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Will Synthetic Biology Save the World?

By www.wconline.com
Published On :: Sun, 01 Sep 2013 00:00:00 -0400

What do skin moisturizer, anti-malarial drugs and diesel fuel all have in common?


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Synthesis, crystal structure and Hirshfeld surface analysis of N-(4-methoxyphenyl)picolinamide

By journals.iucr.org
Published On :: 2024-11-14

The synthesis, crystal structure, and Hirshfeld surface analysis of N-(4-methoxyphenyl)picolinamide (MPPA), C13H12N2O2, are presented. MPPA crystallizes in the monoclinic space group P21/n, with a single molecule in the asymmetric unit. Structural analysis reveals that all non-hydrogen atoms are nearly coplanar, and the molecule exhibits two intramolecular hydrogen bonds that stabilize its conformation. Supramolecular features include significant intermolecular interactions, primarily C—H...π and various hydrogen bonds, contributing to the overall crystal cohesion, as confirmed by energy framework calculations yielding a total interaction energy of −138.3 kJ mol−1. Hirshfeld surface analysis indicates that H...H interactions dominate, followed by C...H and O...H interactions, highlighting the role of van der Waals forces and hydrogen bonding in crystal packing.


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LDN Research Trust Invites Screening of Their Documentary Demystifying Stealth Syndromes

By www.24-7pressrelease.com
Published On :: Thu, 14 Nov 2024 08:00:00 GMT

Imagine having a complex debilitating syndrome that affects nearly every part of your body. Because it's invisible, and almost nobody has heard of it, you look like a hypochondriac. Now imagine having 3 such syndromes that exacerbate one another.


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Modular synthesis: the ultimate beginner's guide

By www.musicradar.com
Published On :: 2024-11-14T07:22:42+00:00

A look into the wonderfully complex world of modular


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How to get started with Eurorack Modular Synthesizers

By riemannkollektion.com
Published On :: 2024-11-14T07:30:44+00:00


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Synth Bass: The Definitive Guide

By emastered.com
Published On :: 2024-11-14T08:26:12+00:00

Learn everything you need to know about creating killer synth bass sounds in this comprehensive guide. From the TB-303 to the MS-20, we've got you covered.


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SEMIFIVE and Synopsys Collaborate on HPC Chiplet Platform for Advanced Multi-Die Designs

By www.hpcwire.com
Published On :: Thu, 14 Nov 2024 02:26:10 +0000

SEOUL, South Korea, Nov. 13, 2024 — SEMIFIVE, a leading design solution provider and pioneer of platform-based custom silicon solutions, has announced its collaboration with Synopsys to develop a cutting-edge […]

The post SEMIFIVE and Synopsys Collaborate on HPC Chiplet Platform for Advanced Multi-Die Designs appeared first on HPCwire.


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Synduality: Ellie Spinoff Manga Ends With 2nd Volume

By www.animenewsnetwork.com
Published On :: Wed, 13 Nov 2024 18:00:00 -0500

Second volume ships on January 28


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C–H activation-enabled synthesis of a piperazine-embedded azadibenzo[a,g]corannulene analogue

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00415A, Research Article
Lin Huang, Mengyu Qiu, Zhihao Chang, Duncan L. Browne, Jianhui Huang
The first example of an azadibenzo[a,g]corannulene analogue with an embedded piperazine ring on the flank of its polycyclic skeleton is reported.
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Synthesis of 10B-enriched 2,1-borazaronaphthalenes from o-aminostyrenes and 10BF3

By pubs.rsc.org
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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00176A, Research Article
Weihua Qiu, Jide Zhu, Rencai Tao, Kai Yang, Qiuling Song
Herein we present a practical approach for preparing 10B-enriched 2,1-borazaronaphthalenes from o-aminostyrenes and 10BF3 (the primary source of boron-10) in the presence of chlorosilane.
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Synthesis of multisubstituted carbazol-4-amines from tetrahydrocarbazol-4-one oximes

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00386A, Research Article
Jiahua Wang, Dandan Gao, Aanuoluwapo O. Oyejobi, Na Ji, Xiang-Ying Tang, Long Wang
A sequential synthetic method toward 1,3-disubstituted carbazol-4-amines is reported and an interesting C–S metathesis process is disclosed.
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A Pd(II)-catalyzed denitrative alkyne annulation reaction for the synthesis of cyclopenta[b]chromanes

By pubs.rsc.org
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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00344F, Research Article
Pratiksha Bhorali, Deep J. Kalita, Babulal Das, Sanjib Gogoi
The first denitrative Pd(II)-catalyzed alkyne annulation reaction is reported for the synthesis of cyclopenta[b]chromanes.
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DBU-catalyzed substitution-controlled synthesis of oxa[3.3.1] bridged ring and naphthylamine derivatives

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00012A, Research Article
Shiyu Xu, Zhihui Sun, Pengyutian Liu, Yuanlin Wei, Fan Sun, Man Zhao, Ying Wang, Ming Zhang, Guofeng Li, Hong Liang
A switchable cascade cyclization reaction of ortho-alkynyl arylketones with amines has been developed, where the different reaction pathways are controlled by the substituent on the α-carbon of in-situ-generated ortho-alkynyl arylaldimines.
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Modular synthesis of C2-symmetric nitrogen-containing polyaromatics via visible light-enabled reductive aza-6π electrocyclization

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00140K, Research Article
Qun-Liang Zhang, Qing-Tian Fan, Yirong Zhou, Jingli Zhang, Fang-Lin Zhang
Here, an unprecedented one-step modular construction of C2-symmetric N-PACs through  reduction/aza-6π electrocyclization was reported and the resultant C2-symmetric N-PAC could be  converted into  a powerful organic photocatalyst.
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Computational insights into the synergistic interplay of ligand and fluorine effects in palladium-catalyzed regiodivergent decarboxylative allylic alkylation

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00147H, Research Article
Shiyu Wang, Hongli Wu, Xiangyang Tang, Genping Huang
DFT calculations were performed to investigate palladium-catalyzed decarboxylative allylic alkylation of allyl difluoro-β-ketoesters. The synergistic effects of ligand and fluorine substituents on regioselectivity were uncovered.
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Chiral guanidine catalyzed cyclization reactions of 1,3-enynes for lactone synthesis: switchable H-bond catalysis

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00374H, Research Article
Yongyan Zhang, Lichao Ning, Tianxin Zhu, Zheng Xie, Shunxi Dong, Xiaoming Feng, Xiaohua Liu
Cyclization and 1,4-conjugate addition/cyclization between 2-activated 1,3-enynes and azlactones were achieved with chiral guanidine-amides for enol-type activation to yield a range of δ-lactone derivatives.
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Sustainable synthesis of long-acting local anesthetics ropivacaine and levobupivacaine under batch and continuous flow via asymmetric hydrogenation

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00072B, Research Article
Zhi Yang, Hanlin Chen, Linxi Wan, Xinyi Feng, Lingshuang Ma, Pei Tang, Fen-Er Chen
A sustainable synthesis method was developed for long-acting local anesthetics, ropivacaine and levobupivacaine, using both batch and continuous flow processes via asymmetric hydrogenation.
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Synthesis of a helical boron-doped PAH by post-functionalization of 3,9-diboraperylene

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00421C, Research Article
Carina Mützel, Kazutaka Shoyama, Ana-Maria Krause, Frank Würthner
A doubly helical boron-doped polycyclic aromatic hydrocarbon was synthesized, which showed a low LUMO level, a high absorption coefficient and fluorescence (ΦF = 0.73), combined with a one-dimensional π–π stacking interaction in the solid state.
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Regio- and stereo-selective synthesis of β-phenylthio enamides via intramolecular 1,2-thiol migration

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D3QO02078A, Research Article
Yunqing Zhuang, Jin Zhang, Kai Yang, Gehua Bi, Xin Huang, Weimin Zhang
An efficient and novel method for the direct synthesis of β-phenylthio enamides via intramolecular 1,2-thiol migration has been developed.
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Enantioselective synthesis of 8-membered lactone derivatives via organocatalytic cascade reactions

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00148F, Research Article
Dong-Sheng Ji, Rui Zhang, Xu-Yan Han, Hai-Long Chai, Yucheng Gu, Xiu-Qin Hu, Peng-Fei Xu
The challenging 8-membered lactone derivatives bearing two vicinal chiral stereocenters were synthesized via a cascade reaction mediated by the chiral squaramide.
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Stereodivergent synthesis of chiral spiropyrazolones through Pd-catalyzed asymmetric sequential hydroalkylation of 1,3-enynes: unusual solvent effects on the enantioselectivity

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00358F, Research Article
Shan Wang, Long Li, Yifei Zheng, Luqing Li, Yingcheng Wang, Fangzhi Peng, Zhihui Shao
Chiral spiropyrazolones were constructed through Pd-catalyzed asymmetric sequential hydroalkylation of 1,3-enynes. Four stereoisomers could be obtained through substrate control and chiral ligand control.
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Electrochemically dehydrogenative C(sp2)–H/S–H cross-coupling: efficient synthesis of ortho-aminophenyl thioglycoside derivatives

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00171K, Research Article
Li-Yan Hu, Li Zhu, Shen-Yuan Zhang, Yu-Xin Guo, Yuan Li, Jie Zhu, Lei Wu
A method has been reported for synthesizing aryl thioglycosides through direct electrocatalytic dehydrogenative C(sp2)–H/S–H cross-coupling.
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Blue light-mediated carbene transfer reaction of thioesters with diazoesters: efficient synthesis of tetrasubstituted Z-enol esters

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00265B, Research Article
Shuncheng Wang, Hua Zhang, Jin Yang, Dongfang Zhang, Xin-Ping Hui
An efficient metal-free, blue light-mediated carbene transfer reaction of thioesters with diazoesters has been achieved. This protocol produced tetrasubstituted Z-enol esters containing arylsulfur groups in good yields under mild conditions.
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Correction: Stereodivergent and enantioselective total syntheses of isochaetominines A–C and four pairs of isochaetominine C enantiomers: a six-step approach

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO90034K, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhong-Yi Mao, Hui Geng, Tian-Tian Zhang, Yuan-Ping Ruan, Jian-Liang Ye, Pei-Qiang Huang
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Visible-light-mediated catalyst-free synthesis of trifluoromethyl(spiro)-epoxides bearing contiguous quaternary centers

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00184B, Research Article
Jingchuan Lin, Yu Zhang, Jinxin Wang, Xinyu Han, Shenglan Zhu, Tong Li, Yanping Zhu, Wei-Dong Zhang
Herein, we describe a non-covalent complex-mediated epoxidation strategy that can yield highly selective central spiro-epoxides by irradiation with visible light without the need for catalyst addition.
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Synthesis of benzothiophenes via sulfonium-[3,3]-rearrangement of aryl sulfoxides with allenenitriles

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, 11,2208-2214
DOI: 10.1039/D4QO00121D, Research Article
Lei Zhang, Kun Wan, Huanhuan Wang, Mengyao Wang, Ao Cui, Xin Huang, Bo Peng
A facile synthesis of benzothiophenes from readily available aryl sulfoxides and allenenitriles has been established through sulfonium-rearrangement triggered cyclization.
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A formal (3 + 2) annulation–Cannizzaro cascade of bifunctional peroxides for the synthesis of dihydrofurans

By pubs.rsc.org
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Org. Chem. Front., 2024, 11,2215-2219
DOI: 10.1039/D4QO00215F, Research Article
Yiwei Chen, Min Gao, Qianlan Xu, Jiumeng Zhang, Lin Hu
Tunable tandem processes of bifunctional peroxides allow the divergent construction of functionalized dihydrofurans and epoxides by simply changing the basic conditions.
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Synthesis of enantiopure 1,2,3-triazolylidene-type mesoionic carbene (MIC) conjugate acids featuring a rigid bicyclic scaffold

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, 11,2178-2181
DOI: 10.1039/D4QO00269E, Research Article
Vojtěch Dočekal, Mohand Melaimi, Simona Petrželová, Jan Veselý, Xiaoyu Yan, Guy Bertrand
Chiral NHCs have found numerous applications as ligands for transition metals and in their own right for asymmetric catalysis. We report a synthetic route from L-malic acid to enantiopure 1,2,3-triazoliums with the chiral center in a fused ring.
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Selective photochemical synthesis of primary arylamines and symmetric diarylamines via amination of aryl bromides using Ni(NH3)6Cl2 as a nitrogen source and catalyst

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, 11,2313-2318
DOI: 10.1039/D4QO00116H, Research Article
Zhehui Xu, Jianyang Dong, Geyang Song, Fuqiang Kong, Gang Li, Dong Xue
The selective synthesis of primary arylamines and diarylamines via coupling reactions with ammonia as a nitrogen source is still challenging.
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Prins cyclization of 1,3-dioxinone: synthesis of 11-epi-badkhysin

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, 11,2332-2338
DOI: 10.1039/D4QO00162A, Research Article
Xiaoliang Xu, Ping Hua, Yiren Xu, Baoqing He, Jingfeng Zhao, Liang Li, Wen Chen, Hongbin Zhang
The asymmetric synthesis of highly functional 11-epi-badkhysin has been accomplished using a structure-unit based approach.
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Concise synthesis of succinimide-fused densely 1,3-cyclohexadienes via Co-catalyzed [2+2+2] cycloaddition of 1,6-diynes and maleimides

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00435C, Research Article
Jinhui Cai, Kaili Cen, Ziyi Zhai, Yuan Liu, Jiahao Wei, Mixia Ouyang, Guojun He, Shuyu Huang, Feng Zhao
Herein, we report a new route towards succinimide-fused densely 1,3-cyclohexadienes through the reaction of 1,6-diynes with electron-deficient alkenes under cobalt catalysis. This method shown high efficiency, wide substrate scope, good...
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Development of a photoenzymatic one-pot hybrid system for the direct synthesis of 3,3-disubstituted indole-2-ketones from N-methyl indoles

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00371C, Research Article
Yao Yao, Yuan Yu, Ming-Liang Shi, Xin-Yue Fan, Ru-De Lin, Kun Li, Wen-Dian Li, Fei-Yan Tao, Na Wang
The effective combination of photocatalysis and enzyme catalysis has been widely utilized for the synthesis of high-value-added products.
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Efficient Synthesis of Benzophosphole Oxides by Ag-Promoted Radical Cycloisomerization

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00552J, Research Article
Open Access
Liyao Ma, Sonia Mallet-Ladeira, Julien MONOT, Blanca Maria MARTIN VACA, Didier Bourissou
Cycloisomerization reactions involving C–P bond formation have been overlooked to prepare P-heterocycles. We discovered here a simple, efficient and versatile route to benzophosphole oxides by reacting ortho-alkynyl secondary phosphine oxides...
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Synthesis of oxindole fused 1,3-oxazepanes via hydride transfer initiated ring expansion of pyrrolidine

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00474D, Research Article
Peng He, Zongkang Wang, Qiongwen Kang, Nana Fei, Chengyu Wang, Yanzhong Li
An efficient B(C6F5)3 catalyzed protocol for the synthesis of oxindole fused 1,3-oxazepanes from pyrrolidine substituted aryl alkynones has been developed.
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NHC-Catalyzed Stereoselective Synthesis of Spirooxindole Lactones by in situ Generated Oxindole-embedded o-Quinone Methides and Aldehydes

By pubs.rsc.org
Published On ::

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00347K, Research Article
Zhengqiang Cao, Fang Hu, Yunpeng Chu, Jiaxue Pei, Xin-Ping Hui
A novel N-heterocyclic carbene-catalyzed asymmetric [4 + 2] annulation of in situ generated oxindole-embedded o-quinone methides with aldehydes has been developed for the assembly of complicated spirooxindoles. The methodology provides...
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Non-equilibrium defect chemistry in oxygen-rich zinc oxide nano-tetrapods synthesized using atmospheric pressure microplasma

By pubs.rsc.org
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J. Mater. Chem. A, 2024, 12,9212-9231
DOI: 10.1039/D3TA06821H, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Dilli babu Padmanaban, Paul Maguire, Davide Mariotti
We demonstrate the synthesis of zinc oxide (ZnO) nanoscale tetrapods (nTPs) using an atmospheric pressure microplasma with a metal wire as a sacrificial electrode.
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Structure/interface synergistic stabilizes high-nickel cathodes for lithium-ion batteries

By pubs.rsc.org
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J. Mater. Chem. A, 2024, Accepted Manuscript
DOI: 10.1039/D4TA01230E, Paper
Guihong Mao, Liming Zeng, Jieyu Yang, Tengyu Yao, Fanming Xiao, Renheng Tang, Xin Shu, Ying Wang, Laifa Shen
Due to with high specific capacity, high nickel layered oxides have been at the forefront of the development of high-energy density lithium-ion batteries. However, high nickel cathodes invariably suffer from...
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Synthesis of a pyridine-based covalent organic framework as an anode material for lithium-ion batteries

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J. Mater. Chem. A, 2024, Advance Article
DOI: 10.1039/D4TA00892H, Paper
Shixi Zhong, He Zhao, Yingming Ji, Xiuhua Li, Ting Shu, Zhiming Cui, Shijun Liao
Covalent organic framework (COF) materials with redox activity have emerged as promising electrode materials for lithium-ion batteries.
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Bi-intercalated vanadium pentoxide synthesized via hydrogen peroxide-induced phase transition for highly stable cathode in aqueous zinc ion batteries

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J. Mater. Chem. A, 2024, Advance Article
DOI: 10.1039/D3TA07984H, Paper
Jian-an Chen, Xuejun Hou, Xueli Wang, Chunxia Wang, Jiawei Wen, Yongjie Bu, Guoyong Huang, Tiantian Cao, Shengming Xu
Operating principle of aqueous zinc-ion batteries (ZIBs).
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A bioinspired sulfur-surrounded iron catalyst for ammonia synthesis

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J. Mater. Chem. A, 2024, Advance Article
DOI: 10.1039/D4TA00710G, Paper
Na Zhang, Yubing Si, Qiang Fu, Xing Chen
A nitrogenase-inspired inorganic compound consisting of iron (Fe) and molybdenum disulfide (MoS2) is designed with a promising capability of N2 fixation using first principles.
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Co–Co2C catalysts supported on carbon-coated ordered mesoporous silica with promoted CO insertion and C–C coupling for higher alcohol synthesis from syngas

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J. Mater. Chem. A, 2024, Advance Article
DOI: 10.1039/D4TA01179A, Paper
Zhuoshi Li, Siqi Fan, Zhuang Zeng, Shaoxia Guo, Xiaofeng Pei, Shouying Huang, Yong Wang, Yue Wang, Xinbin Ma
Co–Co2C catalysts supported on carbon-coated ordered mesoporous silica showed superior performance for HAS than catalysts with uncoated and amorphous supports.
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Plasticity tunable artificial synapses based on organic electrochemical transistors with aqueous electrolytes

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J. Mater. Chem. C, 2024, Advance Article
DOI: 10.1039/D4TC03569K, Paper
Ruhua Wu, Miao Xie, Yuhua Cheng, Dan Zhao, Liang-Wen Feng, Jianhua Chen, Wei Huang
By regulating ion transporting kinetics and ion diffusion distances in organic mixed ionic–electronic conductor channels, highly tunable short- and long-term plasticity are obtained in vOECTs with aqueous electrolytes.
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Multimodal anti-counterfeiting inks: modern use of an ancient pigment in synergy with a persistent phosphor

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J. Mater. Chem. C, 2024, Accepted Manuscript
DOI: 10.1039/D4TC04228J, Paper
ALESSANDRO LO BIANCO, Francesco Armetta, Vitalii Boiko, Dariusz Hreniak, Maria Luisa Saladino
A multi-level luminescent, transparent and not-permanent inks for anti-counterfeiting systems and security was developed. The inks emit a radiation of different wavelength depending on the radiation used to illuminate them,...
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Synthesis of highly condensed phospholes by Lewis acid-assisted dehydrogenative Mallory reaction under visible light irradiation

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Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05657D, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ikki Kamiyoshi, Yuki Kojima, Shibo Xu, Kosuke Yasui, Yuji Nishii, Koji Hirano
A photo-promoted oxidative cyclization, that is, Mallory reaction of 2,3-diarylbenzophopholes has been developed. With an assistance of Bi(OTf)3 Lewis acid, the reaction proceeds smoothly under visible light irradiation even without...
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Chemical synthetic approaches to mimic the TRAIL: promising cancer therapeutics

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RSC Med. Chem., 2024, 15,3639-3651
DOI: 10.1039/D4MD00183D, Review Article
Abdullah-Al Masum, Shin Aoki, Md. Mahbubur Rahman, Yosuke Hisamatsu
TRAIL induced apoptosis signalling by death receptors (DR4/DR5).
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New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation

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RSC Med. Chem., 2024, 15,3759-3777
DOI: 10.1039/D4MD00498A, Research Article
Lucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. Enriz
A diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.
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Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation

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RSC Med. Chem., 2024, 15,3778-3794
DOI: 10.1039/D4MD00281D, Research Article
Carolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. Pilli
A novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.
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Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction

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RSC Med. Chem., 2024, 15,3652-3673
DOI: 10.1039/D4MD00425F, Review Article
Semim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra Borah
Metabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.
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Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators

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RSC Med. Chem., 2024, 15,3800-3816
DOI: 10.1039/D4MD00585F, Research Article
Marwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-Karmalawy
Novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.
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Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation

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RSC Med. Chem., 2024, 15,3880-3888
DOI: 10.1039/D4MD00414K, Research Article
Phuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. Vo
Novel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.
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