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New York Gov. Cuomo Offers Coronavirus Assistance To Atlanta

Atlanta Mayor Keisha Lance Bottoms is taking up New York Gov. Andrew Cuomo on his offer to send a team to conduct testing and contact tracing of people exposed to the coronavirus. Cuomo announced Monday that New York State will deploy coronavirus assistance to the capital of Georgia as the state continues to experience an increase in COVID-19 cases.




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On Site Opera Offers Live Performances Over The Phone For Just 1 Person At A Time

Copyright 2020 NPR. To see more, visit SARAH MCCAMMON, HOST: Performing artists are struggling to find ways to reach audiences during the coronavirus lockdown. Musicians are streaming concerts from their homes. Theaters are trying everything from Zoom plays to radio dramas. And one opera company is trying to reach its audience one listener at a time over the telephone. Reporter Jeff Lunden decided to take the call. JEFF LUNDEN, BYLINE: This is a story of love and separation. Two days before my phone rang, I got an email. And it says, my love, I miss you terribly. Each day without you is like... JENNIFER ZETLAN: A day without breathing. I long to see your face, the twinkle of your eyes. LUNDEN: The email is from my beloved. She says she's written some lyrics to songs she wants to sing to me and adds a postscript. ZETLAN: I've taken up learning a new language in quarantine, so all the songs will be in German. Here's the English translation. LUNDEN: I waited. Then the phone rang.




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Thomas Jefferson Descendant Reflects On His Ancestor's Complicated Legacy

Copyright 2020 NPR. To see more, visit https://www.npr.org.




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Jefferson Martínez: No hay mañana. El semestre se define esta semana




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Jefferson Mena, ilusionado con Bucaramanga: Queremos ponerle a estrellita a nuestra camisa

Jefferson Mena, autor del gol de la victoria del Bucaramanga ante Jaguares, se mostró esperanzado en los resultados que pueda tener el equipo durante este campeonato. El jugador de 34 años sueña en poder alcanzar el primer título de Liga para los santandereanos.




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Disabled golfers to be Empowered at North Turramurra

After damaging his spinal cord, James Gribble decided it was time the golf industry included people of all abilities with North Turramurra Golf Course getting on board.




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Unsafe culture permeates Aurora VA’s ICU, staffers allege. The message? “Shut up and do what you’re told.”

The allegations in the ICU come as the Aurora VA has been roiled by controversy in recent months. When clinicians do raise concerns to management, they say they're met with admonition and retaliation.




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This city offers people moving to Colorado the best bang for the buck

With fewer people moving across state lines, and population growth slowing, places within Colorado will have to compete harder with each other to attract new residents.




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Voters let RTD, Arapahoe and Jefferson counties keep tax revenue in TABOR measures

Metro Denver voters in Tuesday's election decided to let the Regional Transportation District and Arapahoe and Jefferson counties keep tax money that otherwise, under Colorado's Taxpayer Bill of Rights, must be returned to taxpayers. 





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Dr. Marc Lamont Hill Suffers Mild Heart Attack



“Please listen to your bodies,” he wrote.




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Deion Sanders Offers To Help Jackson State's HBCU Rival Secure Trainers For Players

“This is about these kids,” he said.




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Mosaic Offers Terrorism & Sabotage Coverage

Mosaic Insurance has “launched customized global terrorism and sabotage coverage for fine art and specie insureds, with syndicated capacity extending up to $215 million per risk.” A spokesperson said, “The new product offers coverage for physical loss or damage caused by acts of terrorism and sabotage, protecting artwork and other high-value contents housed in museums, […]




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BNT Raffle Offers Solar Panel Installation

BE Solar has partnered with the Bermuda National Trust to offer a solar panel installation as the grand prize for the annual Bermuda National Trust raffle. A spokesperson said, “In 2020, BE Solar provided an 8 panel solar installation as the grand prize for the raffle. The funds raised through the raffle helped BNT to continue […]




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Golfers Back In Four-Ball Championships Action

The Caribbean Golf Association Four-Ball Championships continued at the Plantation Golf Course in Trinidad & Tobago. In the mid-amateur men’s division, Bermuda pair Eric West and Jonathan James opened up a 7 stroke lead after their second round with an overall score of 4-under par. The pair shot 3-under par on the day. Mark Ray […]




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Scott Barnes Suffers Bad Luck In Series

[Written by Stephen Wright] Karting driver Scott Barnes endured a weekend blighted by bad luck during the second round of the Stars Championship Series, the King of the Castle, in New Castle, Indiana. Barnes, who made a flying start to the series at Queen City Gambit at the Charlotte Motor Speedway in North Carolina last […]




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BermudAir Offers Special Cup Match Rates

BermudAir is celebrating Cup Match with special rates, saying that “the sale runs from now through to August 1st 2024, with 20% off all Economy class flights and 30% off all Business class flights.” A spokesperson said, “BermudAir is celebrating this year’s Cup Match with the community by offering special rates for the rest of […]




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The NYSE Stumble Offers a Lesson for All Leaders

Recently, the New York Stock Exchange agreed to sell itself to the German exchange, Deutsche Boerse. For generations, the NYSE was the place to trade equities of the finest companies in the U.S. Its sale to a German exchange is a sign of how desperate its market situation has become. The NYSE’s fall offers some important lessons for a market leader in any industry.


The NYSE’s market share has fallen out of bed. Six years ago, 75% of the traded shares of companies listed on the New York Stock Exchange traded on that exchange. Today, only 35% of those shares trade on the NYSE. This precipitous fall came because the NYSE fell behind in both service and price. The market changed and new competitors emerged.


First, the market changed. High frequency traders, using computerized trading algorithms, do two-thirds of share trades today. These market-dominating customers demand the highest speeds in their transactions and the industry’s lowest prices. The New York Stock Exchange struggled to meet these requirements.


Second, new competition emerged. There are roughly fifty trading venues which will provide these high-frequency traders with fast services and low prices. The majority of these venues did not even exist ten years ago. They sprang up using relatively inexpensive computers in low-cost outlying and suburban locations. These new trading venues offer newer, faster technology and lower prices than the NYSE.


The NYSE held a price umbrella over these emerging firms. The new firms grew and became ever more capable. Today, they can compete and win in competition for even small trades.


The New York Stock Exchange was a dominant market leader. Its precipitous fall holds lessons for all market leaders in any market. Among these lessons are these:


1. Always protect your relationships with the industry’s heart-of-the-market customers. These are the key, primary and secondary relationships with the industry’s large customers, those purchasing 80% of the industry’s unit volume. These key relationships usually hold 65% or so of the total industry sales.


2. Avoid consistent failure with these heart-of-the-market relationships, especially failures in function and price. Customers generally will not leave an established relationship until their supplier fails them. Any failure, especially consistent failure over time, opens the customer relationship to other competitors.


3. Parry fast-growing competitors at any price point. The fast growth of these competitors tells us that customers like what they offer. Their growth in share will not stop until the market leader itself puts an end to it. The NYSE has allowed many new competitors into its marketplace. It would have been much easier to stop them when they were much smaller or, indeed, even before they entered the market. This market will consolidate again into far fewer competitors. But now it is going to be a bloody fight.


4. Fix the products that are losing share in the heart-of-the-market. Customer retention is important in any market, but it is critical in markets where prices are falling. The first demand of product innovation is to fix problems that cause the company to lose customer relationships.


5. Cover any price point your heart-of-the-market customer purchases. Companies often have price point biases, either against a low price point because it pulls down margins, or against a high price point because it makes operations less efficient. If the heart-of-the-market customers are buying the price point, you have to cover it.


6. In a falling price environment, develop pricing that discourages competition. This pricing can, and should, involve more than simple reductions in list prices. There are several components of a price. The NYSE can use these components to beat back many of these competitors. In a low, or falling, price environment, the only real function that price serves is to discourage competitors from competing for your customers. Ultimately, low prices push competitors out of the marketplace. This takes a long period of time when there are as many competitors as the NYSE faces today.


7. Develop and exploit economies of scale to support the falling prices the company faces and to maintain the best returns in the industry. The NYSE is still the largest competitor in the market. It no longer enjoys dominant share, but it is still large enough to create a more productive cost structure, especially by matching benefits and overhead costs to customer segments and eliminating benefits that customers do not need.





  • New York Stock Exchange

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The Kindle with Special Offers…not your typical low-end product

Amazon has introduced a low-end Kindle product, the Kindle with special offers. This Kindle sells for $114 compared to the standard $139 Kindle with Wi-Fi. This is not a typical low-end product. Low-end products offer fewer benefits than industry-leading products (we call these Standard Leader products) for either the buyer or the user of the product in return for a lower price. We call these low-end products Price Leaders. There are two kinds of Price Leaders. The first, called Strippers, strip out benefits for both the user and the buyer of the product in order to achieve a very low price. The second, Predators, offers the user equivalent benefits to the industry’s main product but fewer benefits for the buyer. On average, Price Leaders cost about 33% less than Standard Leader products.




You will note that the Kindle with special offers does not fit easily into either of these two Price Leader categories. It reduces the user benefits by delaying the use of the product until the customer has viewed advertisements. There is no change to the benefits offered the buyer of the product. The Kindle with special offers deviates from the norms of Price Leader products with its level of discount. The Kindle with special offers sells for about 18% less than the standard Kindle product.



The Kindle with special offers varies from the Price Leader pricing norm in another interesting and important dimension. Some of these “special offers” are really good deals for the average Amazon customer. In one particularly interesting offer, Amazon will sell an Amazon Gift Card worth $20 for just $10. So, an avid fan of the Amazon web site receives additional user benefits with this new low-end product. In many cases, these special offers may more than offset the disadvantage to the user of a delay in using the product while the user views an ad.



This new Kindle with special offers is a very creative product innovation. Congratulations to Amazon.




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NFPA offers free 1st Responder Connection App

The National Fire Protection Association (NFPA) has released a free 1st Responder Connection App offering firefighters, EMS, command staff, public educators, wildland fire personnel, and authorities having jurisdiction (AHJs) convenient, digital access to best practices, safety tips, and emergency response content.






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New Android Banking Malware 'ToxicPanda' Targets Users with Fraudulent Money Transfers

Over 1,500 Android devices have been infected by a new strain of Android banking malware called ToxicPanda that allows threat actors to conduct fraudulent banking transactions. "ToxicPanda's main goal is to initiate money transfers from compromised devices via account takeover (ATO) using a well-known technique called on-device fraud (ODF)," Cleafy researchers Michele Roviello, Alessandro Strino




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NHS offers 'improved' stop smoking pill

People in England will be able to get free varenicline tablets to help them quit cigarettes.




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Mauritius government suffers electoral wipeout

Navin Ramgoolam, 77, is appointed prime minister and begins his third stint in the job.




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Transfers - October 2024

Check out the significant signings and departures in the Premier League, Scottish Premiership, EFL and Women's Super League.




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Meet the new Trump administration staffers who will shape key US policies

Trump has started filling key White House roles, starting with Susie Wiles as his chief of staff.




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High-throughput and site-specific N-glycosylation analysis of human alpha-1-acid glycoprotein offers a great potential for new biomarker discovery

Toma Keser
Dec 29, 2020; 0:RA120.002433v1-mcp.RA120.002433
Research




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High-throughput and site-specific N-glycosylation analysis of human alpha-1-acid glycoprotein offers a great potential for new biomarker discovery [Research]

Alpha-1-acid glycoprotein (AGP) is an acute phase glycoprotein in blood, which is primarily synthetized in the liver and whose biological role is not completely understood. It consists of 45% carbohydrates that are present in the form of five N-linked complex glycans. AGP N-glycosylation was shown to be changed in many different diseases and some changes appear to be disease-specific, thus it has a great diagnostic and prognostic potential. However, AGP glycosylation was mainly analyzed in small cohorts and without detailed site-specific glycan information. Here, we developed a cost-effective method for a high-throughput and site-specific N-glycosylation LC-MS analysis of AGP which can be applied on large cohorts, aid in search for novel disease biomarkers and enable better understanding of AGP’s role and function in health and disease. The method does not require isolation of AGP with antibodies and affinity chromatography, but AGP is enriched by acid precipitation from 5 μl of bloodplasma in a 96 well format. After trypsinization, AGP glycopeptides are purified using a hydrophilic interaction chromatography based solid-phase extraction and analyzed by RP-LC-ESI-MS. We used our method to show for the first time that AGP N-glycan profile is stable in healthy individuals (14 individuals in 3 time points), which is a requirement for evaluation of its diagnostic potential. Furthermore, we tested our method on a population including individuals with registered hyperglycemia in critical illness (59 cases and 49 controls), which represents a significantly increased risk of developing type 2 diabetes. Individuals at higher risk of diabetes presented increased N-glycan branching on AGP’s second glycosylation site and lower sialylation of N-glycans on AGP’s third and AGP1’s fourth glycosylation site. Although this should be confirmed on a larger prospective cohort, it indicates that site-specific AGP N-glycan profile could help distinguish individuals who are at risk of type 2 diabetes.




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EPB Offers Commercial Quantum Network for Quantum Developers

We hear a lot about quantum computers – sometimes too much – but not as much about quantum networking which will also be a critical component in making widespread use […]

The post EPB Offers Commercial Quantum Network for Quantum Developers appeared first on HPCwire.




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Watch: Rita Ora offers heartfelt tribute to Liam Payne during MTV's EMAs

MTV's Europe Music Awards included a heartfelt tribute to late musician Liam Payne.




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NASA offers virtual launch attendance, guest passport for next SpaceX supply mission

NASA is inviting pubic participation in some virtual activities to watch the SpaceX space station resupply mission scheduled for a Monday night liftoff from NASA's Kennedy Space Center in Florida.




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A Once Homeless Teen Earned $3 Million in Scholarship Offers. Here's What Made His Story Possible

Tupac Mosley overcame homelessness to graduate as valedictorian, writes Jonathan E. Collins, but there’s an overlooked part of his inspirational story: policy.




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For Educators Vying for State Office, Teachers' Union Offers 'Soup to Nuts' Campaign Training

In the aftermath of this spring's teacher protests, more educators are running for state office—and the National Education Association is seizing on the political moment.




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Belgian Train Station Offers a Glimpse of the Future

The Liège-Guillemins railway station looks like it belongs far in the future: a vast curving monolith of glass, steel and concrete curves extending high above the train tracks. Just as astonishing as its design is the fact that it was built while the normal train schedules continued, with no disruption.




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What It Took to Recreate a Portrait of Thomas Jefferson

Television reporter Shannon LaNier is a direct descendant of the third President of the United States. (Credit: Drew Gardner)




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The Portraits of Thomas Jefferson

Read more about Thomas Jefferson: http://j.mp/w07Y8G At the turn of the 18th century, Americans learned what their leaders looked like through paintings and drawings, explains a historian at the National Portrait Gallery




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The Books of Thomas Jeffersons Library

Jeffersons respect for the enlightenment ideals of memory, reason and imagination shaped how he organized his library (Video: Molly Roberts). Read more at https://www.smithsonianmag.com/history/on-the-hunt-for-jeffersons-lost-books-38566672/




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'Adorable' Baby Hippo Moo Deng Is More Than a Viral Sensation. She Offers a Rare Glimpse of an Endangered Species

The baby pygmy hippopotamus in a Thailand zoo has taken the internet by storm, and keepers hope she will help gain momentum for conservation efforts




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Nurses' union blasts health authority over lack of job offers for nursing students

Nurses' union president Yvette Coffey says more must be done to ensure young nurses stay in the province. Newfoundland and Labrador Health Services says work is underway to match students with job openings.



  • News/Canada/Nfld. & Labrador

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Cape Breton food bank offers salon experience to clients needing haircuts

Volunteers will be cutting hair at a salon based inside a Cape Breton food bank. The goal is to provide clients with the same salon experience paying customers would receive.



  • News/Canada/Nova Scotia

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Fort McMurray museum offers hands-on insights into the meaning of Remembrance Day

A museum in Fort McMurray is helping visitors gain a deeper understanding of Canada’s role in previous wars. The Wood Buffalo Military Museum Centre is offering a chance to get up close to military artifacts. Young visitors say seeing the remnants of conflict gives them a new understanding of Remembrance Day's meaning.




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Hamilton council defers vote on banning encampments in parks to next year

City will wait for legal advice, staff report before voting early next year to avoid potential rights violations. While some people in the community argue Hamilton doesn't have enough shelter beds to justifiably remove encampments, others say they feel unsafe in their homes and unable to access parks.



  • News/Canada/Hamilton

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SolidWorks Corporation offers new technology software grants for teachers

SolidWorks software donation supports fusion of science, technology, engineering, and math (STEM) in education




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SOLIDWORKS World 2007 offers packed agenda

World's largest annual 3D CAD event will feature special guest Steve Wozniak this year




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Penn State offers free online courses focused on driving community change

People who want to support the well-being of youth and families in their communities can register for free online courses through Penn State’s Prevention Learning Portal. The portal offers instruction and resources on how to choose, implement and sustain programs and practices that promote healthy communities.




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OWC Thunderbolt 5 Hub offers high-speed port expansion for Apple's newest Macs

OWC's new Thunderbolt 5 Hub aims to provide even more access to the fastest ports, by splitting one off into three more.


OWC Thunderbolt 5 Hub - Image credit: OWC

In 2021, OWC introduced the Thunderbolt Hub, a dock that provided three additional Thunderbolt 4 ports when it was plugged into a Mac's Thunderbolt 4 connections. Three years later, it's doing it again, but for the newest Mac models.

The OWC Thunderbolt 5 Hub is the same concept as before, with one Thunderbolt 5 cable connecting to the host Mac while providing three more Thunderbolt 5 ports to plug devices into. The hub also adds a single USB-A port to the equation too.


Continue Reading on AppleInsider | Discuss on our Forums




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New school offers hope to orphans

OM Malawi opens a new school to help educate children in need.




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Yes, Colleges Can Rescind Admission Offers. Here's What Educators Need to Know

In a recent high-profile case, Harvard College rescinded its offer to a school-shooting survivor after racist comments he’d written online surfaced. But how common is it for colleges to take back offers? And do students have any recourse?




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Stress Can Lead to Student Failure. New Research Offers a Path for Success

When students are overwhelmed, their schoolwork suffers. But two growth-mindset researchers, Jamie M. Carroll and David Yeager, say teachers can help increase kids' resilience.