Ankylosing Spondylitis (AS) is a common, inflammatory rheumatic disease, which primarily affects the axial skeleton and is associated with sacroiliitis, uveitis and enthesitis. Unlike other autoimmune rheumatic diseases, such as rheumatoid arthritis or systemic lupus erythematosus, autoantibodies have not yet been reported to be a feature of AS. We therefore wished to determine if plasma from patients with AS contained autoantibodies and if so, characterize and quantify this response in comparison to patients with Rheumatoid Arthritis (RA) and healthy controls. Two high-density nucleic acid programmable protein arrays expressing a total of 3498 proteins were screened with plasma from 25 patients with AS, 17 with RA and 25 healthy controls. Autoantigens identified were subjected to Ingenuity Pathway Analysis in order to determine patterns of signalling cascades or tissue origin. 44% of patients with Ankylosing Spondylitis demonstrated a broad autoantibody response, as compared to 33% of patients with RA and only 8% of healthy controls. Individuals with AS demonstrated autoantibody responses to shared autoantigens, and 60% of autoantigens identified in the AS cohort were restricted to that group. The AS patients autoantibody responses were targeted towards connective, skeletal and muscular tissue, unlike those of RA patients or healthy controls. Thus, patients with AS show evidence of systemic humoral autoimmunity and multispecific autoantibody production. Nucleic Acid Programmable Protein Arrays constitute a powerful tool to study autoimmune diseases.

Is people's empathy reducing towards those struggling with mental health issues?

Kentucky Attorney General Daniel Cameron has joined a private school in a lawsuit against Gov. Andy Beshear, arguing that a school closure order not only violated state law but also the First Amendment.

The switch to remote learning in rural New Mexico has left some students profoundly isolated—cut off from others and the grid by sheer distance.

Kentucky Attorney General Daniel Cameron has joined a private school in a lawsuit against Gov. Andy Beshear, arguing that a school closure order not only violated state law but also the First Amendment.

The ability to discern fact from fiction and to recognize reliable news is fundamental, writes News Literacy Project’s Charles Salter.

Challengers of state executive orders, to open schools for in-person instruction in some places and keep them closed in others, are having difficulty getting meaningful relief from the courts.

The switch to remote learning in rural New Mexico has left some students profoundly isolated—cut off from others and the grid by sheer distance.

Newspaper editor Horace Greeley unsuccessfully ran against incumbent Ulysses S. Grant in November 1872. Twenty-four days later, he died of unknown causes at a private mental health facility

Hamilton's Santa Claus Parade will take place on the mountain this year, starting on Upper Sherman Road at 2 p.m. on Saturday.

It was only the second time the Saskatchewan Huskies and the Regina Rams have met in the Hardy Cup championship game. This time it was the Rams coming out on top 19-14. Huskies head coach Scott Flory says there were too many turnovers and too many plays left on the field after a hard fought game.

An investment writer at Allan Gray discusses how investors can overcome the fear of losing money.

This school year doesn't have to repeat the educational inequities of the spring. We talked with educators, parents, and experts to find a better way.

The leader said: "This is a secret; if we started to teach about Jesus in our mosques then we might as well open churches."

Learn why integrating EHR data with pharmacy and claims data improves patient care.

The post Closing data gaps to promote integrated health care appeared first on The Data Roundtable.

Jalen Johnson had 18 points, 13 rebounds, 10 assists and three steals to lead the visiting Atlanta Hawks to a 117-116 victory over the Boston Celtics on Tuesday in the first NBA Cup game for each team. Jaylen Brown and Derrick White scored season highs of 37 points and 31 points, respectively, for the Celtics. Brown was 7 of 12 from 3-point territory and 10 of 15 overall. White added six rebounds and five assists. Atlanta took a 117-116 lead when Onyeka Okongwu tipped in a missed shot with 6.1 seconds to play. After each team turned the ball over […]...

Keep on reading: NBA Cup: Hawks catch Celtics in closing seconds for win

Fewer lakes are freezing over each winter compared with past years, posing environmental and economic consequences around the world

Title: Does Loose Skin Go Away After Weight Loss? How to Tighten After Losing Weight?
Category: Health and Living
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

Title: Health Tip: Losing Hair After Pregnancy
Category: Health News
Created: 8/24/2016 12:00:00 AM
Last Editorial Review: 8/24/2016 12:00:00 AM

Title: Ankylosing Spondylitis
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/12/2022 12:00:00 AM

Title: 8 Reasons You Are Not Losing Weight on Keto
Category: Health and Living
Created: 8/26/2022 12:00:00 AM
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You can purchase Steven Camley's cartoons by calling 0141 302 7000 or visiting thepicturedesk.co.uk.

Today in "person you already like says something you already agree with, but it’s still good to hear them say it" news, Arkane founder and im-simmy RPG studio WolfEye head Raphael Colantonio has spoken on Microsoft’s decision to shutter Prey (2017) studio Arkane Austin - alongside a handful of others - back in May.

Colantonio, who founded Arkane in 1999 and departed in 2017 to form Weird West studio WolfEye, recently chatted to Jeremy Peel for PC Gamer about Arkane’s closure, saying:

I think if you look a little bit, it's obvious that Arkane Austin was a very special group of people that have made some cool things and that could pull it off again. I think it was a decision that just came down to, 'We need to cut something.' Was it to please the investors, the stock market? They're playing a different game.

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Take-Two Interactive have sold their publishing label Private Division to an unnamed party, along with five of Private Division's "live and unreleased titles". The GTA 6 publisher have also finally confirmed that they have shut down OlliOlli World and Rollerdrome devs Roll7 together with Kerbal Space Program 2 creators Intercept Games, months after performing mass layoffs at both studios.

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With no conclusive laboratory results, researchers are turning to other methods to find the elusive substance

By adopting a contingent workforce model and investing in the right data tools to power better informed decision-making and talent strategy, healthcare organizations can begin to address staffing challenges and turn their talent goals into reality. 

The post Closing Staffing Gaps in Healthcare by Utilizing Diverse Pipelines of Contingent Talent appeared first on MedCity News.

While the BJP-led NDA won resoundingly in the 2019 Lok Sabha election, it has lost power in five major State assemblies since December 2018.

Growth Unlocked: Closing the Strategy-to-Execution Gap

Closing Bell Opens Doors for Students

International Stars at the Closing of the XVIII Habanos Festival

Spinach extract for losing weight?

Fewer lakes are freezing over each winter compared with past years, posing environmental and economic consequences around the world

Tyreek Hill scores his first touchdown since the opening week of the season, as the Miami Dolphins beat the Los Angeles Rams 23-15 to end a three-game losing streak.

Extensive costs of salt-damaged soils include $27 billion+ in lost crop value per year.

The post Press Release: World Losing 2,000 Hectares of Irrigated Farmland to Salt-Induced Degradation Daily first appeared on International Water Management Institute (IWMI).

There's a growing sense that people or their children are wasting hours on screens, from gaming to endless medlinksocial media/medlink scrolling (!--ref1--).

New open access database is valuable for sustainable development in the energy and water sectors.

The post Closing the African data gap first appeared on International Water Management Institute (IWMI).

ADVENTRX Pharmaceuticals Announces Closing of Financing

Factors affecting one’s increasing waist circumstances mainly include heredity, dietary habits, physical activity,sedentary lifestyles and so on. Among these factors, genetic background relatively attracts...

Thinking of tweaking rent rates? Read this article for tips on striking the perfect balance between being competitive and earning higher revenue.

Some Democrats urge President Biden to step down so Kamala Harris despite losing to Trump to become the first...

[s.l.] : Duke University Press, 2023.

Durham : Duke University Press, 2022.