The divalent anion sodium symporter (DASS) family (SLC13) plays critical roles in metabolic homeostasis, influencing many processes, including fatty acid synthesis, insulin resistance, and adiposity. DASS transporters catalyze the Na+-driven concentrative uptake of Krebs cycle intermediates and sulfate into cells; disrupting their function can protect against age-related metabolic diseases and can extend lifespan. An inward-facing crystal structure and an outward-facing model of a bacterial DASS family member, VcINDY from Vibrio cholerae, predict an elevator-like transport mechanism involving a large rigid body movement of the substrate-binding site. How substrate binding influences the conformational state of VcINDY is currently unknown. Here, we probe the interaction between substrate binding and protein conformation by monitoring substrate-induced solvent accessibility changes of broadly distributed positions in VcINDY using a site-specific alkylation strategy. Our findings reveal that accessibility to all positions tested is modulated by the presence of substrates, with the majority becoming less accessible in the presence of saturating concentrations of both Na+ and succinate. We also observe separable effects of Na+ and succinate binding at several positions suggesting distinct effects of the two substrates. Furthermore, accessibility changes to a solely succinate-sensitive position suggests that substrate binding is a low-affinity, ordered process. Mapping these accessibility changes onto the structures of VcINDY suggests that Na+ binding drives the transporter into an as-yet-unidentified conformational state, involving rearrangement of the substrate-binding site–associated re-entrant hairpin loops. These findings provide insight into the mechanism of VcINDY, which is currently the only structurally characterized representative of the entire DASS family.

Adopting a Market-based Approach to Boost Energy Access in Displaced Contexts Research paper sysadmin 25 March 2019

This paper evaluates the market-based approaches adopted in the MEI projects in Kenya and Burkina Faso. It articulates how such commercial strategies can be applied to the delivery of energy in displacement settings and compares this to real world examples.

• Development of long-term energy solutions in displacement settings tends to be perceived as investment that falls outside the remit of emergency responses. In addition, when emergency energy supply measures are implemented they often result in expensive, unreliable and unhealthy energy provision for those in protracted or recurrent crises.
• There is widespread agreement among humanitarian and development experts that an effective refugee response should include long-term development solutions as well as emergency relief.
• The energy access imperative is more pronounced when considering the need for effective energy distribution in practically all camp activities and basic necessities: pumping and treatment of clean water; heating and cooling for food storage and cooking; energy for livelihood activities; and provision of light for schooling, hospitals and the prevention of violence against women and children.
• Minor shifts in household energy use to basic solar lighting options and non-wood fuels would save $303 million annually on refugee fuel costs.
• Within refugee contexts in Kenya and Burkina Faso, the MEI sought to examine opportunities to use market interventions, rather than in-kind distributions, to improve clean energy access over the long-term and test the delivery of market-based approaches.

Building science lessons around phenomena that students know equally and can see in their own lives is making the subject more relevant and interesting.

The money, which will be allocated over three years, is expected to make major and minor improvements to schools throughout the city.

Building science lessons around phenomena that students know equally and can see in their own lives is making the subject more relevant and interesting.

A state leader shares how research helped raise important considerations for increasing college success and completion in Indiana.

Mississippi, Arkansas, and New Mexico have the highest percentages of students who lack adequate home technology for remote learning.

Ahead of the Food Systems Summit, join the Publications team to find out more about where to find FAO publications, the different formats available, how you can re-use the [...]

Ahead of the Food Systems Summit, join the Publications team to find out more about where to find FAO publications, the different formats available, how you can re-use the [...]

Ahead of the Food Systems Summit, join the Publications team to find out more about where to find FAO publications, the different formats available, how you can re-use the [...]

The  Food and Agriculture Organization of the United Nations (FAO) is happy to announce significant updates and upgrades to the FAO CONNECT CRM Database section [...]

In the new year, Ontario is supposed to be fully accessible for disabled people, but advocates say the province is ‘nowhere near’ meeting standards it created 20 years ago.

New Licensing, Support Programs For Certification Accompany Software Upgrades

MatWeb's new export engine pipes data from its 47,000 material information sheetsdirectly into SolidWorks and COSMOSWorks

A News24 Business reader who resigned from her job with R300 000 accumulated in her retirement savings wants to know if she should access some of her funds.

In the world’s wealthiest country, why is broadband access denied to so many and in such high numbers? Mark Lieberman investigates.

SARS continues to deny amaBhungane and the Financial Mail's requests for access to former president Jacob Zuma's tax records despite the seminal judgment of the Constitutional Court handed down in May 2023.

In a new Government Accountability Office report, districts cite funding constraints as the main reason for not making their buildings accessible, a longstanding problem.

Penn State's Campus-wide Accessible Syllabus Competition highlights the importance of accessibility in higher education and the University's new tool in Canvas — Anthology Ally.

WILMINGTON – The Delaware Children’s Department has launched a program that links pediatric primary care providers with free psychiatry consultations and assistance to streamline behavioral health care for children and youth. Implemented in 2019, the Delaware Child Psychiatry Access Program (DCPAP) is a beneficial resource for primary care providers serving young people with behavioral health needs. […]

A comprehensive look at how U.S. schools served students in the aftermath of the coronavirus closures finds that schools responded more fully in communities where parents' education levels were higher.

NEW CASTLE (Sept. 7, 2021) – The Biden Administration has awarded Delaware $10,831,203 through the Centers for Medicare & Medicaid Services (CMS) to improve access to affordable, comprehensive health insurance coverage through its section 1332 state-based reinsurance waiver. Delaware is one of 13 states to receive these funds, also known as “pass-through funding,” which are available […]

With schools facing the challenge of unfinished learning due to the pandemic, the Delaware Department of Education (DDOE) is providing access to online books to every K-12 student in the state. Students can use their school credentials to read required and recreational digital books in the OverDrive Education Sora student reading app. Students also now have seamless access to age-appropriate popular ebooks and audiobooks from the Delaware Libraries’ OverDrive digital collection.

Wilmington, Del. (January 26, 2022) – The Delaware Division of the Arts is pleased to announce the launch of the Arts Incubator Project, an assessment, training, and planning initiative built on the principles of Inclusion, Diversity, Equity and Access (IDEA) for the state’s arts industry with a $1.25 million investment in the initiative. “A diverse […]

DOVER, Del. – Lt. Governor Bethany Hall-Long, Governor John Carney, and community leaders are encouraging Delawareans to check their eligibility for free or low-cost internet options as Delaware kicks off summer learning and enrichment activities. The awareness coincides with the Biden Administration’s Affordable Connectivity Program (ACP) Week of Action this June.  Starting this summer, libraries across Delaware will be hosting free enrollment events so […]

Federal judge ensures mifepristone access in Delaware Attorney General Kathy Jennings announced Friday that Judge Thomas O. Rice of the U.S. District Court for the Eastern District of Washington has issued an order reiterating that his injunction protecting access to mifepristone in 17 states — including Delaware — and the District of Columbia remains in […]

$2M in seed funding to stabilize and strengthen family farms and local food supply chain operations WILMINGTON, Del. – Governor John Carney, the Delaware Department of Agriculture, and the Delaware Council on Farm and Food Policy on Thursday announced a $2 million investment in seed funding to establish the First State Integrated Food System Program. This new […]

Starting Dec. 15, all requests for a homebound vaccination or booster will be filtered through a toll-free number – 1-888-491-4988 – to be assessed and scheduled. Live operators will staff the toll-free line from 8 a.m. to 8 p.m. Monday through Friday, and 8:30 a.m. to 6 p.m. Saturdays.

DOVER, DE (Dec. 21, 2021) – The Delaware Division of Public Health (DPH) announced today that individuals vaccinated in Delaware will now have access to a QR code when downloading their COVID-19 vaccination record. The digital COVID-19 vaccination card now includes the QR code and is available through the DelVAX Public Portal, a site where those who were […]

The Delaware Division of Public Health (DPH) is announcing five additional cases of monkeypox (MPX), bringing the state’s total to 11. All cases are considered probable pending confirmatory testing by the Centers for Disease Control and Prevention (CDC).

The Delaware Division of Public Health (DPH) is announcing additional locations where those who meet eligibility criteria can get the monkeypox (MPX) vaccine. On Monday, DPH expanded access to the vaccine to those living with HIV and those receiving HIV pre-exposure prophylaxis (PrEP).

The Delaware Division of Public Health (DPH) is sharing upcoming opportunities for individuals to get vaccinated against the monkeypox virus (MPX). The current case count for MPX in the state is 33, including 22 cases in New Castle County, two cases in Kent County, and nine cases in Sussex County. Delaware continues to offer vaccinations to people […]

DOVER, DE (Dec. 20, 2022) – The Delaware Division of Public Health (DPH) is announcing changes to COVID-19 testing access in Delaware. Based on operational needs, DPH’s valued partner Curative has decided not to renew its testing contract with the state when it ends in the next two weeks. As a result, Wednesday, Dec. 28 will […]

The Accessions Committee met on April 20, 2023, to review all proposed accessions received since the last quarterly meeting. All accepted donations have been pre-processed and assigned to archivists for further processing. In the meantime, here’s a sneak peek at the latest additions to our holdings.

The post 2023 – Second Quarter Accessions appeared first on Delaware Public Archives - State of Delaware.

The Accessions Committee met on August 7, 2023. All accepted donations have been pre-processed and assigned to archivists for further processing. In the meantime, here’s a sneak peek at the latest additions to our holdings.

The post 2023 – Third Quarter Accessions appeared first on Delaware Public Archives - State of Delaware.

These accessions include University of Delaware Yearbooks, the Broujos Family Records, Photographs and Postcards. All accepted donations are assigned for further processing.

The post 2023 – Fourth Quarter Accessions appeared first on Delaware Public Archives - State of Delaware.

The Accessions Committee met on January 30, 2024 to review proposed accessions. New accessions include photographs from De La Warr High School, interviews by Michael Richards, and digital photographs of the Salmons family.

The post 2024 – First Quarter Accessions appeared first on Delaware Public Archives - State of Delaware.

The Accessions Committee met on May 8, 2024, to review proposed accessions. New accessions include correspondence from World War II, photographs of the New Castle County Paramedic Unit, and a scrapbook of the Washington Memorial Bridge dedication ceremony.

The post 2024 – Second Quarter Accessions appeared first on Delaware Public Archives - State of Delaware.

The Accessions Committee met on July 30, 2024, to review proposed accessions. New accessions include records related to the Delaware Industrial School for Girls, photos of the St. George's Bridge under construction, and an Employees' Handbook from the Nylon Division of the E. I. du Pont de Nemours and Company.

The post 2024 – Third Quarter Accessions appeared first on Delaware Public Archives - State of Delaware.

The 7th Street Boating and Fishing Area on the Christina River has officially reopened to Wilmington's Eastside community, with DNREC, in partnership with the city, celebrating the $2.9 million project with a ribbon-cutting ceremony in John Barbiarz Park, where the popular facility is located.

  Wilmington Based Non-Profit, Four Youth, Awarded Funding   Statewide, DEL. (October 2, 2024) – The National Endowment for the Arts (NEA) is pleased to announce 112 organizations recommended for awards under ArtsHERE—a new pilot program in partnership with South Arts and in collaboration with the other five U.S. Regional Arts Organizations—designed to expand access […]

Attorney General Kathy Jennings has secured a six-month suspension from a former Delaware investment adviser for viewing current financial account information of former Delaware clients while unregistered. The Investor Protection Unit (the “Unit”), the state securities regulator for Delaware, received a complaint from a former client of Robert Brandon Prettyman, an unregistered investment advisor that the Unit had previously suspended for making false statements […]

Kindergarteners across Delaware are participating in the Kindergarten Oral Health Screening Program for the first time this school year, provided by the Bureau of Oral Health and Dental Services (BOHDS) within the Delaware Division of Public Health (DPH). This new annual program is intended to improve the oral health of Delaware children and prepare them for […]

Samsung has an early Black Friday deal for its accessories and wearables, so don’t miss out if you want some savings!

The post INCREDIBLE early Black Friday deal saves you on Samsung wearables and accessories! appeared first on Phandroid.

Have you ever thought of a handy utility to specify all necessary transmission line parameters to decide upon the stackup?   

Starting SPB 23.1, a handy feature Transmission Line Calculator, is built into Allegro X Advanced Package Designer (Allegro X APD). This feature will require either an SiP Layout license or can be accessed through SiP Layout Bundle. 

From the Analyze dropdown menu in the 23.1 Allegro X APD toolbar, you can choose Transmission Line Calculator. 

You can use this calculator to help decide constraints and stackup for laminate-based PCB or Packages. You can calculate the correct stackup material and width/spacing to meet any requirements that may be later entered in a constraint. This is truly a calculated number and not a true field solver. 

The different types of calculations that the Transmission Line Calculator can provide are Microstrip, Embedded microstrip, Stripline, CPW (Coplanar), FGCPW (frequency-dependent Coplanar), Asymmetric stripline, Coupled microstrip (Differential Pair), Coupled stripline (Differential Pair), and Dual striplines. 

This feature is important for customers relying on fabricators/spreadsheets to provide this information or need to test a quick spacing/width as per the impedance value. 

Let us know your comments on this new feature in 23.1 Allegro X APD. 

Hello,

I'm reading the Design specification for IP6514E.

We will use the DAC mode.

It would seem to be very simple but I don't see any code sequence, i.e.

  1.Write 03(Basic Read) to this register

  2, Write start adress to this register

  3. Write "execute" to this register

  4. Read the data from this register

Thanks,

Stefan

I have tried replicating the setup described in a previous post (here), with the proposed solution.

The MDL measurements return a value of 0 for all exported result but the first.

Using Viva I can actually see the correct value for each contribution.

I am using :
- Spectre 23.1.0.538.isr10
- Viva IC23.1-64b.ISR8.40

What should I do differently?

Thanks!

**** test.measure ****

Measurement Name   :  noi_test
Analysis Type      :  noise
noi_total             =  6.9282e-06
r1_flicker            =  0
r1_thermal            =  0
r1_total              =  0
r2_flicker            =  0
r2_thermal            =  0
r2_total              =  0