¹⁸F-labeled prostate-specific membrane antigen (PSMA) PET tracers are increasingly used in preference to ⁶⁸Ga-PSMA-11 for restaging biochemical recurrence (BCR) of prostate cancer. They are associated with longer half-lives, larger-scale production, and lower positron range than their ⁶⁸Ga-labeled counterparts. Here, we describe the efficacy of an ¹⁸F-labeled radiohybrid PSMA, rhPSMA-7, a novel theranostic PSMA-targeting agent for imaging BCR of prostate cancer. Methods: Datasets from 261 consecutive patients with noncastrate BCR after radical prostatectomy who underwent ¹⁸F-rhPSMA-7 PET/CT at our institution between June 2017 and March 2018 were reviewed retrospectively. All lesions suspected of being recurrent prostate cancer were recorded. The detection rate for sites of presumed recurrence was correlated with patients’ prostate-specific antigen (PSA) level, primary Gleason score, and prior therapy (androgen deprivation therapy and external-beam radiation therapy). Results: The 261 patients had a median PSA level of 0.96 ng/mL (range, 0.01–400 ng/mL). The median injected activity of ¹⁸F-rhPSMA-7 was 336 MBq, with a median uptake time of 76 min. In total, 211 patients (81%) showed pathologic findings on ¹⁸F-rhPSMA-7 PET/CT. The detection rates were 71% (42/59), 86% (44/51), 86% (42/49), and 95% (76/80) at PSA levels of 0.2 to <0.5 ng/mL, 0.5 to <1 ng/mL, 1 to <2 ng/mL, and ≥2 ng/mL, respectively. In 32% patients (7/22) with a PSA of less than 0.2 ng/mL, suggestive lesions were present. ¹⁸F-rhPSMA-7 PET/CT revealed local recurrence in 43% of patients (113). Lymph node metastases were present in the pelvis in 42% of patients (110), in the retroperitoneum in 17% (45), and in a supradiaphragmatic location in 8.0% (21). Bone and visceral metastases were detected in 21% (54) and 3.8% (10), respectively. Detection efficacy was not influenced by prior external-beam radiation therapy (79.1% vs. 82.1%, P = 0.55), androgen deprivation therapy within the 6 mo preceding imaging (80.6% vs. 80.9%, P = 0.54), or primary Gleason score (77.9% for ≤7 vs. 82.6% for ≥8, P = 0.38). Conclusion: ¹⁸F-rhPSMA-7 PET/CT offers high detection rates in early BCR after radical prostatectomy, especially among patients with low PSA values.

Restaurants are preparing for life after lockdown with a range of radical measures that will keep diners safe but will involve drastic changes to the way Londoners eat out.

Parents, relatives and friends were today urged to raise the alarm if they fear that children are being radicalised during the lockdown as the Met warned that tip-offs about suspected extremists have plummeted.

Eric Foner

The post The Making of the Radical Republicans appeared first on The Nation.

Many of us need a modern-day Bob Ross in the shape of Grayson Perry, writes Lucy Jones, to help us reconnect with the child within who just wants to push paint around the page

With the help of oatmeal chocolate chip cookies.

The new documentary "Spaceship Earth" breaks the mystery of the Biosphere 2 experiment wide open, revealing the facts in a story that feels more like science fiction than reality.

Dec 7, 2018

Architype demonstrates that simple forms and careful window choices are the way to build efficient, affordable homes.

Critics have been quick to say that Phonebloks isn't realistic with the current market. What they are missing is that this is the entire point of the project. Phonebloks aims to alter the present, but re-imagining the future.

Alphabet's X moonshot factory spins out a ground source heat pump company.

The leader of the Catholic Church used his strongest language yet to call for 'decisive action, here and now.'

"This is our last chance to avert a climate disaster. We must act now."

The KISS principle applies to everything, including building design.

What happens when you restrict cars? Transit use, cycling and walking increase dramatically.

The French government has set a goal of eliminating all single-use plastics by 2040. Phase one has begun.

This past Thursday, at the business conference Opportunity Green, one panel entitled Next Generation Carbon Mapping: Radical Transparency and Truth in Advertising captured the attention of the standing room only audience at

People are finally beginning to take this issue seriously.

But the hotel design competition is always interesting, even in an off year.

This week The Man with A Spear in His Chest, founder of Interface Ray Anderson, held a press conference to mark a milestone in his company's journey up "Mount Sustainability". They are making excellent progress towards their target of zero

Check out an insulated stainless steel mug for free, as you would a library book.

The small gardens are new and innovative and changing the way we look at them.

Grigory Sokolov
(Deutsche Grammophon, 2 CDs, 1 DVD)
He last gave a concert in the UK in 2007, so any opportunity to hear one of the world’s finest pianists is welcome, though this is uneven

For over a decade now, the British government’s stringent visa requirements for visiting musicians from outside the EU have ensured that Grigory Sokolov has not played in Britain. The Russian gave his last recitals here in 2007, and as he no longer performs concertos, and shuns studio recordings, opportunities to hear a pianist who many regard as one of the finest alive today get fewer by the year. This compilation at least brings us more or less up to date, with performances taken from recitals that Sokolov gave in 2019 in Zaragoza, Wuppertal and in the Tyrolean village of Rabbi, where the great Italian pianist Arturo Benedetti Michelangeli had a house, and where a festival is now held in his memory.

There is no link between oral infections and the risk of stem cell transplantation patients dying of or getting a serious infection within six months of the procedure, found new study.

The OECD, UN Environment and World Bank Group today called on leaders of G20 countries to do more to enable a radical shift of investment into low-carbon, climate-resilient infrastructure as a way to limit the impact of climate change.

Traditional rulemaking is unable to keep up with new digital businesses

Newer employees like their appraisals upfront and often

‘The old globalised order is fracturing. We are seeing wartime-style falls in GDP’

My mother, a former actress, adored Little Women and read the book aloud to my sisters and me, with different voices for each of the March sisters.

Julian King (pictured in Brussels) said there were more than 1,000 people being held on terror charges and said that others imprisoned for unrelated crimes may also have been radicalised.

Salah Abdeslam spent his first night in Fleury-Mérogis prison in south Paris on Wednesday. He was arrested over last November's attacks in the French capital which claimed 130 lives.

Traffic police working in the 18th arrondissement area of Paris in France recognised the radical cleric from a picture that had been handed out to all officers but had not been released publicly.

SIR CLIVE WOODWARD: Professional rugby's financial vulnerability has been cruelly exposed and, frankly, it has always been built on shifting sands.

The former President made the remarks to a room full of wealthy donors at a Democracy Alliance meeting on Thursday night.

St George-Illawarra coach Paul McGregor is the latest to throw his support behind a Magic-Round style concept of isolating all 16 teams in one city as the growing pandemic spreads.

Police and military personnel will be deployed to secure Christmas and New Year's Eve celebrations across the country and focused on predominantly Christian regions like Papua.

EXCLUSIVE: EFL clubs want to access funds made available to business as part of the Coronavirus Job Retention Scheme announced by Chancellor Rishi Sunak last week.

The new prototype is a two-door 'crossover' aimed at young families but the final version will be a four-door petrol-electric hatchback crossover. It includes a permanent integrated child seat.

Some of the taxes we currently pay and a number of the tax breaks we are given to encourage us to save for old age are either too onerous or far too complicated.

SIR CLIVE WOODWARD: Professional rugby's financial vulnerability has been cruelly exposed and, frankly, it has always been built on shifting sands.

Some of the taxes we currently pay and a number of the tax breaks we are given to encourage us to save for old age are either too onerous or far too complicated.

Greek architect Tilemachos Andrianopoulos provides a tour of his design: a triangular home that blurs the line between inside and the olive grove outside. "Even for a completely new structure, there is always something that already exists there," he says. Photo: Rob Alcaraz/The Wall Street Journal

Formula One will introduce budget caps, a new car, and rules designed to develop closer and more environmentally-friendly racing come the 2021 season.

New York, NY : Oxford University Press, 2020.

Oxford : Oxford University Press, 2020.

Hayden Library - GE197.W66 2018

Dewey Library - HB501.P6457 2018

Dewey Library - HB501.A96 2020