Title: Deepwater Horizon Oil Spill Cleanup Put Workers at Risk for Asthma
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/22/2022 12:00:00 AM

Title: Lamisil (terbinafine) vs. Lotrimin (clotrimazole)
Category: Medications
Created: 6/10/2019 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM

Title: Zoryve
Category: Medications
Created: 8/10/2022 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM

Title: FDA Warns Amazon, Other Vendors About Sale of Skin Tag Removal Products
Category: Health News
Created: 8/10/2022 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM

Title: Ketoconazole cream vs. clotrimazole cream
Category: Medications
Created: 5/29/2019 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

Title: Metronidazole (Flagyl) vs. Fluconazole (Diflucan)
Category: Medications
Created: 11/27/2018 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM

Title: oteseconazole
Category: Medications
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Title: Ondansetron (Zofran) vs. Dramamine
Category: Medications
Created: 7/24/2019 12:00:00 AM
Last Editorial Review: 8/2/2022 12:00:00 AM

Title: Cyclobenzaprine vs. Xanax (alprazolam)
Category: Medications
Created: 6/6/2019 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

Metastatic porocarcinomas (PCs) are vanishingly rare, highly aggressive skin adnexal tumors with mortality rates exceeding 70%. Their rarity has precluded the understanding of their disease pathogenesis, let alone the conduct of clinical trials to evaluate treatment strategies. There are no effective agents for unresectable PCs. Here, we successfully demonstrate how functional precision medicine was implemented in the clinic for a metastatic PC with no known systemic treatment options. Comprehensive genomic profiling of the tumor specimen did not yield any actionable genomic aberrations. However, ex vivo drug testing predicted pazopanib efficacy, and indeed, administration of pazopanib elicited remarkable clinicoradiological response. Pazopanib and its class of drugs should be evaluated for efficacy in other cases of PC, and the rationale for efficacy should be determined when PC tumor models become available. A functional precision medicine approach could be useful to derive effective treatment options for rare cancers.

BackgroundIncident benzodiazepine prescriptions in primary care for anxiety decreased between 2003 and 2018. However, from 2008, incident prescribing of benzodiazepines for anxiety increased among those aged 18–34 years. There are increasing concerns around prescribing of benzodiazepines. Further, although guidelines state benzodiazepines should only be prescribed short term, in 2017, 44% of incident prescriptions were prescribed for longer than the recommended duration of 2–4 weeks.AimTo understand when and why GPs prescribe benzodiazepines for anxiety in young adults.Design and settingA qualitative study was undertaken using in-depth interviews with 17 GPs from 10 general practices in South West England.MethodInterviews were conducted by telephone or videocall. A topic guide was used to ensure consistency across interviews. Interviews were audio-recorded, transcribed verbatim, and data analysed using reflexive thematic analysis.ResultsGPs described caution in prescribing benzodiazepines for anxiety in young adults, but thought they had an important role in acute situations. GPs described caution in prescribing duration, but some thought longer-term prescriptions could be appropriate. In light of these views, some GPs questioned whether primary care needs to revisit how clinicians are using benzodiazepines. GPs perceived that some young adults requested benzodiazepines and suggested this might be because they wanted quick symptom relief. GPs noted that refusing to prescribe felt uncomfortable and that the number of young adults presenting to general practice, already dependent on benzodiazepines, had increased.ConclusionPatient-driven factors for prescribing benzodiazepines suggest there are current unmet treatment needs among young adults with anxiety. Given increases in prescribing in this age group, it may be timely to revisit the role of benzodiazepines in the management of people with anxiety in primary care.

A nudibranch from the midnight zone has fingers on its tail, collects food with a hood, and glows.

Kelley hoards all the PS5s. Chris needs a build for the I'm Bad playstyle. And Josh gets treatment for his cat's demon tapeworm.

The post RPG Cast – Episode 645: “Rob Zombie’s Drag-Gula Lost” appeared first on RPGamer.

Matt makes twenty slices of toast. Josh is still fighting sewer rat six. Kelley's dog is NOT a baby. And Chris saves E3 with the power of...no...he can't do it. No GEX allowed.

The post RPG Cast – Episode 684: “Remember What I Said at the Fazoli’s Drive Thru?” appeared first on RPGamer.

A TV series based on the video game series Mass Effect is officially in development at Amazon, according to a report from Variety.

F9: The Fast Saga writer Daniel Casey will write and be an executive producer on the series. Karim Zreik will also be an executive producer under his Cedar Tree Productions, which is under an overall deal at Amazon.

Ari Arad and BioWare's Michael Gamble will also be executive producers. Arad previously was a producer on other video game adaptations - Borderlands and Uncharted.

Developer BioWare is developing a new entry in the Mass Effect series. 

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463013/mass-effect-tv-series-has-been-greenlit-by-amazon/

Hori's latest addition to its controller lineup, the "Horipad Wireless for Steam," is now available for preorder on Amazon. After already releasing in Japan at the end of October, now the gamepad is coming to the US.

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Life simulation game Inzoi will launch on PC via Steam early access on 28th March 2025, publishers Krafton have announced. Billed as a potential Sims 4 usurper, and equipped with syrupy Unreal Engine 5 visuals, it was originally slated for launch this year.

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A distant planet should have been consumed when its star expanded to become a red giant, perhaps offering insights into planetary migration

Don’t worry, you’ll still be able to watch Jury Duty for freevee.

Black Ops 6 is here, and it's Black Ops 2's anniversary, so what better time than to rank the Call of Duty Black Ops titles? Here's our ranking of every mainline version.

A judge recused himself Tuesday from presiding over Arizona's fake electors case after an email surfaced in which he told fellow judges to speak out against attacks on Democratic Vice President Kamala Harris' campaign for the presidency.

Amazon's Black Friday sales event starts Friday, Nov. 22. Kurt the CyberGuy offers some tips on how to get the best deals on merchandise.

The Italian is reportedly set to leave Stamford Bridge at the end of his contract..

Imagine a world without Facebook. For just half an hour. A group of AI leaders get together but don’t seem to invite Elon Musk. Amazon takes data centres nuclear. A new competitor for ChatGPT and Google. And public trust in AI is declining.  All this and more on the “just breath, Facebook will be back” […]

More blazes break out where wild land and urban areas overlap.

“I used to be proud of my work and excited about my future here. I don't feel that anymore."

The pathogen takes over the brains of its hosts and controls them for its own sinister ends

Shop these deep discounts of up to 50% off of loads of styles of Rebecca Minkoff handbags at Amazon's Big Summer Sale.

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

Shop discounts of up to 60% off of stylish Kate Spade handbags, jewelry, watches and accessories from Amazon's Big Summer Sale.

[[ This is a content summary only. Visit my website for full links, other content, and more! ]]

The business secretary Jonathan Reynolds has called for a change of culture at the Post Office, as he gave evidence to the inquiry into the Horizon scandal.

A federal administrative law judge says Amazon interfered in the last election on unionization at its warehouse in Bessemer, Ala.

The pedigree of the producers and writers involved is cause for concern, though.

Here is a complete list of highlights on Prime Video this week

‘Horizon Zero Dawn Remastered’ elevates a classic with breathtaking visuals, smooth performance, and a gripping narrative on PS5 and PC

The ‘Umrao Jaan’ director speaks about reviving his passion project ‘Zooni,’ which was shelved in 1989 due to the insurgency in Kashmir, and his artwork of the Kashmiri muse that evolved out of the sketches he made for the Dimple Kapadia-starrer

During Gamescom Opening Night Live 2024, HoYoverse had reveals and new information for each of its main games. Genshin Impact …

Continue reading "Gamescom 2024: Zenless Zone Zero, Honkai Star Rail, and Genshin Impact See New Announcements and Trailers"

Amazon is reportedly developing smart glasses for its delivery drivers, according to sources who spoke to Reuters. These glasses are intended to cut “seconds” from each delivery because, well, productivity or whatever. Sources say that they are an extension of the pre-existing Echo Frames smart glasses and are known by the internal code Amelia.

These seconds will be shaved off in a couple of ways. First of all, the glasses reportedly include an embedded display to guide delivery drivers around and within buildings. They will allegedly also provide drivers with “turn-by-turn navigation” instructions while driving. Finally, wearing AR glasses means that drivers won’t have to carry a handheld GPS device. You know what that means. They’ll be able to carry more packages at once. It’s a real mitzvah.

I’m being snarky, and for good reason, but there could be some actual benefit here. I’ve been a delivery driver before and often the biggest time-sink is wandering around labyrinthine building complexes like a lost puppy. I wouldn’t have minded a device that told me where the elevator was. However, I would not have liked being forced to wear cumbersome AR glasses to make that happen.

To that end, the sources tell Reuters that this project is not an absolute certainty. The glasses could be shelved if they don’t live up to the initial promise or if they’re too expensive to manufacture. Even if things go smoothly, it’ll likely be years before Amazon drivers are mandated to wear the glasses. The company is reportedly having trouble integrating a battery that can last a full eight-hour shift and settling on a design that doesn’t cause fatigue during use. There’s also the matter of collecting all of that building and neighborhood data, which is no small feat.

Amazon told Reuters that it is “continuously innovating to create an even safer and better delivery experience for drivers” but refused to comment on the existence of these AR glasses. "We otherwise don’t comment on our product roadmap,” a spokesperson said.

The Echo Frames have turned out to be a pretty big misfire for Amazon. The same report indicates that the company has sold only 10,000 units since the third-gen glasses came out last year.

Black Friday may technically just be one day, but it’s evolved to consume the entire month of November in the US at this point. For the past few years, retailers like Amazon, Walmart and Target have ushered in the holiday shopping season earlier and earlier, and this year is no different.

Early Black Friday deals are already here, bringing discounts to some of our favorite tech we’ve tested this year. While it’s still advisable to wait until the week before Thanksgiving to ensure you’re getting the best of the best deals, you have plenty of opportunities to save right now if you’re eager to get a jump on your gift list this year. These are the best early Black Friday deals we could find; we’ll be updating this post regularly throughout November, so check back for the latest discounts.

Engadget's top picks

• Apple AirTags (four-pack) for $70 ($30 off)

• Apple MagSafe charger pad for $25 ($14 off)

• Apple iPad (9th gen) for $200 ($129 off)

• Dyson V11 cordless vacuum cleaner for $400 ($170 off)

• Anker MagGo 3-in-1 foldable charging station for $82.50 (25 percent off with coupon)

• Fitbit Charge 6 fitness tracker for $100 ($60 off)

• Xbox Series X (1TB) with extra controller for $490 ($110 off)

• Headspace annual plan for $35 ($35 off)

The best early Black Friday deals

Apple Black Friday deals

• Apple AirTags (four-pack) for $70 ($30 off): These are the Bluetooth trackers to get if you have an iPhone, and they allow you to keep track of your keys, wallet and other belongings from within the Find My app. Just make sure to pick up an AirTag holder or case if you plan on using them with your keys.

• Apple MagSafe charger pad for $25 ($14 off): Apple's newest MagSafe charger provides up to 25W of fast-charging power to iPhone 16 handsets when paired with a 30W or 35W adapter. It works with older iPhones too, of course, and will provide that satisfying magnetic snap with the latest Apple smartphones (and AirPods, too).

• Apple iPad (9th gen) for $200 ($129 off): Apple discontinued this model with the release of the new iPad Pro and Air models earlier this year. In what's likely an effort to get rid of current stock, the price is down to a new record low of $200. The 9th generation iPad is the former budget pick in our guide to the best Apple tablets and will serve well as a casual browsing, streaming and game playing machine. 

• Apple MacBook Air (M3, 13-inch) fore $899 ($200 off): The latest MacBook Air is our top pick for the best laptop for most people, and this model has 16GB of RAM built in — double the previous base amount.

• Apple 2024 M4 iMac desktop computer for $1,204 ($95 off): Apple just released the refreshed iMac last month, and now the silver model is $85 off and down to $1,214 at Amazon. It has the latest Apple silicon, the M4 system on a chip that gives it a speed boost and enables the new Apple Intelligence features in macOS Sequoia. 

Anker Black Friday deals

• Anker MagGo 3-in-1 foldable charging station for $82.50 (25 percent off with coupon): This Qi2 charging station supports up to 15W of power output and can charge an iPhone, Apple Watch and a pair of AirPods all at once. It also comes with a 40W USB-C charger and connecting cable, so you get everything you need to use it in the box.

• Anker 10K MagGo power bank for $70 ($20 off, Prime exclusive): This is one of our top picks for the best power banks you can buy today thanks to its versatile capacity, speedy Qi2 charging capabilities, clear screen that shows remaining battery power and its built-in kickstand.

• Anker 3-in-1 10K portable charger for $36 ($9 off, Prime exclusive): A top pick in our best power banks guide, this 10K brick has a built-in USB-C cable so you don't need to remember to bring one with you, plus it has an extra USB-C port for charging other devices.

• Anker Prime Power Bank 200W with charging base for $110 ($75 off): This high-capacity power bank is one of our favorites thanks to its speedy charging performance, onboard display which shows how much juice is flowing to each connected device and the included charging station that provides a neat space for the brick to live when you're not using it.

• Anker Soundcore Space A40 for $44.25 ($35.75 off): The Space A40 is the longtime top pick in our guide to the best budget earbuds, as it delivers the kind of robust feature set we expect from pairs that cost three times as much. Call quality isn't the best, and it won't auto-pause when you take out an earbud, but its warm sound, powerful ANC, eight-ish hours of battery life and comfy design all impress for the money. This deal ties the lowest price we've seen — it's only available to Prime subscribers at Amazon, but you can also grab it at Anker's online store with an on-page coupon.

• Anker Soundcore Motion+ for $75 at Amazon ($25 off with coupon): We recommend the Soundcore Motion+ in our guide to the best portable Bluetooth speakers. While it isn't especially light or compact, it pumps out a more spacious sound than most speakers in its price range, it's waterproof and it lasts a decent 12 to 15 hours per charge. We've seen this discount a few times before, but it comes within a few bucks of the lowest price we've tracked. Also at Anker's online store with an on-page coupon.

Google Black Friday deals

• Fitbit Charge 6 fitness tracker for $100 ($60 off): Our top pick for the best fitness tracker, the Charge 6 has a comfortable design, built-in GPS and heart rate monitors and 20 exercise modes ready to be tracked.

• Google Pixel Watch 3 for $280 ($70 off): Google's latest smartwatch is down to an all time low price. This is the model we recommend for anyone with an Android phone in our guide to the best smartwatches and it earned an 84 in our review. It detects workouts quickly, has an extra long battery life and is one of the more attractive smartwatches on the market. The deal applies to the 41mm size with GPS only but the larger and cellular-enabled models are on sale too. Also at Best Buy and Target.

• Google Pixel 8a for $399 ($100 off): This is the best midrange smartphone on the market right now thanks to its solid performance, 120Hz OLED touchscreen and excellent camera array. The standard Pixel 8 is also on sale for $449.

• Google Nest Indoor security camera (wired) for $70 ($30 off): Google's security camera can tell the difference between people, animals and vehicles while it's monitoring your home, and it supports 1080p video, night vision and two-way audio.

• Google Nest Wi-Fi Pro 6E (three-pack) for $279 ($120 off): We consider the Nest Wi-Fi Pro mesh system to be one of the easiest for folks who have never installed their own router, and the three-pack provides coverage for up to 6,600 square feet. Also available at Google.

Black Friday subscription deals

• Audible Premium Plus (3-month) for $1 ($29 off): Those who don't currently subscribe to Audible can get three months of the audiobook service's Premium Plus plan for $1. Normally, the service costs $15 per month after a 30-day free trial. As a refresher, Premium Plus is Audible's upper tier: In addition to giving access the full Audible Plus library, it lets you keep one title from a curated selection of audiobooks each month. We wouldn't call it essential, but if you've been on the fence, this is a good way to see if it'd work for you. Just note that the plan will auto-renew until you cancel.

• Headspace annual plan for $35 ($35 off): Our top pick for the best meditation app has tons of courses that address specific anxieties and worries, a good in-app search engine that makes it easy to find the right meditation you need and additional yoga routines, podcasts and music sessions to try out.

• ExpressVPN two-year plan plus six extra months for $150 (82 percent off): Our top pick for best VPN for travelers provides access to tons of servers and had some of the fastest connections of any VPN service we tested. In addition to a VPN, this subscription tier gives you access to an ad blocker and password manager.

Black Friday tech deals

• LG 65-inch B3 OLED smart TV for $998 ($301 off): This OLED TV has a 120Hz refresh rate, LG's a7 AI processor Gen 6, and support for NVIDIA G-Sync, AMD FreeSync Premium and VRR for an even better gaming experience.

• Xbox Series X (1TB) with extra controller for $490 ($110 off): This bundle includes a total of two Xbox wireless controllers with the Series X console, and the built-in 1TB SSD is a good starting point for most gamers.

• Blink Outdoor 4 (6-pack) for $180 ($300 off): The Outdoor 4 is a wireless, IP65-rated outdoor security camera we highlight in our guide to the best smart home gadgets. It captures decent (if not class-leading) 1080p video, it's relatively painless to install and it supports features like night vision, motion alerts, local storage and two-way talking. The catch is that it locks things like person detection and cloud storage behind a subscription plan. Still, it's a solid value on balance, and this deal furthers that. We've seen this price on a six-camera bundle for a few weeks, but it's still an all-time low. An eight-camera pack is also on sale for $250, another low.

• Amazon Fire HD 10 for $75 ($65 off): No Fire HD tablet comes close to matching the performance, build quality and app support of an iPad, but they're significantly more affordable, and they still work well enough if all you need is something for casual streaming, e-reading and web browsing. At this price, the 10.1-inch Fire HD 10 is likely a better value than the smaller Fire HD 8, as it has a sharper display, it's a tick faster and it can last slightly longer on a charge. Just be ready to deal with a bunch of ads for Amazon's own apps and services. This discount ties an all-time low, and it's also available at Best Buy and Target.

• Samsung Music Frame for $248 ($150 off): This unique smart speaker can show art or your own photos while it plays music, and it can sync with your Samsung TV speakers. Also available at Full Article