Amid the ongoing civil unrest in Haiti due to gang violence, levels of internal displacement have soared. Mass internal displacements in Haiti have led to a host of adverse consequences. This includes a disruption of schooling, increased levels of violence and exploitation, and limited access to essential services such as healthcare. Just last week, clashes […]

It was two weeks before October 7—when Hamas attacked Israel—that Prime Minister Benjamin Netanyahu stood behind the rostrum in the United Nations General Assembly hall clutching a crude map of what he called the “new Middle East,” a visual that erased the land of Palestine. A year later, Israel’s retaliatory war in Gaza has accelerated, […]

He is one of the most famous composers of our time. His compositions are heard in the greatest music halls in the world and now, the chamber music studio The Symphonians, is bringing Ludovico Einaudi’s music to life in Limassol. A special concert is planned for November 20 as Pattichio Theatre welcomes an ensemble to […]

How did the supermassive black holes we’re now seeing in the early universe get so big so fast? Astrophysicist Sophie Koudmani is using sophisticated galaxy simulations to figure it out

Researchers have reshaped single electrons into spiralling matter waves with distinct handedness that could be used to study and control materials

Inside a hunk of a material called a semimetal, scientists have uncovered signatures of bizarre particles that sometimes move like they have no mass, but at other times move just like a very massive particle

Chris Packham's new BBC series, Earth, looks at significant moments in Earth's history, including anthropogenic climate change and biodiversity loss, "It's not a sixth mass extinction event that we're precipitating," he says, "it's a mass extermination event"

Inside a hunk of a material called a semimetal, scientists have uncovered signatures of bizarre particles that sometimes move like they have no mass, but at other times move just like a very massive particle

Title: One-Third of Mass Shootings Worldwide Occur in U.S.
Category: Health News
Created: 8/23/2015 12:00:00 AM
Last Editorial Review: 8/24/2015 12:00:00 AM

Massively parallel reporter assays (MPRAs) are powerful tools for quantifying the impacts of sequence variation on gene expression. Reading out molecular phenotypes with sequencing enables interrogating the impact of sequence variation beyond genome scale. Machine learning models integrate and codify information learned from MPRAs and enable generalization by predicting sequences outside the training data set. Models can provide a quantitative understanding of cis-regulatory codes controlling gene expression, enable variant stratification, and guide the design of synthetic regulatory elements for applications from synthetic biology to mRNA and gene therapy. This review focuses on cis-regulatory MPRAs, particularly those that interrogate cotranscriptional and post-transcriptional processes: alternative splicing, cleavage and polyadenylation, translation, and mRNA decay.

Exogenous substances, including drugs and chemicals, can transfer into human seminal fluid and influence male fertility and reproduction. In addition, substances relevant in the context of sports drug testing programs, can be transferred into the urine of a female athlete (after unprotected sexual intercourse) and trigger a so-called adverse analytical finding. Here, the question arises as to whether it is possible to distinguish analytically between intentional doping offenses and unintentional contamination of urine by seminal fluid. To this end, 480 seminal fluids from nonathletes were analyzed to identify concentration ranges and metabolite profiles of therapeutic drugs that are also classified as doping agents. Therefore, a screening procedure was developed using liquid chromatography connected to a triple quadrupole mass spectrometer, and suspect samples (i.e., samples indicating the presence of relevant compounds) were further subjected to liquid chromatography-high-resolution accurate mass (tandem) mass spectrometry. The screening method yielded 90 findings (including aromatase inhibitors, selective estrogen receptor modulators, diuretics, stimulants, glucocorticoids, beta-blockers, antidepressants, and the nonapproved proliferator-activated receptor delta agonist GW1516) in a total of 81 samples, with 91% of these suspected cases being verified by the confirmation method. In addition to the intact drug, phase-I and -II metabolites were also occasionally observed in the seminal fluid. This study demonstrated that various drugs including those categorized as doping agents partition into seminal fluid. Monitoring substances and metabolites may contribute to a better understanding of the distribution and metabolism of exogenous substances in seminal fluid that may be responsible for the impairment of male fertility.

A STING (stimulator of interferon genes) agonist GSK3996915 under investigation in early discovery for hepatitis B was orally dosed to a mouse model for understanding the parent drug distribution in liver, the target organ. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) was used to quantify the distribution of GSK3996915 in liver collected from mice administered a single oral dose at 90 mg/kg. GSK3996915 was detected with a zonal distribution localized in the portal triad and highly concentrated in the main bile ducts, indicating clearance through biliary excretion. High spatial resolution imaging showed the distribution of the parent drug localized to the cellular populations in the sinusoids, including the Kupffer cells. Additionally, a series of drug-related metabolites were observed to be localized in the central zones of the liver. These results exemplify the potential of utilizing MALDI IMS for measuring not only quantitative drug distribution and target exposure but also drug metabolism and elimination in a single suite of experiments.

At least 231 people were killed and hundreds more wounded after a massive truck bomb on Saturday struck Somalia’s capital city of Mogadishu.

The Somali government has blamed the al-Qaida-linked militant group al-Shabab for the attack, and called it the deadliest ever to hit the nation.

The blast took place outside the Safari Hotel, where rescue workers dug through the rubble of collapsed buildings overnight in search of survivors. Witnesses described a devastating scene with large-scale carnage, as doctors worked feverishly to attend to the dead and injured, many badly burned.

“The hospital is overwhelmed by both dead and wounded,” Dr. Mohamed Yusuf, the director of Medina hospital located near the blast, told the Associated Press. “We also received people whose limbs were cut away by the bomb. This is really horrendous, unlike any other time in the past.”

Photos and videos of the bombing, which took place on a busy street near a section of the city housing foreign embassies, showed collapsed walls, twisted metal, and sporadic fires spewing smoke. The Qatari government said its embassy was “severely damaged” in the strike.

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Family members searched through the wreckage and waited at local hospitals with the hopes of finding relatives who survived the bombing.

Somali President Mohamed Abdullahi Mohamed announced three days of mourning. The attacks received international condemnation, including from the United States.

The post Hundreds dead after massive truck bomb strikes Mogadishu appeared first on PBS NewsHour.

World-building, identity and decolonising spaces in the digital and offline realms.

The post Interview: Gabriel Massan & LYZZA appeared first on Fact Magazine.

A TV series based on the video game series Mass Effect is officially in development at Amazon, according to a report from Variety.

F9: The Fast Saga writer Daniel Casey will write and be an executive producer on the series. Karim Zreik will also be an executive producer under his Cedar Tree Productions, which is under an overall deal at Amazon.

Ari Arad and BioWare's Michael Gamble will also be executive producers. Arad previously was a producer on other video game adaptations - Borderlands and Uncharted.

Developer BioWare is developing a new entry in the Mass Effect series. 

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463013/mass-effect-tv-series-has-been-greenlit-by-amazon/

Journalists at CNN, including some of the network’s biggest personalities, are living in fear of “inevitable” layoffs and pay cuts as its new CEO looks to shore up finances amid declining ratings.

That’s according to The Ankler, which reported Wednesday that 77-year-old Chris Wallace—whose already been relegated to a weekend program—is among the network’s most well-known names whose future is in limbo.

Wallace’s $8.5 million contract, signed by the ex-CNN boss Jeff Zucker to recruit him away from Fox News three years ago, is reportedly up and he was spotted in CEO Mark Thompson’s office on Tuesday.

Read more at The Daily Beast.

BioWare currently has no plans for Dragon Age: The Veilguard expansions, according to reports. Instead the studio will support the fantasy RPG with smaller updates and otherwise turn their full attention towards Mass Effect 5.

Read more

Back in the mists of 2021, No Man's Sky revealed its very own Normandy SR1 space frigate. "The Normandy in No Man's Sky?" you cry. "Why, that's a Mass Effect vessel. Some mistake here surely?" 1) My name's not Shirley, and 2) Indeed it is a Mass Effect ship, but HelloGames struck a time-limited deal with BioWare to create a version for their own space sim.

"Blast, if only I'd noticed this at the time and acquired one," you mourn. "Ah, so many years I have wasted." Be of good cheer, my friend, for No Man's Sky has a Normandy once again, just in time for the latest N7 Day of assorted Mass Effect celebrations. For the next two weeks, you'll be able to get a-hold of it by way of a revised version of 2021's Beachhead Expedition. Tray-tray, away!

Read more

How did the supermassive black holes we’re now seeing in the early universe get so big so fast? Astrophysicist Sophie Koudmani is using sophisticated galaxy simulations to figure it out

It's hard to imagine opposing Trump's proposal. Who would want to help murderers and drug dealers who entered the country illegally remain in the United States?

Fisheries and Oceans Canada whale researchers recently spotted one of the largest pods of orca whales ever reported off the coast of Newfoundland and Labrador.

Fast Radio Bursts (FRBs) are millisecond-duration events detected from beyond our Milky Way Galaxy.

The post Fast Radio Bursts Mostly Come from Massive Star-Forming Galaxies appeared first on Sci.News: Breaking Science News.

Immigration and Customs Enforcement has arrested another illegal immigrant charged with child sex offenses, as the state's governor says police won't help the Trump administration.

Fox News host Sean Hannity says the "decentralization of power as our founders intended is very much on its way to DC."

Xbox hardware sales dropped 29 percent, but that barely made a dent.

The pedigree of the producers and writers involved is cause for concern, though.

The actor, who stars in the upcoming film ‘The Sabarmati Report’, based on the 2002 Godhra train burning incident, emphasised his secular credentials while saying that his perspective on the state of the nation has shifted in the last ten years

Summer holidays might be over, but fans of Gunship Battle: Total Warfare are still in for a treat as Joycity …

Continue reading "‘Gunship Battle: Total Warfare’ Launches Massive Sky Ace Update"

The state’s vote to abolish its high-school exit exam keeps us from knowing how well they’re educating students — which is just how teachers’ unions like it.

During a recent panel, experts discussed the Massachusetts Child Psychiatry Access Program (MCPAP) for Moms and how it achieved scale.

The post How One Massachusetts Maternal Mental Health Program Scaled Across the Country appeared first on MedCity News.

Jun 26, 2024

The first-ever town-level spatial analysis of the effect of heat pump adoption on residential heating bills finds that air-source heat pump adoption will increase heating costs for approximately half of all Massachusetts households due to high electricity prices, challenging the state’s ability to achieve its recently announced ambitions for heat pump adoption.

Donald Trump has made the mass deportation of immigrants a centerpiece of his plans for a second term, vowing to forcibly remove as many as 20 million people from the country. Historian Ana Raquel Minian, who studies the history of immigration, says earlier mass deportation programs in the 1930s and '50s led to widespread abuse, tearing many families apart through violent means that also resulted in the expulsion of many U.S. citizens. “These deportations that Trump is claiming that he will do will have mass implications to our civil rights, to our communities and to our economy, and of course to the people who are being deported themselves,” says Minian. She also says that while Trump's extremist rhetoric encourages hate and violence against vulnerable communities, in terms of policy there is great continuity with the Biden administration, which kept many of the same policies in place.

President-elect Donald Trump reportedly plans to appoint his former senior adviser Stephen Miller as his deputy chief of staff for policy. Miller will play a key role along with Trump’s border czar Tom Homan and South Dakota Governor Kristi Noem, who will reportedly be the secretary of the Department of Homeland Security. Miller is the architect of Trump’s anti-immigrant agenda, an avowed white nationalist and a man who is spurred by his “animus to the notion of the United States as a multicultural and multiethnic democracy,” says author Jean Guerrero, author of Hatemonger: Stephen Miller, Donald Trump, and the White Nationalist Agenda. Guerrero says the Trump administration’s “obsessive deportation” attempt to “radically reengineer the racial demographics of the United States” will “backfire” on the U.S. economy and destroy “the United States’ global reputation as a safe haven for the persecuted.”

Incoming President Trump’s vow to deport millions of undocumented immigrants when he starts his term has sent private prison stocks soaring. Immigrant rights advocates, including our guest, the executive director of Detention Watch Network, Silky Shah, are preparing for the Trump administration’s threats of mass deportation, a central tenet of his presidential campaign. “The first Trump campaign was defined by the border wall, and this one is really defined by mass deportations,” says Shah. If the Biden administration wants to protect immigrants’ rights before Trump takes office, she adds, it must begin reducing detention capacity by “shutting down facilities now.”

American Coup: Wilmington 1898 premieres tonight on PBS and investigates the only successful insurrection conducted against a U.S. government, when self-described white supremacist residents stoked fears of “Negro Rule” and carried out a deadly massacre in Wilmington, North Carolina. Their aim was to destroy Black political and economic power and overthrow the city’s democratically elected, Reconstruction-era multiracial government, paving the way for the implementation of Jim Crow law just two years later. We feature excerpts from the documentary and speak to co-director Yoruba Richen, who explains how the insurrection was planned and carried out, and how the filmmakers worked to track down the descendants of both perpetrators and victims, whose voices are featured in the film.

Amazon's Children's Day Store is now open, featuring an array of products specially discounted for the occasion, including top-selling Android tablets ideal for e-learning. With price reductions of up to 75% on select items such as headphones, tablets, and kids' smartwatches,

After months of speculation, the OnePlus Ace 5 is inching closer to its official debut. Leaks first surfaced in August detailing the device's display and processing power, and now a well-known tipster, Digital Chat Station, has confirmed that the smartphone is

Inside a hunk of a material called a semimetal, scientists have uncovered signatures of bizarre particles that sometimes move like they have no mass, but at other times move just like a very massive particle

The Indian healthcare sector has become a top target for hackers, experiencing an average of 6,935 cyberattacks per week in the last six months, according to a new report.

The 12th Fail actor is being heavily criticised for his recent stance on the safety of Muslims in the country. He also referred to India as the most livable country in present times.

Ahead of the release of his upcoming film "The Sabarmati Report," actor Vikrant Massey made a surprise visit at Godhra Station, which inspired the movie.

PwC’s asset management leader, Ken Woo, said Japan’s commitment to creating a regional market for managed funds represents a ‘tipping point’ in terms of momentum for the initiative.

Vikrant Massey: এক সাক্ষাত্‍কারে বিক্রান্ত বলেন, "আমাদের বুঝতে হবে যে আমরা একটি খুব তরুণ জাতি। আমরা ফরাসি, ডাচ এবং মুঘল এবং অবশেষে ব্রিটিশদের দ্বারা আক্রমণ ও শাসিত হয়েছিলাম। শত শত বছর পর নিপীড়নের শিকার হয়ে অবশেষে আমরা পেয়েছি 'সো কলড স্বাধীনতা', কিন্তু আসলে কি সেটা স্বাধীনতা?" 

Our Sun provides light, heat and the energy essential for survival. But it also has a fiery underbelly. The Sun has once again demonstrated its raw power. It has shot one of the strongest solar flares in recent history and our

All eyes will be on Gill as he prepares for the upcoming Border-Gavaskar Trophy series against Australia, beginning November 22

Dhoni is all set to play his 18th season of the marquee tournament after being retained by his franchise under the 'uncapped player category.'

This remarkable achievement came during a thrilling match against Bangladesh in Sharjah