In this episode of the Brave Commerce podcast, hosts Rachel Tipograph, founder and CEO of MikMak, and Sarah Hofstetter, president of Profitero, sit down with Meghan Archer, vice president of digital commerce at PepsiCo. Archer shares her unique career journey from consumer electronics at T-Mobile, to a dynamic decade at Amazon, to her current role...

Greg Loman spent his youth playing music at a time when “grunge was kind of at its peak.” After listening to the tunes of Alice in Chains, he stopped the late-night Nintendo gaming sessions and decided to take his music playing to another level…

Cryptocurrency markets are trading higher as meme coins Pepe and Dogwifhat were listed for trading on Coinbase COIN. Notable Statistics: - IntoTheBlock data shows large transaction volume increased by 18.7% and daily active addresses growing by 7.8%. Transactions greater than $100,000 are up from…

A new meme coin on Solana, Peanut the Squirrel, has surged over the past 24 to 48 hours towards its… Continue reading PNUT Jumps Over 300% Today – Best Time to Buy, or Could $PEPU Offer Higher Returns?

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Pepe Unchained has raised over $28 million in its presale and is rapidly making a name for itself in the… Continue reading Pepe Unchained Presale Hits $28 Million as Analysts Predict 10x Gains in Ongoing Bull Market Rally

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Coinbase has officially listed PEPE, marking a historic shift given the platform’s past controversy with the PEPE community. In May… Continue reading Coinbase Lists PEPE, Robinhood Brings Back Top Altcoins

The post Coinbase Lists PEPE, Robinhood Brings Back Top Altcoins appeared first on ReadWrite.

Wednesday 13 November 2024 – Pepe Unchained ($PEPU), the next big meme coin, has already raised $28 million in what’s shaping… Continue reading Pepe Unchained (PEPU) Sees Whale Interest as the Largest Meme Coin Presale Nears Its End in 30 Days

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Pepe has recently experienced a price rally, fueled by both increased market capitalization and a remarkable surge in the trading… Continue reading This Trader Predicted The Pepe Coinbase Listing: What Meme Coins Is He Watching Next

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Peperdure schoenenroof: ex-werkneemster Louboutin zou voor 1,5 miljoen euro artikelen illegaal hebben verkocht  Het Laatste Nieuws

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Not going to lie, think I'm a touch melancholy when it comes to this installment of Peppa Pig. I've reviewed several of these titles for "The Talk" already, largely because my son has liked seeing them and has a little bit of the merchandise from the show. However, I think we may have moved on a little? Someone has started taking note of different shows on Nick Jr., and I'm not sure how to handle it.

Anyway, Peppa Pig The Easter Bunny is a collection of self-explanatory episodes around Easter and the Easter bunny. The web shorts run about 5-6 minutes each and don't overstay their welcome, running just over one hour in total. Ranging from Series 3-5, they get into all of the members of Peppa's family (Daddy and Mommy Pig and Peppa's little brother ...Read the entire review

Manuel De Lorenzi e Pepe @ Clickhouse Party (Mc) - report by Shy

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Washington – A pilot program that provides prison workers with pepper spray as a safety measure has been expanded to six additional correctional facilities.

"Whether you're a member or the chairperson, you can add energy and life to the committee in a number of ways," says safety pro turned motivational speaker Richard Hawk.

Siete products will bring a rich, new aspect to the PepsiCo multicultural portfolio with food that plays an important role in meal occasions and culinary experiences.

The protein trend has promised to continue at a steady pace, with interest in, and consumption of, plant proteins increasing at record levels. This is due in large part to the rapid expansion in consumer demand for meat, dairy, and seafood analogs. But alongside the growth in protein as a whole ingredient, the various parts that make up a protein molecule are not being ignored. 

Each variety offers a burst of authentic Italian taste that complements a diverse array of dishes, from al dente pasta and paninis to crostini, pizza, poultry, seafood and beyond. Barilla Pesto is ready to enjoy.

HORMEL® Pepperoni Confetti stands out with its unique ribbon shape, designed for even distribution across a pizza and allowing for maximum pepperoni goodness in every bite. 

PeptiStrong™ by Nuritas, the leader in AI-based peptide discovery, is a clinically proven, fava bean ingredient that serves as an advanced plant-based solution for boosting muscle protein synthesis, reducing muscle protein breakdown, and decreasing exercise-induced inflammation. 

Pepperoni fans can enjoy all the flavors of APPLEGATE NATURALS® pepperoni, now in new, organic options. 

GHOST's net sales have more than quadrupled over the past three years, and GHOST Energy is one of the fastest-growing brands in the energy category, characterized by its unique identity, distinctive flavors and packaging, and strong consumer appeal.  

By leveraging Einride's offering of connected electric trucks, charging infrastructure and digital freight platform that optimizes operations with data-driven insights, PepsiCo aims to reduce its Scope 3 emissions.

Keurig Dr Pepper’s 1.5-million-sq.-ft. production facility and distribution center in Allentown, Pa., has been named the 2021 Food Engineering Plant of the Year. Cuisine Solutions was named winner of the 2021 Sustainable Plant of the Year for its plant in San Antonio.

Keurig Dr Pepper wins the 2021 Food Engineering Plant of the Year award for its production facility and regional distribution center in Allentown, Pennsylania.

PepsiCo has moved up from #2 to take the top spot. The company reported a 20.5% increase in net revenue in its Q2 results, raising its full-year guidance for organic revenue growth. 

PepsiCo said investments made in its brands, consumer insights, manufacturing and go-to-market execution are fueling growth across the portfolio.

Most people have likely never heard of The Hausbeck Pickle Co. in Saginaw, MI, but there’s a good chance they’ve had one of its pickles, banana peppers or jalapeños.

PBNA tripled its local warehouse footprint with the relocation of its former downtown Nashville distribution warehouse facility.

PepsiCo says the acquisition will complement its portfolio with the addition of an authentic, Mexican-American brand, while also growing its better-for-you food offerings.

KDP will initially purchase a 60% stake in GHOST, which will be followed by the acquisition of the remaining 40% stake in 2028.

On March 8, McDonald's fast food restaurant chain announced a temporary closure of all of its restaurants in Russia. It goes about 850 outlets that employ 62,000 employees. McDonald's CEO Chris Kempczinski said that employees would still be paid their salaries during this period, but did not specify for how long and in what amount. McDonalds' decided to suspend its activities in Russia due to the ongoing crisis in Ukraine as the company cannot ignore the human suffering. Starbucks coffee chain made a similar decision the same day. Starbucks CEO Kevin Johnson said that all activities in Russia were suspended, including all shipments of all products.

Hot peppers are tasty and nutritious fruits (not vegetables!) that create a spicy sensation on your tastebuds. They have been a staple of spicy foods for thousands of years, but in the last half-century, scientists have developed advanced cross-breeding techniques to craft the hottest pepper in the world — hotter than nature would concoct on its own.

Brucella ovis is an etiologic agent of ovine epididymitis and brucellosis that causes global devastation in sheep, rams, goats, small ruminants and deer. There are no cost-effective methods for the worldwide eradication of ovine brucellosis. B. ovis and other protein targets from various Brucella species are currently in the pipeline for high-throughput structural analysis at the Seattle Structural Genomics Center for Infectious Disease (SSGCID), with the aim of identifying new therapeutic targets. Furthermore, the wealth of structures generated are effective tools for teaching scientific communication, structural science and biochemistry. One of these structures, B. ovis leucine-, isoleucine-, valine-, threonine- and alanine-binding protein (BoLBP), is a putative periplasmic amino acid-binding protein. BoLBP shares less than 29% sequence identity with any other structure in the Protein Data Bank. The production, crystallization and high-resolution structures of BoLBP are reported. BoLBP is a prototypical bacterial periplasmic amino acid-binding protein with the characteristic Venus flytrap topology of two globular domains encapsulating a large central cavity containing the peptide-binding region. The central cavity contains small molecules usurped from the crystallization milieu. The reported structures reveal the conformational flexibility of the central cavity in the absence of bound peptides. The structural similarity to other LBPs can be exploited to accelerate drug repurposing.

The methanol-to-hydrocarbons (MTH) process involves the conversion of methanol, a C1 feedstock that can be produced from green sources, into hydrocarbons using shape-selective microporous acidic catalysts – zeolite and zeotypes. This reaction yields a complex mixture of species, some of which are highly reactive and/or present in several isomeric forms, posing significant challenges for effluent analysis. Conventional gas-phase chromatography (GC) is typically employed for the analysis of reaction products in laboratory flow reactors. However, GC is not suitable for the detection of highly reactive intermediates such as ketene or formaldehyde and is not suitable for kinetic studies under well defined low pressure conditions. Photoelectron–photoion coincidence (PEPICO) spectroscopy has emerged as a powerful analytical tool for unraveling complex compositions of catalytic effluents, but its availability is limited to a handful of facilities worldwide. Herein, PEPICO analysis of catalytic reactor effluents has been implemented at the FinEstBeAMS beamline of MAX IV Laboratory. The conversion of dimethyl ether (DME) on a zeolite catalyst (ZSM-5-MFI27) is used as a prototypical model reaction producing a wide distribution of hydrocarbon products. Since in zeolites methanol is quickly equilibrated with DME, this reaction can be used to probe vast sub-networks of the full MTH process, while eliminating or at least slowing down methanol-induced secondary reactions and catalyst deactivation. Quantitative discrimination of xylene isomers in the effluent stream is achieved by deconvoluting the coincidence photoelectron spectra.

An X-ray absorption spectroscopy (XAS) electrochemical cell was used to collect high-quality XAS measurements of N-truncated Cu:amyloid-β (Cu:Aβ) samples under near-physiological conditions. N-truncated Cu:Aβ peptide complexes contribute to oxidative stress and neurotoxicity in Alzheimer's patients' brains. However, the redox properties of copper in different Aβ peptide sequences are inconsistent. Therefore, the geometry of binding sites for the copper binding in Aβ4–8/12/16 was determined using novel advanced extended X-ray absorption fine structure (EXAFS) analysis. This enables these peptides to perform redox cycles in a manner that might produce toxicity in human brains. Fluorescence XAS measurements were corrected for systematic errors including defective-pixel data, monochromator glitches and dispersion of pixel spectra. Experimental uncertainties at each data point were measured explicitly from the point-wise variance of corrected pixel measurements. The copper-binding environments of Aβ4–8/12/16 were precisely determined by fitting XAS measurements with propagated experimental uncertainties, advanced analysis and hypothesis testing, providing a mechanism to pursue many similarly complex questions in bioscience. The low-temperature XAS measurements here determine that CuII is bound to the first amino acids in the high-affinity amino-terminal copper and nickel (ATCUN) binding motif with an oxygen in a tetragonal pyramid geometry in the Aβ4–8/12/16 peptides. Room-temperature XAS electrochemical-cell measurements observe metal reduction in the Aβ4–16 peptide. Robust investigations of XAS provide structural details of CuII binding with a very different bis-His motif and a water oxygen in a quasi-tetrahedral geometry. Oxidized XAS measurements of Aβ4–12/16 imply that both CuII and CuIII are accommodated in an ATCUN-like binding site. Hypotheses for these CuI, CuII and CuIII geometries were proven and disproven using the novel data and statistical analysis including F tests. Structural parameters were determined with an accuracy some tenfold better than literature claims of past work. A new protocol was also developed using EXAFS data analysis for monitoring radiation damage. This gives a template for advanced analysis of complex biosystems.

Human peptidylarginine deiminase isoform VI (PAD6), which is predominantly limited to cytoplasmic lattices in the mammalian oocytes in ovarian tissue, is essential for female fertility. It belongs to the peptidylarginine deiminase (PAD) enzyme family that catalyzes the conversion of arginine residues to citrulline in proteins. In contrast to other members of the family, recombinant PAD6 was previously found to be catalytically inactive. We sought to provide structural insight into the human homologue to shed light on this observation. We report here the first crystal structure of PAD6, determined at 1.7 Å resolution. PAD6 follows the same domain organization as other structurally known PAD isoenzymes. Further structural analysis and size-exclusion chromatography show that PAD6 behaves as a homodimer similar to PAD4. Differential scanning fluorimetry suggests that PAD6 does not coordinate Ca2+ which agrees with acidic residues found to coordinate Ca2+ in other PAD homologs not being conserved in PAD6. The crystal structure of PAD6 shows similarities with the inactive state of apo PAD2, in which the active site conformation is unsuitable for catalytic citrullination. The putative active site of PAD6 adopts a non-productive conformation that would not allow protein–substrate binding due to steric hindrance with rigid secondary structure elements. This observation is further supported by the lack of activity on the histone H3 and cytokeratin 5 substrates. These findings suggest a different mechanism for enzymatic activation compared with other PADs; alternatively, PAD6 may exert a non-enzymatic function in the cytoplasmic lattice of oocytes and early embryos.

This work focuses on molecules that are encoded by the major histocompatibility complex (MHC) and that bind self-, foreign- or tumor-derived peptides and display these at the cell surface for recognition by receptors on T lymphocytes (T cell receptors, TCR) and natural killer (NK) cells. The past few decades have accumulated a vast knowledge base of the structures of MHC molecules and the complexes of MHC/TCR with specificity for many different peptides. In recent years, the structures of MHC-I molecules complexed with chaperones that assist in peptide loading have been revealed by X-ray crystallography and cryogenic electron microscopy. These structures have been further studied using mutagenesis, molecular dynamics and NMR approaches. This review summarizes the current structures and dynamic principles that govern peptide exchange as these relate to the process of antigen presentation.

The aberrant fibrillization of huntingtin exon 1 (Httex1) characterized by an expanded polyglutamine (polyQ) tract is a defining feature of Huntington's disease, a neurodegenerative disorder. Recent investigations underscore the involvement of a small EDRK-rich factor 1a (SERF1a) in promoting Httex1 fibrillization through interactions with its N terminus. By establishing an integrated approach with size-exclusion-column-based small- and wide-angle X-ray scattering (SEC-SWAXS), NMR, and molecular simulations using Rosetta, the analysis here reveals a tight binding of two NT17 fragments of Httex1 (comprising the initial 17 amino acids at the N terminus) to the N-terminal region of SERF1a. In contrast, examination of the complex structure of SERF1a with a coiled NT17-polyQ peptide (33 amino acids in total) indicates sparse contacts of the NT17 and polyQ segments with the N-terminal side of SERF1a. Furthermore, the integrated SEC-SWAXS and molecular-simulation analysis suggests that the coiled NT17 segment can transform into a helical conformation when associated with a polyQ segment exhibiting high helical content. Intriguingly, NT17-polyQ peptides with enhanced secondary structures display diminished interactions with SERF1a. This insight into the conformation-dependent binding of NT17 provides clues to a catalytic association mechanism underlying SERF1a's facilitation of Httext1 fibrillization.

The oxidation of me­thionyl peptides can contribute to increased biological (oxidative) stress and development of various inflammatory diseases. The conformation of peptides has an important role in the mechanism of oxidation and the inter­mediates formed in the reaction. Herein, the crystal structures of the isomeric dipeptides Gly-Met (Gly = glycine and Met = me­thio­nine) and Met-Gly, both C7H14N2O3S, are reported. Both mol­ecules exist in the solid state as zwitterions with nominal proton transfer from the carb­oxy­lic acid to the primary amine group. The Gly-Met mol­ecule has an extended backbone structure, while Met-Gly has two nearly planar regions kinked at the C atom bearing the NH3 group. In the crystals, both structures form extensive three-dimensional hydrogen-bonding networks via N—H⋯O and bifurcated N—H⋯(O,O) hydrogen bonds having N⋯O distances in the range 2.6619 (13)–2.8513 (13) Å for Gly-Met and 2.6273 (8)–3.1465 (8) Å for Met-Gly.

Rwanda’s Human Resources for Health (HRH) Program – funded in part by the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) from 2012 to 2017 – more than tripled the country’s physician specialist workforce and produced major increases in the numbers and qualifications of nurses and midwives, says a new report from the National Academies of Sciences, Engineering, and Medicine.

It’s time for seasoned greetings at Dunkin’ Donuts!

The brand is introducing new flavors across categories and dayparts, including April's pancake of the month and new Sonic the Hedgehog partnership.

To celebrate the holiday season, The Cheesecake Factory welcomes back its festive Peppermint Bark Cheesecake. 

The brand is bringing its Milano Pumpkin Spice Cookies and Pepperidge Farm Pumpkin Spice Swirl Bread back to shelves this fall.

Genio’s Uncured Pepperoni Pizza is handmade in Italy using ingredients such as locally grown tomatoes, buffalo mozzarella, hand torn Ligurian basil, and uncured pepperoni.

Old El Paso is taking the flavor intensity up a notch this fall with its new Takis Fuego-inspired Hot Chili Pepper and Lime-Flavored Stand 'N Stuff Taco Shells.

Limagrain Ingredients has developed Pep's Balls: a new range of extruded pulses to enrich products with plant-based proteins, without any compromise on taste and offering a great mouthfeel.