The invention relates to a process for preparing 1-aryl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.

The present invention relates to a compound of formula (I) including any stereochemically isomeric form thereof, wherein the substituents are as defined in the specification and the claims; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof; provided that the compound is other than or a pharmaceutically acceptable salt thereof. The claimed compounds are useful for the treatment of a disease, the treatment of which is affected, mediated or facilitated by activating the GHS1A-r receptor. The invention also relates to pharmaceutical compositions thereof and processes for the preparation thereof.

A storage stable capsule suspension formulation comprising clomazone encapsulated within a polymeric shell wall of microcapsules, a process for the preparation thereof and method of controlling weeds utilizing said formulation.

Benzoyl derivatives of the formula I where the variables have the following meanings: R1, R2 are hydrogen, nitro, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl or C1-C6-haloalkylsulfonyl;R3 is hydrogen, halogen or alkyl;R4, R5 are hydrogen, halogen, cyano, nitro, alkyl, alkoxy, alkylthio, dialkylamino, phenyl or carbonyl, it being possible for the 6 last-mentioned radicals to be substituted;X is O, S, NR9, CO or CR10R11;Y is O, S, NR12, CO or CR13R14;R15 is pyrazole which is unsubstituted or substituted, linked in the 4-position and has attached to it in the 5-position a hydroxyl or sulfonyloxy radical; and the agriculturally useful salts thereof; processes and intermediates for the preparation of the 3-heterocyclyl-substituted benzoyl derivatives; compositions comprising them; and the use of these derivatives or compositions comprising them for controlling undesirable plants.

A wireless access system and, more particularly, a method and apparatus for more efficiently performing zone switch are disclosed. The method of performing zone switch by an advanced mobile station (AMS) in a mixed-mode advanced base station (ABS) which operates in a mixed mode of a broadband wireless access system includes receiving a ranging response (RNG-RSP) message including system information of an AMS support zone from a legacy zone (LZone) of the ABS, and performing ranging to the AMS support zone using the system information.

A description is given of N-(1,2,5-oxadiazol-3-yl)pyridinecarboxamides of the general formula (I) as herbicides. R in this formula (I) stands for radicals such as hydrogen, organic radicals, and other radicals such as halogen. W stands for a substituted pyridyl radical.

The present invention is directed to a compound of Formula (I) and to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

There are provided compounds of formula (I), wherein R1, R6, R8, Q2, Q3, Q3a, Q4, L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation and/or cancer.

This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.

A platinum complex of a formula (I): whereR1 and R2 are each fluoroalkyl,X is C—H or nitrogen, andL1 is a bidentate, nitrogen-containing heteroaromatic ligand.

The present invention relates to novel bicyclic thiazoles which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”) and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.

A horizontal machining center includes: a table driven in first and second directions (directions indicated by arrows 530p and 530q, respectively) allowing the table to approach and move away from a spindle, respectively; a magazine having a plurality of tool gripping claws; and a coupling mechanism for coupling the table and the magazine together and moving the magazine in one of the first and second directions when the table is driven in the other of the first and second directions. When a tool attached to the spindle is removed from the spindle, the table is driven in the first direction, and when a tool accommodated by the magazine is attached to the spindle, the table is driven in the second direction. A horizontal machining center having a simple structure and prevented from having a bulky structure can thus be accomplished.

Ozone generator cells that include two thermally conductive plates that maintain contact between various layers of the cells in the absence of a bonding agent. The cells lack aluminum-containing materials in the discharge region of the cell.

An accommodating intraocular lens (AIOL) includes an optic adapted to produce a trapezoidal phase shift and a plurality of haptics. Each haptic extends from a haptic-optic junction to at least one transverse arm contacting a capsular bag of the eye, and each haptic has sufficient length and rigidity to stretch a capsular bag of the eye to contact ciliary muscles of the eye. The haptic-optic junctions vault the optic forward relative to the haptics and compression of the haptics by the ciliary muscles moves the anterior optic forward. A combined accommodative power produced by the motion of the anterior optic and the trapezoidal phase shift is at least 0.5 Diopters.

Black disazo dyes of general formula (V) wherein A is a moiety of formula (VI) or of formula (VII) and B is a moiety of formula (VII) or of formula (IX) and wherein M, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, and R24, are as defined in the specification, are excellent black dyes for dying and printing cellulose containing materials and textile materials and, in particular, for preparation of recording liquids for ink jet printing and for writing utensils.

This invention relates to novel Ln(III) complexes of pybox, and methods of making the same. The present invention also relates to a method of use of pybox as a chelating moiety and sensitizer for Ln(III) ion luminescence. Derivatives of pybox and methods of making the same are also provided.

The invention relates to basic bisazo compounds according to formula (I) wherein all substituents are defined as in Claim 1, their production, their use as dyestuffs as well as material dyed with these dyestuffs.

A coloring matter which exhibits excellent (ozone) gas resistance, high print density, low color rendering properties, low color saturation, and high-quality black hue when is recorded on a paper only for inkjet exclusive use, i.e., an azo compound represented by formula (1), a tautomer of the azo compound, or a salt of the azo compound or the tautomer; and an ink composition containing the coloring matter, particularly a black ink composition for inkjet recording applications.

The new metal azo pigments comprising the adduct of a) at least two metal azo compounds of the formula (I) or their tautomeric forms in which the substituents have the definition indicated in the description,and b) at least one compound of the formula (II) in whichR6 has the definition indicated in the description, are characterized in that in the X-ray diffractogram with a lattice constant of d=10.3 (±0.2) Å the metal azo pigment has a signal S1 with an intensity I1 and in the lattice constant range from d=16.05 Å to d=11.78 Å has no signal S2 whose intensity I2 in relation to the intensity I1 of signal S1, expressed as ratio I2/I1 of the background-corrected intensities, exceeds a value of 0.02,and are outstandingly suitable for producing pigment preparations and especially for producing color filters.

Disclosed is an azo compound represented by the formula (1) below, a salt thereof, or a copper complex salt compound thereof. (In the formula, R1 and R2 independently represent a hydrogen atom, a sulfonic acid group, a lower alkyl group or a lower alkoxyl group; R3-R6 independently represent a hydrogen atom, a lower alkyl group or a lower alkoxyl group; R7 represents a lower alkyl group or a lower alkoxyl group; and n represents 0 or 1.)

This invention relates to bis-azo colorants for use as bluing agents, laundry care compositions comprising bis-azo colorants that may serve as bluing agents, processes for making such bluing agents and laundry care compositions and methods of using the same. The bluing agents are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. These bluing agents are advantageous in providing a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics.

The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.

The present disclosure relates to an azoquinone compound represented by formula (1) below. In formula (1), R1 to R4 are identical or different and each represents a hydrogen atom, a C1 to C6 alkyl group or a C6 to C12 aryl group, and Ar represents a C6 to C12 aryl group.

A hypoxia contrast medium including nitroimidazole-amino acid chelate with a positively charged radioactive nuclide, a preparation method and use thereof. The contrast medium can be used in imaging cerebral thrombosis, tumors or other diseases such as ulceration, thrombosis, and so on.

An OLED device comprises a cathode, an anode, and located therebetween a light-emitting layer containing a host material and a tris-C^N-cyclometallated complex of Ir or Rh wherein at least one of the ligands comprises a substituted quinazoline moiety. The device provides useful emission and stability attributes.

A tool system for moulding an article is provided which comprising a tool (100) having a tool surface (104) for forming an article, the tool surface comprising a plurality of tool zones (106). Heating and cooling means (102a) are independently associated with at least some of said tool zones (106). A control means is adapted to control the heating and cooling means (102a) to individually heat or cool the tool zones (106) having heating and cooling means (102a) associated therewith so as to regulate the heat transfer into and out of the article at each tool zone (106) at any particular time throughout the moulding process.

A piezoelectric element comprises a piezoelectric layer made of a perovskite compound containing sodium, potassium, lithium, niobium and tantalum and bismuth manganate and electrodes for applying a voltage to the piezoelectric layer.

The present invention provides methods for preventing clumping of cells in microfluidic devices by addition of diazolidinyl urea (DU). DU can be added to samples at the time of collection or can be added to samples post-collection. DU can also be pre-added to sample collection devices.

A cushion element for a vehicle seat or headrest comprises a non-woven layer and a fiber composite material. An insert material is arranged between the non-woven layer and the fiber composite material, and has different compression properties than the fiber composite material. The fiber composite material forms together with the insert material and the non-woven layer a one-piece material composite.

Disclosed is a system for managing multiple objects in an object zone. The system comprises multiple machine-readable object identification tags configured to be respectively attached to the multiple objects; a storage unit moving through the object zone to store the selected objects which are respectively attached with the machine-readable object identification tags; at least one machine-readable storage unit identification tag attached to the storage unit; and multiple spaced reading units capable of remotely reading the multiple machine-readable object identification tags and the at least one machine-readable storage unit identification tag, wherein the objects attached with the machine-readable object identification tags within a predefined spatial range defined based on the at least one machine-readable storage unit identification tag are associated with the storage unit. A method thereof and a storage unit are also disclosed.

In one embodiment, a catalyst for ozone oxidation of pollutant components dispersed in a gas is provided. The ozone oxidation catalyst has a porous body formed from a metal body, a ceramic, or polymeric fibers coated with metal. A catalytic noble metal composition is deposited on the surface of the porous body. The catalytic noble metal composition is formed from particles of a noble metal supported by a mesoporous molecular sieve.

A cooling assembly for a machine tool including at least first and second nozzle rings mounted on the spindle housing, respectively defining first and second coolant conduits and respectively including first and second pluralities of nozzles in fluid communication with the respective conduit. Each first nozzle is oriented with an outlet thereof directed toward a first machining zone containing cutting edges of at last one tool having a first length. Each second nozzle is oriented with an outlet thereof directed toward a second machining zone different from the first machining zone and containing the cutting edges of at least one tool having a second length.

A control apparatus C of a horizontal axis wind turbine apparatus WTG calculates the value en of a pitch angle command for each blade based on the rate of change ΨD of the azimuth angle Ψ of a Nacelle N and the rotor azimuth angle of the blades B1, B2 and B3, causes the rotor R to generated torque around the yaw axis by periodically controlling the angle change of the pitch angle of the blades B1, B2 and B3, and using that torque, controls the rate of change of the azimuth angle of the nacelle N. The value of that angle change is calculated as a value that increases as the inputted value of the rate of the change ΨD increases.

An apparatus comprises a plasma flood gun for neutralizing a positive charge buildup on a semiconductor wafer during a process of ion implantation using an ion beam. The plasma flood gun comprises more than two arc chambers, wherein each arc chamber is configured to generate and release electrons into the ion beam in a respective zone adjacent to the semiconductor wafer.

A thermally zoned substrate holder including a substantially cylindrical base having top and bottom surfaces configured to support a substrate. A plurality of temperature control elements are disposed within the base. An insulator thermally separates the temperature control elements. The insulator is made from an insulting material having a lower coefficient of thermal conductivity than the base (e.g., a gas- or vacuum-filled chamber).

A system for diverting fluids from a wellhead in a subsea environment has a capping stack with a connector suitable for connection or interconnection to the wellhead, a flow base fixedly positioned in the subsea environment, and a conduit connected to the outlet of a diverter line of the capping stack and connected to the inlet of an interior passageway of the flow base. The conduit is suitable for passing fluids from the capping stack toward the flow base. The flow base is a modified horizontal Christmas tree. The interior passageway within the horizontal Christmas tree has a plug therein located a level below the level of the inlet to the flow base. The flow base can be attached to a wellhead or to an anchor pile in the subsea environment.

The invention describes a method for treating near-wellbore zones involving the steps of injecting a magnesium metal with a catalyst into the desired area of the formation to be treated. Subsequently, combustive-oxidizing solution (COS) is injected into the zone of the formation to be treated. The COS initially reacts with the magnesium, which in turn initiates a vigorous oxidation reaction of the COS. The reaction gases and heat produced by the COS oxidation reaction are harnessed to enhance the productivity of the well by creating fractures in the treatment zone and by melting of paraffin and resin deposits in the treatment zone. As a final step, acid is injected into the formation to react with the formation thereby further enhancing the porosity of the fractures. In one embodiment, the COS uses ammonium nitrate as the oxidizer, and in another, urea or ethylene glycol may be added as a reaction fuel.

A power winch horizontal-pull clutch device provides dynamic forces from a power source and uses a deceleration device to retard the force transmission to a cable pulley for releasing and rewinding a steel cable on the cable pulley. A connecting slot is formed on a casing of the deceleration device. The deceleration device includes an outer ring body and at least one insert slot formed on an external surface. The power winch includes a clutch device for selectively fixing the connecting slot to the insert slot to transmit the dynamic force from the deceleration device to the cable pulley. The clutch device is a sealed assembly and a control handle is provided for making a horizontal movement to achieve the clutching effect and prevent water, dust or other foreign matters from entering into the clutch device, damaging components, causing failure or malfunction, or clamping an operator's hand or foreign matters.

A carbazole derivative represented by the general formula (1) is provided. In the formula, Ar1 represents a substituted or unsubstituted aryl group having 6 to 10 carbon atoms which form a ring; α and β independently represent a substituted or unsubstituted arylene group having 6 to 12 carbon atoms which form a ring; R1 represents an alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted aryl group having 6 to 10 carbon atoms which form a ring; and R11 to R17 and R21 to R28 independently represent hydrogen, an alkyl group having 1 to 4 carbon atoms, or a substituted or unsubstituted aryl group having 6 to 10 carbon atoms which form a ring.

A piezoelectric driving device includes: a substrate including a fixed portion, and a vibrating body portion which is provided with a piezoelectric element and is supported by the fixed portion; and a contact portion which comes into contact with a driven body, and transmits movement of the vibrating body portion to the driven body, the contact portion is provided at an end portion in the longitudinal direction of the vibrating body portion, and a difference between a distance between the end portion when the contact portion is not pressed against the driven body and a tip end of the contact portion, and a distance between the end portion when the contact portion is pressed against the driven body and the tip end, is smaller than a total amplitude in the longitudinal direction in a case where the vibrating body portion is driven.

A razor cartridge has a housing, a guard located at a front of the housing and a cap located at a rear of the housing. A skin contact element is disposed in the housing partway between the guard and the cap. A skin contact plane defines a plane tangential to the guard and the skin contact element and a plane tangential to the skin contact element and the cap. One or more blades are located between the guard and the skin contact element, each of the blades having a cutting edge located at a distance y1 between 70 μm and 300 μm and at an angle α1 between 20° and 45° below the skin contact plane. One or more blades are located between the skin contact element and the cap, each of the blades having a cutting edge located at an angle α2 above or below the skin contact plane, wherein α2 is lower in magnitude than α1.

A razor cartridge includes razor blade assemblies having an inter-blade guard attached to a side of a razor blade. The razor blade is formed from strip that is manufactured including a thermal oxidation process to form a chromium oxide layer on the side surface of the razor blade. This oxide film prevents electrochemical corrosion of the razor blade that may be visible to a user and prevents real or perceived premature failure of the razor blade and thus the razor cartridge during its extended life. The razor blade assembly may also have an array of closely spaced droplets of a liquid adapted to inhibit corrosion of the razor blade applied to the side of the razor blade visible to a user.

A razor comprises a first component comprising a first indicia on a surface of the first component. The razor also comprises a second component configured to rotate relative to the first component about a first axis of rotation, the second component comprising at least one blade and a second indicia on a surface of the second component, the second component configured to rotate relative to the first component about a second axis of rotation, wherein the second axis of rotation and the first axis of rotation are non-coplanar. The second component is in a preloaded neutral position when at rest such that rotation about the second axis of rotation generates a return torque and wherein the first indicia and the second indicia are in alignment at rest and out of alignment when the second component has been rotated about the first axis of rotation.

A control system for an HVAC system serving at least two zones, each zone receiving conditioned air by way of a zone duct, each zone duct including a zone damper having a first portion responsive to the static pressure in a HVAC system to open and bleed an amount of conditioned air past the damper when the static pressure of the system increases above a selected level, a second portion controlled by a actuator to move between an open and a closed position in response to a zone thermostat, and a coupling mechanism coupling the first and second portions to limit the relative movements of the two portions with respect to each other, and a biasing mechanism exerting a torque against the system static pressure differential. The first portion can be a single one-piece undivided blade pivotally mounted with a shell surrounding the zone damper.

A concrete saw is disclosed having a rigid metal frame, a hydraulic drive system, a water-cooled hub, and an axially rotatable trigger assembly comprising a 12 volt switch. The saw may include a hydraulic pump operable to supply pressurized hydraulic fluid to the drive system. In some embodiments, the saw may includes a flow sharing valve fluidly coupled to the hydraulic drive system to distribute the pressurized hydraulic fluid from the a hydraulic pump in a portable power pack. A method of removing trip hazards with the saw is also disclosed.

A system for separating contaminants from wellbore cuttings that includes a processing chamber, a heat source connected to the processing chamber adapted to vaporize hydrocarbons and other contaminants disposed on the material, a condenser operatively connected to an outlet of the process chamber and adapted to condense the vaporized hydrocarbons and other contaminants, and an ozone source operatively connected to the condenser.

A system for treating recovered fluids in-line that includes a thermal reactor for separating contaminated drill cuttings into drill cuttings and contaminants by applying heat to the contaminated drill cuttings so as to vaporize contaminants from the contaminated drill cuttings; a first condenser in fluid connection with the thermal reactor for condensing the vaporized contaminants; a separator in fluid connection with the first condenser for separating the condensed vapors into an oleaginous liquid and an aqueous liquid, wherein at least a portion of one of the aqueous liquid and oleaginous liquid is fed back into the first condenser via a feedback line; and an ozone generator operatively coupled to the feedback line, wherein at least the portion of the fed back liquid is ozonated by the ozone generator and fed into the condenser is disclosed.

An apparatus is disclosed for placement on a support surface between the support surface and a living being, wherein the living being has a bony prominence. The apparatus includes a first zone having a first coefficient of friction, the first zone being configured for positioning proximate the bony prominence. A second zone is adjacent the first zone, the second zone having a second coefficient of friction higher than the first coefficient of friction. The second zone is configured for positioning remote from the bony prominence. A method of preventing or healing decubitus ulcers includes positioning the bony prominence over the first zone and positioning an area remote from the bony prominence over the second zone.

A knit sock includes a foot portion having an upper instep area and a lower sole area integrally knit of a body yarn in circumferential courses and axial wales. The lower sole area defines inner and outer arch regions. The inner arch region incorporates a targeted compression zone adapted to reside generally adjacent an inner arch of a wearer's foot. The compression zone includes axially extending compression ridges of variable length spaced apart from a top of the compression zone to a bottom of the compression zone. When the sock is worn, a compression force applied by the foot portion within the targeted compression zone is greater than the compression force in directly adjacent areas of said foot portion.

System for application of ozone on grains made up essentially by one or more ozone mixers with particulates separator (1) for injecting air in the grains mass, one or more ozone mixers (2) for injecting air in the grains mass, a base of the device for grains treatment with ozone (3), a transport and discharge device (4), and an air cooling filter (5) that can be used individually or jointly to apply ozone on the grains mass.