Here, in my neighborhood, life is a mix of re-revised rules for living and reality checks. Every day the local authorities publish new data on the where of illness. Daily a new national atrocity snaps a klieg light on us. Reading these days is a necessary escape from, and immersion into, reckoning. And so it is with Asako Serizawa's stunning and visceral debut, The Inheritors . Every page speaks to our current zeitgeist. Each character in these stories is occupied and occupier, trapped in a moral and existential crisis that's unnerving because it's evergreen, because the nature of human tragedy is our own making and the lessons we keep learning never seem to take. The book is a labyrinth of collected stories which follow a Japanese family's history over 150 years, beginning in 1868 and emerging into a future set in the 2030's, and connecting one family's multi-generational experiences living in a colonial and post-colonial world — in Japan, China, and the United States. The inheritors

The Blue Prosperity Plan has unveiled revised draft maps for the proposed marine protected area [MPA] network which “highlight significant changes that accommodate feedback received from the commercial fishing industry.” A Government spokesperson said, “After extensive consultation, a series of new draft maps were revealed that form the proposed marine protected area [MPA] network as […]

Show your love for Mother Earth this Earth Day! For the month of April, take 20% off our entire line of World maps. All proceeds from the sale will go to support the Society’s many worldly causes. Use code EARTHLOVE09.

Take 20% off All World Maps!
1. Visit natgeomaps.com/vip
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National Geographic’s Maps Division and Center for Sustainable Destinations teamed up to produce the first NG-developed Online Geotourism MapGuide to support sustainable tourism across the Greater Yellowstone region of Wyoming, Montana, and Idaho.

The site, http://www.yellowstonegeotourism.org/, which launched on March 31st, is open to anyone to discover and share information about unique features, tours, and businesses that best represent and sustain the natural and cultural character of the region. Visitors can also request a free print MapGuide.

Geotourism is the kind of travel that sustains or enhances the geographical character of a place — its environment, culture, aesthetics, heritage, and the well-being of its residents. Online Geotourism MapGuides are web versions of the print maps that National Geographic has developed for a number of regions around the world, including Crown of the Continent, Baja California, and Vermont’s Northeast Kingdom to name a few.

In addition to producing print and/or web maps, these projects bring together diverse representatives from the local communities to collectively define what makes their region special and how best to communicate it to the rest of the world. NG Maps is excited to participate in these projects that help travelers and local communities discover and preserve special places around the world. Anyone interested in developing a Geotourism MapGuide for their region, or simply becoming a “Geotraveler” should visit http://www.nationalgeographic.com/travel/sustainable/.

Since our inception as a division of the National Geographic Society in 1915, National Geographic Maps (originally the Cartographic Division) has routinely published maps that illustrate the news of the world. Our first supplement map, which appeared in the May 1918 issue of NATIONAL GEOGRAPHIC, titled the Western Theatre of War, served as a useful reference for overseas military personnel and soldier's families alike. Similarly our February 1967 map of Vietnam, Cambodia, and Laos, and recently, our Iraq and the Heart of the Middle East titles filled similar roles.

Maps are an excellent tool for the newshound, providing an accurate sense of place to issues local and abroad. To assist those that are interested in further understanding global news stories through good maps - we're pleased to announce a new monthly feature here on Contours that will highlight maps pertinent to today's news stories.

:: December 2009, Maps of the News ::

Afghanistan and Pakistan. Revised in Fall of 2009, this political map of the region contains thousands of place names, ideal for following news stories and deployed family members. Like all National Geographic cartography, our new Afghanistan and Pakistan map was carefully researched and edited and contains thousands of place names.

Iraq, Iran and the Middle East. This region dominates daily news stories. Our Middle East wall map covers over 18 nations in the region including: Iran, Iraq, Afghanistan, Pakistan, Syria, Jordan, and more.

Philippines. Follow the recent eruption of the Mayon volcano in the Philippines, with our Asia classic and executive style wall maps for the continent.

Vancouver and the Winter Olympics. A detailed city guide, perfect for global travelers attending the 2010 Winter Olympics.

January has been a big month for global news. From the devastating earthquake in Haiti to the damaging storms throughout the US which brought mudslides to California and snow to Florida.

On a more positive side, the Winter Olympics in Vancouver start in just 16 days, with opening ceremonies taking place on February 12th.

To illustrate these stories and more - here are this month's suggested National Geographic Maps:

Haiti::
West Indies Two-Sided Wall Map:: Has a political map of the Caribbean, including Haiti. For a historical perspective on the region, NATIONAL GEOGRAPHIC published three different supplement maps in 1913, 1922, and 1947 which specifically detailed the Caribbean region. These maps are available via our NG Map Collection Website - simply search for "caribbean".

US Weather::
National Geographic has a wide variety of US wall maps. Our most popular two titles are our US Clasic and US Executive editions. Both maps come in a variety of sizes and formats including enlarged and laminated. Additionally we started publishing a new series of State specific wall maps last year, and have released 8 States so far, including California.

Winter Olympics::
For those lucky enough to be heading to Vancouver to attend the 2010 Winter Olympics, be sure to carry along our Destination Vancouver city travel map. Updated in 2009, the Vancouver city map contains a detailed and easy to read street map with the locations of points of interest, hotels, public transportation and more.

Check back in a few weeks for our February installment of "Maps of the News". Additionally, we love your questions and comments. If you have a place or news story that you're looking for a map of, feel free to post a comment below, or connect with us on twitter @NatGeoMaps.

For those actively following the World's news, here is our monthly quick reference to National Geographic maps which add perspective to today's news stories.

WORLD

The 8.8 Magnitude earthquake in Chile, has left substantial devastation to the port town on Concepcion and left thousands homeless in the Capital city of Santiago. Our recently updated South America Wall Map contains place names for most major and secondary cities, plus physical features, and major transportation networks.



When I first heard about the Tsunami threat for the Hawaiian Islands, Australia, Japan and the islands of the Pacific on Saturday, I turned to our World Pacific Centered wall map. Unlike the wall map you likely had hanging in your classroom, which was Atlantic Ocean centered, our Pacific Centered edition provides a seamless view of the entire Ocean. This different perspective made it easier to understand the path of the Tsunami waves and helped clarify why places such as the California, Oregon and Washington coasts were under the warning as well.

Beyond the Chilean earthquake, this winter seems especially harsh, and on Sunday, France and four other countries were battered by a deadly storm named "Xynthia". In its wake the storm left 51 dead, millions without power, and generated extensive property damage throughout the region. Winds in excess of 130MPH were recorded over the Pyrenees with 100 MPH gusts along the Atlantic coast. National Geographic has a collection of up-to-date reference maps for most of the countries in Europe including: France, Belgium & The Netherlands, Spain & Portugal, and Germany. Additionally we recently revised our Europe wall map, which is available in several styles.


US

Here on the home front, winter weather continued to make headlines last week with the Northeast receiving another record breaking snowfall. National Geographic publishes a wide variety of United States Wall Maps, varying in style, size, and format that will assist with following nearly any US based news story.

The Tsunami warning for the Hawaiian Islands last Saturday had me turning to one of our most beautiful wall maps, The Hawaiian Islands, which exposes the dramatic terrain of the ocean floor around the island chain.




SPORTS

Now that the Winter Olympics have concluded, it's time to turn our eyes south to Arizona and Florida as MLB Spring Training kicks off today. If you're heading to watch any of the games, we have two useful maps for your glovebox, the Florida State Guide Map and the Arizona State Guide Map. Both maps have up-to-date road networks for the State, plus detailed inset maps for the major cities, like the Spring Training hubs of Tampa, Ft. Myers, Scottsdale and Tucson. While I'm a big fan of GPS for turn-by-turn directions, sometimes its just a little faster to use a real map, and you certainly get a better perspective of what's ahead when on a road trip.



As always - we love to hear your comments, questions and ideas for future posts.

Five new National Geographic maps complete coverage of Washington Cascades

Published: Tuesday, September 07, 2010, 3:15 AM
Terry Richard, The Oregonian
Washington's Cacades are covered.

With the release of five new maps this summer by National Geographic, the rugged mountains of Washington are covered from the British Columbia border to Oregon.

The maps are sold under the Trails Illustrated brand.

New titles this year area Mount St. Helens/Mount Adams, Goat Rocks/Norse Peak/William O. Douglas Wilderness Areas, Alpine Lakes Wilderness, Glacier Peak Wilderness and Mount Baker/Boulder River Wilderness Areas.

They go along with several other titles already in print to complete the coverage: North Cascades National Park, Mount Rainier National Park and Columbia River Gorge National Scenic Area.

The full-color maps are printed on hefty water-proof, tear resistant paper. National Geographic is one of the best mapmakers in the business, so the maps meet the highest standards.

The maps are topographical, but they cover such a large area that the contour interval is 50 feet. This is a little too big for serious off-trail mountain navigation, but National Geographic also sells state map series on CD Roms under the Topo brand with 20-foot contour intervals.

The new printed maps maps are excellent for hiking and driving. They show most of the trails and most of the roadside amenities, in easy-to-read formats.

Your map files may already contain U.S. Forest Service maps of the areas, but these maps often go 15 years or more between updates. The new Nat Geo maps are the best new maps at this time for the areas they cover.

Look for them at stores that sell maps, though getting this many new titles in any particular store may be difficult.

One place that does have them all is the Nature of the Northwest in Portland, at 800 N.E. Oregon St., Suite 965. Phone number is 971-673-2331.

You can also order them from National Geographic. Cover price is $11.95. For more information visit Trails Illustrated Washington maps.

-- Terry Richard

National Geographic Maps & Satmap Systems

Announce Alliance to Deliver Digital Mapping for Handheld Sports GPS

For the first time, National Geographic’s suite of Trails Illustrated, TOPO! and Adventure maps are made available on a handheld GPS; Satmap Active 10 TREK Launches in the U.S. this week.

November 17, 2010 - London, England... National Geographic Maps and Satmap Systems today announced the integration of the best-selling National Geographic outdoor recreation maps into the award-winning Satmap Active 10 handheld GPS. This integration is the result of a new product development alliance between the two organizations, both of which will launch the Active 10 TREK for sale in the United States this week.

The content offered on Satmap devices will include the complete line of National Geographic outdoor recreation maps, including the TOPO! USGS topographic map series, the AdventureMap series of international adventure travel maps, and, for the first time on any GPS, National Geographic’s premier Trails Illustrated series of maps for national parks, national forests and many popular recreation areas. National Geographic maps will be available via SD-Cards, which will plug-and-play into the Active 10 TREK handheld GPS.

The alliance brings together the mapping excellence of National Geographic with the engineering expertise of Satmap Systems Ltd., and the result is a product that meets the needs of outdoor enthusiasts. The Active 10 TREK will suit users of all skill levels in all weather conditions throughout the year. It has gained wide acceptance in Europe with outdoor professionals and consumers engaged in various activities such as mountain rescue, hiking, mountain biking, hunting and geocaching.

Charlie Regan, general manager and vice president, National Geographic Maps, said: “National Geographic prides itself on publishing the best maps, whether for outdoor recreation, education, travel or reference. We are pleased to announce this alliance with Satmap and are eager to see outdoor enthusiasts and professionals begin using the Active 10 TREK to guide them on their adventures. Satmap’s sterling reputation and the critical acclaim that their Active 10 has garnered in Europe made the decision to partner, as they expand into the U.S. market, an easy one.”

Richard Calthrop-Owen, managing director of Satmap Systems, commented: “We are really excited about launching into the U.S., especially with such a globally respected brand as National Geographic. This alliance is good news for everyone who spends time in the great outdoors, and this is a major product first. The Active 10 TREK, combined with the superb National Geographic map data, gives users the freedom to focus on the enjoyment of their sport rather than worrying about location. Accurate navigation is an essential part of enjoying the outdoors, and this quality of map detail will help users to keep on track and stay safe.”

Fourteen TOPO! USGS-based SD Map Cards will be available at launch, covering many popular outdoor recreation states including Arizona, California, Colorado, Idaho, the Mid-Atlantic region, Montana, Nevada, New England, New Mexico, North and South Carolina, Oregon, Utah, Washington and Wyoming. SD Map Cards for the remaining states and regions will be released in the first quarter of 2011. Three additional Trails Illustrated SD Map Cards also will be part of the initial offering, covering California’s Sierra Nevada, the Southern Appalachians and America’s “Greatest National Parks.” New Trails Illustrated Map Cards featuring some of the most important recreational areas in the country will be available in the coming months.

In addition to recreation users, Satmap Systems Ltd. supplies GPS handsets to search and rescue teams, police, military and other professionals in Europe, giving the company a unique insight into and understanding of the needs of outdoor users. Central to this is the need to see the best quality mapping possible on a large screen in a handheld device that is rugged and user friendly.

The Active 10 TREK

The Active 10 TREK comes pre-loaded with World and USA Base Maps. Customers can then buy the National Geographic SD Map Cards that slot into the GPS, making map reading fast and easy. The map is displayed on a large 3.5” screen in full color suitable for day and night use, including a red backlight option to help protect night vision.

The Active 10 TREK is priced at $369.99, and the National Geographic SD Map Cards cost $99.99 each. Customers also can purchase topographical mapping for most countries in Western Europe, making the GPS useful for home and when travelling abroad. There is a range of high-quality accessories such as Bike Mount, Vehicle Mount and a Deluxe Carry Case, which retail from $14.99.

The Active 10 TREK and National Geographic SD Map Cards will be sold online at www.shopng.com, www.satmap.com, www.topo.com, and www.amazon.com and will be available at premier outdoor retailers nationwide in the upcoming months.

Frank Biasi, Director, Conservation and Special Projects
National Geographic Maps

We all know (or should know!) that geography is the study of the Earth and its lands, features, inhabitants, and phenomena. This breadth of fascinating subjects is what led me to become a geographer 25 years ago. The sub-discipline of cartography allowed me to combine my earlier interest in visual art with my newfound passion for geography. I was lucky to come of age early in the growth of computer mapping technologies, including Geographic Information Systems (GIS). Seeing the potential of GIS to make a difference in the world and to build a career, I quickly jumped on that bandwagon.

I first used GIS to do maps and analysis for geography courses, and to inventory property parcels around my campus as part of an internship. After graduation, I worked for a regional planning agency to help design transportation corridors that maximize business opportunities and minimize environmental impacts. I went on to work for a state environmental agency where I helped to map all of the wetlands in Massachusetts to aid in the permitting of development and construction projects.

I further developed my geographic thinking and skills working for The Nature Conservancy, where I used GIS to help conservation planners and preserve managers map biodiversity and design and execute ways to save it. I realized that conservation, as with many other fields, deals with a wide variety of systems operating across the landscape, including biological, geological, hydrological, climatological, political, transportation, and economic systems. GIS provides a powerful platform to create and combine data layers representing each of these systems in order to make maps and answer questions about the world. Seeing these maps and answering these questions helps organizations across all sectors make informed decisions about what to do and where to do it.

Recently, we as individuals have begun using simple GIS tools on our PCs and mobile phones to make maps and answer spatial questions to help us decide where to eat, shop, travel, and invest. The growing phenomena of geo-browsing and geo-searching are enabled by interactive mapping services by Google, Microsoft, Yahoo, MapQuest, and others. These services are becoming increasingly personalized through GPS-enabled mobile phones and apps that tell us who and what is near us, wherever we are. The initial applications of these services have been for commercial and social uses. However, they can also help us discover and decide how we can make a positive difference in the world.

Many people are unaware of the fact that there are hundreds of thousands of dedicated nonprofit organizations working around the world to reduce human suffering, protect wildlife and ecosystems, preserve cultures, and advance scientific knowledge. These heroic people and organizations are stepping in to fill critical gaps that governments and businesses are unable or unwilling to fill. Most of the organizations have very limited financial and human resources to accomplish their objectives, yet they still manage to make an enormous difference in the lives of people, animals, and society at large.

At National Geographic, we have begun an initiative called the Global Action Atlas to highlight the work of these heroic nonprofits, and to give our audience tangible opportunities to discover and get involved in this work by donating, volunteering, advocating, visiting, and sharing with their social networks. Although it is still a beta site, ActionAtlas.org has over 400 on-the-ground projects by more than 100 reputable nonprofits around the world. Users can browse projects on an interactive global map or by themes including Conservation, Humanitarian, Cultures, Exploration, Climate Change, and Energy. They can also enter keywords to get a list of relevant projects in the U.S and around the world.
Every project has an interactive profile where the organization summarizes the issues the project is working to address, their goals, and the progress being made. They also include photos, videos, documents, blogs, maps, links to more information, and lists of similar and nearby projects. Once a user has found a project that interests them, they can become a fan or comment on the project, as well as donate, volunteer, visit, or share the project with their Facebook friends. Users can build up a portfolio of their favorite projects to follow and interact with over time, thus establishing their own “Geography of Action.” We plan to add thematic layers to the map viewer such as infant mortality, biodiversity, and cultural hotspots to help people decide where they should invest their time and resources in making a difference.

We hope that the Global Action Atlas provides the public a useful and trusted service that advances National Geographic’s mission of “inspiring people to care about the planet,” by enabling them to turn inspiration into action. Over the past century National Geographic’s writers, photographers, and filmmakers have richly documented places and cultures and the challenges facing communities and the planet. Our Mission Programs have funded thousands of field-based projects to understand and conserve wildlife and cultures and advance the frontiers of science. The Global Action Atlas is the beginning of a new effort to deeply engage our audience in this wonderful, but challenged world, and to help them become active participants in making it more wonderful.

Our Blogging Delay Update First off, if anyone who is a subscriber has been wondering why the news letter has been the same for about two months now, it has been because of being extremely busy. There has been an extensive amount of work being completed elsewhere for another company over the last few months. […]

This workshop will introduce participants to the primary features of ArcGIS StoryMaps and the necessary preparation to publish an effective StoryMaps project. As a member of the Princeton community, you have access to ArcGIS Online and its many apps like StoryMaps. Skills taught or addressed include: pairing maps, multimedia, and text; geolocation; embedding content; digital map making; using ArcGIS templates and layouts; digital storytelling strategies. Please bring a laptop. If you have not already activated your Princeton ArcGIS Online account, you are encouraged to do so beforehand.

Rubén Medina and Andrés Quilis
Proc. Amer. Math. Soc. 152 (), 5137-5148.
Abstract, references and article information

Gerhard Liebisch
Dec 1, 2020; 61:1539-1555
Special Report

A comprehensive and standardized system to report lipid structures analyzed by MS is essential for the communication and storage of lipidomics data. Herein, an update on both the LIPID MAPS classification system and shorthand notation of lipid structures is presented for lipid categories Fatty Acyls (FA), Glycerolipids (GL), Glycerophospholipids (GP), Sphingolipids (SP), and Sterols (ST). With its major changes, i.e., annotation of ring double bond equivalents and number of oxygens, the updated shorthand notation facilitates reporting of newly delineated oxygenated lipid species as well. For standardized reporting in lipidomics, the hierarchical architecture of shorthand notation reflects the diverse structural resolution powers provided by mass spectrometric assays. Moreover, shorthand notation is expanded beyond mammalian phyla to lipids from plant and yeast phyla. Finally, annotation of atoms is included for the use of stable isotope-labeled compounds in metabolic labeling experiments or as internal standards. This update on lipid classification, nomenclature, and shorthand annotation for lipid mass spectra is considered a standard for lipid data presentation.

Visitors to Delaware state forests can now use a mobile phone to locate trails, hunting stands, or parking areas using the Avenza Maps® mobile app (available for iPhone or Android devices from the App Store or Google Play.) All state forest maps are free to download. The app uses the phone's built-in GPS to locate it on the map, even when the device is out of range of a network or Internet connection. Users can select a particular map of interest, which can be downloaded and stored on their phone. A blue dot follows users wherever they go so they always know where they are on the map. More info at de.gov/forestmaps

1. Google Chrome on iPhones gets new features with Drive, Maps integration  Business Standard
2. Stop Using Chrome On Your iPhone, Warns Apple—Millions Of Users Must Now Decide  Forbes
3. 4 new Chrome improvements for iOS  The Keyword
4. Chrome on iOS now lets you search using images and text at the same time  TechCrunch
5. Google rolls out new features in Chrome for iPhone users  Moneycontrol

T-Mobile, Mint Mobile outage maps: See which regions are affected

Geographer Alastair Bonnett on his pick of the most diverse maps, from a collection of 100,000 galaxies to a 12th-century Chinese depiction of rivers on a grid

As a major type of structural variants, tandem duplication plays a critical role in tumorigenesis by increasing oncogene dosage. Recent work has revealed that noncoding enhancers are also affected by duplications leading to the activation of oncogenes that are inside or outside of the duplicated regions. However, the prevalence of enhancer duplication and the identity of their target genes remains largely unknown in the cancer genome. Here, by analyzing whole-genome sequencing data in a non-gene-centric manner, we identify 881 duplication hotspots in 13 major cancer types, most of which do not contain protein-coding genes. We show that the hotspots are enriched with distal enhancer elements and are highly lineage-specific. We develop a HiChIP-based methodology that navigates enhancer–promoter contact maps to prioritize the target genes for the duplication hotspots harboring enhancer elements. The methodology identifies many novel enhancer duplication events activating oncogenes such as ESR1, FOXA1, GATA3, GATA6, TP63, and VEGFA, as well as potentially novel oncogenes such as GRHL2, IRF2BP2, and CREB3L1. In particular, we identify a duplication hotspot on Chromosome 10p15 harboring a cluster of enhancers, which skips over two genes, through a long-range chromatin interaction, to activate an oncogenic isoform of the NET1 gene to promote migration of gastric cancer cells. Focusing on tandem duplications, our study substantially extends the catalog of noncoding driver alterations in multiple cancer types, revealing attractive targets for functional characterization and therapeutic intervention.

Call Of Duty: Black Ops 6 has been out for a little while already, what with me giving its multiplayer largely a thumbs up. Still, it's an ever-evolving thing and Activision have announced the game's first seasonal drop. It's a hefty one with a lot of additions, so I'll try my best to break down the good stuff. TLDR: there's some new maps for multiplayer and zombies, new modes, and a few extra bits. I'm mildly excited for more. More in this case is good.

Read more

Black Ops 6 is here, and fans have been itching to know what's included in Season 1 - and now we have an answer. Here's what's included, and when you can play

MundoFox estrenará “¿Quién Mató a Patricia Soler?” el lunes 9 de febrero a las 9PM/8c.

Check out the latest developer updates for Google Earth and Google Maps Platform, including grounding with Maps.

From helping you explore even more with Immersive View to taking the stress out of your drive, here are updates on Google Maps you won’t want to miss.

Here are all the latest updates for Google Maps, Earth, Waze and our developer platforms.

For the first time, maps have been prepared by a consortium consisting of IWMI, the Disaster Management Centre of the Ministry of Disaster Management (MoDM) and the UN’s space based information service for disaster management and emergency response (UN-SPIDER).

The post Press Release: New maps aid flood relief efforts first appeared on International Water Management Institute (IWMI).

IWMI provides data that will inform response and relief efforts to Super Cyclone Amphan.

The post Using maps to save lives when a super cyclone strikes first appeared on International Water Management Institute (IWMI).

A medical engineering professor at the University of South Florida is utilizing advanced imaging and virtual reality techniques to craft an intricate brain map.

Google Maps is heading down a new road steered by artificial intelligence

Dialect coach Erik Singer is back, this time to take a look at tongue twisters. We've all tried tongue twisters in our lives, and know how hard they can be! But "why" are they hard? What makes one group of words more difficult to speak fluidly than others? Erik explains why our tongues get so twisted up, and breaks down how different tongue twisters affect different people with different accents. Ultrasound Tongue Twister footage courtesy of Professor Ian Wilson, CLR Phonetics Lab at the University of Aizu, Japan Sagittal Section Diagram courtesy of Professor Daniel C. Hall, Linguistics & Department of English Saint Mary’s University, Halifax, N.S. https://incl.pl/sammy/ Thank you for all our tongue twister participants! Nicole Cunniff Larry Chan Taylor Faires Nichole Holze Alina Peng Sarah Jack Siobhan Pesce Bob Wendland Anushka Conway Maxine Jones Jordan Trafford Elizabeth Cartwright Brooke Henzell Tim Mills Clare/Clisare Cullen Kamal Batra Dylan Rogers Kayla Pereira Marcus A Siler Louise Starks

Researchers at Yale have unveiled a new interactive map that estimates public opinion on global warming right down to the county level.

U.S. employers are demanding skilled workforces, but are not always able to find a local supply, says a new OECD study looking at Job Creation and Local Economic Development.

U.S. employers are demanding skilled workforces, but are not always able to find a local supply, says a new OECD study looking at Job Creation and Local Economic Development.

The public consultation took place from 1 August to 31 October 2016.

U.S. employers are demanding skilled workforces, but are not always able to find a local supply, says a new OECD study looking at Job Creation and Local Economic Development.

Historic maps from the Library's collections documenting battles and campaigns of the Civil War, and other historical events.  The site sill be updated regularly with a selection of new maps, accompanied by captions, in chronological order.

Click here for more information.

The concept of statistical signal detection by controlling the false-discovery rate (FDR) to aid the atomic model interpretation of cryo-EM density maps is reviewed. The recommended usage of the FDR software tool is presented together with its successful integration into the CCP-EM suite.

Model building into experimental maps is a key element of structural biology, but can be both time consuming and error prone for low-resolution maps. Here we present Namdinator, an easy-to-use tool that enables the user to run a molecular dynamics flexible fitting simulation followed by real-space refinement in an automated manner through a pipeline system. Namdinator will modify an atomic model to fit within cryo-EM or crystallography density maps, and can be used advantageously for both the initial fitting of models, and for a geometrical optimization step to correct outliers, clashes and other model problems. We have benchmarked Namdinator against 39 deposited cryo-EM models and maps, and observe model improvements in 34 of these cases (87%). Clashes between atoms were reduced, and the model-to-map fit and overall model geometry were improved, in several cases substantially. We show that Namdinator is able to model large-scale conformational changes compared to the starting model. Namdinator is a fast and easy tool for structural model builders at all skill levels. Namdinator is available as a web service (https://namdinator.au.dk), or it can be run locally as a command-line tool.

In this article, a method is presented to estimate a new local quality measure for 3D cryoEM maps that adopts the form of a `local resolution' type of information. The algorithm (DeepRes) is based on deep-learning 3D feature detection. DeepRes is fully automatic and parameter-free, and avoids the issues of most current methods, such as their insensitivity to enhancements owing to B-factor sharpening (unless the 3D mask is changed), among others, which is an issue that has been virtually neglected in the cryoEM field until now. In this way, DeepRes can be applied to any map, detecting subtle changes in local quality after applying enhancement processes such as isotropic filters or substantially more complex procedures, such as model-based local sharpening, non-model-based methods or denoising, that may be very difficult to follow using current methods. It performs as a human observer expects. The comparison with traditional local resolution indicators is also addressed.

Confidence maps provide complementary information for interpreting cryo-EM densities as they indicate statistical significance with respect to background noise. They can be thresholded by specifying the expected false-discovery rate (FDR), and the displayed volume shows the parts of the map that have the corresponding level of significance. Here, the basic statistical concepts of confidence maps are reviewed and practical guidance is provided for their interpretation and usage inside the CCP-EM suite. Limitations of the approach are discussed and extensions towards other error criteria such as the family-wise error rate are presented. The observed map features can be rendered at a common isosurface threshold, which is particularly beneficial for the interpretation of weak and noisy densities. In the current article, a practical guide is provided to the recommended usage of confidence maps.

Silicon nanowire-based sensors find many applications in micro- and nano-electromechanical systems, thanks to their unique characteristics of flexibility and strength that emerge at the nanoscale. This work is the first study of this class of micro- and nano-fabricated silicon-based structures adopting the scanning X-ray diffraction microscopy technique for mapping the in-plane crystalline strain (∊044) and tilt of a device which includes pillars with suspended nanowires on a substrate. It is shown how the micro- and nanostructures of this new type of nanowire system are influenced by critical steps of the fabrication process, such as electron-beam lithography and deep reactive ion etching. X-ray analysis performed on the 044 reflection shows a very low level of lattice strain (<0.00025 Δd/d) but a significant degree of lattice tilt (up to 0.214°). This work imparts new insights into the crystal structure of micro- and nanomaterial-based sensors, and their relationship with critical steps of the fabrication process.

The sin2ψ and cosα methods are compared via diffracting-grain identification from electron backscatter diffraction maps. Artificial textures created by the X-ray diffraction measurements are plotted and X-ray elastic constants of the diffracting-grain sets are computed.

The genomes of modern birds tell a story of how they emerged and evolved after the mass extinction that wiped out dinosaurs 66 million years […]

The post International team maps ‘big bang’ of bird evolution appeared first on Smithsonian Insider.

Sustainable consumption and production (SCP) programmes are frameworks to systemically develop sustainability. New research has analysed three national SCP programmes in the UK, Sweden and Finland and concluded that, rather than provide a strong roadmap for sustainability, they tend to be a toolbox of good but scattered initiatives.