radical OSCE Mission, police to discuss how to help prevent violent extremism and radicalization in Kosovo By feeds.osce.org Published On :: Mon, 27 Jun 2016 12:34:40 +0000 PRISHTINË/PRIŠTINA, 27 June 2016 – The OSCE Mission together with the Kosovo Police will hold a two-day conference on preventing violent extremism and radicalization, starting tomorrow in Prishtinë/Priština. The conference will gather representatives of law enforcement agencies, religious communities, civil society, academia and media, and will explore a multi-disciplinary approach to addressing the threats of violent extremism and radicalization in Kosovo. Participants will also elaborate on measures taken so far to prevent violent extremism and radicalization, as well as the challenges they face. Major Fatos Makolli, Director of the Directorate against Terrorism of the Kosovo Police, and Naim Hoxha, Organized Crime Advisor at the OSCE Mission, will deliver opening remarks. Media representatives are invited to attend the opening of the conference on Tuesday, 28 June 2016, at the Hotel Sirius in Prishtinë/Priština, starting at 09:30 hrs. Related StoriesOSCE Mission assesses implementation of new Criminal Procedure Code of KosovoMini-Olympic Games 2016OSCE Mission-organized Junior Basketball Tournament Full Article OSCE Mission in Kosovo Policing South-Eastern Europe Media advisory
radical A Mn(III)-catalyzed arylboronic acid-based cascade reaction via a nonclassical organometallic-radical mechanism By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00244J, Research ArticleHui-Min Qian, Jian-Dong Zhang, Shun-Jun Ji, Xiao-Ping XuAn efficient Mn(III)-catalyzed cascade reaction of arylboronic acids, o-cyanoaryl isocyanides, and indoles was developed. The mechanism was fully investigated and elucidated.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
radical Photoredox catalyzed hydroazolylation of alkenes via phosphoranyl radicals By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00233D, Research ArticleFan Zhu, Zhi Qiao, Na He, Chunxiao Nong, Qiping He, Meilan Xi, Xizhong Song, Jun Lin, Jingbo Chen, Yi JinA general protocol for the hydroazolylation of alkenes with N-hydroxyl azoles is reported. These reactions proceed via a phosphoranyl radical, followed by radical coupling of the resulting azole radical to the alkene radical.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
radical Spiro-centre substitution effects in the intramolecular spin–spin interactions of spirobiacridine diradicals By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00419A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shinichi Ogawa, Takuya Kanetomo, Masaya EnomotoSpirodiradicals with the Si and Ge spiro atoms exhibit a S = 1 state. The magnetic interaction in the Si derivative was found to be lower than that in the Ge derivative, implying a negative effect on σ*(Si–Cα)–π* hyperconjugation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
radical Metal-free photoinduced denitrogenative alkylation of vinyl azides with alkyl radicals toward ketones By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO00280F, Research ArticleHui Yin, Siqi Jian, Xiujuan Feng, Ming Bao, Xuan ZhangA metal-free method for the synthesis of ketones via a visible-light induced denitrogenative alkylation of vinyl azides with alkyl radicals is presented.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
radical Efficient Synthesis of Benzophosphole Oxides by Ag-Promoted Radical Cycloisomerization By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO00552J, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Liyao Ma, Sonia Mallet-Ladeira, Julien MONOT, Blanca Maria MARTIN VACA, Didier BourissouCycloisomerization reactions involving C–P bond formation have been overlooked to prepare P-heterocycles. We discovered here a simple, efficient and versatile route to benzophosphole oxides by reacting ortho-alkynyl secondary phosphine oxides...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
radical Cationic Radical Metal–Organic Framework Enabling Low Water Evaporation Enthalpy and High Photothermal Conversion Efficiency for Solar-Driven Water Purification By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Accepted ManuscriptDOI: 10.1039/D4TA01126K, PaperZi-Yu Wang, Rui Wang, Hannah M Johnson, Lei Cai, An-An Zhang, Qiang Zhang, Tianfu LiuSolar vapor generation is a promising and sustainable strategy to purify seawater and contaminated water sources. Yet, efficient integration between solar capture and desalination remains a critical challenge. In this...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
radical Youth ‘hooked to radical content online’ detained in J&K’s Kulgam By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:42:21 +0530 The youth was “misusing social media for radical propaganda aimed at to instigate common people against the Government of India and also glamourising terrorism in J&K” Full Article India
radical Wikipedia: Matilda Joslyn Gage (1826 - 1898) -- Gage was considered to be more radical than either Susan B. Anthony or Elizabeth Cady Stanton (with whom she wrote History of Woman Suffrage) - Along with Stanton, she was a vocal critic of the Christian Chu By en.wikipedia.org Published On :: Family: A daughter of the early abolitionist Hezekiah Joslyn, Gage was the wife of Henry Hill Gage, with whom she had five children: Charles Henry (who died in infancy), Helen Leslie, Thomas Clarkson, Julia Louise, and Maud. Gage maintained residence in Fayetteville, New York for the majority of her life. Though Gage was cremated, there is a memorial stone at Fayetteville Cemetery that bears her slogan "There is a word sweeter than Mother, Home or Heaven. That word is Liberty." -- Maud, who was ten years younger than Julia, initially horrified her mother when she chose to marry The Wonderful Wizard of Oz author L. Frank Baum at a time when he was a struggling actor with only a handful of plays (of which only The Maid of Arran survives) to his writing credit. However, a few minutes after the initial announcement, Gage started laughing, apparently realizing that her emphasis on all individuals making up their own minds was not lost on her headstrong daughter, who gave up a chance at a law career when the opportunity for women was rare. Gage spent six months of every year with Maud and Frank, and died in the Baum home in Chicago, Illinois in 1898. -- Gage's son Thomas Clarkson Gage and his wife Sophia had a daughter named Dorothy Louise Gage, who was born in Bloomington, IL, on June 11, 1898 and died just five months later on November 11, 1898. The death so upset the child's aunt Maud, who had always longed for a daughter, that she required medical attention. Thomas Clarkson Gage's child was the namesake of her uncle Frank Baum's famed fictional character, Dorothy Gale. In 1996, Dr. Sally Roesch Wagner, a biographer of Matilda Joslyn Gage, located young Dorothy's grave in Bloomington. A memorial was erected in the child's memory at her gravesite on May 21, 1997. This child is often mistaken for her cousin of the same name, Dorothy Louise Gage (1883-1889), Helen Leslie (Gage) Gage's child. As theosophists, both the Baums and the Gages believed in reincarnation, and thought this child might have been Matilda Joslyn Gage, whose personal spark is apparently written into the character. -- In The Dreamer of Oz: The L. Frank Baum Story, Gage was played by Rue McClanahan, whose relationship with Frank was wrongly portrayed as antagonistic, and falsely presented Gage as the inspiration for the Wicked Witch of the West. Annette O'Toole played Maud, and Nancy Morgan and Pat Skipper played Helen and Charles, respectively. Full Article Christian Church History Study 4. 1881 A.D. to Present (2012) - Corrupt modern bible translations and compromised Seminaries and Universities
radical Zero Motorcycles adopts radical 'Big Hole' technology to boost range By newatlas.com Published On :: Tue, 12 Nov 2024 17:27:00 GMT UK-based R&D shop White Motorcycle Concepts (WMC) punched a gaping hole in a Zero SR/S electric motorcycle to reduce aerodynamic drag by 10%. The prototype now goes faster, and can deliver extended range at highway speeds – proving this method can serve as an effective way to increase EV efficiency.Continue ReadingCategory: Motorcycles, TransportTags: Zero Motorcycles, WMC (White Motorcycle Concepts), Electric Motorcycles, Aerodynamics Full Article
radical Radical Monogamy By www.ancientfaith.com Published On :: 2012-05-02T15:48:00+00:00 What do the Scriptures and the Fathers say about fidelity in marriage, sex outside of marriage, or same-sex marriage? Fr. Tom gives extensive teaching on this subject in today's episode. Full Article
radical The Radical Reformation - Part 1a By www.ancientfaith.com Published On :: 2016-02-07T02:45:34+00:00 Fr. Andrew begins a survey of the Radical Reformation which introduced the effects of pietism into the Protestant church. Full Article
radical The Radical Reformation - Part 1b By www.ancientfaith.com Published On :: 2016-02-07T02:46:16+00:00 Fr. Andrew continues his survey of the Radical Reformation by discussing the impact of Antinomianism and the theory of the Great Apostasy. Full Article
radical The Radical Reformation - Part 2a By www.ancientfaith.com Published On :: 2016-02-18T03:01:25+00:00 Fr. Andrew examines the theological developments of the Radical Reformers, and introduces some of the Anabaptist denominations which developed. Brethren Mennonite Amish Hutterite Moravian Full Article
radical The Radical Reformation - Part 2b By www.ancientfaith.com Published On :: 2016-02-18T03:01:45+00:00 Fr. Andrew completes our survey of the Radical Reformation with a discussion of the denominations that arose, such as: Puritans Quakers Shakers Baptist Full Article
radical Radical Repentance By www.ancientfaith.com Published On :: 2015-10-13T03:26:47+00:00 Fr. Christopher takes a lesson from the life of St. Mary of Egypt on what it means to repent. Full Article
radical Radical Communion By www.ancientfaith.com Published On :: 2015-05-31T13:22:07+00:00 Full Article
radical Radical Communion By www.ancientfaith.com Published On :: 2016-06-19T12:37:41+00:00 Full Article
radical Council faces 'radical action' to save £28m in budget By www.bbc.com Published On :: Wed, 13 Nov 2024 06:18:24 GMT Cash-strapped Slough Borough Council says it is facing an "unprecedented magnitude" of cuts. Full Article
radical Gauche radicale : demandez le pogrom ! By www.lepoint.fr Published On :: Wed, 13 Nov 2024 07:00:00 +0100 CHRONIQUE. Les accusations de << genocide >> contre Israel se multiplient, revelant la derive antisioniste d'une partie de la gauche radicale. Full Article
radical Determinants of Radical and Incremental Innovation: The Roles of Human Resource Management Practices, Knowledge Sharing, and Market Turbulence By Published On :: 2023-05-06 Aim/Purpose: Given the increasingly important role of knowledge and human resources for firms in developing and emerging countries to pursue innovation, this paper aims to study and explore the potential intermediating roles of knowledge donation and collection in linking high-involvement human resource management (HRM) practice and innovation capability. The paper also explores possible moderators of market turbulence in fostering the influences of knowledge-sharing (KS) behaviors on innovation competence in terms of incremental and radical innovation. Background: The fitness of HRM practice is critical for organizations to foster knowledge capital and internal resources for improving innovation and sustaining competitive advantage. Methodology: The study sample is 309 respondents and Structural Equation Model (SEM) was used for the analysis of the data obtained through a questionnaire survey with the aid of AMOS version 22. Contribution: This paper increases the understanding of the precursor role of high-involvement HRM practices, intermediating mechanism of KS activities, and the regulating influence of market turbulence in predicting and fostering innovation capability, thereby pushing forward the theory of HRM and innovation management. Findings: The empirical findings support the proposed hypotheses relating to the intermediating role of KS in the HRM practices-innovation relationship. It spotlights the crucial character of market turbulence in driving the domination of knowledge-sharing behaviors on incremental innovation. Recommendations for Practitioners: The proposed research model can be applied by leaders and directors to foster their organizational innovation competence. Recommendation for Researchers: Researchers are recommended to explore the influence of different models of HRM practices on innovation to identify the most effective pathway leading to innovation for firms in developing and emerging nations. Impact on Society: This paper provides valuable initiatives for firms in developing and emerging markets on how to leverage the strategic and internal resources of an organization for enhancing innovation. Future Research: Future studies should investigate the influence of HRM practices and knowledge resources to promote frugal innovation models for dealing with resource scarcity. Full Article
radical A ‘radically realistic’ vision for adult social care By ifp.nyu.edu Published On :: Fri, 01 Nov 2024 08:36:23 +0000 The post A ‘radically realistic’ vision for adult social care was curated by information for practice. Full Article Grey Literature
radical Doing Radical Things Right: Ethical Good Practice for Basic Income Experiments By ifp.nyu.edu Published On :: Fri, 01 Nov 2024 13:02:34 +0000 The post Doing Radical Things Right: Ethical Good Practice for Basic Income Experiments was curated by information for practice. Full Article Grey Literature
radical Elderly Supreme Court judges are again resolving our most contentious social debates. Here’s a radically democratic alternative. By www.vox.com Published On :: Tue, 05 Jun 2018 12:55 -0500 Prof. Eric Posner explains a voting system for protecting the rights of minorities Full Article
radical Radical Fulani herdsmen slaughter Christians in Nigeria, clergy kidnapped By www.christianpost.com Published On :: Thu, 07 Nov 2024 15:41:07 -0500 Fulani herdsmen killed six Christians on Friday and Saturday in Benue state, Nigeria, after slaughtering 15 Christians in a nearby village two days earlier, sources said. Full Article
radical Cybersecurity Awareness Month needs a radical overhaul – it needs legislation By www.welivesecurity.com Published On :: Tue, 01 Oct 2024 09:00:00 +0000 Despite their benefits, awareness campaigns alone are not enough to encourage widespread adoption of cybersecurity best practices Full Article
radical Vasquez de Lara Law Group Breaks Down Governor Desantis' 5 Radical Changes to Florida Family Law By www.24-7pressrelease.com Published On :: Mon, 06 Nov 2023 08:00:00 GMT As Florida Governor Ron DeSantis puts his signature on several bills, the state's family law landscape is set to undergo a dramatic transformation. Vasquez de Lara Law Group, a leading Miami-based family law firm, details the implementation. Full Article
radical Sorting Through the Noise of Fitness Industry Information: Embracing the Power of Back-to-Basics and Radical Consistency By www.24-7pressrelease.com Published On :: Fri, 16 Feb 2024 08:00:00 GMT Renowned Athlete and Bestselling Author Juliet Starrett Declares War on Health Industry Noise, Paving the Way for Lasting Well-being Full Article
radical Radical Expansion of New Jersey WARN Act Nears By www.littler.com Published On :: Mon, 17 May 2021 20:36:08 +0000 Updated June 8, 2021 Full Article
radical NYC Pet Leave Bill Marks 'Radical Departure' In Sick Time Use By www.littler.com Published On :: Tue, 05 Nov 2024 21:57:28 +0000 Kelly M. Cardin provides insight about why New York City is expanding its sick leave law to let workers use it to care for pets and service animals. Law360 View (Subscription required) Full Article
radical Defiance, Defused: A Roadmap to Radical Behavior Change By www.additudemag.com Published On :: Fri, 01 Nov 2024 09:23:32 +0000 Hard-to-meet goals can frustrate children with ADHD. Deploy these approaches to prevent meltdowns and transform relationships. Full Article ADHD Parenting Behavior & Discipline Oppositional Behavior Parenting the Difficult Child treating kids Winter 2024 Issue of ADDitude Magazine
radical Radically Reimagining Our Future Through Climate Fiction By www.yesmagazine.org Published On :: Mon, 01 Apr 2024 13:00:00 +0000 When it comes to telling the story of climate change, we need both journalism and fiction to imagine a better world. Full Article Environment Climate climate solutions Climate Fiction cli fi
radical Mothering As a Radical Climate Solution By www.yesmagazine.org Published On :: Thu, 09 May 2024 21:12:08 +0000 Emily Raboteau’s latest book is a meditation on how we can more clearly see and care for all we hold dear. Full Article Women Environment Racial Justice Water Climate Crisis Parenting climate justice Motherhood care Emily Raboteau
radical OSCE Mission, police to discuss how to help prevent violent extremism and radicalization in Kosovo By feeds.osce.org Published On :: Mon, 27 Jun 2016 12:34:40 +0000 PRISHTINË/PRIŠTINA, 27 June 2016 – The OSCE Mission together with the Kosovo Police will hold a two-day conference on preventing violent extremism and radicalization, starting tomorrow in Prishtinë/Priština. The conference will gather representatives of law enforcement agencies, religious communities, civil society, academia and media, and will explore a multi-disciplinary approach to addressing the threats of violent extremism and radicalization in Kosovo. Participants will also elaborate on measures taken so far to prevent violent extremism and radicalization, as well as the challenges they face. Major Fatos Makolli, Director of the Directorate against Terrorism of the Kosovo Police, and Naim Hoxha, Organized Crime Advisor at the OSCE Mission, will deliver opening remarks. Media representatives are invited to attend the opening of the conference on Tuesday, 28 June 2016, at the Hotel Sirius in Prishtinë/Priština, starting at 09:30 hrs. Related StoriesOSCE Mission in Kosovo organizes Junior Basketball TournamentOSCE Mission assesses implementation of new Criminal Procedure Code of KosovoMini-Olympic Games 2016 Full Article OSCE Mission in Kosovo Policing South-Eastern Europe Media advisory
radical OSCE Mission, police to discuss how to help prevent violent extremism and radicalization in Kosovo By feeds.osce.org Published On :: Mon, 27 Jun 2016 12:34:40 +0000 PRISHTINË/PRIŠTINA, 27 June 2016 – The OSCE Mission together with the Kosovo Police will hold a two-day conference on preventing violent extremism and radicalization, starting tomorrow in Prishtinë/Priština. The conference will gather representatives of law enforcement agencies, religious communities, civil society, academia and media, and will explore a multi-disciplinary approach to addressing the threats of violent extremism and radicalization in Kosovo. Participants will also elaborate on measures taken so far to prevent violent extremism and radicalization, as well as the challenges they face. Major Fatos Makolli, Director of the Directorate against Terrorism of the Kosovo Police, and Naim Hoxha, Organized Crime Advisor at the OSCE Mission, will deliver opening remarks. Media representatives are invited to attend the opening of the conference on Tuesday, 28 June 2016, at the Hotel Sirius in Prishtinë/Priština, starting at 09:30 hrs. Related StoriesOSCE Mission in Kosovo organizes Junior Basketball TournamentOSCE Mission assesses implementation of new Criminal Procedure Code of KosovoMini-Olympic Games 2016 Full Article OSCE Mission in Kosovo Policing South-Eastern Europe Media advisory
radical Cybersecurity Awareness Month needs a radical overhaul – it needs legislation By channelbuzz.ca Published On :: Thu, 17 Oct 2024 14:45:21 +0000 In this guest post, ESET's Tony Anscombe suggests that despite their benefits, awareness campaigns alone are not enough to encourage widespread adoption of cybersecurity best practices. Full Article ESET Sponsored Content Sponsored Content
radical Centro político: ¿la alternativa a las posturas radicales? By www.spreaker.com Published On :: Tue, 24 Nov 2020 02:40:00 +0000 Panelistas creen que espectro político tiene matices y que no debería ser blanco o negro. Otros creen que el “centro” puede ser antitécnico. Full Article
radical ¿Qué tan radical es el cambio en la nueva política antidrogas de EE. UU.? By www.spreaker.com Published On :: Wed, 27 Oct 2021 02:14:06 +0000 Panelistas consideran que hay cambios en los enfoques de prevención y desarrollo territorial, así como continuidades al no avanzar hacia una visión de legalización de las drogas. Full Article
radical ¿Qué tan radical es el cambio en la nueva política antidrogas de EE. UU? By www.spreaker.com Published On :: Wed, 27 Oct 2021 02:22:06 +0000 Panelistas consideran que hay cambios en los enfoques de prevención y desarrollo territorial, así como continuidades al no avanzar hacia una visión de legalización de las drogas. Full Article
radical Cecilia López: “El nombramiento de Cristo es reconocer que Petro con su radicalización no pudo” By www.spreaker.com Published On :: Thu, 04 Jul 2024 16:03:00 +0000 La exministra de Agricultura se refirió en 10AM al nombramiento del nuevo jefe de la cartera del Interior, de la Constituyente y de sus reparos al Gobierno del que hizo parte Full Article
radical Radical Futures Performance Piece: Rhodonea By audiocookbook.org Published On :: Thu, 16 May 2024 20:03:21 +0000 On Wednesday, May 8, I debuted a performance piece titled Rhodonea at the Radical Futures conference at University College Cork, Ireland. At the concert I had the privilege of sharing the bill with Brian Bridges, Cárthach Ó Nuanáin, Robin Parmar, … Continue reading → Full Article Audio News Performance Processing Ableton Live Arturia KeyStep Collision Composition Drift Experimental Generative Meld Processing.org Sound Art Sound Design Video
radical “La intervención a EPS Sanitas es un atropello”: director de Cambio Radical By www.spreaker.com Published On :: Wed, 10 Apr 2024 15:41:00 +0000 En 6AM Hoy por Hoy de Caracol Radio estuvo Germán Córdoba, director del partido político Cambio Radical, para hablar sobre la acción del Gobierno de intervenir a la EPS Sánitas. Full Article
radical Turn the Other Cheek: the radical case for nonviolent resistance By www.cbc.ca Published On :: Fri, 14 Oct 2022 15:52:02 EDT The Sermon on the Mount is one of the greatest gifts of scripture to humanity; just ask Mahatma Gandhi, Martin Luther King Jr., and Leo Tolstoy. In a time when an eye for an eye still seems to hold sway, IDEAS producer Sean Foley explores the logic of Christian non-violence, beginning with Jesus' counsel to 'turn the other cheek.' Full Article Radio/Ideas
radical The Alt-Right Pipeline and the Rise of Trump: How Digital Radicalization Found Its Political Voice By feminist.org Published On :: Tue, 12 Nov 2024 18:54:00 +0000 When Trump descended the escalator at Trump Tower in 2015 to announce his presidential campaign, he tapped into something that had been brewing in online spaces for years. What made Trump unique wasn’t just his message, but his ability to speak the language of internet culture – his unfiltered tweets, his willingness to be politically […] The post The Alt-Right Pipeline and the Rise of Trump: How Digital Radicalization Found Its Political Voice appeared first on Feminist Majority Foundation. No related posts. Full Article Politics alt right Gen Z news podcasts
radical Harris is open to ‘reparations.’ It’s ore proof she’s a radical. By quinhillyer.com Published On :: Mon, 21 Oct 2024 00:16:42 +0000 (Oct. 17) When Vice President Kamala Harris repeated on Oct. 15 that she thinks the idea of racial “reparations” should be studied further, she evinced a radicalism she just can’t […] The post Harris is open to ‘reparations.’ It’s ore proof she’s a radical. appeared first on Quin Hillyer. Full Article Miscellaneous National Politics
radical South Africa's radical opposition rocked by high-profile defections By www.bbc.com Published On :: Thu, 07 Nov 2024 20:47:40 GMT What is behind the exodus of Economic Freedom Fighters members to ex-President Jacob Zuma's party? Full Article
radical Islamic radicalisation in Central Asia By www.chathamhouse.org Published On :: Tue, 20 Aug 2024 15:47:13 +0000 Islamic radicalisation in Central Asia 18 September 2024 — 10:00AM TO 11:30AM Anonymous (not verified) 20 August 2024 Chatham House and Online Experts analyse rising foreign recruitment, current counter-radicalisation efforts and challenge past Chatham House predictions made of the Central Asia region. In 2014, Chatham House released a report titled The Myth of Post-Soviet Muslim Radicalisation in the Central Asian Republics. At that time, a significant, Western-funded counter-radicalisation industry was addressing what was believed to be a major issue of Islamic violent extremism in the region.Over the past decade, two key developments have occurred. First, Western interest in the region has declined in favour of traditional geopolitical concerns. Second, while violent extremism incidents within Central Asia remain rare, there has been a notable recruitment of Central Asians by foreign groups, with several attacks carried out by Central Asians overseas.In this event, the original report’s authors, John Heathershaw and David Montgomery, will discuss whether the report’s arguments are still valid and how we might answer these questions today.This raises several questions:What did the report accurately predict, and where did it fall short?How can we explain the lack of violent extremist organisations (VEOs) within Central Asia but the presence of Central Asians in VEOs abroad?Could repression by Central Asian states both domestically and transnationally have contributed to this issue?What, if anything, can the counter-radicalisation industry do today to address this problem more effectively?Please note that in-person places are limited. Please wait for confirmation before participating. Full Article
radical Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes [Microbiology] By www.jbc.org Published On :: 2020-12-04T00:06:05-08:00 Despite its major importance in human health, the metabolic potential of the human gut microbiota is still poorly understood. We have recently shown that biosynthesis of Ruminococcin C (RumC), a novel ribosomally synthesized and posttranslationally modified peptide (RiPP) produced by the commensal bacterium Ruminococcus gnavus, requires two radical SAM enzymes (RumMC1 and RumMC2) catalyzing the formation of four Cα-thioether bridges. These bridges, which are essential for RumC's antibiotic properties against human pathogens such as Clostridium perfringens, define two hairpin domains giving this sactipeptide (sulfur-to-α-carbon thioether–containing peptide) an unusual architecture among natural products. We report here the biochemical and spectroscopic characterizations of RumMC2. EPR spectroscopy and mutagenesis data support that RumMC2 is a member of the large family of SPASM domain radical SAM enzymes characterized by the presence of three [4Fe-4S] clusters. We also demonstrate that this enzyme initiates its reaction by Cα H-atom abstraction and is able to catalyze the formation of nonnatural thioether bonds in engineered peptide substrates. Unexpectedly, our data support the formation of a ketoimine rather than an α,β-dehydro-amino acid intermediate during Cα-thioether bridge LC–MS/MS fragmentation. Finally, we explored the roles of the leader peptide and of the RiPP precursor peptide recognition element, present in myriad RiPP-modifying enzymes. Collectively, our data support a more complex role for the peptide recognition element and the core peptide for the installation of posttranslational modifications in RiPPs than previously anticipated and suggest a possible reaction intermediate for thioether bond formation. Full Article
radical Radical Change? New Political Paradigms in Brazil and Mexico By f1.media.brightcove.com Published On :: Tue, 12 Feb 2019 00:00:00 +0000 Full Article
radical Design in an Age of Crisis: The Search for Radical Solutions By brightcove.hs.llnwd.net Published On :: Fri, 14 Aug 2020 00:00:00 +0100 Full Article