Instability in Libya, a country where militias rove the land, was demonstrated last week when Prime Minister Ali Zeidan was captured in Tripoli.

Through his increasingly belligerent position toward Palestinians and Iran, Netanyahu has managed to incense the United States, Israel's one indispensable ally.

The British government has banned the stimulant khat, which will have consequences for Kenyan farmers who had been fetching inflated prices for the crop.

Netanyahu urged Iranians to imagine their free lives without 'the tyrants of Tehran' in an unusual English message.

LIVE: Leaders and experts talk aliyah, how to manage finances, real estate in the middle of war.

It is still unclear if Eliezer Feldstein, the PM's media team advisor suspected of leaking the documents, did so at the prime minister's orders.

[Capital FM] NAIROBI -- Talks between the National Assembly Education Committee,university lecturers, and public universities failed to kick off on Tuesday amid a stalement over a strike declared unprotected by courts.

[Capital FM] Nairobi -- The Politics surrounding the control of the Sh10.5 billion Road Maintenance Levy Fund between MPs and Governors has continued to stall talks to iron out the stalemate over the equitable revenue share to the devolved units.

[The Conversation Africa] It's two years since Kenyan president William Ruto, in what seemed like a political gamble, rolled out a government-run microcredit scheme popularised as the Hustler Fund. Worth 50 billion shillings (US$409 million) a year over a five-year period, the low-interest loans were touted as the "magic formula" to start or grow micro, small and medium businesses. Now the fund faces an uncertain future owing to a high default rate. Eric Magale, who studies the complex relationship between finance, livelihoods and

The elections are over and the transition towards a democratic government in Myanmar is currently underway. However, the sailing isn't smooth.

Bronisław Malinowski (1884 – 1942) did for several years conduct socio-anthropological research in the Trobriand Islands. Returning to England after World War I, he wrote several ground breaking books, among them Magic, Science, and Religion in which he assumed that people’s feelings and motives are crucial for understanding the way their society functions. Malinowski considered […]

[Shabelle] Riyadh, Saudi Arabia -- Somali President Hassan Sheikh Mohamud has touched down in Riyadh on Sunday evening for the Extraordinary Arab and Islamic States Summit.

Halevi gave this message after the IDF killed 1,000 Hamas terrorists in the northern Gazan city and additionally captured another 1,000 terrorists.

A weekly selection of opinions and analyses from the Arab media around the world.

Israeli Prime Minister Netanyahu says he and Donald Trump 'see eye to eye' on Iran

Netanyahu admits Israel behind pager attack in Lebanon

Christ’s parables were never delivered in a vacuum. They were always provoked by the circumstances, discussions, and debates that surrounded Him. That kind of contextual background information is especially critical concerning the parable of the vineyard.

Jesus made a regular habit of upending established social conventions. The Lord spent much of His earthly ministry illustrating the sharp contrast between the world and His heavenly kingdom. One of those key teaching moments is found in the preface and epilogue to Christ’s parable of the vineyard.

Yale University introduces Beyoncé course: Deets insideBeyoncé’s fans are in for a surprise as Yale University has announced a new course centering on the singer and her iconic legacy.According to Yale Daily News, the new students will “dive deep” into...

Princess Beatrice stepped into the spotlight earlier this week during a visit to The King’s Foundation’s Future Textiles exhibition at the Garrison Chapel in London. The 36-year-old royal was warmly greeted by Jacqueline Farrell, the charity’s Education Director, and had the...

Princess Kate has found a trusted mentor in the Duchess of Edinburgh, Sophie, 59, as she adjusts to her new role as Princess of Wales. Royal biographer Claudia Joseph revealed that Kate "jumped at the chance" to be mentored by Sophie, describing her as a "tower of strength" and a reliable...

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A male fourth-year business administration student of PHINMA Cagayan de Oro College stressed that the delay [of allowances] could affect students’ academic performance, especially those who do not have parents to rely on like him.

As climate change threatens the cryosphere — the frozen parts of the Earth — at an alarming rate putting almost a quarter of humanity at risk, Pakistan has advocated for coordinated regional efforts and international support to save the eco-system and build climate resilience, particularly across the Hindu Kush and Himalaya region.

The study ‘The State of the Cryosphere 2024’, released on Tuesday on the sidelines of COP29 in Baku, urged urgent action to control emissions to save glaciers, which are melting at a rapid pace due to global warming.

“Under a high emissions scenario…Hindu Kush Himalaya (HKH), may experience up to 80% of ice loss. With very low emissions however, up to 40% of glacier ice in the HKH region could be preserved,” it said, adding that projections in a few glacier regions even show slow re-growth beginning between 2100 and 2300, but only with very low emissions and essentially carbon neutrality by 2050.

Against this backdrop, the environment ministers from the HKH met on Tuesday at the Baku Olympics Stadium to come together to save the “third pole” and to keep global temperatures below 1.5 Celsius.

This gathering aimed to discuss the rapidly increasing climate risks and vulnerabilities in the region and beyond, while identifying areas for urgent collective actions, inevitable to addressing the pressing challenges and fulfilling the hopes of the quarter of humanity impacted by these changes, said a statement.

It stated that over the past decade, the rate of glacier melting in the HKH has accelerated by 65 per cent compared to the previous decade (2000-2010) and the trend is projected to continue.

“Over the last decade, the rate of glacier melting in the HKH has accelerated by 65% compared to the previous decade (2000- 2010), and the trend is projected to continue.”

Speaking at the event, Bhutan Prime Minister Tshering Tobgay said this was an opportune time for the region to unite to push for a new collective quantified role that would directly address the need of the countries which were most vulnerable to climate change.

Pakistan Prime Minister Adviser on Climate Change Romina Khurshid Alam said no country across the HKH region could tackle the climate crisis in isolation and besides regional unity, international response was essential.

She said Pakistan stood for regional partnership aiming to save the ecosystem and species, and build climate resilience. She argued for easy access to climate finance to ensure these countries could erect safeguards to protect themselves from climate change.

She said Pakistan was experiencing first-hand the impacts of climate change, increasing the risk of natural disasters in the form of GLOFs and threatening water security and agriculture as well as biodiversity.

Other speakers included delegates from China, Bangladesh, India, and Nepal. The event was organised by the Kingdom of Bhutan and the International Centre for Integrated Mountain Development.

Bleak state of Cryosphere

According to the State of Cryosphere 2024 report, if the current Nationally Determined Contributions (NDCs) are met, global temperatures will likely reach 2.3°C by 2100, leading to irreversible ice loss, significant sea-level rise, and severe impacts on coastal regions, mountain communities, and polar ecosystems.

In case of a high emissions scenario, the temperature may rise to 3-3.5°C, which will cause extreme damage, including rapid ice sheet loss, the disappearance of glaciers, and widespread permafrost thaw.

However, the 1.5°C temperature in line with the Paris Agreement can help stabilise the cryosphere and preserve part of glaciers but that cannot happen unless there is a drastic cut in emissions.

“This requires urgent action, however, with emergency-scale tightening of mitigation commitments and fossil fuel emissions declining 40% by 2030,” the report added.

In case there is no action to stop the melting of glaciers, “severe and potentially permanent changes to the water cycle, due to loss of snowpack and ice run-off during the warm summer growing season, will impact food, energy and water security.”

Produced as part of the 2024 Climate Change Media Partnership, a journalism fellowship organised by Internews’ Earth Journalism Network and the Stanley Centre for Peace and Security.

Header image: View of the landscape from Langtang, Nepal can be seen in this undated handout image. — Tika Gurung via Reuters

Published in Dawn, November 13th, 2024

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The project will continue the support of the Asian Development Bank (ADB) to Bangladesh in managing the influx of around one million displaced people from Myanmar (DPFM) since 2017. Now a protracted situation, the crisis is putting significant pressure on infrastructure and causing substantial challenges in terms of food, shelter, health, security, water, sanitation, and other services in the DPFM camps and host communities.

The proposed project will undertake a long-term and strategic approach to deliver climate adaptive solutions for water resources management in the Amu Darya River Basins in Uzbekistan. Predicted climate change impacts include increased temperatures, increased frequency and severity of extreme events such as floods and droughts, and a reduction of water availability and increased variability of water flows in the major river basins. Decreasing availability and increased water requirements by different sectors are leading to a growing seasonal and absolute supply-demand gap.

In the foundations of a Maya temple, researchers found the charred bones of royal individuals – possibly evidence of a fiery ritual to mark the end of one dynasty and the beginning of another

On a recent expedition, researchers braved summer storms in northern Greenland to learn the secrets of the ancient peoples who lived there 4500 years ago

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The poly(A) signal, together with auxiliary elements, directs cleavage of a pre-mRNA and thus determines the 3' end of the mature transcript. In many species, including humans, the poly(A) signal is an AAUAAA hexamer, but we recently found that the deeply branching eukaryote Giardia lamblia uses a distinct hexamer (AGURAA) and lacks any known auxiliary elements. Our discovery prompted us to explore the evolutionary dynamics of poly(A) signals and auxiliary elements in the eukaryotic kingdom. We use direct RNA sequencing to determine poly(A) signals for four protists within the Metamonada clade (which also contains G. lamblia) and two outgroup protists. These experiments reveal that the AAUAAA hexamer serves as the poly(A) signal in at least four different eukaryotic clades, indicating that it is likely the ancestral signal, whereas the unusual Giardia version is derived. We find that the use and relative strengths of auxiliary elements are also plastic; in fact, within Metamonada, species like G. lamblia make use of a previously unrecognized auxiliary element where nucleotides flanking the poly(A) signal itself specify genuine cleavage sites. Thus, despite the fundamental nature of pre-mRNA cleavage for the expression of all protein-coding genes, the motifs controlling this process are dynamic on evolutionary timescales, providing motivation for future biochemical and structural studies as well as new therapeutic angles to target eukaryotic pathogens.

Organic anion transporting polypeptides (OATP, gene symbol SLCO) are well-recognized key determinants for the absorption, distribution, and excretion of a wide spectrum of endogenous and exogenous compounds including many antineoplastic agents. It was therefore proposed as a potential drug target for cancer therapy. In our previous study, it was found that low-dose X-ray and carbon ion irradiation both upregulated the expression of OATP family member OATP1A2 and in turn, led to a more dramatic killing effect when cancer cells were cotreated with antitumor drugs such as methotrexate. In the present study, the underlying mechanism of the phenomenon was explored in breast cancer cell line MCF-7. It was found that the nonreceptor tyrosine kinase v-YES-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES-1) was temporally coordinated with the change of OATP1A2 after irradiation. The overexpression of YES-1 significantly increased OATP1A2 both at the mRNA and protein level. The signal transducer and activator of transcription 3 (STAT3) pathway is likely the downstream target of YES-1 because phosphorylation and nuclear accumulation of STAT3 were both enhanced after overexpressing YES-1 in MCF-7 cells. Further investigation revealed that there are two possible binding sites of STAT3 localized at the upstream sequence of SLCO1A2, the encoding gene of OATP1A2. Electrophoretic mobility shift assay and chromatin immunoprecipitation analysis suggested that these two sites bound to STAT3 specifically and the overexpression of YES-1 significantly increased the association of the transcription factor with the putative binding sites. Finally, inhibition or knockdown of YES-1 attenuated the induction effect of radiation on the expression of OATP1A2.

Secretary of State Rex Tillerson speaks at the Center for Strategic and International Studies on Wednesday.

WASHINGTON — Secretary of State Rex Tillerson is condemning reported atrocities committed against Rohingya Muslims in Myanmar, and he says those responsible — perhaps the country’s military — will be held accountable.

Tillerson says accounts of the suffering of the Rohingya are “heartbreaking” — and that if those reports are true, then “someone is going to be held to account for that.”

Tillerson — who’s set to visit South Asia next week — is urging the Myanmar government to improve humanitarian access to the population in western Rakhine state.

Amnesty International has accused Myanmar’s security forces of killing hundreds of men, women and children during a systematic campaign to expel the Rohingya. More than 580,000 refugees have fled to neighboring Bangladesh since late August.

“We really hold the military leadership accountable for what’s happening,” Tillerson said at the Center for Strategic and International Studies, a Washington think tank. “What’s most important to us is that the world can’t just stand idly by and be witness to the atrocities that are being reported in that area.”

He also called Wednesday for the U.S. and India to expand strategic ties. He pointedly criticized China, which he accused of challenging international norms needed for global stability.

He said the world needed the U.S. and India to have a strong partnership. The two nations share goals of security, free navigation, free trade and fighting terrorism in the Indo-Pacific, and serve as “the eastern and western beacons” for an international rules-based order which is increasingly under strain, he said.

Both India and China had benefited from that order, but Tillerson said India had done so while respecting rules and norms, while China had “at times” undermined them. To make his point, he alluded to China’s island building and expansive territorial claims in seas where Beijing has long-running disputes with Southeast Asian neighbors.

“China’s provocative actions in the South China Sea directly challenge the international law and norms that the United States and India both stand for,” Tillerson said in an address at the Center for Strategic and International Studies, a Washington think tank.

He added that the U.S. seeks constructive relations with China but “won’t shrink” from the challenges it poses when it “subverts the sovereignty of neighboring countries, and disadvantages the U.S. and our friends.”

U.S.-India relations have generally prospered in the past decade, in part because of their shared concerns about the rise of China. While President Donald Trump has looked to deepen cooperation with China on addressing the nuclear threat from North Korea, he’s also sought a closer relationship with India, which shares U.S. worries on Islamic extremism.

“In this period of uncertainty and angst, India needs a reliable partner on the world stage. I want to make clear: with our shared values and vision for global stability, peace and prosperity, the United States is that partner,” Tillerson said.

Tillerson said the U.S. wants to help improve India’s military capabilities, and also improve security cooperation among the region’s major democracies, which included Japan and Australia.

Tillerson said the U.S. and India were leading regional efforts on counterterrorism. He called for India’s archrival Pakistan “to take decisive action against terrorist groups based within their own borders that threaten its own people and the broader region.”

The post Tillerson: ‘Heartbreaking’ reports of suffering in Myanmar appeared first on PBS NewsHour.

More than 500,000 Rohingya Muslims have fled their homes since August to escape systematic violence at the hands of government soldiers in Myanmar. The U.N. has called the actions taken by Myanmar forces against the group “a textbook example of ethnic cleansing.”

A report released by Amnesty International on Wednesday documents widespread rape, killings and burnings of Rohingya across the Rakhine State in Myanmar. The report includes extensive interviews of Rohingya refugees who tell stories of live burnings, sexual violence and mass shootings at the hands of soldiers.

To escape persecution, Rohingya refugees are fleeing in droves to neighboring Bangladesh, a country described by some as a reluctant host for the thousands of refugees behind its borders. Conditions within Bangladesh show refugee camps beyond capacity, as organizations struggle to keep up with humanitarian aid.

Find out more: Rohingya Muslims have been denied citizenship in Myanmar since 1982, though they’ve lived in the area since the 12th century. They are not considered one of the country’s official ethnic groups. As such, their lack of official identity bars them from government services and travel.

Officials from Myanmar, a majority Buddhist state, claim Rohingya are actually immigrants from Bangladesh to justify their exclusion of the group. This most recent burst of violence comes from Myanmar’s crackdown following clashes with the Arakan Rohingya Salvation Army (ARSA). After the government declared ARSA a terrorist organization, the retaliation escalated into hundreds of Rohingya villages.

Where to give: BRAC, a top-ranked NGO based out of Bangladesh, is scaling up humanitarian efforts for clean water, health, sanitation and child care for refugees from Myanmar. You can learn more about their efforts here.

An emergency appeal was made by the Disasters Emergency Committee for immediate crisis relief funds. DEC distributes funds to 13 member aid organizations.
UNHCR, UNICEF and Save the Children have donation pages dedicated to the crisis, as does the International Rescue Committee. CNN’s Public Good page provides a user-friendly resource to find NGOs that match your giving goals.

To give to starvation relief, try Action Against Hunger or the World Food Programme.

Be sure to research organizations receiving your financial contributions, not only to find the best organization aligned with your goals, but also to avoid potential scams. For the latest information on aid organizations and charities, visit GuideStar or Charity Navigator to ensure your donations are going in the right direction.

The post As Rohingya refugees continue to flee from persecution, here’s how you can help appeared first on PBS NewsHour.

Kelley graduates from Canada. Josh discovers Tactics Advance is an isekai. Meanwhile Chris calculates the skill check for suplexing a train.

The post RPG Cast – Episode 619: “That One Time I Got Reincarnated as a Canadian Yankee in King Arthur’s Court” appeared first on RPGamer.

I never completed the original Red Dead Redemption, but not for the usual reasons of being terrible at the game, or thinking that open worlds are too big and boring these days and I just want to lie down forever and watch anime. I never finished it because my Xbox 360 version was not, in practice, an open world game, but a lonely farm at the bottom of a vortex of butchered spacetime. In the prologue, reformed outlaw John Marston confronts an old bandit acquaintance and gets himself roundly shot to bits. He’s rescued by local rancher Bonnie MacFarlane, who nurses him back to health and gives him a few odd jobs to warm him up for the next plot point.

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Some days, I wonder if every word written before a trailer is actually superfluous. It’s a visual medium, after all. What can a description achieve save to clumsily gesture at the true shape of something; a dog-eared tour brochure for a thrilling weekend spelunking in Plato’s cave? I can usually shake this feeling, but gory zombie action game Showa American Story is my breaking point. There is nothing I can impart about this thing that will not be conveyed better by allowing its new trailer to wash over you like a tide of sheer videogame. Here’s it:

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The Elder Scrolls: Legends, the free-to-play card game set in Bethesda's fantasy world, has been removed from sale on Steam. Its servers will shut down for good on January 30th, 2025, after which it will no longer be playable. The closure comes five years after the game was last updated.

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Halo Infinite recently received a big update in the form of Delta Arena, a playlist that features recreations of Halo 2's most popular maps and a special third-person mode. The true highlight, though, is yet to come. And that's through an entirely different Halo game: The Master Chief Collection. Soon enough, you'll be able to play Halo 2's lost E3 demo on it, thanks to some lovely modders.

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To transport our planet across the universe, we would need to bring the whole solar system to sustain life on Earth – on this episode of Dead Planets Society, our hosts contemplate how to shepherd all that baggage on this scenic journey

A neural network can recreate the classic computer game Doom despite using none of its code or graphics, hinting that generative AI could be used to create games from scratch in future

Gary is up to his usual schtick with Dani. Will he or the new stews ever learn? (Don’t answer that.)

Here’s everything you need to know about the allegations, diss tracks, and that $12 million NDA.