(Telecompaper) Spanish rural broadband providers Adamo and Avatel as well as MasOrange have secured the majority of the funds made available under the government's Unico Broadband 2024 call...
Este martes, al volver a llenar los pasillos, nos buscamos unos a otros con la mirada. "¿Estás bien?", nos preguntábamos entre los profes. "¿Cómo os sentís?", repetíamos dentro de las aulas. Una extrañeza tristísima nos atravesaba Leer
Carmen Pellicer organiza una red de solidaridad por toda España. "No es fácil sostener la solidaridad en el tiempo", admite Leer
Radio Liechtenstein acapara más del 70% de la financiación del estado para los medios, lo que le da una ventaja injustificada Leer
Panelistas consideran que, si bien siempre han existido, fenómenos como cambio climático y la densidad poblacional influyen en las recientes apariciones masivas.
Panelistas debatieron sobre cómo logran mayor impacto con las alertas tempranas e interlocución con las instituciones del Estado. También analizaron la crisis con el ELN.
Escuche el programa de este miércoles 27 de marzo. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.
Iris Marin, Defensora del Pueblo, habló en 10AM Hoy por Hoy, cobre los retos al frente de la entidad y las declaraciones realizadas por el presidente Gustavo Petro.
6AM Hoy por Hoy habló con Adriana Martínez Ardila para corrobar si es cierta la denuncia en la que aseguran que es la hermana del funcionario del CTI de la Fiscalía en Buenaventura, a quien han acusado de narcotráfico.
Decisiones del gobierno tienen en riesgo la atención en salud del magisterio. La crisis, como informó Caracol Radio en las últimas horas, estallaría en los próximos días.
En 6AM Hoy por Hoy de Caracol Radio estuvo Luis Guillermo Vélez, exsuperintendente de Sociedades, para hablar sobre cómo impactará la publicación de la actividad contractual en el SECOP de la UNGRD y Fiduprevisora.
Dereck Chisora appeals against the withdrawal of his licence by the British Boxing Board of Control.
Adobe is venturing into generative AI for video with its Firefly Video Model, which was first hinted at earlier this year. This model is now being integrated into new tools, including some within Premiere Pro. These tools enable users to extend
The present invention provides compounds for the inhibition of soluble epoxide hydrolase and associated disease conditions.
Bela D Media has announced the release of Native Voice Sora, a Kontakt instrument library featuring vocal phrases by a soprano solo voice. Broken into a four part series, Bela D Media has reinvented a classic vocal library. Originally recorded in 2009 by producer Rishabh Rajan Native Voice – with advanced scripting control and remastered […]
The post Bela D Media releases Native Voice Sora vocal Kontakt library appeared first on rekkerd.org.
(United States Second Circuit) - Affirmed the denial of a motion to dismiss based on foreign sovereign immunity under the Foreign Sovereignty Immunity Act in a securities lawsuit filed by the shareholder of an Argentine petroleum company against the Argentine Republic which held a majority of shares in the company. In affirming the denial and rejecting the claim of sovereign immunity, the appeals court noted that the plaintiff was seeking relief for injuries caused by commercial, rather than sovereign, activity.
(United States Second Circuit) - Affirmed the denial of a motion to dismiss based on foreign sovereign immunity under the Foreign Sovereignty Immunity Act in a securities lawsuit filed by the shareholder of an Argentine petroleum company against the Argentine Republic which held a majority of shares in the company. In affirming the denial and rejecting the claim of sovereign immunity, the appeals court noted that the plaintiff was seeking relief for injuries caused by commercial, rather than sovereign, activity.
IBM (NYSE: IBM) et Boursorama, filiale du groupe Société Générale, renouvellent leur accord par la signature d’un contrat de Cloud hybride d’une durée de 5 ans afin d’enrichir l'offre de nouveaux produits et services proposés par la banque.
In randomized clinical trials (RCTs), no survival benefit has been observed for selective internal radiotherapy (SIRT) over sorafenib in patients with advanced hepatocellular carcinoma (aHCC). This study aimed to assess by means of a meta-analysis whether overall survival (OS) with SIRT, as monotherapy or followed by sorafenib, is non-inferior to sorafenib, and compare safety profiles for patients with aHCC. Methods: We searched MEDLINE, EMBASE, and the Cochrane Library up to February 2019 to identify RCTs comparing SIRT as monotherapy, or followed by sorafenib, to sorafenib monotherapy among patients with aHCC. The main outcomes were OS and frequency of treatment-related severe adverse events (AEs grade ≥3). The per-protocol population was the primary analysis population. A non-inferiority margin of 1.08 in terms of hazard ratio (HR) was pre-specified for the upper boundary of 95% confidence interval (CI) for OS. Pre-specified subgroup analyses were performed. Results: Three RCTs, involving 1,243 patients, comparing sorafenib with SIRT (SIRveNIB and SARAH) or SIRT followed by sorafenib (SORAMIC), were included. After randomization, 411/635 (64.7%) patients allocated to SIRT and 522/608 (85.8%) allocated to sorafenib completed the studies without major protocol deviations. Median OS with SIRT, whether or not followed by sorafenib, was non-inferior to sorafenib (10.2 and 9.2 months, [HR 0.91, 95% CI 0.78–1.05]). Treatment-related severe adverse events were reported in 149/515 patients (28.9%) who received SIRT and 249/575 (43.3%) who received sorafenib only (p<0.01). Conclusion: SIRT as initial therapy for aHCC is non-inferior to sorafenib in terms of OS, and offers a better safety profile.
Long noncoding RNAs (lncRNA) have been found to play critical roles in tumorigenesis and the development of various cancers, including hepatocellular carcinoma (HCC). Metastasis associated with lung adenocarcinoma transcript-1 (MALAT1) has been identified as an oncogene and prognostic biomarker in HCC. Here, we demonstrated that MALAT1 expression was obviously high in sorafenib-resistant HCC cells. Furthermore, knockdown of MALAT1 increased sorafenib sensitivity in nonresponsive HCC cells, whereas forced expression of MALAT1 conferred sorafenib resistance to responsive HCC cells in vitro. In addition, loss/gain-of-function assays revealed that MALAT1 promoted cell proliferation, migration, and epithelial–mesenchymal transition in HCC cells. Mechanistically, MALAT1 regulated Aurora-A expression by sponging miR-140-5p, thus promoting sorafenib resistance in HCC cells. Moreover, MALAT1 inhibition enhanced the antitumor efficacy of sorafenib in vivo. Clinically, we found that MALAT1 expression was negatively correlated with miR-140-5p expression but positively correlated with Aurora-A expression in patients with HCC and that upregulated MALAT1 was closely correlated with poor survival outcomes in patients with HCC. These findings indicated that MALAT1 may be a novel target for prognosis prediction and therapeutic strategies in patients with HCC treated with sorafenib.
JEFF POWELL COLUMN: Dereck Chisora prefaced his Saturday night fight at the O2 by sending an Instagram cartoon to Eddie Hearn of his promoter preparing to stab him in the back.
Joseph Parker has finally received an offer to fight Derek Chisora in London this October, according to manager David Higgins. He is ready to accept terms despite 'frustrating communication''.
David Haye (left) believes Dereck Chisora (right) can go on to a world heavyweight title challenge if he wins his KO shoot-out with David Price on Saturday night.
David Haye has revealed that discussions are taking place for Dereck Chisora to face Oleksandr Usyk in a February blockbuster at the 02 Arena.
EDDIE HEARN: You probably have seen the video of Dereck Chisora and Dillian Whyte going at each other. That's made us think very carefully about how put them face to face in the build up to their fight.
EDDIE HEARN: There is a fine line between hyping a fight and going against the codes of conduct of the sport. Dereck Chisora went too far and now there will be a British Boxing Board of Control meeting.
Chisora and Usyk were initially pencilled in to fight later this month but a deal was re-agreed back in February and promoter Eddie Hearn confirmed the fight is now official for May 23.
David Haye has revealed that Derek Chisora's sparring partners will all be 'quarantined' inside one flat to help ensure his clash with Oleksandr Usyk does not succumb to coronavirus.
JEFF POWELL: Chisora knows there is likely to be a log-jam once the UK opens up to a staging of Anthony Joshua's defence of his belts and Dillian Whyte's attempt to cement his challenger position.
The Matchroom Boxing chief has seen his business severely affected due to the escalating pandemic, after the British Boxing Board of Control put a halt to fights amid concern for safety.
Interview with F. Christopher Holsinger, MD, author of A Next-Generation Single-Port Robotic Surgical System for Transoral Robotic Surgery: Results From Prospective Nonrandomized Clinical Trials