A method to optimize the thermal deformation of an indirectly cryo-cooled silicon crystal monochromator exposed to intense X-rays at a low-emittance diffraction-limited synchrotron radiation source is presented. The thermal-induced slope error of the monochromator crystal has been studied as a function of heat transfer efficiency, crystal temperature distribution and beam footprint size. A partial cooling method is proposed, which flattens the crystal surface profile within the beam footprint by modifying the cooling contact area to optimize the crystal peak temperature. The optimal temperature varies with different photon energies, which is investigated, and a proper cooling strategy is obtained to fulfil the thermal distortion requirements over the entire photon energy range. At an absorbed power up to 300 W with a maximum power density of 44.8 W mm−2 normal incidence beam from an in-vacuum undulator, the crystal thermal distortion does not exceed 0.3 µrad at 8.33 keV. This method will provide references for the monochromator design on diffraction-limited synchrotron radiation or free-electron laser light sources.

Maximizing the performance of crystal monochromators is a key aspect in the design of beamline optics for diffraction-limited synchrotron sources. Temperature and deformation of cryo-cooled crystals, illuminated by high-power beams of X-rays, can be estimated with a purely analytical model. The analysis is based on the thermal properties of cryo-cooled silicon crystals and the cooling geometry. Deformation amplitudes can be obtained, quickly and reliably. In this article the concept of threshold power conditions is introduced and defined analytically. The contribution of parameters such as liquid-nitro­gen cooling efficiency, thermal contact conductance and interface contact area of the crystal with the cooling base is evaluated. The optimal crystal illumination and the base temperature are inferred, which help minimize the optics deformation. The model has been examined using finite-element analysis studies performed for several beamlines of the Diamond-II upgrade.

The title compound, C14H12O3, is an α-hy­droxy­carb­oxy­lic acid whose ortho­rhom­bic polymorph has been reported earlier [Qiu et al. (2007). Inorg. Chim. Acta, 360, 1819–1824]. The asymmetric unit contains two complete mol­ecules. Classical hydrogen bonds, as well as C—H⋯O contacts, connect the mol­ecules to infinite chains along the crystallographic c-axis direction.

Mevalonate kinase is central to the isoprenoid biosynthesis pathway. Here, high-resolution X-ray crystal structures of two mevalonate kinases are presented: a eukaryotic protein from Ramazzottius varieornatus and an archaeal protein from Methanococcoides burtonii. Both enzymes possess the highly conserved motifs of the GHMP enzyme superfamily, with notable differences between the two enzymes in the N-terminal part of the structures. Biochemical characterization of the two enzymes revealed major differences in their sensitivity to geranyl pyrophosphate and farnesyl pyrophosphate, and in their thermal stabilities. This work adds to the understanding of the structural basis of enzyme inhibition and thermostability in mevalonate kinases.

Serial electron diffraction (SerialED), which applies a snapshot data acquisition strategy for each crystal, was introduced to tackle the problem of radiation damage in the structure determination of beam-sensitive materials by three-dimensional electron diffraction (3DED). The snapshot data acquisition in SerialED can be realized using both transmission and scanning transmission electron microscopes (TEM/STEM). However, the current SerialED workflow based on STEM setups requires special external devices and software, which limits broader adoption. Here, we present a simplified experimental implementation of STEM-based SerialED on Thermo Fisher Scientific STEMs using common proprietary software interfaced through Python scripts to automate data collection. Specifically, we utilize TEM Imaging and Analysis (TIA) scripting and TEM scripting to access the STEM functionalities of the microscope, and DigitalMicrograph scripting to control the camera for snapshot data acquisition. Data analysis adapts the existing workflow using the software CrystFEL, which was developed for serial X-ray crystallography. Our workflow for STEM SerialED can be used on any Gatan or Thermo Fisher Scientific camera. We apply this workflow to collect high-resolution STEM SerialED data from two aluminosilicate zeolites, zeolite Y and ZSM-25. We demonstrate, for the first time, ab initio structure determination through direct methods using STEM SerialED data. Zeolite Y is relatively stable under the electron beam, and STEM SerialED data extend to 0.60 Å. We show that the structural model obtained using STEM SerialED data merged from 358 crystals is nearly identical to that using continuous rotation electron diffraction data from one crystal. This demonstrates that accurate structures can be obtained from STEM SerialED. Zeolite ZSM-25 is very beam-sensitive and has a complex structure. We show that STEM SerialED greatly improves the data resolution of ZSM-25, compared with serial rotation electron diffraction (SerialRED), from 1.50 to 0.90 Å. This allows, for the first time, the use of standard phasing methods, such as direct methods, for the ab initio structure determination of ZSM-25.

The application of grazing-incidence total X-ray scattering (GITXS) for pair distribution function (PDF) analysis using >50 keV X-rays from synchrotron light sources has created new opportunities for structural characterization of supported thin films with high resolution. Compared with grazing-incidence wide-angle X-ray scattering, which is only useful for highly ordered materials, GITXS/PDFs expand such analysis to largely disordered or nanostructured materials by examining the atomic pair correlations dependent on the direction relative to the surface of the supporting substrate. A characterization of nanocrystalline In2O3-derived thin films is presented here with in-plane-isotropic and out-of-plane-anisotropic orientational ordering of the atomic structure, each synthesized using different techniques. The atomic orientations of such films are known to vary based on the synthetic conditions. Here, an azimuthal orientational analysis of these films using GITXS with a single incident angle is shown to resolve the markedly different orientations of the atomic structures with respect to the planar support and the different degrees of long-range order, and hence, the terminal surface chemistries. It is anticipated that orientational analysis of GITXS/PDF data will offer opportunities to extend structural analyses of thin films by providing a means to qualitatively determine the major atomic orientation within nanocrystalline and, eventually, non-crystalline films.

As an important characterization method, pair distribution function (PDF) has been extensively used in structural analysis of nanomaterials, providing key insights into the degree of crystallinity, atomic structure, local disorder etc. The collection of scattering signals with good statistics is necessary for a reliable structural analysis. However, current conventional electron diffraction experiments using PDF (ePDF) are limited in their ability to acquire continuous diffraction rings for large nanoparticles. Herein, a new method – tilt-ePDF – is proposed to improve the data quality and compatibility of ePDF by a combination of electron diffraction and specimen tilting. In the present work, a tilt-series of electron diffraction patterns was collected from gold nanoparticles with three different sizes and a standard sample polycrystalline aluminium film for ePDF analysis. The results show that tilt-ePDF can not only enhance the continuity of diffraction rings, but can also improve the signal-to-noise ratio in the high scattering angle range. As a result, compared with conventional ePDF data, tilt-ePDF data provide structure parameters with a better accuracy and lower residual factors in the refinement against the crystal structure. This method provides a new way of utilizing ePDF to obtain accurate local structure information from nanoparticles.

A new polymorph of the diuretic chloro­thia­zide, 6-chloro-1,1-dioxo-2H-1,2,4-benzo­thia­zine-7-sulfonamide, C7H6ClN3O4S2, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than the known triclinic polymorph and to feature only N—H⋯O type inter­molecular hydrogen bonds as opposed to the N—H⋯O and N—H⋯N type hydrogen bonds found in the P1 form.

The major principles and requirements of asymmetric and inclined double-crystal monochromators are re-examined and presented to guide their design and development for significantly reducing heat load density and gradient on the monochromators of fourth-generation synchrotron light sources and X-ray free-electron lasers.

A slit-less wavelength-dispersive spectrometer design using a single-bounce monocapillary that aligns the sample on the Rowland circle, enhancing photon throughput and maintaining resolution. The compact design supports flexibility and reconfiguration in facilities without complex beamline infrastructure, significantly improving detection efficiency.

Structural modelling of operando pair distribution function (PDF) data of complex functional materials can be highly challenging. To aid the understanding of complex operando PDF data, this article demonstrates a toolbox for PDF analysis. The tools include denoising using principal component analysis together with the structureMining, similarityMapping and nmfMapping apps available through the online service `PDF in the cloud' (PDFitc, https://pdfitc.org/). The toolbox is used for both ex situ and operando PDF data for 3 nm TiO2-bronze nanocrystals, which function as the active electrode material in a Li-ion battery. The tools enable structural modelling of the ex situ and operando PDF data, revealing two pristine TiO2 phases (bronze and anatase) and two lithiated LixTiO2 phases (lithiated versions of bronze and anatase), and the phase evolution during galvanostatic cycling is characterized.

Despite a scarce supply, a substantial amount of COVID-19 monoclonal antibody (mAb) treatment courses remain unused, says a new rapid expert consultation from the National Academies of Sciences, Engineering, and Medicine.

Scientists at Iowa State University have developed a new formulation that helps to explain the self-assembly of atoms into nanoclusters and to advance the scientific understanding of related nanotechnologies. Their research offers a theoretical framework to explain the relationship between the distribution of "capture zones," the regions that surround the nanoscale "islands" formed by deposition on surfaces, and the underlying nucleation or formation process.

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Econocorp will be unveiling the newest addition to its line of secondary packaging machinery, the Spartan M-Pro cartoning machine, at PACK EXPO this year.

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BILIE Human Rights Initiative, a registered charitable organisation in England and Wales, expresses profound concern over recent developments in Nigeria regarding the Biafra Day Terrorist Attack in Aba

Everyone—especially agents—knows the feeling of having two seemingly identical sessions of business-building create vastly different results. Two hours of door-knocking one week might land you half a dozen hot leads, while a similar session the next week leaves you empty handed with ears ringing from all the door slammed in your face. Many agents are…

The post Best Days (and Hours) for Cold Calling, Door Knocking and Everything Else appeared first on RISMedia.

Monoclonal antibodies (mAbs) have revolutionized targeted cancer therapies with unmatched specificity and potency. Since the first mAb approval in 1986, ad

This study has added to evidence that the cerebellum has important roles that are underappreciated.

Event Begins: Wednesday, November 13, 2024 7:00pm
Location: Off Campus Location
Organized By: Center for South Asian Studies

Continuing our Spotlight On Women Directors series, Nocturnes is a 2024 documentary on how moths convey a mysterious message.

In the dense forests of the Eastern Himalayas, moths are whispering something to us. In the dark of night, two curious observers shine a light on this secret universe. Together, they are on an expedition to decode these nocturnal creatures in a remote ecological “hot spot” on the border of India and Bhutan. The result is a deeply immersive film that transports audiences to a rarely-seen place and urges us all to look more closely at the hidden interconnections of the natural world. From directors Anirban Dutta and Anupama Srinivasan.

This screening is FREE and open to the public (must reserve free tickets/RSVP in advance)

Tickets: https://marquee-arts.org/event-page/tickets/?showingId=892704

Film website: https://www.sandboxfilms.org/films/nocturnes/

*Made possible with the generous support of the Title VI grant from the U.S. Department of Education.*

Proteomics Analysis of Interactions between Drug-Resistant and Drug-Sensitive Cancer Cells: Comparative Studies of Monoculture and Coculture Cell Systems  ACS Publications

Proteomic analysis of the combined effects of cannabigerol and 3- O -ethyl ascorbic acid on kinase-dependent signalling in UVB-irradiated human keratinocytes  Nature.com

Can we protect ourselves from future outbreaks? COVID-19 isn't the first pandemic, and likely not the last. This hour, TED speakers share lessons from past pandemics and what they mean for our future. Guests on the show include science journalist Laura Spinney, anthropologist Heidi Larson, ecologist and animal-borne disease researcher Daniel Streicker, and physician economist Anupam Jena. We also hear some personal stories on coping with COVID-19 from TED speakers Susan Pinker, Leticia Gasca, Dixon Chibanda, and Dawn Wacek.

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An immersive new exhibition at Queensborough Community College's renowned Kupferberg Holocaust Center documents the vastness of the Nazi's system of genocide. The center's Laura Cohen and Cary Lane discuss the exhibit and the emotional toll of creating it.

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WARSAW / BUCHAREST, 2 August 2016 – Michael Georg Link, Director of the OSCE Office for Democratic Institutions and Human Rights (ODIHR) and Ambassador Mihnea Constantinescu, Chair of the International Holocaust Remembrance Alliance (IHRA), called today for greater efforts to protect endangered memorial sites related to the Roma and Sinti genocide during World War II.

Speaking on the occasion of the commemoration of the liquidation of the “Gypsy family camp” at Auschwitz-Birkenau in 1944, when the close to 3,000 remaining Roma and Sinti in the camp were murdered, they stressed that states have to do more to demonstrate their sincere and strong commitment to education about and remembrance of the genocide.

“Positively, we have seen increasing attention in recent years on the part of OSCE participating States to commemorate the Roma and Sinti genocide, and to educate people about this horrible event. This practice and these experiences should be widely shared and replicated,” Director Link said. “Promoting understanding of the Holocaust and its effect on different communities can help to create empathy and promote equality and non-discrimination for all.”

“Accurate and ethical education about the Holocaust includes the respectful and dignified preservation of memorial sites,” said Ambassador Constantinescu. “States have to take resolute action to protect endangered memorial sites and continue to do more to commemorate the Roma and Sinti victims. The history of these endangered sites should be included as part of broader efforts to educate about the consequences of indifference to racism.”

They called on governments to ensure that endangered memorial sites for Roma and Sinti victims are preserved and protected, to include this history as an integral part of civic and human rights education in their countries. They stressed that current developments, including a disturbing rise in xenophobic public rhetoric and racism, mean it is even more essential to build strong alliances among different communities.

In 2003, with the Action Plan on Improving the Situation of Roma and Sinti within the OSCE Area, the OSCE participating States committed themselves to strengthen education about the Roma and Sinti genocide. Through its Contact Point for Roma and Sinti Issues, ODIHR promotes knowledge about and recognition of the plight of Roma and Sinti during the Holocaust to counter present-day discrimination and racism, and to promote tolerance. According to ODIHR’s recent publication Teaching about and Commemorating the Roma and Sinti Genocide: Practices within the OSCE Area, seven OSCE participating States officially commemorate the Roma and Sinti genocide on 2 August, while a larger number of states commemorate the Roma and Sinti victims on the International Holocaust Memorial Day, 27 January.

The International Holocaust Remembrance Alliance is an inter-governmental organization and the foremost international network of political leaders and professionals advancing and shaping Holocaust education, remembrance and research. Its 31 member countries are committed to the tenets of the Stockholm Declaration. The IHRA Committee on the Genocide of the Roma aims to increase the commitment of IHRA Member Countries to educate, research and commemorate the genocide of the Roma.

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WARSAW / BUCHAREST, 2 August 2016 – Michael Georg Link, Director of the OSCE Office for Democratic Institutions and Human Rights (ODIHR) and Ambassador Mihnea Constantinescu, Chair of the International Holocaust Remembrance Alliance (IHRA), called today for greater efforts to protect endangered memorial sites related to the Roma and Sinti genocide during World War II.

Speaking on the occasion of the commemoration of the liquidation of the “Gypsy family camp” at Auschwitz-Birkenau in 1944, when the close to 3,000 remaining Roma and Sinti in the camp were murdered, they stressed that states have to do more to demonstrate their sincere and strong commitment to education about and remembrance of the genocide.

“Positively, we have seen increasing attention in recent years on the part of OSCE participating States to commemorate the Roma and Sinti genocide, and to educate people about this horrible event. This practice and these experiences should be widely shared and replicated,” Director Link said. “Promoting understanding of the Holocaust and its effect on different communities can help to create empathy and promote equality and non-discrimination for all.”

“Accurate and ethical education about the Holocaust includes the respectful and dignified preservation of memorial sites,” said Ambassador Constantinescu. “States have to take resolute action to protect endangered memorial sites and continue to do more to commemorate the Roma and Sinti victims. The history of these endangered sites should be included as part of broader efforts to educate about the consequences of indifference to racism.”

They called on governments to ensure that endangered memorial sites for Roma and Sinti victims are preserved and protected, to include this history as an integral part of civic and human rights education in their countries. They stressed that current developments, including a disturbing rise in xenophobic public rhetoric and racism, mean it is even more essential to build strong alliances among different communities.

In 2003, with the Action Plan on Improving the Situation of Roma and Sinti within the OSCE Area, the OSCE participating States committed themselves to strengthen education about the Roma and Sinti genocide. Through its Contact Point for Roma and Sinti Issues, ODIHR promotes knowledge about and recognition of the plight of Roma and Sinti during the Holocaust to counter present-day discrimination and racism, and to promote tolerance. According to ODIHR’s recent publication Teaching about and Commemorating the Roma and Sinti Genocide: Practices within the OSCE Area, seven OSCE participating States officially commemorate the Roma and Sinti genocide on 2 August, while a larger number of states commemorate the Roma and Sinti victims on the International Holocaust Memorial Day, 27 January.

The International Holocaust Remembrance Alliance is an inter-governmental organization and the foremost international network of political leaders and professionals advancing and shaping Holocaust education, remembrance and research. Its 31 member countries are committed to the tenets of the Stockholm Declaration. The IHRA Committee on the Genocide of the Roma aims to increase the commitment of IHRA Member Countries to educate, research and commemorate the genocide of the Roma.

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"If I were free, I'd fight for what was mine. I'd fight for my people." Bleecker Street FIlms has revealed an official trailer for The Return, a brand new take on the The Odyssey story from Italian filmmaker Uberto Pasolini. This film skipped Venice and ended up premiering at the Toronto & Chicago Film Festivals this fall, with a US release now set for December in theaters. Based on the classic story written by Homer. After 20 years Odysseus finally returns to Ithaca, where he finds his wife held prisoner by suitors vying to be king and his son facing death at their hands. To win back his family and all he has lost, Odysseus must rediscover his strength and fight back. The film reunites actors Ralph Fiennes and Juliette Binoche 30 years after their Academy Award winning triumph in The English Patient. The cast also includes Charlie Plummer, Marwan Kenzari, Claudio Santamaria, and Angela Molina. This looks damn good! Playing the story of Odysseus more as a tale of revenge, once he returns home and has to reclaim his own home against those who tried to take it from him. I stand with Odysseus! Go kick some ass Ralph […]

With his acclaimed drama Nowhere Special finally getting a U.S. release this past summer, four years after its premiere, Uberto Pasolini is now back with his next feature. The Return, which reunites the powerhouse duo of Ralph Fiennes and Juliette Binoche, is an adaptation of Homer’s Odyssey. Following a TIFF world premiere, Bleecker Street will release it in […]

The post The Return Trailer: Ralph Fiennes and Juliette Binoche Reunite For Homer Adaptation first appeared on The Film Stage.

El alojamiento se sitúa a 15 minutos en coche del centro histórico Leer

Que en medio de un debate nacional sobre una ley española, se intente presionar al Ejecutivo mediante una falsa lista negra, sería algo completamente inaceptable y debería dar lugar a reclamaciones diplomáticas. De no ser porque el autor es español.

El municipio de la Axarquía está a 45 minutos de la capital y tiene un famoso pasado histórico Leer

 Leer

El partido de Ortuzar asegura que aún no hay "ningún indicio" de financiación del PSOE a través de la trama el ex ministro de Transportes. El PNV empuja para asegurar la estabilidad del presidente socialista mientras se aleja aún más del PP de Feijóo. Leer

El actor falleció este viernes en su casa de Los Ángeles, sin que hayan trascendido las causas de su muerte Leer

Se valora la seguridad por las noches (92,2%), seguida de la gran oferta de transporte público (92,1%) y de la calidad del servicio y el estilo musical de los locales (81,6%). Leer

Le escribió mientras volvía de la India, y el presidente valenciano le contestó que la situación era muy mala. A Montero le pidió a las 21.03 "movilizar" al Ejército Leer