FEDtalk host Jason Briefel, a non-attorney partner and Director of Government and Public Affairs at Shaw Bransford & Roth P.C., sits down with Kettle and Eggers to discuss how the government agencies can break free from organizational boxes and rigid, top-down leadership to enact meaningful change.

The post Bridgebuilders – How Government Can Transcend Boundaries to Solve Big Problems first appeared on Federal News Network.

A new survey found that TSP participant satisfaction is at 84%, a 2% increase over last year’s results from the Federal Retirement Thrift Investment Board.

The post TSP participant satisfaction rebounds slightly in 2024 survey first appeared on Federal News Network.

The added training will begin in October and comes as the Army tries to reverse years of dismal recruiting when it failed to meet its enlistment goals.

The post As recruiting rebounds, the Army will expand basic training to rebuild the force for modern warfare first appeared on Federal News Network.

The Navy will meet its goal to sign up 40,600 recruits by the end of September thanks to several new recruiting programs. But the crush of last-minute enlistments means the service won’t be able to get them all through boot camp by next month, falling 5,000 sailors short of its target. The gaps are hurting the Navy’s ability to fully staff its warships. Navy Vice Adm. Rick Cheeseman tells The Associated Press that the Navy has “not gotten to the point where we can’t do things." All of the military services have struggled in the past several years to attract recruits in a tight job market.

The post Navy recruiting rebounds, but it will miss its target to get sailors through boot camp first appeared on Federal News Network.

As the demand for weight loss injectables soars, so too does the market for off-brand alternatives, some of which may not be safe or effective.

Panaya is seeking talented inside sales person for lead qualification and development in a fast growing startup. Office is located in Raanana.

EXPECTATIONS AND TASKS

• Generate outbound leads
• Respond to and qualify Incoming web, email, and phone inquiries
• Develop the lead until it's sales ready
• Route qualified opportunities to the appropriate sales person for further development and closure
• Achieve monthly and quarterly quota of qualified opportunities and closed deals
• Provide timely and accurate management reports

• Minimum 2-3 years of inside sales (ideally 5-6)
• Enterprise sales - great advantage
• Proven over achievement record
• An aggressive hunter
• Excellent phone & email communication skills
• Positive Attitude
• Organized
• English at mother tongue level, German and French a plus
• Willingness to work in non standard hours to support multiple time zones
• Salesforce.com expertise- a plus

Company in Raanana is seeking talented inside sales person for lead qualification and development in a fast growing startup.

EXPECTATIONS AND TASKS

• Generate outbound leads
• Respond to and qualify Incoming web, email, and phone inquiries
• Develop the lead until it's sales ready
• Route qualified opportunities to the appropriate sales person for further development and closure
• Achieve monthly and quarterly quota of qualified opportunities and closed deals
• Provide timely and accurate management reports

• Minimum 2-3 years of inside sales (ideally 5-6)
• Enterprise sales - great advantage
• Proven over achievement record
• An aggressive hunter
• Excellent phone & email communication skills
• Positive Attitude
• Organized
• English at mother tongue level, German and French a plus
• Willingness to work non-standard hours to support multiple time zones
• Salesforce.com expertise- a plus

Location: Main Media Collection - Video record 42439 DVD

Location: Jerusalem
URL: http://www.hasadvantage.com

Description:

— Dec 31, 2010: new positions available

The first ever Support Israel Visa Card Company, is hiring for Full-time night shift Outbound Sales/Account Management positions at its Jerusalem office. Be a part of a growing American company here in Israel.

Your primary responsibilities include placing outbound calls to sign up new cardholders, as well as Account Management in the form of activating new customers’ cards and account retention.

This position is ideal for outgoing, energetic and charismatic people who are interested in working in a fulfilling and well paying job in a fun environment with great incentives.

Requirements
• Native English speaker.
• Strong communication skills.
• Proficiency in Microsoft Office.
• Previous sales experience a plus.
• Personable individuals with a flair for sales, and who are responsible, motivated, organized.

Hours: Sunday-Thursday, 10:45 p.m. – 5:45 a.m.
Location: Har Chozvim, Jerusalem.

Compensation: Competitive Salary + Commission, and benefits. Paid training is provided by the company.

Attn: Sarah

Kings Heath’s Hare and Hounds was the venue last night for the first appearance in Birmingham of Police Dog Hogan

Driven by strong demand from the US and growth in the domestic market, India's home textile industry is poised for a 6-8% growth this fiscal year. Despite economic concerns in the EU, the industry's credit profiles are expected to remain stable, supported by healthy cash accrual and moderate capital expenditure plans.

FirstCry reported a 15% increase in operating revenue to Rs 6,481 crore and reduced losses by 34% in FY24. The Pune-based firm's international business, which is seeing faster growth than domestic operations, reported a revenue of Rs 753 crore, growing by over 50%. The firm plans to use a significant portion of its IPO proceeds for expansion in Saudi Arabia.

Dr. Anthony Fauci, President Biden’s top pandemic adviser, sought to discourage doubts about the antiviral drug Paxlovid following what appeared to be a “rebound” of Covid-19 after taking the pills.

Commenting on the latest CIPS UK Manufacturing Purchasing Managers’ Index which has decreased to 49.9 from 51.5, Mike Thornton, national head of manufacturing at RSM UK, said: “The manufacturing PMI dipped in October, falling below 50 for the first time in six months.

“The sun’s angle, in combination with the hill and the highway’s configuration, can create a blinding sun glare for drivers as they head eastbound up Floyd Hill."

Southbound Interstate 25 is once again open in Pueblo after a vehicle struck and killed a pedestrian Saturday morning, shutting down the roadway.

RNA-protein interfaces control key replication events during the HIV-1 life cycle. The viral trans-activator of transcription (Tat) protein uses an archetypal arginine-rich motif (ARM) to recruit the host positive transcription elongation factor b (pTEFb) complex onto the viral trans-activation response (TAR) RNA, leading to activation of HIV transcription. Efforts to block this interaction have stimulated production of biologics designed to disrupt this essential RNA-protein interface. Here, we present four co-crystal structures of lab-evolved TAR-binding proteins (TBPs) in complex with HIV-1 TAR. Our results reveal that high-affinity binding requires a distinct sequence and spacing of arginines within a specific β2-β3 hairpin loop that arose during selection. Although loops with as many as five arginines were analyzed, only three arginines could bind simultaneously with major-groove guanines. Amino acids that promote backbone interactions within the β2-β3 loop were also observed to be important for high-affinity interactions. Based on structural and affinity analyses, we designed two cyclic peptide mimics of the TAR-binding β2-β3 loop sequences present in two high-affinity TBPs (KD values of 4.2 ± 0.3 and 3.0 ± 0.3 nm). Our efforts yielded low-molecular weight compounds that bind TAR with low micromolar affinity (KD values ranging from 3.6 to 22 μm). Significantly, one cyclic compound within this series blocked binding of the Tat-ARM peptide to TAR in solution assays, whereas its linear counterpart did not. Overall, this work provides insight into protein-mediated TAR recognition and lays the ground for the development of cyclic peptide inhibitors of a vital HIV-1 RNA-protein interaction.

Ran Gu and Bing Gao
Math. Comp. 93 (), 2837-2860.
Abstract, references and article information

Song Dai and Qiongling Li
Trans. Amer. Math. Soc. 377 (), 5445-5481.
Abstract, references and article information

Ning Jiang, Yi-Long Luo and Shaojun Tang
Trans. Amer. Math. Soc. 377 (), 5323-5359.
Abstract, references and article information

Friedrich Haslinger
Proc. Amer. Math. Soc. 152 (), 5219-5227.
Abstract, references and article information

The kinesin-3 family contains the fastest and most processive motors of the three neuronal transport kinesin families, yet the sequence of states and rates of kinetic transitions that comprise the chemomechanical cycle and give rise to their unique properties are poorly understood. We used stopped-flow fluorescence spectroscopy and single-molecule motility assays to delineate the chemomechanical cycle of the kinesin-3, KIF1A. Our bacterially expressed KIF1A construct, dimerized via a kinesin-1 coiled-coil, exhibits fast velocity and superprocessivity behavior similar to WT KIF1A. We established that the KIF1A forward step is triggered by hydrolysis of ATP and not by ATP binding, meaning that KIF1A follows the same chemomechanical cycle as established for kinesin-1 and -2. The ATP-triggered half-site release rate of KIF1A was similar to the stepping rate, indicating that during stepping, rear-head detachment is an order of magnitude faster than in kinesin-1 and kinesin-2. Thus, KIF1A spends the majority of its hydrolysis cycle in a one-head-bound state. Both the ADP off-rate and the ATP on-rate at physiological ATP concentration were fast, eliminating these steps as possible rate-limiting transitions. Based on the measured run length and the relatively slow off-rate in ADP, we conclude that attachment of the tethered head is the rate-limiting transition in the KIF1A stepping cycle. Thus, KIF1A's activity can be explained by a fast rear-head detachment rate, a rate-limiting step of tethered-head attachment that follows ATP hydrolysis, and a relatively strong electrostatic interaction with the microtubule in the weakly bound post-hydrolysis state.

Abudukadier Abulizi
Dec 1, 2020; 61:1565-1576
Research Articles

Microsomal triglyceride transfer protein (MTTP) deficiency results in a syndrome of hypolipidemia and accelerated NAFLD. Animal models of decreased hepatic MTTP activity have revealed an unexplained dissociation between hepatic steatosis and hepatic insulin resistance. Here, we performed comprehensive metabolic phenotyping of liver-specific MTTP knockout (L-Mttp^–/–) mice and age-weight matched wild-type control mice. Young (10–12-week-old) L-Mttp^–/– mice exhibited hepatic steatosis and increased DAG content; however, the increase in hepatic DAG content was partitioned to the lipid droplet and was not increased in the plasma membrane. Young L-Mttp^–/– mice also manifested normal hepatic insulin sensitivity, as assessed by hyperinsulinemic-euglycemic clamps, no PKC activation, and normal hepatic insulin signaling from the insulin receptor through AKT Ser/Thr kinase. In contrast, aged (10-month-old) L-Mttp^–/– mice exhibited glucose intolerance and hepatic insulin resistance along with an increase in hepatic plasma membrane sn-1,2-DAG content and PKC activation. Treatment with a functionally liver-targeted mitochondrial uncoupler protected the aged L-Mttp^–/– mice against the development of hepatic steatosis, increased plasma membrane sn-1,2-DAG content, PKC activation, and hepatic insulin resistance. Furthermore, increased hepatic insulin sensitivity in the aged controlled-release mitochondrial protonophore-treated L-Mttp^–/– mice was not associated with any reductions in hepatic ceramide content. Taken together, these data demonstrate that differences in the intracellular compartmentation of sn-1,2-DAGs in the lipid droplet versus plasma membrane explains the dissociation of NAFLD/lipid-induced hepatic insulin resistance in young L-Mttp^–/– mice as well as the development of lipid-induced hepatic insulin resistance in aged L-Mttp^–/– mice.

Is China's economy on the rebound? 5 April 2023 — 6:00PM TO 7:00PM Anonymous (not verified) 28 February 2023 Chatham House and Online

Exploring the domestic and international signals from the first annual session of the 14th National People’s Congress.

2022 proved to be a difficult year for China. War, COVID-19 and economic turbulence presented a cocktail of significant challenges for the ruling CCP in China. Having dispensed of the infamous zero-COVID-19 policy, China is apparently back open for business.

On the international front, continued tensions with the West, war in Europe and climate change are just some of the obstacles standing in the way of Chinese economic recovery. 

Domestically, China must find ways to reinvigorate demand and move on from a low of 3 per cent GDP growth in 2022. With a frustrated population, people are also keen to be freed from the shackles of a stream of lockdowns and quarantining.

The in-tray for the 14th National People’s Congress, as it begins its first session, is substantial. The implications, at home and abroad, from its recent summit in Beijing reverberate around the world.

The experts on the panel discuss:

• What has been the true extent of COVID-related damage to China’s economy and wider society?
• What economic scars are visible post-recovery?
• Will there be longer-term implications for China’s economic and diplomatic footprint globally post-COVID? 

As with all member events, questions from the audience drive the conversation.

It’s a wrap! The Texas Advanced Computing Center (TACC) at UT Austin welcomed more than 100 participants for the 7th annual TACC Symposium for Texas Researchers (TACCSTER). The event exists […]

The post Research Insights, HPC Expertise, Meaningful Collaborations Abound at TACCSTER 2024 appeared first on HPCwire.

A new “health check” for our planet sounds an alarm bell on rising ocean acidification, which is driven by carbon dioxide levels in the atmosphere

Farmer sentiment saw an unexpected surge in October ahead of the upcoming U.S. election, according to the latest Purdue University/CME Group Ag Economy Barometer. The index rose to 115, marking a...

Analyzing packing case design with COSMOS and modifying in SOLIDWORKS yields light, strong container that reduces manufacturers' shipping costs

A recent poll shows "rationalistic" French society still highly bound to superstition.

Starting Dec. 15, all requests for a homebound vaccination or booster will be filtered through a toll-free number – 1-888-491-4988 – to be assessed and scheduled. Live operators will staff the toll-free line from 8 a.m. to 8 p.m. Monday through Friday, and 8:30 a.m. to 6 p.m. Saturdays.

Read the in depth Review of Acer Boundless 50 inch 4K LED Smart TV TV. Know detailed info about Acer Boundless 50 inch 4K LED Smart TV configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

When using Shape > Create Bounding Shape on an arc, the outer side works well, but on the inner side it just draws a straight line from the begging to the end of the curve.  Is anyone aware of a fix for this?

I'm attaching  a picture as an example, it works great on lines.

I want to plot the inductance through formula L1=(imag(Z(1,1))/(2*pi*freq)), but the system tells me that the freq is unbound variable? What can I do?

The number of foreign companies investing in Lagos increased in 2018 after four years of decline.

Nicole Kidman shared she was afraid to sing in the movie. Nicole Kidman brought back her iconic '90s look with her curly hair.The 57-year-old was spotted flaunting her strawberry blonde curls at the Spellbound premiere on November 11th. The American and Australian actress stunned in a...

Protein abundance data of drug-metabolizing enzymes and transporters (DMETs) are useful for scaling in vitro and animal data to humans for accurate prediction and interpretation of drug clearance and toxicity. Targeted DMET proteomics that relies on synthetic stable isotope-labeled surrogate peptides as calibrators is routinely used for the quantification of selected proteins; however, the technique is limited to the quantification of a small number of proteins. Although the global proteomics-based total protein approach (TPA) is emerging as a better alternative for large-scale protein quantification, the conventional TPA does not consider differential sequence coverage by identifying unique peptides across proteins. Here, we optimized the TPA approach by correcting protein abundance data by the sequence coverage, which was applied to quantify 54 DMETs for characterization of 1) differential tissue DMET abundance in the human liver, kidney, and intestine, and 2) interindividual variability of DMET proteins in individual intestinal samples (n = 13). Uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7), microsomal glutathione S-transferases (MGST1, MGST2, and MGST3) carboxylesterase 2 (CES2), and multidrug resistance-associated protein 2 (MRP2) were expressed in all three tissues, whereas, as expected, four cytochrome P450s (CYP3A4, CYP3A5, CYP2C9, and CYP4F2), UGT1A1, UGT2B17, CES1, flavin-containing monooxygenase 5, MRP3, and P-glycoprotein were present in the liver and intestine. The top three DMET proteins in individual tissues were: CES1>CYP2E1>UGT2B7 (liver), CES2>UGT2B17>CYP3A4 (intestine), and MGST1>UGT1A6>MGST2 (kidney). CYP3A4, CYP3A5, UGT2B17, CES2, and MGST2 showed high interindividual variability in the intestine. These data are relevant for enhancing in vitro to in vivo extrapolation of drug absorption and disposition and can be used to enhance the accuracy of physiologically based pharmacokinetic prediction of systemic and tissue concentration of drugs.

MLAs in Karnataka have on average assets worth ₹34.6 crore, the highest among all the States

Mar 28, 2024

Many issues in the Arctic are transboundary in nature and cannot be solved at the national level. A study group, led by Arctic Initiative Senior Fellow Margaret Williams, examined several key Arctic issues - maritime safety and security, commercial fisheries, and climate change and energy - and the difficulties of addressing them without Russian involvement.

Medical professionals, specifically doctors, play an important role in delivering good quality patient care. However, they are frequently confronted with

Shakhimardan river basin in the spotlight of the EU funded “Hydro4U (Hydropower for you)” project

The post Assessments and benefits sharing in the context of the Water-Food-Energy-Climate NEXUS in transboundary basin: Shakhimardan first appeared on International Water Management Institute (IWMI).

Located in the Thar Desert, this seasonal salt marsh called the ‘Rann of Kutch’ is in the Kutch district of Gujarat. Rann Utsav is a yearly.

Citadel: Honey Bunny intertwines elements of romance, humour, and suspense, navigating between the 1990s and 2000s, highlighting the lead actors' chemistry and action sequences. Directed by Raj & DK, the series also stars Kay Kay Menon.

With less than a week to go for campaigning to end in poll-bound Maharashtra, Prime Minister Narendra Modi is set to address three public meetings on Tuesday and campaign for MahaYuti candidates in the state.

"Good Morning Priya", wished Suzanne, her colleague who had just entered the office. She was late to the office as she always was most of the days. "Good Morning Suzanne", she wished back with a smile. Priya was under a lot