cell surface to form adenosine, a potent suppressor of the immune response. Blocking CD73 activity in the tumor microenvironment can have a beneficial effect on tumor eradication and is a promising approach for cancer therapy. Biparatopic antibodies binding different regions of CD73 may be a means to antagonize its enzymatic activity. A panel of biparatopic antibodies representing the pairwise combination of 11 parental monoclonal antibodies against CD73 was generated by Fab-arm exchange. Nine variants vastly exceeded the potency of their parental antibodies with ≥90% inhibition of activity and subnanomolar EC50 values. Pairing the Fabs of parents with nonoverlapping epitopes was both sufficient and necessary whereas monovalent antibodies were poor inhibitors. Some parental antibodies yielded potent biparatopics with multiple partners, one of which (TB19) producing the most potent. The structure of the TB19 Fab with CD73 reveals that it blocks alignment of the N- and C-terminal CD73 domains necessary for catalysis. A separate structure of CD73 with a Fab (TB38) which complements TB19 in a particularly potent biparatopic shows its binding to a nonoverlapping site on the CD73 N-terminal domain. Structural modeling demonstrates a TB19/TB38 biparatopic antibody would be unable to bind the CD73 dimer in a bivalent manner, implicating crosslinking of separate CD73 dimers in its mechanism of action. This ability of a biparatopic antibody to both crosslink CD73 dimers and fix them in an inactive conformation thus represents a highly effective mechanism for the inhibition of CD73 activity.

In addition to their well-known role in the control of cellular proliferation and cancer, cell cycle regulators are increasingly identified as important metabolic modulators. Several GWAS have identified SNPs near CDKN2A, the locus encoding for p16INK4a (p16), associated with elevated risk for cardiovascular diseases and type-2 diabetes development, two pathologies associated with impaired hepatic lipid metabolism. Although p16 was recently shown to control hepatic glucose homeostasis, it is unknown whether p16 also controls hepatic lipid metabolism. Using a combination of in vivo and in vitro approaches, we found that p16 modulates fasting-induced hepatic fatty acid oxidation (FAO) and lipid droplet accumulation. In primary hepatocytes, p16-deficiency was associated with elevated expression of genes involved in fatty acid catabolism. These transcriptional changes led to increased FAO and were associated with enhanced activation of PPARα through a mechanism requiring the catalytic AMPKα2 subunit and SIRT1, two known activators of PPARα. By contrast, p16 overexpression was associated with triglyceride accumulation and increased lipid droplet numbers in vitro, and decreased ketogenesis and hepatic mitochondrial activity in vivo. Finally, gene expression analysis of liver samples from obese patients revealed a negative correlation between CDKN2A expression and PPARA and its target genes. Our findings demonstrate that p16 represses hepatic lipid catabolism during fasting and may thus participate in the preservation of metabolic flexibility.

Visual Abstract

Gα proteins promote dynamic adjustments of cell shape directed by actin-cytoskeleton reorganization via their respective RhoGEF effectors. For example, Gα13 binding to the RGS-homology (RH) domains of several RH-RhoGEFs allosterically activates these proteins, causing them to expose their catalytic Dbl-homology (DH)/pleckstrin-homology (PH) regions, which triggers downstream signals. However, whether additional Gα proteins might directly regulate the RH-RhoGEFs was not known. To explore this question, we first examined the morphological effects of expressing shortened RH-RhoGEF DH/PH constructs of p115RhoGEF/ARHGEF1, PDZ-RhoGEF (PRG)/ARHGEF11, and LARG/ARHGEF12. As expected, the three constructs promoted cell contraction and activated RhoA, known to be downstream of Gα13. Intriguingly, PRG DH/PH also induced filopodia-like cell protrusions and activated Cdc42. This pathway was stimulated by constitutively active Gαs (GαsQ227L), which enabled endogenous PRG to gain affinity for Cdc42. A chemogenetic approach revealed that signaling by Gs-coupled receptors, but not by those coupled to Gi or Gq, enabled PRG to bind Cdc42. This receptor-dependent effect, as well as CREB phosphorylation, was blocked by a construct derived from the PRG:Gαs-binding region, PRG-linker. Active Gαs interacted with isolated PRG DH and PH domains and their linker. In addition, this construct interfered with GαsQ227L's ability to guide PRG's interaction with Cdc42. Endogenous Gs-coupled prostaglandin receptors stimulated PRG binding to membrane fractions and activated signaling to PKA, and this canonical endogenous pathway was attenuated by PRG-linker. Altogether, our results demonstrate that active Gαs can recognize PRG as a novel effector directing its DH/PH catalytic module to gain affinity for Cdc42.