Data suggest low-income communities are hit much harder than affluent ones, writes researcher Heather C. Hill.

Yang Hu
Feb 24, 2021; 41:1699-1715
BehavioralSystemsCognitive

As evidence mounts that the cardiac-sympathetic nervous system reacts to challenging cognitive settings, we ask if these responses are epiphenomenal companions or if there is evidence suggesting a more intertwined role of this system with cognitive function. Healthy male and female human participants performed an approach-avoidance paradigm, trading off monetary reward for painful electric shock, while we recorded simultaneous electroencephalographic and cardiac-sympathetic signals. Participants were reward sensitive but also experienced approach-avoidance "conflict" when the subjective appeal of the reward was near equivalent to the revulsion of the cost. Drift-diffusion model parameters suggested that participants managed conflict in part by integrating larger volumes of evidence into choices (wider decision boundaries). Late alpha-band (neural) dynamics were consistent with widening decision boundaries serving to combat reward sensitivity and spread attention more fairly to all dimensions of available information. Independently, wider boundaries were also associated with cardiac "contractility" (an index of sympathetically mediated positive inotropy). We also saw evidence of conflict-specific "collaboration" between the neural and cardiac-sympathetic signals. In states of high conflict, the alignment (i.e., product) of alpha dynamics and contractility were associated with a further widening of the boundary, independent of either signal's singular association. Cross-trial coherence analyses provided additional evidence that the autonomic systems controlling cardiac-sympathetics might influence the assessment of information streams during conflict by disrupting or overriding reward processing. We conclude that cardiac-sympathetic control might play a critical role, in collaboration with cognitive processes, during the approach-avoidance conflict in humans.

Part of the visual album of Joan Baez' "Whistle Down the Wind," this cover of Joe Henry's "Civil War" was directed by New York University's Deborah Willis

Hailing from an area known for its raucous music and dance traditions, the Kalapriya Dance Troupe perform at the opening of the "Garden and Cosmos" exhibit (Anika Gupta). Read more at: https://www.smithsonianmag.com/smithsonian-institution/dance-of-the-desert-hindu-folk-performance-brings-raucous-rhythms-to-the-mall-1-180941518/

Julie Montagu, the American-born Viscountess Hinchingbrooke, is meeting up with an expert on 18th century dance. Her aim is to learn about the dances performed in that era.

Canada's Roman Sadovsky is in third place after the men's short program with 84.59 points, meanwhile Canadian ice dancing duo Laurence Fournier Beaudry and Nikolaj Soerensen.

Montreal's Laurence Fournier Beaudry and Nikolaj Sorensen finished the Rostelecom Cup in bronze position Saturday for their fourth medal in as many figure skating competitions this season.

That Figure Skating Show recaps the ice dance event at Rostelecom Cup that saw Canadians Laurence Fournier Beaudry and Nikolaj Sorensen take their second bronze this season.

The establishment of neural connectivity is a major part of neural development. The central nervous system (CNS) midline is the most characterized axon guidance choice point, and work in Drosophila has played a pivotal role in understanding the molecular mechanisms responsible. Axons respond to attractive cues such as Netrin via the Frazzled receptor, and repulsive cues such as Slit via Robo receptors. Both signals are expressed at the CNS midline, affect pioneer axons, and have dramatic effects on the axon scaffold as a whole. Here, we focus on previous research analyzing classic mutants in the Slit/Robo pathway, which can readily be detected with a dissecting microscope. We also discuss analyzing these mutants in a teaching lab situation. The combination of sophisticated genetics and reliable axonal markers in Drosophila allows phenotypic analysis to be performed at the single-cell level. The elaborate architecture of neurons is very sensitive to disruption by genetic mutations, allowing the effects of novel mutations to be easily detected and assessed.

An OM DanceLink team shares the gospel with crowds during impromptu dance performances on city streets in Portugal.

A team of OM Dancelink dancers in Portugal impact the community through workshops, shows and street performances.

A Transform 2012 Dancelink team in Mondim, Portugal, clears the way for a Transform Transit team to see the Gospel bear fruit four months later.

OM Arts dancers come to Israel and share their art and testimony with locals.

An OM Arts student shares how picking up trash led to sharing the gospel in Israel.

New sheets outlines how districts can support English-learner students, but concedes that "schools may not be able to provide all services in the same manner they are typically provided."

2024-25 Penn State Laureate Michele Dunleavy, professor of dance at the University Park campus, will give a presentation and performance, “Improvising a Life,” at Penn State Shenango in the Shenango Auditorium at 12:15 p.m. on Wednesday, Sept. 18.

Penn State Laureate Michele Dunleavy, professor of dance at the University Park campus, will continue her tour of the Commonwealth Campuses with a visit to Penn State Abington on Nov. 11. She will present “Improvising a Life” at 12:15 p.m. in 9 Sutherland Auditorium with musician Jennifer Peacock.

Penn State Altoona’s Ivyside Dance Ensemble will present its fall 2024 performance at 7:30 p.m. Nov. 14-15 in the Wolf Kuhn Theatre of the Misciagna Family Center for Performing Arts. The performance will consist of seven dances from director KT Huckabee, choreographer and instructor Jaye Mackinson, and returning guest choreographer Ana Rossi-Lanzendorfer.

After the Transform conference last July in Rome, about 10 of the participants in eastern France started to meet together in order to share the Gospel through dance.

The Penn State DuBois Office of Student Engagement will welcome students and members of the public to Hiller Auditorium on Tuesday, Nov. 12, when the Piscataway Nation Singers & Dancers visit campus.

Hemansh Kohli wore a green kurta at his mehendi ceremony

Process and regulatory changes developed in partnership with the Delaware Captive Insurance Association Insurance Commissioner Trinidad Navarro and the Delaware Captive Insurance Association (DCIA) are proud to announce a series of process and regulatory improvements intended to ensure Delaware remains a top domicile for businesses seeking to form captive insurance companies. The news was shared […]

December 28, 2020 For Immediate Release Kenneth Briscoe Email: kenneth.Briscoe@Delaware.gov   Wilmington, DE (Dec. 28, 2020) – On December 27, 2020, the President signed the latest COVID-19 Relief bill, which extends certain federal unemployment benefits available under the CARES Act. The bill provides the extension of the Pandemic Unemployment Assistance program (PUA) and Pandemic Emergency […]

The Delaware Department of Agriculture (DDA) issued guidance today to help local U-Pick farms safely open to the public for the season. This guidance will help farm staff and visitors to U-Pick farm operations participate in a safe manner to reduce the spread of COVID-19.

DOVER, DE (Dec. 28, 2021) – The Division of Public Health announced that it will implement updated guidance issued Monday by the Centers for Disease Control and Prevention (CDC) to shorten the recommended time that people should isolate or quarantine from 10 days to 5 days based on certain conditions and vaccination status.  The change is motivated by […]

DOVER, DE (March 4, 2022) – With new positive cases and hospitalizations continuing to decline in Delaware, mask mandates for schools and state buildings were lifted earlier this week across the state, consistent with updated guidance from the Centers for Disease Control and Prevention (CDC). The CDC guidance is based on county or community levels of spread and the level […]

DOVER, DE (Dec. 15, 2022) – The Delaware Division of Public Health (DPH) is providing several key updates related to COVID-19 data and vaccines.  According to the most recent data on the state’s My Healthy Community data dashboard, the statewide 7-day average of new positive COVID-19  cases has increased slightly following Thanksgiving and other gatherings over the past month. Hospitalizations have also increased. As holiday travel […]

The Delaware Department of Education has developed guidance for districts and charter schools on generative artificial intelligence (AI) in the classroom.

WILMINGTON, Del. – Governor John Carney on Friday issued a statewide drought watch after receiving guidance from the Delaware Water Supply Coordinating Council (WSCC). Delawareans are asked to voluntarily reduce outdoor uses of water during the drought watch. This decision follows an assessment of conditions by the WSCC on October 25. The drought watch will remain in effect until […]

A man climbed an electric tower in Uttar Pradesh's Noida Sector 76 on Sunday afternoon. After nearly two hours, he was brought down by the police and fire department officials.

Achieving optimal power transfer in RF PCBs hinges on meticulously routed traces that meet specific impedance requirements. Impedance matching is essential to ensure that traces have the same impedance to prevent signal reflection and inefficient pow...(read more)

hello,

We have a number of workstations with version 17.2 that work on a floating license server

We want to know if it can be upgraded to version 17.4

If so, should the floating license server be upgraded as well?

In addition, how can you know where the license was purchased from?

Thanks!

Dear Community,

I have created a PCB board and let's say I have found some parts of the PCB board where there are impedance issues, then how to resolve that impedance issue using the OrCAD X Professional.

Regards,

Rohit Rohan

Why don't the rich pay their fair share in taxes?

Princess Kate has found a trusted mentor in the Duchess of Edinburgh, Sophie, 59, as she adjusts to her new role as Princess of Wales. Royal biographer Claudia Joseph revealed that Kate "jumped at the chance" to be mentored by Sophie, describing her as a "tower of strength" and a reliable...

Title: Major Study Gives Women More Guidance on Hormone Therapy During Menopause
Category: Health News
Created: 8/29/2019 12:00:00 AM
Last Editorial Review: 8/30/2019 12:00:00 AM

Influenza A virus (IAV) is one of the leading causes of respiratory infections. The lack of efficient anti-influenza therapeutics requires a better understanding of how IAV interacts with host cells. Alveolar macrophages are tissue-specific macrophages that play a critical role in lung innate immunity and homeostasis, yet their role during influenza infection remains unclear. First, our review highlights an active IAV replication within alveolar macrophages, despite an abortive viral cycle. Such infection leads to persistent alveolar macrophage inflammation and diminished phagocytic function, alongside direct mitochondrial damage and indirect metabolic shifts in the alveolar micro-environment. We also discuss the "macrophage disappearance reaction", which is a drastic reduction of the alveolar macrophage population observed after influenza infection in mice but debated in humans, with unclear underlying mechanisms. Furthermore, we explore the dual nature of alveolar macrophage responses to IAV infection, questioning whether they are deleterious or protective for the host. While IAV may exploit immuno-evasion strategies and induce alveolar macrophage alteration or depletion, this could potentially reduce excessive inflammation and allow for the replacement of more effective cells. Despite these insights, the pathophysiological role of alveolar macrophages during IAV infection in humans remains understudied, urging further exploration to unravel their precise contributions to disease progression and resolution.

Protein abundance data of drug-metabolizing enzymes and transporters (DMETs) are useful for scaling in vitro and animal data to humans for accurate prediction and interpretation of drug clearance and toxicity. Targeted DMET proteomics that relies on synthetic stable isotope-labeled surrogate peptides as calibrators is routinely used for the quantification of selected proteins; however, the technique is limited to the quantification of a small number of proteins. Although the global proteomics-based total protein approach (TPA) is emerging as a better alternative for large-scale protein quantification, the conventional TPA does not consider differential sequence coverage by identifying unique peptides across proteins. Here, we optimized the TPA approach by correcting protein abundance data by the sequence coverage, which was applied to quantify 54 DMETs for characterization of 1) differential tissue DMET abundance in the human liver, kidney, and intestine, and 2) interindividual variability of DMET proteins in individual intestinal samples (n = 13). Uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7), microsomal glutathione S-transferases (MGST1, MGST2, and MGST3) carboxylesterase 2 (CES2), and multidrug resistance-associated protein 2 (MRP2) were expressed in all three tissues, whereas, as expected, four cytochrome P450s (CYP3A4, CYP3A5, CYP2C9, and CYP4F2), UGT1A1, UGT2B17, CES1, flavin-containing monooxygenase 5, MRP3, and P-glycoprotein were present in the liver and intestine. The top three DMET proteins in individual tissues were: CES1>CYP2E1>UGT2B7 (liver), CES2>UGT2B17>CYP3A4 (intestine), and MGST1>UGT1A6>MGST2 (kidney). CYP3A4, CYP3A5, UGT2B17, CES2, and MGST2 showed high interindividual variability in the intestine. These data are relevant for enhancing in vitro to in vivo extrapolation of drug absorption and disposition and can be used to enhance the accuracy of physiologically based pharmacokinetic prediction of systemic and tissue concentration of drugs.

BackgroundDuring the COVID-19 pandemic, global trends of reduced healthcare-seeking behaviour were observed. This raises concerns about the consequences of healthcare avoidance for population health.AimTo determine the association between healthcare avoidance during the early stages of the COVID-19 pandemic and all-cause mortality.Design and settingThis was a 32-month follow-up within the population-based Rotterdam Study, after sending a COVID-19 questionnaire at the onset of the pandemic in April 2020 to all communty dwelling participants (n = 6241/8732, response rate 71.5%).MethodCox proportional hazards models assessed the risk of all-cause mortality among respondents who avoided health care because of the COVID-19 pandemic. Mortality status was collected through municipality registries and medical records.ResultsOf 5656 respondents, one-fifth avoided health care because of the COVID-19 pandemic (n = 1143). Compared with non-avoiders, those who avoided health care more often reported symptoms of depression (n = 357, 31.2% versus n = 554, 12.3%) and anxiety (n = 340, 29.7% versus n = 549, 12.2%), and more often rated their health as poor to fair (n = 336, 29.4% versus n = 457, 10.1%) . Those who avoided health care had an increased adjusted risk of all-cause mortality (hazard ratio [HR] 1.30, 95% confidence interval [CI] = 1.01 to 1.67), which remained nearly identical after adjustment for history of any non-communicable disease (HR 1.20, 95% CI = 0.93 to 1.54). However, this association attenuated after additional adjustment for mental and physical self-perceived health factors (HR 0.93, 95% CI = 0.71 to 1.20).ConclusionThis study found an increased risk of all-cause mortality among individuals who avoided health care during COVID-19. These individuals were characterised by poor mental and physical self-perceived health. Therefore, interventions should be targeted to these vulnerable individuals to safeguard their access to primary and specialist care to limit health disparities, inside and beyond healthcare crises.

A DWP employee who has been working in the welfare system for 42 years has shared some key advice for new claims for the likes of PIP and Attendance Allowance

Video Friday is your weekly selection of awesome robotics videos, collected by your friends at IEEE Spectrum robotics. We also post a weekly calendar of upcoming robotics events for the next few months. Please send us your events for inclusion.

ICRA@40: 23–26 September 2024, ROTTERDAM, NETHERLANDS

IROS 2024: 14–18 October 2024, ABU DHABI, UAE

ICSR 2024: 23–26 October 2024, ODENSE, DENMARK

Cybathlon 2024: 25–27 October 2024, ZURICH

Enjoy today’s videos!

I think it’s time for us all to admit that some of the most interesting bipedal and humanoid research is being done by Disney.

[ Research Paper from ETH Zurich and Disney Research]

Over the past few months, Unitree G1 robot has been upgraded into a mass production version, with stronger performance, ultimate appearance, and being more in line with mass production requirements.

[ Unitree ]

This robot is from Kinisi Robotics, which was founded by Brennand Pierce, who also founded Bear Robotics. You can’t really tell from this video, but check out the website because the reach this robot has is bonkers.

Kinisi Robotics is on a mission to democratize access to advanced robotics with our latest innovation—a low-cost, dual-arm robot designed for warehouses, factories, and supermarkets. What sets our robot apart is its integration of LLM technology, enabling it to learn from demonstrations and perform complex tasks with minimal setup. Leveraging Brennand’s extensive experience in scaling robotic solutions, we’re able to produce this robot for under $20k, making it a game-changer in the industry.

[ Kinisi Robotics ]

Thanks Bren!

Finally, something that Atlas does that I am also physically capable of doing. In theory.

Okay, never mind. I don’t have those hips.

[ Boston Dynamics ]

Researchers in the Department of Mechanical Engineering at Carnegie Mellon University have created the first legged robot of its size to run, turn, push loads, and climb miniature stairs.

They say it can “run,” but I’m skeptical that there’s a flight phase unless someone sneezes nearby.

[ Carnegie Mellon University ]

The lights are cool and all, but it’s the pulsing soft skin that’s squigging me out.

[ Paper, Robotics Reports Vol.2 ]

Roofing is a difficult and dangerous enough job that it would be great if robots could take it over. It’ll be a challenge though.

[ Renovate Robotics ] via [ TechCrunch ]

Kento Kawaharazuka from JSK Robotics Laboratory at the University of Tokyo wrote in to share this paper, just accepted at RA-L, which (among other things) shows a robot using its flexible hands to identify objects through random finger motion.

[ Paper accepted by IEEE Robotics and Automation Letters ]

Thanks Kento!

It’s one thing to make robots that are reliable, and it’s another to make robots that are reliable and repairable by the end user. I don’t think iRobot gets enough credit for this.

[ iRobot ]

I like competitions where they say, “just relax and forget about the competition and show us what you can do.”

[ MBZIRC Maritime Grand Challenge ]

I kid you not, this used to be my job.

[ RoboHike ]

A FEMA supervisor fired for instructing subordinates to skip over houses with Trump signs says her actions were consistent with agency guidance and were not isolated to her team alone.

Regulatory experts LFH Regulatory have announced their attendance at MEDICA 2024 to provide insights and support to healthcare innovators facing the complexities of the UK and EU markets.

Pharmaceutical and biotech companies breathed a sigh of relief Monday when the Federal Circuit unanimously ruled in a precedential opinion that the mere sale of manufacturing services to create embodiments of a patented product is not a “commercial sale” of the invention that triggers the on-sale bar of 35 U.S.C. § 102(b) (pre-AIA).[1]  The en banc opinion...… Continue Reading