Decades of Western military intervention and training have stoked the fires of sectarianism and warfare in Iraq and the broader region.

One of the issues being debated in Sierra Leone, as the country undergoes a constitutional review, is whether to keep in place presidential term limits.

The current conflict in the Middle East will leave a lasting environmental impact, prompting calls for urgent restoration and cross-border cooperation.

TOKYO, Japan — Japan’s Seven & i Holdings 3382.T is considering launching a management buyout that would see the retailer go private in a deal that could be worth up to $58 billion, Bloomberg News reported on Wednesday. The Nikkei newspaper also reported that the owner of the 7-Eleven convenience store chain was looking at […]...

Keep on reading: Japan's 7-Eleven reportedly considering management buyout of up to $58B

Funeral held for 10 people killed in consecutive Israeli strikes in Lebanon

Last week, UN member states adopted the Pact of the Future – and its two annexes: the Global Digital Compact and the Declaration for Future Generations. These action-oriented documents are envisaged to counter emerging threats to development and acceleration of progress on Agenda 2030. Nonetheless, there remains little political prioritization of reproductive justice on this agenda. […]

Kathy Bates on not having reconstruction surgery after double mastectomy Kathy Bates revealed why she didn’t go for a reconstruction surgery after her double mastectomy and breast cancer diagnosis.In 2012, at age 64, the American Horror Story alum was diagnosed with breast cancer and...

As the UN’s COP16 biodiversity conference continues, the temptation is to focus on the wild flora and fauna under threat. But there is another, less obvious yet just as critical biodiversity crisis unfolding around the world that also deserves attention. A quarter of livestock breeds – from chickens, ducks and geese to horses, camels and […]

The energy regulator said on Tuesday it will review data purporting to show how the Electricity Authority of Cyprus (EAC) could “trim the fat” and cut costs by up to 15 per cent, translating into lower utility bills for consumers. The EAC’s “fat” has become a buzzword after Michalis Persianis, head of the Fiscal Council, […]

Construction company Aktor (formerly Intrakat) is now seeking over €35 million in damages through the courts after the public works department terminated the contract with regarding the Paphos-Polis road project, according to its CEO Alexandros Exarchou, who spoke at an online press conference. “We are compelled to pursue our legal rights in Cyprus and, if […]

Colorado voters will decide whether to repeal the state constitution's now-defunct marriage definition that only recognizes unions between a man and a woman.

Sri Lanka's post-tsunami reconstruction experience provides lessons for future major disasters, particularly for realistic needs assessment.

India’s federal power minister on Tuesday asked the states that are away from coal resources to consider setting up nuclear-based power plants, besides identifying and listing the power utilities to meet investments to support growing power demand.

The Indian government in its federal budget this year had proposed to partner with private players to develop small nuclear reactors to increase the amount of electricity from sources that do not produce carbon dioxide emissions.

States should consider setting up nuclear power plants at the sites where coal-based thermal power plants have completed their life, Manohar Lal, the country’s power minister, told states as per a government statement.

India’s stringent nuclear compensation laws have hampered talks with foreign power plant builders such as General Electric GE.N and Westinghouse.

The country, which currently has about 8 gigawatts of nuclear capacity, aims to increase it to 20 GW by 2032.

The minister also asked the states to identify and list their power utilities in the country’s stock exchange to meet increasing investment demand in the power sector as well as improve the transmission system to add more renewable capacity.

India has pledged to achieve a net zero carbon emission target by 2070 and has a target of 500 GW of renewable energy by 2030.

The Supreme Court (SC) on Tuesday announced that the recently established constitutional bench will start hearing cases on November 14 and 15.

Earlier, the SC constituted a three-judge committee to fix cases, issue court rosters, form benches, and decide weekly caseload for its recently established constitutional bench.

The committee held a meeting today which was chaired by Justice Aminud Din Khan (head of the constitutional bench) and attended by Justice Jamal Khan Mandokhail and Justice Muhammad Ali Mazhar, who participated through a telephone call from Karachi.

The SC said in a press release, a copy of which is available with Dawn.com, that the purpose of the meeting was to discuss matters for the formation of the constitutional bench.

During the meeting, the committee was briefed by the court’s registrar’s office regarding the pending constitutional cases, the statement said adding, “[The] committee resolved that priority shall be accorded to the oldest cases.”

On Nov 5, the Judicial Commission of Pakistan (JCP), in its maiden session, had picked Justice Amin as head of the constitutional bench by a seven-to-five majority.

Chaired by Chief Jus­tice of Pakistan (CJP) Jus­tice Yahya Afridi, the reconstituted JCP for­m­ed a seven-member con­stitutional bench, inc­­luding Justices Ami­nud Din Khan, Jamal Khan Mandokhail, Muha­m­mad Ali Mazhar, Ayesha A. Malik, Hassan Azhar Rizvi, Musarrat Hilali and Naeem Akhtar Afghan.

Today’s press release mentioned that Justice Ayesha Malik will not be available on Nov 14 and 15 and “a bench comprising all available Judges shall be constituted to proceed with cases on these dates.”

The SC Registrar Muh­ammad Salim Khan released the court roster of a six-member constitutional bench which will begin hearing cases at 9:30am on Nov 14.

The bench will include Justice Jamal Khan Mandokhail, Justice Muhammad Ali Mazhar, Justice Hasan Azhar Rizvi, Justice Musarrat Hilali and Justice Naeem Akhtar Afghan.

The SC directed the Registrar to schedule cases for hearing before the bench.

The next meeting of the committee will be held on Nov 13 at 12:30pm after Justice Muhammad Ali Mazhar arrives in Islamabad.

Extending across seven provinces and two autonomous regions, the Yellow River Ecological Corridor (YREC) comprises the second largest river basin in the People's Republic of China (PRC) with a population of 120 million. The basin is critical for food security yet faces complex ecological and environmental challenges. The region suffers from severe water scarcity, impacts from climate change and environmentally unsustainable development.

Lab-reared German cockroaches are susceptible to consumer insecticide sprays, allowing manufacturers to pass US regulatory tests, but insects taken from real-world infestations are able to shrug off the products

Research has found the universe is remarkably similar in structure to the human brain. But does this mean the cosmos has a consciousness of its own?

Research has found the universe is remarkably similar in structure to the human brain. But does this mean the cosmos has a consciousness of its own?

We are living in a vaccine-hesitant moment, with conspiracy theories thriving on social media. We need to push back, says Simon Williams

Babies cannot tell us what they are experiencing, so it is hard to know what they are conscious of. But new research suggesting they perceive the world consciously could change how we care for them, says Claudia Passos-Ferreira

Title: Conservative Talk Show Host Who Railed Against Vaccines Dies of COVID
Category: Health News
Created: 8/23/2021 12:00:00 AM
Last Editorial Review: 8/23/2021 12:00:00 AM

Title: For Better Breastfeeding, 'Lactation Consultants' Can Help
Category: Health News
Created: 8/25/2021 12:00:00 AM
Last Editorial Review: 8/25/2021 12:00:00 AM

The 10q11.22 chromosomal region is a duplication-rich interval of the human genome and one of the last to be fully assembled. It carries copy number–variable genes associated with intellectual disability, bipolar disorder, and obesity. In this study, we characterized the structural diversity at this locus by analyzing 64 haploid assemblies produced by the Human Pangenome Reference Consortium. We identified 11 alternative haplotypes that differ in the copy number and/or orientation of large genomic segments, ranging from hundreds of kilobase pairs (kbp) to over one megabase pair (Mbp). We uncovered a 2.4 Mbp size difference between the shortest and longest haplotypes. Breakpoint analysis revealed that genomic instability results from nonallelic homologous recombination between segmental duplication (SD) pairs with varying similarity (94.4%–99.6%). Nonetheless, these pairs generally recombine at positions where their identity is higher (>99.6%). Recurrent inversions occur with different breakpoints within the same inverted SD pair. Inversion polymorphisms shuffle the entire SD arrangement, creating new predispositions to copy-number variations. The SD architecture is associated with a catarrhine-specific subgroup of the AGAP gene family, which likely triggered the accumulation of SDs at this locus over the past 25 million years of human evolution. Our results reveal extensive structural diversity and genomic instability at the 10q11.22 locus, and expand the general understanding of the mutational mechanisms behind SD-mediated rearrangements.

Neural reflexes occupy a central role in physiological homeostasis. The vagus nerve is a major conduit for transmitting afferent and efferent signals in homeostatic reflex arcs between the body and the brain. Recent advances in neuroscience, immunology, and physiology have revealed important vagus nerve mechanisms in suppressing inflammation and treating rheumatoid arthritis and other autoimmune conditions. Numerous clinical trials indicate that there is significant benefit to vagus nerve stimulation therapy. Although many questions are still unanswered, it will be important, even necessary, to pursue answers that will be useful in guiding interventions to modulate immunological and physiological homeostasis.

Caenorhabditis elegans is an important model organism for human health and disease, with foundational contributions to the understanding of gene expression and tissue patterning in animals. An invaluable tool in modern gene expression research is the presence of a high-resolution ribosome structure, though no such structure exists for C. elegans. Here, we present a high-resolution single-particle cryogenic electron microscopy (cryo-EM) reconstruction and molecular model of a C. elegans ribosome, revealing a significantly streamlined animal ribosome. Many facets of ribosome structure are conserved in C. elegans, including overall ribosomal architecture and the mechanism of cycloheximide, whereas other facets, such as expansion segments and eL28, are rapidly evolving. We identify uL5 and uL23 as two instances of tissue-specific ribosomal protein paralog expression conserved in Caenorhabditis, suggesting that C. elegans ribosomes vary across tissues. The C. elegans ribosome structure will provide a basis for future structural, biochemical, and genetic studies of translation in this important animal system.

The management of chylothorax remains challenging given the limited evidence and significant heterogeneity in practice. In addition, there are no practical guidelines on the optimal approach to manage this complex condition. We convened an international group of 27 experts from 20 institutions across five countries and four specialties (pulmonary, interventional radiology, thoracic surgery and nutrition) with experience and expertise in managing adult patients with chylothorax. We performed a literature and internet search for reports addressing seven clinically relevant PICO (Patient, Intervention, Comparison and Outcome) questions pertaining to the management of adult patients with chylothorax. This consensus statement, consisting of best practice statements based on expert consensus addressing these seven PICO questions, was formulated by a systematic and rigorous process involving the evaluation of published evidence, augmented with provider experience. Panel members participated in the development of the final best practice statements using the modified Delphi technique. Our consensus statement aims to offer guidance in clinical decision making when managing patients with chylothorax while also identifying gaps in knowledge and informing future research.

The consumption of ⁹-tetrahydrocannabinol (THC)- or cannabis-containing edibles has increased in recent years; however, the behavioral and neural circuit effects of such consumption remain unknown, especially in the context of ingestion of higher doses resulting in cannabis intoxication. We examined the neural and behavioral effects of acute high-dose edible cannabis consumption (AHDECC). Sprague-Dawley rats (six males, seven females) were implanted with electrodes in the prefrontal cortex (PFC), dorsal hippocampus (dHipp), cingulate cortex (Cg), and nucleus accumbens (NAc). Rats were provided access to a mixture of Nutella (6 g/kg) and THC-containing cannabis oil (20 mg/kg) for 10 minutes, during which they voluntarily consumed all of the provided Nutella and THC mixture. Cannabis tetrad and neural oscillations were examined 2, 4, 8, and 24 hours after exposure. In another cohort (16 males, 15 females), we examined the effects of AHDECC on learning and prepulse inhibition and serum and brain THC and 11-hydroxy-THC concentrations. AHDECC resulted in higher brain and serum THC and 11-hydroxy-THC levels in female rats over 24 hours. AHDECC also produced: 1) Cg, dHipp, and NAc gamma power suppression, with the suppression being greater in female rats, in a time-dependent manner; 2) hypolocomotion, hypothermia, and antinociception in a time-dependent manner; and 3) learning and prepulse inhibition impairments. Additionally, most neural activity and behavior changes appear 2 hours after ingestion, suggesting that interventions around this time might be effective in reversing/reducing the effects of AHDECC.

The role of somatostatin receptor (SSTR) PET/CT, using ⁶⁸Ga-based tracers or [⁶⁴Cu]Cu-DOTATATE (⁶⁴Cu-DOTATATE), in the management of patients with neuroendocrine neoplasm (NEN) is guided by appropriate use criteria (AUC). In this study, we performed systematic analyses of referral patterns and image findings of routine ⁶⁴Cu-DOTATATE PET/CT scans to support AUC development. Methods: We included all clinical routine ⁶⁴Cu-DOTATATE PET/CT scans performed between April 10, 2018 (start of clinical use), and May 2, 2022, at Copenhagen University Hospital–Rigshospitalet. We reviewed the referral text and image report of each scan and classified the indication according to clinical scenarios as listed in the AUC. Results: In total, 1,290 patients underwent 2,249 ⁶⁴Cu-DOTATATE PET/CT scans. Monitoring of patients with NEN seen both on conventional imaging and on SSTR PET without clinical evidence of progression was the most common indication (defined as "may be appropriate" in the AUC) and accounted for 703 (31.3%) scans. Initial staging after NEN diagnosis ("appropriate" in the AUC) and restaging after curative-intent surgery ("may be appropriate" in the AUC) accounted for 221 (9.8%) and 241 (10.7%) scans, respectively. Selection of patients eligible for peptide receptor radionuclide therapy ("appropriate" in the AUC) and restaging after peptide receptor radionuclide therapy completion ("appropriate" in the AUC) accounted for 95 (4.2%) and 115 (5.1%) scans, respectively. The number of scans performed for indications not defined in the AUC was 371 (16.5%). Image result analysis revealed no disease in 669 scans (29.7%), stable disease in 582 (25.9%), and progression in 461 (20.5%). In 99 of the 461 (21.5%) scans, progression was detected on PET but not on CT. Conclusion: Our study provided real-life data that may contribute to support development of ⁶⁴Cu-DOTATATE/SSTR PET/CT guidelines including AUC. Some scenarios listed as "may be appropriate" in the current AUC were frequent in our data. Monitoring of patients with NEN without clinical evidence of progression was the most frequent indication for ⁶⁴Cu-DOTATATE PET/CT, in which disease progression was detected in more than one third, and a large proportion was visible by PET only. We therefore conclude that this scenario could potentially be classified as appropriate.

Understanding the differences between prognostic and predictive indices is imperative for medical research advances. We have developed a new prognostic measure that will identify the strengths, limitations, and potential applications in clinical practice.

BACKGROUND AND PURPOSE:

Preoperative assessment of meningioma consistency is beneficial for optimizing surgical strategy and prognosis of patients. We aim to develop a noninvasive prediction model for meningioma consistency utilizing MR elastography and DTI.

BACKGROUND AND PURPOSE:

Intracranial vessel wall imaging is technically challenging to implement, given the simultaneous requirements of high spatial resolution, excellent blood and CSF signal suppression, and clinically acceptable gradient times. Herein, we present our preliminary findings on the evaluation of a deep learning–optimized sequence using T1-weighted imaging.

Comprehensive maps of neuronal connectivity provide a foundation for understanding the structure of neural circuits. In a circuit, neurons are diverse in morphology, electrophysiology, gene expression, activity, and other neuronal properties. Thus, constructing a comprehensive connectivity map requires associating various properties of neurons, including their connectivity, at cellular resolution. A commonly used approach is to use the gene expression profiles as an anchor to which all other neuronal properties are associated. Recent advances in genomics and anatomical techniques dramatically improved the ability to determine and associate the long-range projections of neurons with their gene expression profiles. These studies revealed unprecedented details of the gene–projection relationship, but also highlighted conceptual challenges in understanding this relationship. In this article, I delve into the findings and the challenges revealed by recent studies using state-of-the-art neuroanatomical and transcriptomic techniques. Building upon these insights, I propose an approach that focuses on understanding the gene–projection relationship through basic features in gene expression profiles and projections, respectively, that associate with underlying cellular processes. I then discuss how the developmental trajectories of projections and gene expression profiles create additional challenges and necessitate interrogating the gene–projection relationship across time. Finally, I explore complementary strategies that, together, can provide a comprehensive view of the gene–projection relationship.

Billionaire Bill Ackman spent days after the ABC presidential debate promoting false claims that a network “whistleblower” had allegedly uncovered collusion between ABC and Kamala Harris’ campaign. Now, a month and multiple denials later, he sees the claims differently.

“It seems pretty clear that the alleged @abc whistleblower debate story claiming that @KamalaHarris was given questions in advance and other advantages was a fake,” Ackman posted on X alongside a blog post by Megyn Kelly discussing the dubious claims.

What Ackman, CEO of Pershing Square Capital Management, did not acknowledge, however, is that he was one of falsehood’s early boosters. After an X account named “Black Insurrectionist” claimed it had been in touch with a whistleblower who alleged the Harris campaign had been given debate topics ahead of the showdown with Donald Trump and had demanded Trump—and Trump alone—be fact-checked.

Read more at The Daily Beast.

We'll have a review of Planet Coaster 2 soon, but I keep making Brendy do other tasks so he's not had enough time yet to ride the rails. That means it falls to me to at least let you know that Frontier's theme park builder is out now.

Read more

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JUDY WOODRUFF: Now: new questions surrounding the deaths of four Green Berets in the Western African nation of Niger and the role of the president as consoler in chief.

John Yang has the story.

JOHN YANG: Sending young Americans into harm’s way can be the most serious decision a president makes. Consoling the families of the fallen has become the latest controversy to engulf President Trump.

To bolster his claim that he does more than his predecessors, Mr. Trump today invoked the dead son of his chief of staff, retired Marine general John Kelly.

PRESIDENT DONALD TRUMP: To the best of my knowledge, I think I have called every family of somebody that’s died. Now, as far as other representatives, I don’t know. I mean, you could ask General Kelly, did he get a call from Obama?

JOHN YANG: Kelly’s 29-year-old son, Robert, a Marine lieutenant, was killed in 2010 when he stepped on a land mine in Afghanistan, an episode Kelly rarely talks about publicly. Kelly and his wife did attend a 2011 Memorial Day breakfast President Obama hosted for Gold Star families.

President Trump ignited the furor when he was asked about his public silence on four Green Berets killed two weeks ago in Niger.

PRESIDENT DONALD TRUMP: If you look at President Obama and other presidents, most of them didn’t make calls. A lot of them didn’t make calls. I like to call when it’s appropriate, when I think I’m able to do it.

JOHN YANG: Reporters pressed him to back up the claim.

PRESIDENT DONALD TRUMP: I don’t know. That’s what I was told. All I can do — all I can do is ask my generals.

JOHN YANG: The response from former Obama officials was swift and forceful.

Former Attorney General Eric Holder tweeted this photo and insisted: “Stop the damn lying. I went to Dover Air Force base with 44 and saw him comfort families,” a reference to one of Mr. Obama’s late-night trips to pay his respects to troops killed in Afghanistan.

Mr. Obama and President George W. Bush often visited wounded warriors at Walter Reed and Bethesda hospitals, a practice Mr. Trump has continued. In February, the president and his daughter Ivanka went to Dover for the return of the remains of a Navy SEAL killed in Yemen, the first casualty of his administration.

So far this year, the Pentagon says 16 Americans have been killed in action. Another 17 sailors died in accidents. In the first year of the Obama presidency, 344 were killed in action.

During last year’s campaign, Mr. Trump publicly feuded with the Khans, the parents of a Muslim American soldier killed in Iraq, after they criticized him at the Democratic Convention.

Today, the Khans said: “President Trump’s selfish and divisive actions have undermined the dignity of the high office of the presidency.”

The current controversy comes as questions are being raised about how and why the four soldiers died in Niger.

Senator Jack Reed is the top Democrat on the Armed Services Committee.

SEN. JACK REED, D-R.I.: I think the administration has to be much more clear about our role in Niger and our role in other areas in Africa and other parts of the globe.

JOHN YANG: The Pentagon is investigating the deaths. Reportedly among the questions, did commanders adequately assess the risk, and was there ready access to medical support?

Today, President Trump called the families of the four dead Green Berets.

For the PBS NewsHour, I’m John Yang.

The post Trump ignites furor with claim past presidents didn’t console military families by phone appeared first on PBS NewsHour.

From Goats to airplanes, Xbox Game Pass has another bumper month in store for subscribers. Here's everything you need to know about what is heading to PC and console this November 2024

PlayStation 5 Pro is out, and with plenty of availability, scalpers are shifting the £700 console at a loss and turning their attention to a key accessory instead

PS5 owners can play some great games this month, including a Bethesda hit and more. Here's what's free for PS Plus subscribers for November, with more to be announced.

Just got a PS5 or want to know what to prioritise in your backlog? We've got you covered with the best PlayStation 5 games for your console that you can play right now.

We are living in a vaccine-hesitant moment, with conspiracy theories thriving on social media. We need to push back, says Simon Williams

Home users can opt in for a single year of updates at $30 per PC—not 3 years.

Manufacturing efficiency has always been a priority. As competition grows, optimizing every aspect of production becomes critical. Manufacturers turn to experts to make the right improvements and introduce systems that boost overall performance. One key area where many businesses seek help is through Manufacturing Execution Systems (MES). MES consultants play a pivotal role in achieving […]

The post The Role of MES Consultants in Streamlining Manufacturing Operations appeared first on Chart Attack.

As a truck owner who’s watching every penny, you know how quickly maintenance expenses can get out of hand. There’s always another issue, another part to replace, another tool you didn’t know you needed. But there’s good news – plenty of ways exist to keep those trucks running smoothly without draining your wallet. With a […]

The post Maintenance Tips for Budget-Conscious Truck Owners ─ Keeping Costs Down appeared first on Chart Attack.

Sen. John Fetterman (D-PA) weighed in on reports regarding President-elect Donald Trump's choice for secretary of state.

The post Fetterman Calls Rubio ‘Strong Choice’ as Trump Reportedly Considers Him for Secretary of State appeared first on Breitbart.

Republican Senators huddled for over two hours Tuesday night for a family meeting over who will take the reins from Sen. Mitch McConnell (R-KY).

The post Republican Senators Hold Leader Candidate Forum Hours Before Consequential Vote appeared first on Breitbart.

Following its announcement a few weeks ago, the final major update for Dead Cells titled The End is Near, version …

Continue reading "Dead Cells’ Final Major Update 35 ‘The End Is Near’ Is Now Available on PC and Consoles, No Word on Mobile Yet"

Last week, Gameloft announced the next major and free Disney Dreamlight Valley update for PC and consoles alongside Disney Dreamlight …

Continue reading "‘Disney Dreamlight Valley’ Dapper Delights Update Now Available for Apple Arcade, Consoles, and PC"

Hello gentle readers, and welcome to the SwitchArcade Round-Up for August 27th, 2024. In today’s article, we kick things off …

Continue reading "SwitchArcade Round-Up: Today’s Nintendo Direct, Full Review of ‘EGGCONSOLE Star Trader’, Plus New Releases and Sales"