The banquet table is set and the invitation is from God Himself. How will we respond?

Why RSV cases are so high among Inuit children; Wales soccer fans confront their misgivings about Qatar at their first World Cup in 64 years; as Russia ramps up missile strikes, Ukrainians brace for a cold, dark winter; how a provincial billing change could reduce gender-affirming health care in Ontario; and more.

DOVER, DE (OCT. 28, 2022) – The Delaware Division of Public Health (DPH) is concerned about increases in respiratory viruses in the state, particularly influenza (flu) and respiratory syncytial virus (RSV). For the week of Oct. 16, 2022, through Oct. 22, 2022, there were 44 laboratory-confirmed cases of the flu, compared to 19 cases the week […]

Starting in 2025, Australia will provide free respiratory syncytial virus (RSV) vaccinations (!--ref1--) for newborns and pregnant women. Mark

Highlights: Newborns seem safe from respiratory syncytial virus (RSV), but healthy infants can get severely sick

Hampton Inn & Suites Scottsboro, AL offers convenient lodging for the FLW Bass Fishing League Tournament on Lake Guntersville on February 7, 2015.

Hampton Inn & Suites Scottsboro, AL offers convenient lodging for the American Bass Anglers (ABA) fishing tournament on Lake Guntersville on August 15-16, 2015.

Hampton Inn & Suites Scottsboro, AL offers comfortable lodging for Lake Guntersville bass tournaments in September 2015.

Hampton Inn & Suites Scottsboro, AL offers lodging for upcoming bass tournaments on Lake Guntersville.

The legendary James Cotton is playing a free show at the TLA on South Street in Philadelphia on Friday, September 6. It’s the finale concert of the year long Mississippi Blues Project and will be hosted by Jonny Meister, host […]

See the change happening in Bargersville from above

Town leaders and residents prepare for what's to come as the interstate replaces Ind. 37 as the direct route from Martinsville to Indianapolis.

The rural Johnson County town hopes to take advantage of growth while retaining its small-town charm.

One person died after the collapse of a well that was under construction in the 4900 block of W. Road 225 N. in Bargersville.

A Bargersville man died in a head-on crash in Johnson County early Saturday morning. Police believe alcohol was a factor in the crash.

A Bargersville police officer and the driver of an SUV were taken to the hospital with minor injuries after a vehicle crash Friday.

The respiratory epithelium comprises polarized cells at the interface between the environment and airway tissues. Polarized apical and basolateral protein secretions are a feature of airway epithelium homeostasis. Human respiratory syncytial virus (hRSV) is a major human pathogen that primarily targets the respiratory epithelium. However, the consequences of hRSV infection on epithelium secretome polarity and content remain poorly understood. To investigate the hRSV-associated apical and basolateral secretomes, a proteomics approach was combined with an ex vivo pediatric human airway epithelial (HAE) model of hRSV infection (data are available via ProteomeXchange and can be accessed at https://www.ebi.ac.uk/pride/ with identifier PXD013661). Following infection, a skewing of apical/basolateral abundance ratios was identified for several individual proteins. Novel modulators of neutrophil and lymphocyte activation (CXCL6, CSF3, SECTM1 or CXCL16), and antiviral proteins (BST2 or CEACAM1) were detected in infected, but not in uninfected cultures. Importantly, CXCL6, CXCL16, CSF3 were also detected in nasopharyngeal aspirates (NPA) from hRSV-infected infants but not healthy controls. Furthermore, the antiviral activity of CEACAM1 against RSV was confirmed in vitro using BEAS-2B cells. hRSV infection disrupted the polarity of the pediatric respiratory epithelial secretome and was associated with immune modulating proteins (CXCL6, CXCL16, CSF3) never linked with this virus before. In addition, the antiviral activity of CEACAM1 against hRSV had also never been previously characterized. This study, therefore, provides novel insights into RSV pathogenesis and endogenous antiviral responses in pediatric airway epithelium.

The respiratory epithelium comprises polarized cells at the interface between the environment and airway tissues. Polarized apical and basolateral protein secretions are a feature of airway epithelium homeostasis. Human respiratory syncytial virus (hRSV) is a major human pathogen that primarily targets the respiratory epithelium. However, the consequences of hRSV infection on epithelium secretome polarity and content remain poorly understood. To investigate the hRSV-associated apical and basolateral secretomes, a proteomics approach was combined with an ex vivo pediatric human airway epithelial (HAE) model of hRSV infection (data are available via ProteomeXchange and can be accessed at https://www.ebi.ac.uk/pride/ with identifier PXD013661). Following infection, a skewing of apical/basolateral abundance ratios was identified for several individual proteins. Novel modulators of neutrophil and lymphocyte activation (CXCL6, CSF3, SECTM1 or CXCL16), and antiviral proteins (BST2 or CEACAM1) were detected in infected, but not in uninfected cultures. Importantly, CXCL6, CXCL16, CSF3 were also detected in nasopharyngeal aspirates (NPA) from hRSV-infected infants but not healthy controls. Furthermore, the antiviral activity of CEACAM1 against RSV was confirmed in vitro using BEAS-2B cells. hRSV infection disrupted the polarity of the pediatric respiratory epithelial secretome and was associated with immune modulating proteins (CXCL6, CXCL16, CSF3) never linked with this virus before. In addition, the antiviral activity of CEACAM1 against hRSV had also never been previously characterized. This study, therefore, provides novel insights into RSV pathogenesis and endogenous antiviral responses in pediatric airway epithelium.

Most studies on corticoid treatment of respiratory syncytial virus (RSV) respiratory diseases have revealed no beneficial effect. The mechanism by which RSV respiratory-infected patients are insensitive to the antiinflammatory effect of corticosteroids is unknown.

This study helps to understand how a respiratory syncytial viral infection may alter the normal antiinflammatory response to cortisol and the insensitivity to glucocorticoid treatment. The increase expression of β glucocorticoid receptor could be a marker of disease severity. (Read the full article)

NEW DELHI: As many as 29 special economic zone developers including Tata Consultancy ServicesBSE -0.20 %, Parsvnath Infra and Navi Mumbai SEZ Pvt Ltd have sought more time from the government for implementing their projects. The inter-ministerial Board of Approval (BoA) chaired by Commerce Secretary S R Rao will consider these requests at its meeting on November 8. Posco-India Pvt Ltd, Unitech Infracon and Lodha Dwellers have also requested additional time for project implementation from the BoA, according to the agenda note of the meeting. The developers have cited reasons like global meltdown and fluctuating market conditions for delay in completion of projects. TCS, which is setting up IT/ITES zone […]

02:17 - Rich Harris Introduction

• Twitter
• GitHub
• Blog
• The Guardian

02:34 - Oskar Segersvärd Introduction

• Twitter
• GitHub
• Widespace

02:50 - rollup.js

• rollup - npm

04:47 - Caveats and Fundamental Differences Between CommonJS and AMD Modules and ES6 Modules

• lodash
• Static Analysis

11:26 - Where rollup.js Fits in the Ecosystem

• Bundler vs Loader
  • systemjs
  • jspm
• webpack

17:40 - Input Modules

18:35 - Why Focus on Bundling Tools vs HTTP/2

20:13 - Tree-shaking versus dead code elimination

25:53 - ES6/ES2016 Support

27:36 - Other Important Optimizations

32:11 - Small modules: it’s not quite that simple

• three.js

41:54 - jsnext:main – should we use it, and what for?

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