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MAA France: Fall All-Canadian Bowling Night for McGillians

Starts: Thu, 14 Nov 2024 22:00:00 -0500
11/14/2024 07:30:00PM
Location: PARIS, Canada




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Irrigation schemes in Ethiopia’s Awash River Basin: An examination of physical, knowledge, and governance infrastructures

Using a representative sample of irrigation schemes, the study documents the physical, knowledge, and governance infrastructures of irrigation schemes in Ethiopia’s most intensively used river basin, the Awash. The findings show that about 20 percent of the equipped area of irrigation schemes in the basin is not being irrigated, while the number of actual beneficiaries […] Source: IFPRI Ethiopia: Ethiopia Strategy Support Program




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Winter Solstice Isn’t Complete Without a Bowl of Tang Yuan Soup

When you can’t celebrate Dong Zhi with family, a well-prepared bowl of soup can keep traditions alive—and even make new ones.





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How to create an intelligent industrial camera without prior knowledge

Where rule-based machine vision has not been attempted or has reached its limits, there is a high potential for deep learning algorithms to support employees and drive forward automation.




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The Hidden Goldmine: Reducing Costs and Raising Yield by Streamlining Knowledge Work

Are you throwing away a significant portion of your budget without realizing it? How often do engineers, scientists, and analysts regenerate knowledge work—solving problems or similar problems that have already been solved?




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A Parliament of Owls SMALLWORK CANVAS EDITION

A Parliament of Owls SMALLWORK CANVAS EDITION by Scott Gustafson is a(n) Artist Proof. The Edition is Limited to Limited Edition pcs




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PACIFIC MORNING: BLACK SHEEP ON THE PROWL, L.E. PRINT

PACIFIC MORNING: BLACK SHEEP ON THE PROWL, L.E. PRINT by Craig Kodera is a(n) Limited Edition. The Edition is Limited to Limited Edition of 550 pcs




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PACIFIC MORNING: BLACK SHEEP ON THE PROWL

PACIFIC MORNING: BLACK SHEEP ON THE PROWL by Craig Kodera is a(n) Fine Art. The Edition is Limited to Limited Edition 183 of 1000 s/n pcs




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Canadian Blood Services discovery research lab contributes to new knowledge on neutrophils

Canadian Blood Services discovery research lab contributes to new knowledge on neutrophils


Thursday, August 29, 2024 Abby Wolfe

Dr. Donald R. Branch’s work as a discovery scientist at Canadian Blood Services focuses on immunotherapy, seeking to further enhance understanding of the cellular and molecular mechanisms involved in autoimmune diseases. Based in Toronto, Dr. Branch’s laboratory develops models of rheumatoid arthritis, Alzheimer’s disease, immune thrombocytopenia (ITP) and multiple sclerosis in mice. These models are particularly useful in examining how cells affected by these conditions respond to current therapeutic agents like intravenous immunoglobulin – a blood product made from human plasma commonly known as IVIg – and investigating potential alternative therapeutics.  

Over the years, Dr. Branch’s lab research findings have included the discovery of a special reagent that makes identification of antibodies easier by “zapping" autoantibodies,answers around unexpected side effects of IVIg therapy, and insights around recipients’ responses to bone marrow transplantation. It has also earned him numerous awards and accolades, including four from AABB, the Association for the Advancement of Blood & Biotherapies.

Dr. Don Branch, Canadian Blood Services senior scientist

New knowledge about neutrophils

Recently, contributions from Dr. Branch’s lab helped a U.K.-based team of researchers discover new information about how neutrophil function and activity is regulated. Neutrophils are a type of white blood cell that are part of the body’s normal immune response. A person’s neutrophil levels may be affected by infections as well as chronic or acute illnesses. Patients who have very low neutrophil counts and/or persistent infections may receive a boost to their neutrophil levels via granulocyte transfusion therapy. However, in some diseases, overactivation of neutrophils can also create an inflammatory environment and harm healthy tissue.

The research has been published in the high-impact scientific journal, Nature. This publication has filled a gap in knowledge about the mechanisms involved in maintaining balance between neutrophils’ infection-fighting power and inflammation-causing potential. As Dr. Branch describes: “This research by Dr. Brown and team shows that the myeloid inhibitory C-type lectin enzyme, which is known as MICL, controls neutrophil activity in rheumatoid arthritis. It is likely that MICL also regulates neutrophil activity in general. This suggests that if therapeutics can be designed to target MICL, they may be useful in controlling inflammation and infection. It is a fundamental finding that will change our understanding of the biology of neutrophils.”  

Discovery research, like the study to which Don and Ruqayyah contributed, is essential to improving patient care in the long run. New biomedical insights are essential to crafting new drugs and new therapeutic approaches in a rational way.

Dr. William (Bill) Sheffield, Canadian Blood Services senior scientist and associate director of research

Discovery research expertise leads to new collaboration  

The special mouse model that Dr. Branch’s lab uses is known as K/BxN. In this model, two mouse populations are selectively bred to produce offspring whose genetic material carry an antibody that destroys bone cartilage. An arthritis-causing serum containing this destructive antibody can then be obtained from the mice for use as a reagent in research. This process is termed “serum-transfer arthritis” and has been used by many investigators in the study of treatments that may alleviate the condition. 

Knowledge of Dr. Branch’s lab’s expertise in this area prompted a connection to the team of researchers at the Universities of Exeter and Aberdeen in the U.K. for this study. Says Dr. Branch, “In 2021, I supported a successful application to Canadian Blood Services’ Blood Efficiency Accelerator Program (BEAP) by Dr. Maria Fernandes, a researcher from  Héma-Québec who works with neutrophils. Through this collaboration, Dr. Fernandes was aware that I work on rheumatoid arthritis with K/BxN mice, and she also knew that Dr. Gordon Brown in the U.K. was looking to collaborate with a researcher in this area for some planned neutrophil research. My lab, which included postdoctoral fellow Dr. Ruqayyah Almizraq at the time, contributed to Dr. Brown’s research by providing the sera from our K/BxN mice. With this sera, Dr. Brown and his collaborators were able to induce rheumatoid arthritis and show that it could be resolved by removing the inhibition of a specific enzyme.”  

Science that is never boring

The Branch lab is currently using these same mouse models to investigate whether a recombinant protein called IgG1 Fc hexamer could be an effective replacement for IVIg in the treatment of autoimmune conditions like rheumatoid arthritis and ITP. While early results are promising, continued work is needed. In fact, back in 2018, Dr. Branch was asked in a previous R.E.D. blog post to describe what he found to be the most exciting part of science. Reflecting on the same question now, he reiterates that his response still rings true after 50 years in the field:   

The most exciting part of science is that when you do good science, you get more questions than you get answers, which means it is never boring. There is no end to imagination; new ideas, theories, experiments and discoveries occur often and provide a level of excitement to which many other professions cannot attest.

Dr. Donald (Don) Branch, Canadian Blood Services senior scientist


Canadian Blood Services – Driving world-class innovation 

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact.   

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency. 

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Dr. Donald Branch, Canadian Blood Services senior scientist, has received the Dale A. Smith Memorial Award for his discovery of the ZZAP reagent. This award, from the Association for the Advancement of Blood & Biotherapies (AABB), recognizes the application of technology to the practice of transfusion medicine or biotherapies.


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HVACR Industry Knowledge Offers a Valuable Perspective

The industry touches our lives directly, and an HVACR-literate public would be a boon to it.




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Hacking the Edges of Knowledge: LLMs, Vulnerabilities, and the Quest for Understanding

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[image: image.png]

It's impossible not to notice that we live in an age of technological
wonders, stretching back to the primitive hominids who dared to ask "Why?"
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does, in the exact same manner as the Universe at large. It is why all the
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In this episode, Markus talk with Martin Fowler and Rebecca Parsons about domain-specific languages.




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Slowly, slowly catchy monkey

Softly, softly, catchee monkey is a variation of "Softly, softly, catchee monkey". It is an Ashanti (Ghana) proverb quoted by Lord Robert Baden-Powell, Founder of the Boy Scouts.

From the people of Ghana, Baden-Powell learnt the phrase `softly softly catchee monkey' - and he learnt that he could get the best work out of his force by dividing it into small groups, or patrols, and giving responsibility to the captain of each group.

It's discussed in Eric Partridge's "Dictionary of Catch Phrases." Partridge says it means "Gently does it!" and probably appeared in the late 19th century. Origin is hazy because the phrase was largely "neglected by the editors of the relevant works of reference." Partridge quotes a paraphrase by Wilfred Granville, "Dictionary of Theatrical Terms" (1952): "Stalk your prey carefully; or, generally, to achieve an object by quiet application."




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Nowadays, if you do not consider harmonics distortion when designing a new network, you missed the whole point of the network design. Yes, really. The sooner you realize that harmonics problems are on the rise, the better. Modern power networks... Read more

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Financial literacy in Singapore has not been analysed in much detail, despite the fact that this is one of the world’s most rapidly aging nations. In this podcast, Professor of Finance Benedict Koh from the SMU Lee Kong Chian School of Business, discusses the key findings of his research jointly conducted with Olivia Mitchell from the University of Pennsylvania and Susann Rohwedder, Senior Economist at the RAND Corporation and Associate Director of the RAND Center for the Study of Aging. Using a unique new data-set and nationally representative survey - the Singapore Life Panel, they conducted an analysis of older Singaporeans’ financial literacy. Here, Professor Koh discusses his key findings, including: Do older Singaporeans score better on financial knowledge compared to their counterparts in the United States? What are the empirical linkages between financial literacy and retirement preparedness in Singapore? And is financial literacy positively associated with greater wealth and diversity of portfolios?




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Avantium, Royal Vezet to provide PEF-based packaging for Albert Heijn salad bowls

Avantium’s PEF (polyethylene furanoate) is a 100% plant-based, fully recyclable polymer and offers a renewable and circular packaging solution for Royal Vezet’s salad bowls.




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Super Bowl Sunday is only a few days away! Have you decided where you are going to watch Denver and Seattle go head to head? If your game plan includes cheering on your favorite team at a friend’s house or at a local sports bar, be sure to include a sober driver as the final play.




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The Super Bowl is America’s most watched national sporting event. On Super Bowl Sunday, February 1, there will be lots of game day socializing that may include drinking. OHS and law enforcement officials are urging football fans to choose sides now: drinking OR driving.




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A Broad Base of Knowledge Leads to Success for Young FM




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The Husqvarna Norden 901 has finally arrived in the country.




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Gators’ coach Todd Golden acknowledges UF investigation amid stalking, sexual harassment accusations

Todd Golden ran Saturday's practice after the No. 21 Gators had a day off following Thursday night's 81-60 home win against Jacksonville. He is expected to be on the sidelines when  Grambling State visits at the O'Connell Center Monday night.




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A Florida-LSU game with nothing significant at stake is a sign of the Gators' continued decline under coach Billy Napier and the Tigers' sudden stagnation under Brian Kelly.




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Pictures: UCF Knights Men’s basketball team win third straight against Florida Atlantic Owls 100-94.




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Leaders support official acknowledgment of Oscar Mack after Kissimmee documentary screening

On Saturday, that effort may have begun taking another step, as community leaders who attended a screening of the documentary at the Solid Rock Community Church in Kissimmee vowed to work toward a public acknowledgment of Mack’s encounter with the Klan more than 100 years ago.




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Resolution 80 - (Rev. Hammamet, 2016) - Acknowledging the active involvement of the membership in the development of ITU Telecommunication Standardization Sector deliverables

Resolution 80 - (Rev. Hammamet, 2016) - Acknowledging the active involvement of the membership in the development of ITU Telecommunication Standardization Sector deliverables




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3 Ways to Show Your UX Specialist Knowledge in Your Resume

If you’ve ever been on an Easter egg hunt, you understand the thrill and disappointment that typically comes with this activity. You see a colorful object and rush towards it only to find out it’s a candy wrapper. When you eventually stumble upon an easter egg, the thrill and frisson of relief you feel are […]

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Exploded Fruit Bowl

This Exploded Fruit Bowlby by Paul Cocksedge made me smile.





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On the Prowl with Cougar Paws SteelWalker Boots

The original Cougar Paws became the only boots I wear while roofing or conducting elevated training exercises.




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Knowledge is Power and Profitable

By knowing the ins and outs of attic ventilation, roofing contractors can stand out from the rest and earn more contracts, says Shane Gotschi, co-owner of DryHome Roofing & Siding.




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The last time GoDaddy ran an ad during the Super Bowl, Donald Trump had just been inaugurated as president of the U.S. However, the company's decision to return to next year's game was driven by artificial intelligence, not politics. After eight years, GoDaddy will return to the Big Game with a 30-second spot scheduled to...




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That lack of hierarchy sounds threatening to some, perhaps including universities, who are accustomed to being the authorities. Online, we find new sources of authority, though we also have to learn and re-learn when not to trust both online and offline sources. The university's challenge, and all of ours, is to engage with these new sources of information and meta-information. The answer to "too much information" is likely not to shut off the spigot but to hand out better filters and filter-building toolkits (aggregators, search engines, databases, social network tools, and mashups).

I'm headed to Everything Is Miscellaneous for more.




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Knowledge, Contemplation, and Lullism : Contributions to the Lullian Session at the SIEPM Congress - Freising, August 20-25, 2012

Location: Electronic Resource- 




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Former president of France, Nicolas Sarkozy acknowledges the...

Former president of France, Nicolas Sarkozy acknowledges the Assyrian Genocide



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Songbirds swarm their predators and seals appreciate a good rhythm



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New shade for bowling club

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Bowling alley gets go ahead

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