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HACHETTE Employees Protest New Conservative Imprint...

By www.publishersweekly.com
Published On :: 2024-11-13T06:19:36Z


HACHETTE Employees Protest New Conservative Imprint...


(First column, 10th story, link)


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America’s Battery Plant Boom Isn’t Going Bust – Factory Construction Is on Track

By www.discovermagazine.com
Published On :: Sat, 09 Nov 2024 15:00:00 GMT

A new battery plant under construction in South Carolina will supply BMW factories.


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Un modeste conseil au PLQ: laissez les beaux-pères au chalet...

By www.journaldemontreal.com
Published On :: Tue, 12 Nov 2024 05:15:00 EST

Laissez les beaux-pères au chalet et vos candidats libres de vous étonner. S’ils en sont capables, ils le feront.


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'Christmas creep' is here as the retail season starts early. But is it about consumerism or comfort?

By www.cbc.ca
Published On :: Tue, 12 Nov 2024 04:00:00 EST

If it seems like the Christmas shopping season starts earlier every year, you're not wrong. In response to growing customer demand, stores of all stripes brought out their festive collections weeks before the unofficial start of the holiday shopping season.


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What to consider with 3D printing and plastics prototyping

By www.medicalplasticsnews.com
Published On :: Thu, 31 Oct 2024 17:00:00 -0000

Robert Musselle, customer engineering manager EMEA at Protolabs shares what you need to consider with 3D printing and plastics prototyping.


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Consciousness Might Hide in Our Brain’s Electric Fields

By www.scientificamerican.com
Published On :: Fri, 08 Nov 2024 11:00:00 +0000

A mysterious electromagnetic mechanism may be more important than the firing of neurons in our brain to explain our awareness


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Minnesota Becomes 18th State to Adopt Consumer Data Privacy Law

By cohealthcom.org
Published On :: Wed, 05 Jun 2024 15:27:53 +0000

On May 24, Governor Tim Walz signed into law Minnesota’s new comprehensive data privacy law, the Minnesota Consumer Data Privacy Act (HF 4757 referenced as the MCDPA). The MCDPA goes into effect on July 31, 2025, with some exceptions for colleges and universities (who have until 2029). The MCDPA is similar to other state privacy laws, […]


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Rhode Island Governor Vetoes Consumer Data Privacy Act

By cohealthcom.org
Published On :: Wed, 03 Jul 2024 14:32:46 +0000

On June 25th, Rhode Island Governor Daniel McKee transmitted without signature (effectively a pocket veto) the Rhode Island Data Transparency and Privacy Protection Act (SB 2500 / HB 7787). The act is based on the Washington Privacy Act model but diverges from the prevalent forms of that model in two ways. First, the act contains a unique […]


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FTC Finalizes “Click-to-Cancel” Rule to Make It Easier for Consumers to End Recurring Subscriptions and Memberships

By cohealthcom.org
Published On :: Fri, 18 Oct 2024 20:56:52 +0000

Sorry, but you do not have permission to view this content.


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MHRA to consult on making two progestogen-only contraceptives available without a prescription

By www.pharmaceutical-journal.com
Published On :: Mon, 15 Feb 2021 12:22 GMT

Consultations on the reclassification of two progestogen-only contraceptive pills from prescription-only to pharmacy medicines have been launched.


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Deconstructing the Diligence Process: An Approach to Vetting New Product Theses

By lifescivc.com
Published On :: Wed, 24 Apr 2024 11:00:21 +0000

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Ever wondered what goes into diligencing a new idea, program, company, or platform? While each diligence is unique and every investor will have

The post Deconstructing the Diligence Process: An Approach to Vetting New Product Theses appeared first on LifeSciVC.


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Waiver of Informed Consent - proposed changes in the 21st Century Cures Act

By www.placebocontrol.com
Published On :: Tue, 14 Jul 2015 20:21:00 +0000

Adam Feuerstein points out - and expresses considerable alarm over - an overlooked clause in the 21st Century Cures Act:


In another tweet, he suggests that the act will "decimate" informed consent in drug trials. Subsequent responses and retweets  did nothing to clarify the situation, and if anything tended to spread, rather than address, Feuerstein's confusion.

Below is a quick recap of the current regulatory context and a real-life example of where the new wording may be helpful. In short, though, I think it's safe to say:


  1. Waiving informed consent is not new; it's already permitted under current regs
  2. The standards for obtaining a waiver of consent are stringent
  3. They may, in fact, be too stringent in a small number of situations
  4. The act may, in fact, be helpful in those situations
  5. Feuerstein may, in fact, need to chill out a little bit


(For the purposes of this discussion, I’m talking about drug trials, but I believe the device trial situation is parallel.)

Section 505(i) - the section this act proposes to amend - instructs the Secretary of Health and Human Services to propagate rules regarding clinical research. Subsection 4 addresses informed consent:

…the manufacturer, or the sponsor of the investigation, require[e] that experts using such drugs for investigational purposes certify to such manufacturer or sponsor that they will inform any human beings to whom such drugs, or any controls used in connection therewith, are being administered, or their representatives, that such drugs are being used for investigational purposes and will obtain the consent of such human beings or their representatives, except where it is not feasible or it is contrary to the best interests of such human beings.

[emphasis  mine]

Note that this section already recognizes situations where informed consent may be waived for practical or ethical reasons.

These rules were in fact promulgated under 45 CFR part 46, section 116. The relevant bit – as far as this conversation goes – regards circumstances under which informed consent might be fully or partially waived. Specifically, there are 4 criteria, all of which need to be met:

 (1) The research involves no more than minimal risk to the subjects;
 (2) The waiver or alteration will not adversely affect the rights and welfare of the subjects;
 (3) The research could not practicably be carried out without the waiver or alteration; and
 (4) Whenever appropriate, the subjects will be provided with additional pertinent information after participation.

In practice, this is an especially difficult set of criteria to meet for most studies. Criterion (1) rules out most “conventional” clinical trials, because the hallmarks of those trials (use of an investigational medicine, randomization of treatment, blinding of treatment allocation) are all deemed to be more than “minimal risk”. That leaves observational studies – but even many of these cannot clear the bar of criterion (3).

That word “practicably” is a doozy.

Here’s an all-too-real example from recent personal experience. A drug manufacturer wants to understand physicians’ rationales for performing a certain procedure. It seems – but there is little hard data – that a lot of physicians do not strictly follow guidelines on when to perform the procedure. So we devise a study: whenever the procedure is performed, we ask the physician to complete a quick form categorizing why they made their decision. We also ask him or her to transcribe a few pieces of data from the patient chart.

Even though the patients aren’t personally identifiable, the collection of medical data qualifies this as a clinical trial.

It’s a minimal risk trial, definitely: the trial doesn’t dictate at all what the doctor should do, it just asks him or her to record what they did and why, and supply a bit of medical context for the decision. All told, we estimated 15 minutes of physician time to complete the form.

The IRB monitoring the trial, however, denied our request for a waiver of informed consent, since it was “practicable” (not easy, but possible) to obtain informed consent from the patient.  Informed consent – even with a slimmed-down form – was going to take a minimum of 30 minutes, so the length of the physician’s involvement tripled. In addition, many physicians opted out of the trial because they felt that the informed consent process added unnecessary anxiety and alarm for their patients, and provided no corresponding benefit.

The end result was not surprising: the budget for the trial more than doubled, and enrollment was far below expectations.

Which leads to two questions:

1.       Did the informed consent appreciably help a single patient in the trial? Very arguably, no. Consenting to being “in” the trial made zero difference in the patients’ care, added time to their stay in the clinic, and possibly added to their anxiety.
2.       Was less knowledge collected as a result? Absolutely, yes. The sponsor could have run two studies for the same cost. Instead, they ultimately reduced the power of the trial in order to cut losses.


Bottom line, it appears that the modifications proposed in the 21st Century Cures Act really only targets trials like the one in the example. The language clearly retains criteria 1 and 2 of the current HHS regs, which are the most important from a patient safety perspective, but cuts down the “practicability” requirement, potentially permitting high quality studies to be run with less time and cost.

Ultimately, it looks like a very small, but positive, change to the current rules.

The rest of the act appears to be a mash-up of some very good and some very bad (or at least not fully thought out) ideas. However, this clause should not be cause for alarm.


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Enabling an Economic Transformation of Ukraine: Recovery, Reconstruction, and Modernization

By www.belfercenter.org
Published On :: Jan 10, 2023

The aim of the report is to focus specifically on the critical role of private sector investment in Ukraine’s economic reconstruction, and how the private sector, both within Ukraine and internationally, can enable Ukraine to win the peace. It provides a short overview of the economic challenges facing Ukraine, including governance, the sectors that will be critical to Ukraine's reconstruction, the roles and responsibilities for the G7, EU, IFIs, and DFIs, and then recommendations for how Ukraine and its partners can best attract private sector investment.


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EVENT DEBRIEF: The Future of Ukraine: Reconstruction, Energy Security, and Innovation

By www.belfercenter.org
Published On :: Apr 18, 2023

The following is an event write-up about the recent Future of Diplomacy Project (FDP) seminar on “The Future of Ukraine: Reconstruction, Energy Security, and Innovation” moderated by Ambassador Paula J. Dobriansky, Senior Fellow with the Future of Diplomacy Project. 


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Constructing Climate Change: Exploring How Cities Frame Climate Change in the Arctic

By www.belfercenter.org
Published On :: May 23, 2024

Framing climate policy actions to be acceptable by various stakeholders in cities poses a critical task for urban governance. This paper draws on the literature on climate change discourse to analyze the content of framing and its reasoning in the two municipalities located in the Arctic: Murmansk, Russia, and Tromsø, Norway.


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Survey Finds Gap Between Home Protection Concerns And Consumer Actions - Kristin Chenoweth Protect It Or Lose It Video

By www.multivu.com
Published On :: 22 Jul 2014 16:23:00 EDT

Kristin Chenoweth teamed up with Allstate to quiz homeowners on the value of the possessions in their home - see what they know, and don't know!


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Stella Artois Joins Forces with Water.org and Co-Founders Matt Damon and Gary White to Call on Consumers to Leave a Mark and Help End the Global Water Crisis - Stella Artois partners with Water.org

By www.multivu.com
Published On :: 21 Jan 2016 17:15:00 EST

Stella Artois joins forces with Water.org and Co-Founders Matt Damon and Gary White to call on consumers to leave a mark and help end the global water crisis.


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Barometer Promise - BNP Exane "Exclusivity & Desirability" 2015: The Wealthiest Chinese Women Rank Luxury Brands - Philippe Jourdan: Partner - Promise Consulting

By www.multivu.com
Published On :: 02 Feb 2016 16:40:00 EST

Philippe Jourdan: Partner - Promise Consulting


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NASCAR Icons Goodyear, Dale Earnhardt Jr., Expand Relationship - Goodyear�s �Made� Commercial

By www.multivu.com
Published On :: 18 Feb 2016 12:10:00 EST

When it comes to performance under pressure, Dale Jr. and Goodyear are forged from the same fire. Like Goodyear, the Earnhardt name has a long history in NASCAR and we�re proud to say we�re Driven Like Jr.


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Consejos para el Hogar - Consejos para el Hogar

By www.pg.com
Published On :: 23 Apr 2014 17:28:00 EDT

Consejos para el Hogar


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  • Artículos del hogar
  • Artículos de consumo
  • Cosméticos
  • Mejoras al Hogar
  • Productos del Hogar (aspiradoras
  • artículos de limpieza y similares)
  • Noticias para la comunidad hispana
  • Nueva York
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MEXICÁNICOS llega a Discovery en Español con los diseños más sorprendentes de hot rods y limusinas - Conoce al legendario restaurador y mecánico Martín Vaca quien construye autos [..]

By www.multivu.com
Published On :: 17 Feb 2015 12:11:00 EST

Conoce al legendario restaurador y mecánico Martín Vaca quien construye autos fuera de serie desde hace más de 50 años. MEXICÁNICOS, estreno el 2 de marzo a las 10PM


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CONSEJOS PARA UN CAMBIO DE IMAGEN “MAXIMO” EN EL HOGAR - Transforma Tu Hogar para este Verano

By www.3m.com
Published On :: 04 Jun 2015 18:40:00 EDT

Transforma Tu Hogar para este Verano


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  • Artículos del hogar
  • Artículos de consumo
  • Cosméticos
  • Ventas detallistas
  • Mejoras al Hogar
  • Productos del Hogar (aspiradoras
  • artículos de limpieza y similares)
  • Estados Unidos de América
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¿Sientes que el cuidado de belleza te frustra más que funciona durante el verano? - Consejos de belleza para el verano

By www.dove.us
Published On :: 28 Jul 2015 17:15:00 EDT

Consejos de belleza para el verano


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  • Artículos del hogar
  • Artículos de consumo
  • Cosméticos
  • Cosméticos y Cuidado Personal
  • Noticias para la comunidad hispana
  • Estados Unidos de América
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International Survey Released for World Meningitis Day Shows Parents Feel They Don't Know Enough About the Disease and its Consequences - Lenine Cunha, Portuguese Paralympian and Win for Meningitis campaign ambassador

By www.multivu.com
Published On :: 25 Apr 2016 13:10:00 EDT

Lenine Cunha, Portuguese Paralympian and Win for Meningitis campaign ambassador


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Mandatory additional qualifiers in import/export declarations inrespect of Synthetic or Reconstructed Diamonds

By www.caclubindia.com
Published On :: Sat, 2 Nov 2024 10:54:28 GMT

Government of IndiaMinistry of FinanceDepartment of Revenue(Central Board of Indirect Taxes & Customs)North Block, New Delhi. Dated:30th October, 2024To All Principal Chief Commissioners/Chi


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Interest on Capital consider as Capital Infusion

By www.caclubindia.com
Published On :: Mon, 11 Nov 2024 17:27:57 GMT

Hello Members,In one of the client case, he is partner at different firms. In one of the firm, the interest given to him on his Capital is consider as infusion of Capital since they had missed deducting TDS on the same. Now when we are filing his personal ITR, how do we con


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A Little About My Story “Apocalypse Considered Through a Helix of Semiprecious Foods and Recipes” Now Out in The Magazine of Fantasy & Science Fiction

By tobiasbuckell.com
Published On :: Thu, 02 May 2019 21:11:57 +0000

My latest short story is out in The Magazine of Fantasy & Science Fiction. When I first started writing short stories, back in the 90s, F&SF was one of the ‘big three’ that I really wanted to get a story in to cross off my bucket list. The big three were Asimov’s, F&SF, and Analog. […]


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Report from Wisconsin: John Nichols on Harris's Madison Roots & Key Senate/House Races Nationwide

By www.democracynow.org
Published On :: Fri, 01 Nov 2024 08:28:38 -0400

We speak with The Nation's John Nichols in Wisconsin, where Kamala Harris and Donald Trump are spending a lot of their time in the closing days of the election in a tight battle for the state's 10 Electoral College votes. Nichols also discusses the battle for the Senate, with key races in Wisconsin and Nebraska; how New York races could tip control of the House to Democrats; and why Kamala Harris needs to expand her message beyond the threat of Trump’s authoritarianism. “At the doors, people want to talk about economics,” says Nichols.


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Technical Consultancy for Project Development and Management Support Services to MJP are taxable under GST at the rate of 18%

By www.caclubindia.com
Published On :: Thu, 7 Nov 2024 09:30:46 GMT

The AAR Maharashtra, in the case of M/s. The Nisarga Consultancy, In Re [Order No. GST-ARA-21 of 2023-24/2024-25/B-55 dated July 31, 2024] ruled that no tax will be leviable on work allotted by Maharashtra Jeevan Pradhikar ("MJP") as per of Jal Jeevan Mission ("JJM") which is a mission of Government


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Date of online acknowledgement of appeal filed be considered as the date of filing appeal

By www.caclubindia.com
Published On :: Thu, 7 Nov 2024 09:30:48 GMT

The Hon'ble Karnataka High Court in the case of Hitachi Energy India Ltd. v. State of Karnataka and Ors. [Writ Petition No. 14111 of 2024 dated July 02, 2024] allowed the writ petition and further affirmed that the date of provisional acknowledgment for appeal filed would be considered as the date o


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The consequences are painful

By cheezburger.com
Published On :: Tue, 25 Jul 2023 14:00:00 -0700


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10 Ai Generated Memes of Purrfessional Construction Cats Who Caught the Early Bird and Left the Worm in Your Silly Slippers

By cheezburger.com
Published On :: Tue, 12 Nov 2024 15:00:00 -0800

Welcome to the modern age feline fanatics. We have finally made it to the moment when AI has begun working to create cat memes along with the bright minds here at Cheezburger. Finally allowing us to bring you the very freshest in feline funnies hot from the oven of our collective ICanHasCheezburger mind. And today we are taking a dip into the world of cat construction, a little known environment which allows cats access to tools and methods of expression that they are usually not able to comprehend. But thanks to our supportive AI we have made this crossover come true.

So without any further delay we would like to present to you this list of Ai generated memes of purrfessional construction cats who caught the early bird and left the worm in your silly slippers. Prepaw yourself for a funny feline ride through some brand new never before heard feline notions.


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Wildfires Of No Consequence 

By www.waiterrant.net
Published On :: Wed, 13 Nov 2024 01:40:45 +0000

Billowing menace, acrid scents  Old growth, saplings charring together  While out of sight, fawns distressed race And the owl’s perch succumbs.  Golden hordes breaching firebreaks  Rapine alight windswept, rapacious, desiccation stoked   Consuming canopies, no quarter given While rooted tributaries blazing course underfoot.  Slight deluges, drawn from placid lakes Lofted by fraught metaled battalions Plunge pityingly […]

The post Wildfires Of No Consequence  appeared first on Waiter Rant.


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Comic [1610] "OSE: Conscience Enforcement Authority: The New Kitty Case Worker [special comic]"

By megatokyo.com
Published On :: Tue, 02 Jan 2024 11:32:00 -0800

One Shot Episode comic 1610
[read...]
[permalink]


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Should've Hired A Consultant

By questionablecontent.net
Published On :: Sun, 23 Jun 2024 22:02:06 -0300

mmm spaghettification


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'It was nonsense': Entitled employee constantly takes credit for other's work, coworker gets revenge by making a fake presentation for her to present in front of boss

By cheezburger.com
Published On :: Sat, 09 Nov 2024 04:00:00 -0800

There's always that one coworker who knows how to get away with taking credit for everyone else's hard work. You put in the effort, lose sleep over the details, and then they swoop in, ready to present it all like they thought of it themselves. This exact situation happened in one office until one clever employee decided to turn the tables. After watching his entitled coworker repeatedly swipe his projects and pass them off as her own, he put together a presentation just for her. Packed with confusing data points and meaningless buzzwords, the presentation was just convincing enough to look important…until you actually tried to explain it. And sure enough, the coworker snagged it and confidently presented it in front of their boss. The employee watched with quiet satisfaction as she stumbled through, each buzzword making less sense than the last. When the boss turned to him for clarification, he threw her under the bus, telling the boss she had no idea what she was talking about. Sweet, sweet office justice.


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