Rendering innovative designs of accent furniture, contemporary lighting and décor for your lovely residence, online furniture retailers such as Urban Ladder, PepperFry and Houzz.

London handyman company backs women's football in the capital

Misha Ezratti and Itchko Ezratti are thrilled to present an incredible opportunity for homebuyers in one of Palm Beach County's most exciting new communities near Wellington.

She earned her 11th medal on Saturday.

Spanish football writer Guillem Balague talks to former Barcelona and Spain midfielder Andres Iniesta about his plans after retiring.

The 4,000-year-old burial chamber featured hieroglyphs referring to the woman, known as Idi, as the "lady of the house"

Based on the theme, “Lighting the Way,” decorations feature lanterns, lightships, lighthouses, starlight and luminarias.

Adding greenery to your home is the most economical and creative way to spruce up your home. Beautiful plants or greenery via design elements help add a lovely green sheen to any corner or space. From ho-hum to beautiful, you can

You may not have heard of Ottomans, but they can add oomph to your decor in numerous ways. This functional piece of furniture is extremely versatile and can be placed anywhere in your home. If you are bored of adding

More and more of us are drawing inspiration from high-end hotels. Even Harry and Meghan seem to be at it, modelling their marital home, according to reports, on Soho Farmhouse in Oxfordshire.

The structure of a decagonal quasicrystal in the Zn58Mg40Y2 (at.%) alloy was studied using electron diffraction and atomic resolution Z-contrast imaging techniques. This stable Frank–Kasper Zn–Mg–Y decagonal quasicrystal has an atomic structure which can be modeled with a rhombic/hexagonal tiling decorated with icosahedral units at each vertex. No perfect decagonal clusters were observed in the Zn–Mg–Y decagonal quasicrystal, which differs from the Zn–Mg–Dy decagonal crystal with the same space group P10/mmm. Y atoms occupy the center of `dented decagon' motifs consisting of three fat rhombic and two flattened hexagonal tiles. About 75% of fat rhombic tiles are arranged in groups of five forming star motifs, while the others connect with each other in a `zigzag' configuration. This decagonal quasicrystal has a composition of Zn68.3Mg29.1Y2.6 (at.%) with a valence electron concentration (e/a) of about 2.03, which is in accord with the Hume–Rothery criterion for the formation of the Zn-based quasicrystal phase (e/a = 2.0–2.15).

Reusing old household items can give your home a fun, rustic dimension.

Though there's no official timeline for Christmas decor, for one Texas family, early November was unacceptable to their homeowners association.

Tips for Decorating the Thanksgiving Table

Summer 2020 home décor sweepstakes for $10,000 at Ballard Designs. This national furniture & design store is helping sheltering in place… become sheltering in style.

For a memo pad, many sheets 1 are bound at a back face as bound sheets using gum. The memo pad is provided with a cover paper on the top and a mounting paper on the bottom. The sheets 1 are printed from a central area of the sheet surface to over an outer peripheral area, with a decorative pattern. Outer peripheral non glued edges of the memo pad have a rugged shape modeled after the decorative pattern in a direction of the sheet surface and in a direction of the bound sheet thickness, such that even if the sheets 1 are turned up one by one or removed, a three dimensional decorative pattern reappears from the surface of the remaining sheets 1 to over the outer peripheral edge.

MOSCOW (AP) — In the coronavirus lockdown, Russians can’t go to their beloved and renowned museums. So they’re filling the holes in their souls by recreating artworks while stuck at home and posting them on social media. The Facebook group where the works are posted has become a huge hit. The art recreations range from […]

Bokai Song
Apr 28, 2020; 0:RA120.001981v1-mcp.RA120.001981
Research

The cyclic GMP-AMP synthase (cGAS) protein is a pattern-recognition receptor of the mammalian innate immune system that is recognized as a main cytosolic sensor of pathogenic or damaged DNA. cGAS DNA binding initiates catalytic production of the second messenger, cyclic GMP-AMP, which activates the STING-TBK1-IRF3 signaling axis to induce cytokine expression. Post-translational modification (PTM) has started to be recognized as a critical component of cGAS regulation, yet the extent of these modifications remains unclear. Here, we report the identification and functional analysis of cGAS phosphorylations and acetylations in several cell types under basal and immune-stimulated conditions. cGAS was enriched by immunoaffinity purification from human primary fibroblasts prior to and after infection with herpes simplex virus type 1 (HSV-1), as well as from immune-stimulated STING-HEK293T cells. Six phosphorylations and eight acetylations were detected, of which eight PTMs were not previously documented. PTMs were validated by parallel reaction monitoring (PRM) mass spectrometry in fibroblasts, HEK293T cells, and THP-1 macrophage-like cells. Primary sequence and structural analysis of cGAS highlighted a subset of PTM sites with elevated surface accessibility and high evolutionary sequence conservation. To assess the functional relevance of each PTM, we generated a series of single-point cGAS mutations. Stable cell lines were constructed to express cGAS with amino acid substitutions that prevented phosphorylation (Ser-to-Ala) and acetylation (Lys-to-Arg) or that mimicked the modification state (Ser-to-Asp and Lys-to-Gln). cGAS-dependent apoptotic and immune signaling activities were then assessed for each mutation. Our results show that acetyl-mimic mutations at Lys384 and Lys414 inhibit the ability of cGAS to induce apoptosis. In contrast, the Lys198 acetyl-mimic mutation increased cGAS-dependent interferon signaling when compared to the unmodified charge-mimic. Moreover, targeted PRM quantification showed that Lys198 acetylation is decreased upon infections with two herpesviruses—HSV-1 and human cytomegalovirus (HCMV), highlighting this residue as a regulatory point during virus infection.

A new analysis of ancient ostrich eggs at the British Museum underscores the interconnectedness of the ancient world

Decorate a guitar, skateboard, or bike to help veterans, foster children  AZFamily

Theme for the 2019 display is “Here We Go a Caroling.”

As the only canids that can climb trees, gray foxes frequently drag fawn and rabbit skeletons onto the branches with them.

The tree that will decorate Rockefeller Center this holiday season was cut down this week - but was it needlessly killed?

Rendering innovative designs of accent furniture, contemporary lighting and décor for your lovely residence, online furniture retailers such as Urban Ladder, PepperFry and Houzz.

The annual 20ft Norwegian Spruce has been hoisted at Downton Abbey's Highclere Castle. It is the same traditional tree as Trafalgar Square and the job requires a structured plan.

Sir Bradley Wiggins has become the most decorated British Olympian in history after winning his eighth individual medal, as part of the men's team pursuit squad.

Jerry Holliman, 69, says he was exposed to Agent Orange, has battled cancer and diabetes and that he's now stuck in a Mississippi veterans home feeling abandoned by his country.

Nigel Corn shared his advice for embracing the festive season in your garden. The British gardening expert suggests using decorative foliage and Christmas roses for a beautiful show.

This week the Kardashians and Jenners have been updating their millions of fans on how they have been snazzing up their pads with bunnies and pastel colored treats in time for the big day.

Kensington Palace shared a video on Instagram, revealing the work that went into decorating the tuk tuk that ferried William and Kate Middleton to Pakistan's National Monument in Islamabad.

The 30 decorated coffins of men, women and children were found only three feet underground at Asasif, a necropolis on the west bank of the River Nile in Luxor, Egypt.

They've just moved into their $20million mega mansion in Byron Bay. 

The St Germain Penthouse, which dominates the top floor of Paris' Lutetia Hotel, was designed by Oscar-winning director Francis Ford Coppola.