Ying Zou
Dec 1, 2020; 61:1589-1604
Research Articles

Beiging of white adipose tissue (WAT) has beneficial effects on metabolism. Although it is known that beige adipocytes are active in lipid catabolism and thermogenesis, how they are regulated deserves more explorations. In this study, we demonstrate that stearoyl-CoA desaturase 1 (SCD1) in subcutaneous WAT (scWAT) responded to cold stimulation and was able to promote mobilization of triacylglycerol [TAG (triglyceride)]. In vitro studies showed that SCD1 promoted lipolysis in C3H10T1/2 white adipocytes. The lipolytic effect was contributed by one of SCD1’s products, oleic acid (OA). OA upregulated adipose TAG lipase and hormone-sensitive lipase expression. When SCD1 was overexpressed in the scWAT of mice, lipolysis was enhanced, and oxygen consumption and heat generation were increased. These effects were also demonstrated by the SCD1 knockdown experiments in mice. In conclusion, our study suggests that SCD1, known as an enzyme for lipid synthesis, plays a role in upregulating lipid mobilization through its desaturation product, OA.

No abstract

The epidemic of sexually transmitted infections (STIs) in the United States appears to be cooling off after more than two decades, a new Centers for Disease Control and Prevention (CDC) study says.

About 2.25 million U.S. middle- and high-school students this year say they use tobacco products, which is 500,000 fewer than a year ago, the Centers for Disease Control said Thursday.

Slivered onions served on McDonald's Quarter Pounders and other menu items caused a recent E. coli outbreak, the U.S. Centers for Disease Control and Prevention announced Wednesday.

The first step to saving nature is the rewilding of our own minds, says conservationist and former Patagonia CEO Kristine McDivitt Tompkins. With an unwavering commitment to protecting ecosystems, she and her late husband Douglas Tompkins created vast conservation parks across South America that allowed ancient flora and fauna to flourish once again. Now, she's carrying that legacy and mission forward with a bold plan to connect parks across geographic boundaries, creating a system of continental-scale wildlife corridors — before it's too late.

Academic and health offerings have increased in McDowell County, W.Va., due to a private-public partnership.

Connor McDavid retured from injury — well ahead of schedule. The Oilers captain re-entered the lineup when Edmonton hosted the Vegas Golden Knights on Wednesday.

The resignation of the former U.S. Department of Education staffer, who has led ASCD since mid-2015, follows a long run of membership declines for the organization.

The son of a Delaware Revolutionary War veteran, Thomas Macdonough would serve with distinction in the War of 1812. After the climactic Battle of Lake Champlain, Macdonough would go down in history as one of Delaware greatest military heroes. In her biography, Virginia M. Burdick discusses the life and times of Captain Macdonough and tells […]

Report addresses firearm, claims of new evidence The Department of Justice’s Division of Civil Rights & Public Trust (DCRPT) released Tuesday a supplemental report regarding the September 23, 2015 police shooting of Jeremy McDole. After the DOJ was presented in June with claims of new evidence and concerns about the validity of firearms evidence cited […]

DOVER, DE (Dec. 28, 2021) – The Division of Public Health announced that it will implement updated guidance issued Monday by the Centers for Disease Control and Prevention (CDC) to shorten the recommended time that people should isolate or quarantine from 10 days to 5 days based on certain conditions and vaccination status.  The change is motivated by […]

DOVER, DE (June 17, 2022) – The Delaware Division of Public Health (DPH) reports an overall decrease in COVID-19 cases and hospitalization since the previous monthly COVID-19 update released on May 21, 2022. While COVID-19 cases, hospitalizations, and deaths are experiencing a decreasing trend, DPH encourages Delawareans to rely on trusted prevention actions to stay one step ahead of COVID-19 during this event-filled weekend that […]

The Centers for Disease Control and Prevention (CDC) raised Delaware’s COVID-19 community levels to the High category (red) in all three counties on July 28, 2022.   As a result, the Division of Public Health (DPH) is asking Delawareans to follow the CDC’s key strategies at this level of community spread:   ·      Wear a well-fitting mask […]

   DOVER, DE (Aug. 19, 2022) – The Delaware Division of Public Health (DPH) reports that the 7-day average of new positive COVID-19 cases has declined since the previous monthly update in July. However, COVID-19 is still circulating in the community, and at higher levels in some counties. According to the Centers for Disease Control and Prevention’s (CDC) COVID-19 Community Levels data tracker, which was last […]

DOVER, DE (August 31, 2022) – On Aug. 31, the U.S. Food and Drug Administration (FDA) granted Emergency Use Authorization to Pfizer and Moderna for their new bivalent boosters, meaning vaccine could start shipping to states that pre-ordered as early as Friday.  The Centers for Disease Control and Prevention’s (CDC) advisory committee meets Thursday and Friday, Sept. 1 and 2, […]

Early childhood professionals who earn a Child Development Associate credential now also can receive 12 credits at Delaware institutes of higher education under a new agreement with the state.

Read the in depth Review of Audeze LCD-i3 Audio Video. Know detailed info about Audeze LCD-i3 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

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I am trying to remove the cdn_loop_breaker cells from the netlist. 
When I tried the below 2 things, genus synthesis tool removing the cdn_loop_breaker cells but while connecting the cdn_loop_breaker cell input to its proper connection, its somehow misleading the connections

Things i tried:
1.  remove_cdn_loop_breaker -instances *cdn_loop_breaker*
then i just ran remove_cdn_loop_breaker  comand without the -instances switch
2. remove_cdn_loop_breaker  
     
both of the above things are not providing the proper connections after removing the loop_breaker_cells

can anyone suggest the best possible workaround for this please?

Hi,

I am looking to perform a net trace in a CDL file.

There is a net at a lower level and would like to know the net it is connected to at the top level.

Please let me know if there is a way to analyze the CDL file to perform this net trace.

Thanks,

Mallikarjun.

I am scripting gds streamin using 'strmin', which works fine so far.

But, as it apparently doesn't have an option to specify where the cds.lib file is, I have to run it from the directory where the cds.lib file is, or I guess I could create a dummy one to source that one.

Is there a way to tell strmin where the cds.lib file is?

I was trying to remove the cdn_loop_breaker cells from the netlist. 
When I tried the below 2 things, it removing the cdn_loop_breaker cells but while connecting the cdn_loop_breaker cell input to its proper connection, its somehow misleading the connections

Things i tried:
1.  remove_cdn_loop_breaker -instances *cdn_loop_breaker*
then i just ran remove_cdn_loop_breaker  comand without the -instances switch
2. remove_cdn_loop_breaker  
     
both of the above things are not providing the proper connections after removing the loop_breaker_cells

I need to add a new CDF parameter called "mag" to symbols in a given library using skill script in which the symbol size can be controlled and call back it each time this library is used so that all the symbols are updated.

Hi, 
In the MATLAB, I am using cds_srr and cds_innersrr commands. Although I set the path to the spectre root, I face this error:

One or more output arguments not assigned during call to "cds_innersrr".

Error in cds_srr (line 20)
sig = cds_innersrr(dirname, dataset, signame, verbose);

Error in techsweep_spectre_run (line 64)
struct_n = cds_srr(c.outfile, c.sweep, params_n{1});

I would highly appreciate it if you could help me.

MANILA, Philippines — The Office of the Civil Defense (OCD) on Wednesday said the government is ready to respond to the effects of typhoons in the coming days and weeks of the year. OCD head Ariel Nepomuceno, however, admitted that the consecutive storms/typhoons in the past few weeks are unprecedented, even in the current system the government has for disaster response. “Nakalatag naman ‘yung sistema natin, although admittedly itong sistema natin hindi na-assume ‘yung ganitong scenario, bago rin sa’tin ito,” said Nepomuceno during a Kapihan sa Manila Hotel briefing. (Our system is in place, although admittedly our system did not […]...

Keep on reading: Gov't ready for calamity response; staff fatigue a big concern - OCD

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We're finally pinning down the mechanisms that drive obsessive-compulsive disorder, revealing a complex combination of imbalanced brain networks, the immune system and even gut microbes

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Title: Stomach Bug Vaccine for Infants Protects Entire Community: CDC
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Title: Injuries Tied to Illegal Meth Labs on the Rise: CDC
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Title: CDC Advises Pregnant Women to Avoid Miami Beach Due to Zika
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