Constellation Energy will continue to pursue deals to develop data centres on the sites of its U.S. power plants, days after federal regulators dealt a blow to the so-called co-located arrangements, company executives said

Natural ingredients play spices up flavor and fragrance sector

Natural ingredients deal spices up flavor and fragrance sector

Library of 2,500 samples offers clues about hues, both old and new

Nine new science-themed emoji will soon be available on a number of platforms and mobile devices

The German giant may build a new “Verbund” site in Guangdong, China.

The German giant may build a new Verbund site in Guangdong, China

Numerous basic inputs may be hit with a 10% import tax as trade war intensifies

Reagent developed through Scripps and BMS collaboration couples nucleosides with potential applications in antisense therapeutics

Pushes past China on back of affordable homegrown brands; many in global top five

The project, funded by the Universal Service Obligation Fund, involves the design, supply, construction, installation, upgradation, and maintenance of BharatNet’s Middle Mile Network

The shares of HFCL Limited were trading at ₹128.89 up by ₹2.10 or 1.66 per cent on the NSE today at 1.40 pm

Anurag Basu says judging a reality show helped him design “Jagga Jasoos”

The Air Quality Index (AQI) of the national capital remained in 'very poor' category for the 15th consecutive day on Wednesday, i.e., November 13.

The Taliban regime has appointed Ikramuddin Kamil as the acting consul in the Afghan mission in Mumbai, Afghan media has reported. This is the first such appointment made by the Taliban set up to any Afghan mission in India. The appointment, announced by the Ministry of Foreign Affairs of Afghanistan, is seen as an effort to strengthen diplomatic ties with India and enhance its presence abroad. Kamil, who holds a PhD degree in international law, is expected to facilitate consular services and represent the interests of Afghanistan in India.

After trying to make a dent in the cola market with Campa by offering higher trade margins to the supply chain, Reliance Consumer Products is betting on the same strategy to capture the chips, namkeen, and biscuits market in the country's booming snacks sector.

The firm has chosen India's online home design firm Livspace for its first investment.

The post SG’s Venturi Partners to raise $150m consumer fund for India and SEA appeared first on DealStreetAsia.

The fund manager sees opportunities in sectors such as education and microfinance.

The post We are betting on the Indonesian consumer story: Northstar co-founder Walujo appeared first on DealStreetAsia.

The BigBasket and Portea Medical promoter expects to see venture debt rising as an asset class in India.

The post Critical to conserve cash and ride out the storm, says GrowthStory’s K Ganesh appeared first on DealStreetAsia.

Fundraising conversations will increasingly be centred around business models and sustainability.

The post Indonesia 2020: Tougher funding environment to trigger consolidation appeared first on DealStreetAsia.

Generation Z, or people born in the mid-to-late 90s or later, make up 30% of the population in the archipelago.

The post Gen Z is rewriting the Indonesian consumer sector story appeared first on DealStreetAsia.

Modi has launched India’s biggest-ever asset sale, a $29 billion privatization drive that would help prop up the economy.

The post India up for sale as PM Modi offers national icons to plug deficit appeared first on DealStreetAsia.

Economist is working with Pritzker heir to fund local Democratic candidates

Born risk-taker learns from mistakes and pays attention to detail in the horse trade

Australia's top doctor has slammed 'nonsense' conspiracy theories linking 5G technology to coronavirus after anti-5G protesters rallied in Melbourne on Sunday

Some trends are worth the hype and organic hair products is one such trend. Switching to natural and organic products seems like a gamble that we are not too crazy about. Don't you think that it is high time that you

Sheboygan County, Wis. – Today, the U.S.

Boilermakers and the Badgers meet on Feb. 18, 2020

The White House has halted talks with Congress over any further coronavirus stimulus package as it waits for more information about how U.S. state reopenings affect the economy, White House top economic adviser Larry Kudlow told reporters on Friday. The Senate and House of Representatives have already passed four major bills to address the novel coronavirus outbreak, including three aimed at stabilizing the economy as most Americans have sheltered in place and unemployment has soared.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.