radical Metal-free photoinduced-radical hydrocyclization of 2-isocyanides: a unified synthetic approach to facilely assemble diverse N-heteroarenes By pubs.rsc.org Published On :: Green Chem., 2024, 26,10804-10810DOI: 10.1039/D4GC03774J, CommunicationZiyi Wang, Haonan Wei, Jinrong Du, Zhijun ZuoWe present an efficient and sustainable protocol for the photoinduced-radical hydrocyclization of isocyanides, providing a united route to assemble diverse α-unsubstituted N-heteroarenes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
radical Radical Russian Imperial Movement Expanding Global Outreach By www.voanews.com Published On :: Sat, 09 May 2020 21:19:58 -0400 Russian Imperial Movement, based in St. Petersburg, is increasingly expanding its outreach beyond Russia through the establishment of transnational networks with likeminded neo-Nazis and white supremacist groups, experts warn Full Article
radical Republican Congressman on Suspected Islamic Radicals: "Kill Them All" By www.motherjones.com Published On :: Mon, 05 Jun 2017 15:21:09 +0000 In response to the London terror attack, Rep. Clay Higgins (R-La.) had an extreme proposal: kill anyone suspected of being an Islamic radical. On his campaign Faceboook page, Higgins, a former police officer, posted this message: The free world…all of Christendom…is at war with Islamic horror. Not one penny of American treasure should be granted to any nation who harbors these heathen animals. Not a single radicalized Islamic suspect should be granted any measure of quarter. Their intended entry to the American homeland should be summarily denied. Every conceivable measure should be engaged to hunt them down. Hunt them, identity them, and kill them. Kill them all. For the sake of all that is good and righteous. Kill them all. The post went up early on Sunday morning. On Saturday evening, suspected terrorists killed seven people during an attack on London Bridge. ISIS has claimed credit for these murders. With his declaration that Christendom is "at war with Islamic horror," Higgins was embracing a theme of the far right: the fight against extremist jihadists is part of a fundamental clash between Christian society and Islam. And in this Facebook post, he was calling for killing not just terrorists found guilty of heinous actions, but anyone suspected of such an act. He did not explain how the United States could determine how to identify radicalized Islamists in order to deny them entry to the United States. It was unclear whether his proposal to deny any assistance to any nation that harbors "these heathen animals" would apply to England, France, Indonesia, Spain, and other nations where jihadist cells have committed horrific acts of violence. Higgins office refused to allow a Mother Jones reporter to speak to a spokesman for the congressman. But in an email, his spokesman confirmed the Facebook post was authentic. In late January, Higgins delivered a fiery floor speech attacking Democrats and the "liberal media" for opposing President Donald Trump's Muslim travel ban. He declared that "radical Islamic horror has gripped the world and…unbelievably…been allowed into our own nation with wanton disregard." Shortly before running for Congress, Higgins resigned from his post as the public information officer of the St. Landry Parish Sheriff's Office, where he had earned a reputation as the "Cajun John Wayne" for his tough-talking CrimeStopper videos. Higgins abruptly quit after his boss, the sheriff, ordered him to tone down his unprofessional comments. "I repeatedly told him to stop saying things like, 'You have no brain cells,' or making comments that were totally disrespectful and demeaning," the sheriff said. "I don't do well reined in," Higgins noted at the time. "Although I love and respect my sheriff, I must resign." Update: Higgins' campaign spokesman, Chris Comeaux, told Mother Jones in an email: "Rep. Higgins is referring to terrorists. He's advocating for hunting down and killing all of the terrorists. This is an idea all of America & Britain should be united behind." Full Article Politics Congress Crime and Justice Foreign Policy International National Security
radical Split innings, more free hits and powerplays: Big Bash debates radical new rules By www.foxsports.com.au Published On :: 2020-05-09T12:09:00.000+00:00 Watch A Week With Warnie, part of a week-long pop-up channel on Foxtel and Foxtel Now, from Monday 8pm (EST)! Full Article
radical OECD, UN Environment and World Bank call for a radical shift in financing for a low-carbon, climate-resilient future By www.oecd.org Published On :: Wed, 28 Nov 2018 18:00:00 GMT The OECD, UN Environment and World Bank Group today called on leaders of G20 countries to do more to enable a radical shift of investment into low-carbon, climate-resilient infrastructure as a way to limit the impact of climate change. Full Article
radical Towards radical democracy in India By indiatogether.org Published On :: Sun, 14 Feb 2016 03:08:52 +0000 A multitude of grassroots movements are emerging across the country in resistance to the mainstream economy and polity. These initiatives are exploring sustainable, equitable and just paths to human well-being. Ashish Kothari and Pallav Das offer an insight into the need for such movements. Full Article
radical Britney Spears thanks fans with radically different new cover for 2016's 'Glory' By www.newkerala.com Published On :: Sun, 10 May 2020 01:42:01 +0530 Full Article
radical Environmentally persistent free radicals: what do we know about this newly recognised class of pollutants? By ec.europa.eu Published On :: Thur, 07 June 2018 9:23:19 GMT The most important findings from over a decade of research into environmentally persistent free radicals (EPFRs), a new class of environmental pollutants, are presented in a recent review. These toxic particles could be partly responsible for some of the health problems, such as asthma, associated with particulate matter (PM) exposure. The researchers issue a warning that some engineered nanomaterials (ENMs) could increase levels of EPFRs in the environment. Full Article
radical Radical coffee cup design takes aim at plastic lids By www.mnn.com Published On :: Tue, 26 Nov 2019 19:01:26 +0000 The paper Unocup ditches plastic in a bid to reduce waste and improve ergonomics. Full Article Beverages
radical Free Radicals: Destructive Scavengers and the Vital Role Antioxidants Play By www.articlegeek.com Published On :: Several years ago, it was all over the news. Free radicals were damaging - we all had them, and antioxidants were the solution. But what role really do free radicals play in damaging the body, and how are we supposed to best get rid of them? How do antioxidants work and what is the best way of adding them to our diet? Full Article
radical Defining Radical Candor – and How to Do It By hbr.org Published On :: Tue, 18 Feb 2020 12:44:31 -0500 Kim Scott, a cofounder of the executive coaching firm Radical Candor, says that too many managers give meaningless positive feedback, while many others are highly critical without showing any understanding. Scott, who previously worked at Google and has consulted for Twitter and Dropbox, says leaders should learn to give honest feedback in the moment, while also developing a relationship that shows how the hard feedback is coming from a place of caring. She explains the steps managers can take to challenge more directly while also communicating empathy. Scott is the author of the book "Radical Candor: Be a Kick-Ass Boss Without Losing Your Humanity." Full Article
radical Antibodies Could Be ‘Radically Life-Changing’ New Treatment for OCD and Other Mental Disorders By www.goodnewsnetwork.org Published On :: Tue, 21 Apr 2020 16:36:29 +0000 The researchers from Queen Mary University of London say the discovery could lead to ground-breaking treatments with “a reduced chance of side effects.” The post Antibodies Could Be ‘Radically Life-Changing’ New Treatment for OCD and Other Mental Disorders appeared first on Good News Network. Full Article Health Science Treatment Therapy Discovery Mental Health Medical
radical For Rachel Carson, wonder was a radical state of mind By feedproxy.google.com Published On :: Fri, 27 Sep 2019 18:33:25 +0000 By Jennifer Stitt Aeon In 1957, the world watched in wonder as the Soviet Union launched Sputnik 1, the first artificial satellite, into outer space. Despite Cold War anxieties, The New York Times admitted that space exploration ‘represented a step … Continue reading → Full Article ecoView ecological philosophy Ecology Heroes Rachel Carson Silent Spring
radical For Rachel Carson, wonder was a radical state of mind By feedproxy.google.com Published On :: Fri, 27 Sep 2019 18:33:25 +0000 By Jennifer Stitt Aeon In 1957, the world watched in wonder as the Soviet Union launched Sputnik 1, the first artificial satellite, into outer space. Despite Cold War anxieties, The New York Times admitted that space exploration ‘represented a step … Continue reading → Full Article ecoView ecological philosophy Ecology Heroes Rachel Carson Silent Spring
radical Catalyst for living radical polymerization and polymerization method By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT A nonmetallic compound having an ionic bond with a halide ion is used as a catalyst for living radical polymerization. Even if a radical initiator is not used, a monomer can be subjected to a radical polymerization to obtain a polymer having narrow molecular weight distribution. The cost of the living radical polymerization can be remarkably reduced, and it is made possible to prevent adverse effects of using a radical initiator (such as side reactions). The present invention is significantly more environmentally friendly and economically excellent than conventional living radical polymerization methods, due to advantages such as low toxicity of the catalyst, low amount of the catalyst necessary, high solubility of the catalyst, mild reaction conditions, and no coloration/no odor, etc. The catalyst can be applied to various monomers and enables synthesis of high molecular weight polymers. Full Article
radical Continuous production process of tertiary alcohols by radical addition of secondary alcohols to alkenes By www.freepatentsonline.com Published On :: Tue, 03 Nov 1998 08:00:00 EST A process is disclosed for producing tertiary alcohols by radical addition of secondary alcohols to alkenes. The reaction is carried out as a continuous process in the presence of an organic peroxide as a radical initiator and during a mean contact time of the reaction mixture of up to a maximum of 1 hour. Full Article
radical Control over controlled radical polymerization processes By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A procedure for improved temperature control in controlled radical polymerization processes is disclosed. The procedure is directed at controlling the concentration of the persistent radical in ATRP and NMP polymerizations procedures and the concentration of radicals in a RAFT polymerization process by feeding a reducing agent or radical precursor continuously or intermittently to the reaction medium through one of more ports. Full Article
radical Dinitroxide-type biradical compounds optimized for dynamic nuclear polarization (DNP) By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied. Full Article
radical Process of free-radical polymerization or crosslinking in the presence of a selected organic peroxide prepared by an ex situ process By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT The invention relates to free-radical polymerization and free-radical cross-linking and more particularly provides a process of free-radical polymerization or cross-linking wherein at least one polymerizable monomer or at least one compound to be cross-linked is contacted in the presence of at least one selected organic peroxides, characterized in that the organic peroxide is prepared continuously by an ex situ process with the aid of a closed plate exchanger. In the process according to the invention, it's possible to introduce the above selected organic peroxide continuously during the polymerization or cross-linking reaction. Full Article
radical PHOTOCONDUCTOR HAVING CROSSLINKABLE TRANSPORT MOLECULES HAVING FOUR RADICAL POLYMERIZABLE GROUPS AND METHOD TO MAKE THE SAME By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT An improved organic photoconductor drum having a protective overcoat layer and method to make the same is provided. The protective overcoat layer is prepared from a curable composition including a crosslinkable hole transport molecule containing four radical polymerizable functional groups in combination with a crosslinkable acrylate having at least 6 functional groups. Full Article
radical SF’s Lava Mae Brings Showers, ‘Radical Hospitality’ to Oakland Homeless Encampments By www.eastbayexpress.com Published On :: Thu, 25 Oct 2018 11:45:00 -0700 The organization sets up at 27th Street and Northgate Avenue and at 6th and Castro streets. Blair Hippolyte and Jannie Rutledge, two Oakland residents who are homeless, sat on the sidewalk of 27th Street.… Full Article News & Opinion/Feature
radical Jazz Night In America: Radical Imagination: Jazz And Social Justice By www.wemu.org Published On :: Fri, 20 Jan 2017 19:52:39 +0000 "Our best musicians in the jazz tradition were radical imaginers," Samora Pinderhughes says. A pianist and composer in his mid-20s, he has asserted his connection to that lineage with The Transformations Suite , an earnest and ambitious new work combining music, words and visuals. The piece, which took five years to chisel into shape, was inspired by African-American resistance and protest movements, as well as the oppression that many still endure. Pinderhughes now lives in Harlem, but he grew up in the Bay Area, in a family of academics and social activists. Shortly after releasing The Transformations Suite last fall, he brought the project to the Way Christian Center in Berkeley for a performance that was several things at once: a homecoming, an album-release concert, a rousing community gathering. Along with a group of smart young jazz musicians, the ensemble features spoken-word poetry by the accomplished actor Jeremie Harris and passages of soulful singing by Jehbreal Jackson. Full Article
radical BookMark: “The Tangled Tree: A Radical New History Of Life” By David Quammen By radio.wpsu.org Published On :: Thu, 12 Dec 2019 23:20:39 +0000 “The Tangled Tree: A Radical New History of Life” offers those who usually read novels a chance to enjoy ‘creative non-fiction.’ This book is a well-told narrative about the molecular building blocks of life and how they evolved. David Quammen accepts the challenge of documenting the advancement of evolutionary life science while revealing its significance to all of our lives. Quammen also gives us insight into the vibrant communities of scientists carrying out similar work. Quammen begins by introducing the image of the Tree of Life. He describes how it has evolved from the image of a ladder-to-heaven in ancient and medieval thinking into Darwin’s branching, upward-growing tree. Quammen closes his introduction with his own surprising proposition. He suggests Darwin’s tree image is no longer the precise metaphor for what life is. Quammen introduces each new evolutionary twist and turn until the new Tree of Life ends up looking more like a web than an upwardly-reaching tree with Full Article
radical 0x52: Legal Issues from a Radical Community Angle By faif.us Published On :: Wed, 24 Dec 2014 10:30:00 -0500 Bradley and Karen play and discuss Stefano Zacchiroli's talk entitled Legal issues from a radical community angle that he gave 12:00 European/Central time on Sunday 2 February 2014 at FOSDEM 2014. Show Notes: Segment 0 (00:00:35) Karen and Bradley introduce the talk. Segment 1 (00:02:38) Stefano Zacchiroli's talk entitled Legal issues from a radical community angle . You can watch the video instead of listening to our audio and/or follow along with Zach's slides. Segment 2 (00:53:17) Please note: Bradley and Karen recorded these comments before the init system coupling referendum completed, which is why Karen and Bradley don't discuss it. However, their comments about the Debian democratic process are highly relevant to the recent vote. Also, Bradley discussed his views on that specific issue as a guest co-host on Linux Outlaws, Episode 368. Bradley and Karen discussed SPI as Debian's fiscal sponsor and used a few terms like grantor/grantee (01:01:20) Send feedback and comments on the cast to <oggcast@faif.us>. You can keep in touch with Free as in Freedom on our IRC channel, #faif on irc.freenode.net, and by following Conservancy on on Twitter and and FaiF on Twitter. Free as in Freedom is produced by Dan Lynch of danlynch.org. Theme music written and performed by Mike Tarantino with Charlie Paxson on drums. The content of this audcast, and the accompanying show notes and music are licensed under the Creative Commons Attribution-Share-Alike 4.0 license (CC BY-SA 4.0). Full Article Technology
radical A native plant guru’s radical vision for the American yard and the environment By www.seattletimes.com Published On :: Wed, 12 Feb 2020 21:57:14 -0800 How your garden can help the planet and all life around you. Full Article Environment Garden Life Nation Nation & World
radical Can extremists be de-radicalised? By www.abc.net.au Published On :: Sun, 12 Apr 2020 08:05:00 +1000 Two terrifying incidents involving convicted extremists took place in London last year. The first, the London Bridge attack, left two people dead. Nine weeks later, in Streatham, two passersby were stabbed on the street. Both cases occurred after the perpetrators had failed to be rehabilitated in prison. So how effective are the UK's schemes for de-radicalising offenders? The BBC's File on 4 investigates where it is time for a radical overhaul of the way England treats extremists. For copyright reasons there will be no podcast or streaming of this program. Full Article Terrorism Prisons and Punishment Law Crime and Justice
radical Mining workforce undergoes a radical transformation By www.abc.net.au Published On :: Sun, 04 Aug 2019 11:16:00 +1000 Full Article ABC Goldfields goldfields Business Economics and Finance:Industry:Mining Community and Society:Feminism:All Community and Society:Women:All Rural:Rural Women:All Australia:All:All Australia:WA:All Australia:WA:Kalgoorlie 6430
radical Barnawartha police shooting: NSW authorities allege brothers were radicalised before jail time By www.abc.net.au Published On :: Thu, 13 Jun 2019 18:14:00 +1000 The brothers shot by police in Barnawartha North yesterday were radicalised before going to jail last year, NSW Corrective Services allege, as counterterrorism police say one of the men had been on their radar for at least two years. Full Article ABC Goulburn Murray goulburnmurray melbourne Law Crime and Justice:All:All Law Crime and Justice:Crime:All Law Crime and Justice:Police:All Unrest Conflict and War:Terrorism:All Australia:NSW:Albury 2640 Australia:VIC:All Australia:VIC:Barnawartha 3688 Australia:VIC:Melbourne 3000 Australia:VIC:Wodonga 3690
radical Self-directed support: a radical policy? By podcast.iriss.org.uk Published On :: Tue, 19 Feb 2019 17:00:00 +0000 Has self-directed support been the transformational and radical policy that it was set out to be? Dr Charlotte Pearson and Professor Nick Watson spoke to Stuart Muirhead from Iriss about their research on the policy - what the results reveal about the implementation of self-directed support in Scotland. Charlotte was one of the authors of our 2012 Iriss Insight, Self-directed support: preparing for delivery. We also produced a recent evidence summary titled, Self-directed support and workforce development, which explores how the social care workforce in Scotland can be further developed to deliver self-directed support. Transcript of episode Music Credit: Make your dream a reality by Scott Holmes Full Article
radical Lufthansa CEO on How Coronavirus Has Radically Upended the Aviation Industry By www.spiegel.de Published On :: Thu, 2 Apr 2020 15:31:36 +0200 The coronavirus pandemic has inflicted massive damage on the aviation industry. But Lufthansa CEO Carsten Spohr says that the German flag carrier is in a good position to survive, even if it will take several years for the industry to recover. Full Article
radical Stephen Sondheim's 90th birthday bash reminds us why his music remains so radical By www.latimes.com Published On :: Mon, 27 Apr 2020 18:44:24 -0400 The best performances in "Take Me to the World: A Sondheim 90th Birthday Celebration" showed how the composer doesn't traffic in formulas. Full Article
radical Julia Alvarez discusses her radically different novel, 'Afterlife' (and defends 'American Dirt') By www.latimes.com Published On :: Thu, 2 Apr 2020 18:24:09 -0400 Julia Alvarez's "Afterlife" is her first novel for adults in 15 years. She talks about loss, fragmentation and "American Dirt." Full Article
radical Opinion: Michigan coach Jim Harbaugh's radical plan for college football players makes sense By rssfeeds.usatoday.com Published On :: Fri, 08 May 2020 21:16:21 +0000 Michigan coach Jim Harbaugh has long advocated for player freedom in college football. His latest proposal involving NFL draft is his most radical. Full Article
radical BREAKING: Michigan’s Radical Governor Extends Lockdown AGAIN…Only One Day After Church Leaders and MI Lawmakers File Suit Against Her By 100percentfedup.com Published On :: Thu, 07 May 2020 22:53:35 +0000 The following article, BREAKING: Michigan’s Radical Governor Extends Lockdown AGAIN…Only One Day After Church Leaders and MI Lawmakers File Suit Against Her, was first published on 100PercentFedUp.com. Michigan was the first state to see protests against draconian lockdown measures by an overreaching governor. On April 15, the Michigan Conservative Coalition organized an in-vehicle protest in Lansing, MI that drew an estimated 15,000 vehicles. Since that time, several protests by Michigan workers who are being devastated by the one-size-fits-all shut down of the […] Continue reading: BREAKING: Michigan’s Radical Governor Extends Lockdown AGAIN…Only One Day After Church Leaders and MI Lawmakers File Suit Against Her ... Full Article Featured Politics
radical Radical new business model for pharmaceutical industry needed to avert antibiotic resistance crisis By feedproxy.google.com Published On :: Mon, 12 Oct 2015 09:19:24 +0000 7 October 2015 20151009Antibiotics.jpg High-level complex of physiologically active antibiotic substance extracted from blastema at the Arctic Innovation Center (AIC) of Ammosov, North-Eastern Federal University (NEFU) in Yakutsk. Photo: Yuri Smityuk/ITAR-TASS Photo/Corbis. Revenues for pharmaceutical companies need to be 'delinked' from sales of antibiotics to avoid their over-use and avert a public health crisis, says a new report from the think-tank Chatham House.Over-use of antibiotics is contributing to the growing resistance of potentially deadly bacteria to existing drugs, threatening a public health crisis in the near future. The report notes that, by 2050, failing to tackle antibiotic resistance could result in 10 million premature deaths per year. Novel antibiotics to combat resistant pathogens are thus desperately needed, but market incentives are exacerbating the problem. Towards a New Global Business Model for Antibiotics: Delinking Revenues from Sales states that, 'The current business model requires high levels of antibiotic use in order to recover the costs of R&D. But mitigating the spread of resistance demands just the opposite: restrictions on the use of antibiotics.' To tackle this catch-22 problem, the Centre on Global Health Security at Chatham House recommends the establishment of a global body to implement a radical new business model for the industry, which would encourage investment and promote global access to - and conservation of - antibiotics. The current business model has several perverse effects. As R&D is an inherently risky and costly endeavour, the industry is chronically under-investing in new treatments. Today, few large pharmaceutical companies retain active antibacterial drug discovery programmes. Re-stoking the industry's interest in antibiotics would be one of the primary roles of the new body. Secondly, the need to recover sunk cost under the current business model encourages both high prices and over-marketing of successful drugs, making potentially life-saving treatments unaffordable to many in developing countries, while simultaneously encouraging over-use in developed markets and increasing resistance. The new global body would address these challenges by ‘delinking’ pharmaceutical revenues from sales of antibiotics. It would do this by directly financing the research and development of new drugs, which it would then acquire at a price based on production costs rather than the recovery of R&D expenses. Acquisition could take the form of procurement contracts with companies, the purchase of full IP rights or other licensing mechanisms. This would enable it to promote global access to antibiotics while simultaneously restricting over-use. Conservation would be promoted through education, regulation and good clinical practice, with the report recommending that 'proven conservation methods such as antibiotic stewardship programmes… be incentivized and implemented immediately.'Priorities for R&D financing would be based on a comprehensive assessment of threats arising from resistance. Antibiotics would qualify for the highest level of financial incentives if they combat resistant pathogens posing a serious threat to human health. Finance for the new body would come from individual nation states, with the report noting that this could 'begin with a core group of countries with significant research activity and large antibiotic markets, (though) it is envisaged that all high income countries should make an appropriate financial contribution.' It is not yet clear exactly how much funding would be necessary to combat resistance, but with inaction expected to cost $100 trillion in cumulative economic damage, the report argues that 'an additional global investment of up to $3.5 billion a year (about 10 per cent of the current value of global sales of antibiotics) would be a bargain.' Editor's notes Towards a New Global Business Model for Antibiotics: Delinking Revenues from Sales, is a Chatham House report edited by Charles Clift, Unni Gopinathan, Chantal Morel, Kevin Outterson, John-Arne Røttingen and Anthony So.The report is embargoed until 00.01 GMT Friday 9 October.For more information, or to request an interview with the editors, contact the press office. Contacts Press Office +44 (0)20 7957 5739 Email Full Article
radical Radical Change? New Political Paradigms in Brazil and Mexico By feedproxy.google.com Published On :: Tue, 12 Feb 2019 00:00:00 +0000 Full Article
radical New Research from Columbia Business School Shows Radical Changes in Household Spending Habits During COVID-19 Epidemic By www8.gsb.columbia.edu Published On :: Tue, 28 Apr 2020 18:37:51 +0000 Business Economics and Public Policy Operations Risk Management Tuesday, April 28, 2020 - 14:30 Study provides first real-time view into household consumption during outbreak in U.S., showing an initial sharp increase in key categories, followed by a sharp decrease in overall spending Full Article
radical 3-year freedom from progression following 68GaPSMA PET CT triaged management in men with biochemical recurrence post radical prostatectomy. Results of a prospective multi-center trial. By jnm.snmjournals.org Published On :: 2019-11-01T13:36:36-07:00 Background: 68Ga PSMA PET CT (PSMA) is increasingly used in men with biochemical recurrence (BCR) post radical prostatectomy (RP), but its longer term prognostic / predictive potential in these men is unknown. The aim of this study was to evaluate the predictive value of PSMA PET for 3 year freedom from progression (FFP) in men with BCR post RP undergoing salvage radiotherapy (sRT). Methods: This prospective multi-center study enrolled 260 men between 2015 and 2017. Eligible patients were referred for PSMA with rising PSA following RP. Management following PSMA was recorded but not mandated. PSMA protocols were standardised across sites and reported prospectively. Clinical, pathological and surgical information, sRT, timing and duration of androgen deprivation (ADT), 3 year PSA results and clinical events were documented. FFP was defined as a PSA rise ≤ 0.2ng/mL above nadir post sRT, with no additional treatment. Results: The median PSA was 0.26ng/mL (IQR 0.15 - 0.59) and follow-up 38 months (IQR 31-43). PSMA was negative in 34.6% (90/260), confined to prostate fossa 21.5% (56/260), pelvic nodes 26.2% (68/260), and distant disease 17.7% (46/260). 71.5% (186/260) received sRT, 38.2% (71/186) to the fossa only, 49.4% (92/186) fossa + pelvic nodes and 12.4% (23/186) nodes alone/SBRT. PSMA was highly predictive of FFP at 3 years following sRT. Overall, FFP was achieved in 64.5% (120/186) of those who received sRT, 81% (81/100) with negative/fossa confined vs. 45% (39/86) for extra fossa disease (p<0.0001). On logistic regression PSMA was more independently predictive of FFP than established clinical predictors, including PSA, T-stage, surgical margin status or Gleason score (P < 0.002). 32% of men with a negative PSMA PET did not receive treatment. Of these, 66% (19/29) progressed, with a mean rise in PSA of 1.59ng/mL over the 3 years. Conclusion: PSMA PET result is highly predictive of FFP at 3 years in men undergoing sRT for BCR following RP. In particular, men with negative PSMA PET or disease identified as still confined to the prostate fossa demonstrate high FFP, despite receiving less extensive radiotherapy and lower rates of additional ADT than those with extra fossa disease. Full Article
radical Intraoperative 68Gallium-PSMA Cerenkov Luminescence Imaging for surgical margins in radical prostatectomy - a feasibility study By jnm.snmjournals.org Published On :: 2020-02-14T14:01:21-08:00 Objective: To assess the feasibility and accuracy of Cerenkov Luminescence Imaging (CLI) for assessment of surgical margins intraoperatively during radical prostatectomy (RPE). Methods: A single centre feasibility study included 10 patients with high-risk primary prostate cancer (PC). 68Ga-PSMA PET/CT scans were performed followed by RPE and intraoperative CLI of the excised prostate. In addition to imaging the intact prostate, in the first two patients the prostate gland was incised and imaged with CLI to visualise the primary tumour. We compared the tumour margin status on CLI to postoperative histopathology. Measured CLI intensities were determined as tumour to background ratio (TBR). Results: Tumour cells were successfully detected on the incised prostate CLI images as confirmed by histopathology. 3 of 10 men had histopathological positive surgical margins (PSMs), and 2 of 3 PSMs were accurately detected on CLI. Overall, 25 (72%) out of 35 regions of interest (ROIs) proved to visualize a tumour signal according to standard histopathology. The median tumour radiance in these areas was 11301 photons/s/cm2/sr (range 3328 - 25428 photons/s/cm2/sr) and median TBR was 4.2 (range 2.1 – 11.6). False positive signals were seen mainly at the prostate base with PC cells overlaid by benign tissue. PSMA-immunohistochemistry (PSMA-IHC) revealed strong PSMA staining of benign gland tissue, which impacts measured activities. Conclusion: This feasibility showed that 68Ga-PSMA CLI is a new intraoperative imaging technique capable of imaging the entire specimen’s surface to detect PC tissue at the resection margin. Further optimisation of the CLI protocol, or the use of lower-energetic imaging tracers such as 18F-PSMA, are required to reduce false positives. A larger study will be performed to assess diagnostic performance. Full Article
radical The inflamed mind : a radical new approach to depression / Edward Bullmore. By www.catalog.slsa.sa.gov.au Published On :: Depression, Mental -- Etiology. Full Article
radical Discover Asylum the radical mental health magazine By search.wellcomelibrary.org Published On :: Full Article
radical The radical mental health magazine. By search.wellcomelibrary.org Published On :: Full Article
radical Trans reproductive justice: a radical transfeminism mini zine By search.wellcomelibrary.org Published On :: Leith, 2019 Full Article
radical Curling considers 'radical' new rules to preserve tradition and speed up games By www.cbc.ca Published On :: Mon, 9 Mar 2020 18:34:41 EDT The sport is considering radical rule changes as it tries to balance centuries of tradition with the modern need to move things along. Full Article Sports/Olympics/Winter Sports/Curling
radical Elections in Burundi: A Radical Shake-up of the Political Landscape By feedproxy.google.com Published On :: Wed, 24 Aug 2005 22:00:00 GMT Full Article
radical Cameroon: The Threat of Religious Radicalism By feedproxy.google.com Published On :: Thu, 03 Sep 2015 09:56:00 GMT Religious intolerance is a growing but seriously underestimated risk in Cameroon, both between and inside the major faiths. To halt the spread of violent extremism in the country, Cameroon needs to bring all sects into a new social compact and within the bounds of a charter for religious tolerance. Full Article
radical Cameroun : au-delà de Boko Haram, la menace insidieuse du radicalisme religieux By feedproxy.google.com Published On :: Wed, 16 Sep 2015 22:00:00 GMT L’image de havre de paix dans une région en proie aux conflits dont bénéficiait le Cameroun a volé en éclats depuis l’irruption de Boko Haram en 2013 au nord du pays. Ce mouvement, devenu l’Etat islamique en Afrique de l’Ouest en mars 2015, revendique son affiliation à Daech. Néanmoins, l’apparition brutale et sanglante de ce djihadisme africain est moins liée à l’essor de Daech en Irak et en Syrie qu’aux bouleversements du paysage religieux de l’Afrique en général et du Cameroun en particulier. Full Article
radical IHC HR e-briefing 117 - Disability discrimination: in preserving the status quo, the Court of Appeal takes a radical leap! By www.eversheds.com Published On :: 2010-07-30 The Court of Appeal has approved the application of the House of Lords decision in the case of London Borough of Lewisham v Malcolm [2008] IRLR 700 to employment-related cases. See our previous HR e-briefing 366 for further information. In many res... Full Article
radical Radical changes to the civil litigation costs regime? By www.eversheds.com Published On :: 2009-07-14 Over the past decade various attempts have been made to ensure civil litigation and "access to justice" are affordable to all. Indeed when the Woolf reforms were introduced over ten years ago one fundamental tenet of these reforms was to make the co... Full Article
radical A radical idea suggests mental health conditions have a single cause By www.newscientist.com Published On :: Wed, 22 Jan 2020 06:00:00 +0000 The discovery of a link between anxiety, depression, OCD and more is set to revolutionise how we think about these conditions – and offer new treatments Full Article