A circuit and a method for converting an analog signal to a digital value representation is disclosed. In one aspect, the circuit includes an incremental sigma-delta analog-to-digital converter (ADC). The circuit further includes a first input line for providing a primary analog signal representing a sensor measurement to the incremental sigma-delta ADC. The circuit further includes a second input line for providing a secondary analog signal to the incremental sigma-delta ADC. The incremental sigma-delta ADC receives the primary and secondary analog signals during a first period (TADC1) and a second period (TADC2), respectively. The circuit further includes a filter configured to weight the digital values in a sequence of digital values output by the incremental sigma-delta ADC, and to output a single digital value representing the sensor measurement.

System and methods for input path matching in pipelined continuous-time Analog-to Digital Converters (ADCs), including pipelined Continuous-Time Delta Sigma Modulator (CTDSM) based ADCs, includes an input delay circuit disposed in a continuous-time input path from an input of an analog input signal to a first summing circuit of the continuous-time ADC. At least one digital delay line is disposed between an output of an earlier stage sub-ADC (of a plurality of pipelined sub-ADCs) and a sub-digital-to-analog converter (DAC) that is coupled to the first summing circuit, and between the earlier stage sub-ADC and a digital noise cancellation filter. The digital delay line(s) is configured to enable calibration of delay of output of the earlier stage sub-ADC provided to the sub-DAC and the digital noise cancellation filter in accordance with process variations of the input delay match circuit to minimize residue output at first summing circuit.

A short video on using feedback with analog tape.

Today I was reading a post on a facebook group from a guy, let’s call him Jack, concerned with a master that was clean in…

LFO Store has announced the release of 50 Analog & Ambient Sounds, a collection of patches for the iconic Korg M1 synthesizer and music workstation from the 90s. It sounds fantastic but many of the sounds was overused in years & we didn’t find any modern recreations around the globe. So we made a challenge […]

The post LFO Store releases 50 Analog & Ambient Sounds for Korg M1 appeared first on rekkerd.org.

Applied Acoustics Systems has released its new sound pack Kicks & Snares, a collection of 100 drum sounds for the Ultra Analog VA-3 synthesizer and AAS Player plugin. You can never have too many kicks and snares! Resident sound designer Adam Pietruszko signs off on an expertly crafted and clever collection of punchy bass drum […]

The post AAS launches Kicks & Snares + 50% OFF everything Ultra Analog VA-3 appeared first on rekkerd.org.

SampleScience has announced the release of its free instrument plugin Analog Waveforms, featuring the basic waveforms of the Mopho analog monophonic synthesizer from Dave Smith Instruments. Each waveform has been sampled note by note across 7 octaves (each sample being 10 seconds in length) which gives an accurate and genuine sonic representation of an analog […]

The post SampleScience releases Analog Waveforms free rompler plugin for Mac and Windows appeared first on rekkerd.org.

IK Multimedia has announced the launch of the All-in on Analog Sale, offering discounts of up to 60% off on analog-modeled plugins. Are you craving that analog sound for your music production projects? Real analog gear can cost a bundle, be difficult to maintain, and can heavy (as in loud and literally hard on your […]

The post All-in on Analog: Save up to 60% on IK Multimedia analog modeled plugins appeared first on rekkerd.org.

Ghosthack has launched an introductory sale on Analog Wavetables Vol. 2, offering a 67% discount on the collection of wavetables for the Serum synthesizer by Xfer Records. It is a hard task to create analog sounds in a digital environment. With the support of “Analog Wavetables for Serum Volume 2” it got much easier! As […]

The post Analog Wavetables Vol. 2 for Serum by Ghosthack on sale at 67% OFF appeared first on rekkerd.org.

This is Sample Size, our weekly new music feature with KOSU's Ryan LaCroix and LOOKatOKC music critic Matt Carney. Today, Matt plays new music from Suzi Analogue and Liam Betson , and tells us about the lengths audiophiles will go to get pure sound . Follow Matt & Ryan on Twitter at @mdotcarney and @KOSUryan .

Get an in-depth look at Analog Strings by Output, an innovative virtual instrument designed for creating and manipulating string sounds.

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The post Plugin Spotlight: Analog Strings by Output appeared first on Dubspot Blog.

Analog Obsession has released LALA, a freeware emulation of the LA-2A tube compressor in VST, VST3, and AU plugin formats for digital audio workstations on PC and Mac. LALA is Analog Obsession’s first emulation of the LA-2A Classic Leveling Amplifier. The plugin delivers all the core features of the original hardware unit, along with some [...]

View post: LALA Is A FREE LA-2A Limiting Amplifier VST By Analog Obsession

Earlier this year, NORPA presented a show from its Generator arts development program My Radio Heart, an inclusive arts production that brought together differently abled artists to work with performance and technology.

POTUS gets real with Bill Simmons for GQ.

Oh man, this is great! It's perfect for... seeing texts the second they come in? Showing off your cell phone? Watching videos in a horrid orientation? Wait a minute, why is this useful again?

~NSHA

In a few weeks, I will need to stop dithering and make a decision: will I use an analog or digital planner for 2019? When I started my current job at the library, I had a Bullet Journal system in place, which satisfied my two primary drives: recording notes and ideas by hand, because I... Continue Reading →

12 March 2015 , Volume 91, Number 2

Chuanan Wei
Proc. Amer. Math. Soc. 148 (2020), 2287-2296.
Abstract, references and article information

Fabry disease is a heritable lipid disorder caused by the low activity of α-galactosidase A and characterized by the systemic accumulation of globotriaosylceramide (Gb3). Recent studies have reported a structural heterogeneity of Gb3 in Fabry disease, including Gb3 isoforms with different fatty acids and Gb3 analogs with modifications on the sphingosine moiety. However, Gb3 assays are often performed only on the selected Gb3 isoforms. To precisely determine the total Gb3 concentration, here we established two methods for determining both Gb3 isoforms and analogs. One was the deacylation method, involving Gb3 treatment with sphingolipid ceramide N-deacylase, followed by an assay of the deacylated products, globotriaosylsphingosine (lyso-Gb3) and its analogs, by ultra-performance LC coupled to tandem MS (UPLC-MS/MS). The other method was a direct assay established in the present study for 37 Gb3 isoforms and analogs/isoforms by UPLC-MS/MS. Gb3s from the organs of symptomatic animals of a Fabry disease mouse model were mainly Gb3 isoforms and two Gb3 analogs, such as Gb3(+18) containing the lyso-Gb3(+18) moiety and Gb3(−2) containing the lyso-Gb3(−2) moiety. The total concentrations and Gb3 analog distributions determined by the two methods were comparable. Gb3(+18) levels were high in the kidneys (24% of total Gb3) and the liver (13%), and we observed Gb3(−2) in the heart (10%) and the kidneys (5%). These results indicate organ-specific expression of Gb3 analogs, insights that may lead to a deeper understanding of the pathophysiology of Fabry disease.

Fabry disease is a heritable lipid disorder caused by the low activity of α-galactosidase A and characterized by the systemic accumulation of globotriaosylceramide (Gb3). Recent studies have reported a structural heterogeneity of Gb3 in Fabry disease, including Gb3 isoforms with different fatty acids and Gb3 analogs with modifications on the sphingosine moiety. However, Gb3 assays are often performed only on the selected Gb3 isoforms. To precisely determine the total Gb3 concentration, here we established two methods for determining both Gb3 isoforms and analogs. One was the deacylation method, involving Gb3 treatment with sphingolipid ceramide N-deacylase, followed by an assay of the deacylated products, globotriaosylsphingosine (lyso-Gb3) and its analogs, by ultra-performance LC coupled to tandem MS (UPLC-MS/MS). The other method was a direct assay established in the present study for 37 Gb3 isoforms and analogs/isoforms by UPLC-MS/MS. Gb3s from the organs of symptomatic animals of a Fabry disease mouse model were mainly Gb3 isoforms and two Gb3 analogs, such as Gb3(+18) containing the lyso-Gb3(+18) moiety and Gb3(−2) containing the lyso-Gb3(−2) moiety. The total concentrations and Gb3 analog distributions determined by the two methods were comparable. Gb3(+18) levels were high in the kidneys (24% of total Gb3) and the liver (13%), and we observed Gb3(−2) in the heart (10%) and the kidneys (5%). These results indicate organ-specific expression of Gb3 analogs, insights that may lead to a deeper understanding of the pathophysiology of Fabry disease.

Nonalcoholic steatohepatitis has emerged as a major cause of liver diseases with no effective therapies. Here, we evaluate the efficacies and pharmacokinetics of B1344, a long-acting PEGylated FGF21 analog, in a nongenetically modified nonhuman primate species that underwent liver biopsy, and demonstrate the potential for efficacies in humans. B1344 is sufficient to selectively activate signaling from the βKlotho/FGFR1c receptor complex. In cynomolgus monkeys with nonalcoholic fatty liver disease, administration of B1344 via subcutaneous injection for eleven weeks caused a profound reduction of hepatic steatosis, inflammation and fibrosis, and amelioration of liver injury and hepatocyte death as evidenced by liver biopsy and biochemical analysis. Moreover, improvement of metabolic parameters was observed in the monkey, including reduction of body weight and improvement of lipid profiles and glycemic control. To determine the role of B1344 in the progression of murine NAFLD independent of obesity, administration of B1344 were performed in mice fed with methionine and choline deficiency diet. Consistently, B1344 administration prevented the mice from lipotoxicity damage and nonalcoholic steatohepatitis at a dose-dependent manner. These results provide preclinical validation for an innovative therapeutics to NAFLD, and support further clinical testing of B1344 for treating nonalcoholic steatohepatitis and other metabolic diseases in humans.

Tina Vilsbøll
Jun 1, 2007; 30:1608-1610
BR Emerging Treatments and Technologies

Paris : O. Doin, 1881.

Analog and Mixed-signal (AMS) designs are increasingly using active power management to minimize power consumption. Typical mixed-signal design uses several power domains and operate in a dozen or more power modes including multiple functional, standby and test modes. To save power, parts of design not active in a mode are shut down or may operate at reduced supply voltage when high performance is not required. These and other low power techniques are applied on both analog and digital parts of the design. Digital designers capture power intent in standard formats like Common Power Format (CPF), IEEE1801 (aka Unified Power Format or UPF) or Liberty and apply it top-down throughout design, verification and implementation flows. Analog parts are often designed bottom-up in schematic without upfront defined power intent. Verifying that low power intent is implemented correctly in mixed-signal design is very challenging. If not discovered early, errors like wrongly connected power nets, missing level shifters or isolations cells can cause costly rework or even silicon re-spin. 

Mixed-signal designers rely on simulation for functional verification. Although still necessary for electrical and performance verification, running simulation on so many power modes is not an effective verification method to discover low power errors. It would be nice to augment simulation with formal low power verification but a specification of power intent for analog/mixed-signal blocs is missing. So how do we obtain it? Can we “extract” it from already built analog circuit? Fortunately, yes we can, and we will describe an automated way to do so!

Virtuoso Power Manager is new tool released in the Virtuoso IC6.1.8 platform which is capable of managing power intent in an Analog/MS design which is captured in Virtuoso Schematic Editor. In setup phase, the user identifies power and ground nets and registers special devices like level shifters and isolation cells. The user has the option to import power intent into IEEE1801 format, applicable for top level or any of the blocks in design. Virtuoso Power Manager uses this information to traverse the schematic and extract complete power intent for the entire design. In the final stage, Virtuoso Power Manager exports the power intent in IEEE1801 format as an input to the formal verification tool (Cadence Conformal-LP) for static verification of power intent.

Cadence and Infineon have been collaborating on the requirements and validation of the Virtuoso Power Manager tool and Low Power verification solution on real designs. A summary of collaboration results were presented at the DVCon conference in Munich, in October of 2018.  Please look for the paper in the conference proceedings for more details. Alternately, can view our Cadence webinar on Verifying Low-Power Intent in Mixed-Signal Design Using Formal Method for more information.

dsPIC33/PIC24 FRM, High-Speed Analog Comparator with Slope Compensation DAC

Enhancing System Architecture Implementation for AI Applications, Microchip Delivers its Analog Embedded SuperFlash® Technology

During human immunodeficiency virus type 1 (HIV-1) entry into cells, the viral envelope glycoprotein (Env) trimer [(gp120/gp41)₃] binds the receptors CD4 and CCR5 and fuses the viral and cell membranes. CD4 binding changes Env from a pretriggered (state-1) conformation to more open downstream conformations. BMS-378806 (here called BMS-806) blocks CD4-induced conformational changes in Env important for entry and is hypothesized to stabilize a state-1-like Env conformation, a key vaccine target. Here, we evaluated the effects of BMS-806 on the conformation of Env on the surface of cells and virus-like particles. BMS-806 strengthened the labile, noncovalent interaction of gp120 with the Env trimer, enhanced or maintained the binding of most broadly neutralizing antibodies, and decreased the binding of poorly neutralizing antibodies. Thus, in the presence of BMS-806, the cleaved Env on the surface of cells and virus-like particles exhibits an antigenic profile consistent with a state-1 conformation. We designed novel BMS-806 analogues that stabilized the Env conformation for several weeks after a single application. These long-acting BMS-806 analogues may facilitate enrichment of the metastable state-1 Env conformation for structural characterization and presentation to the immune system.

IMPORTANCE The envelope glycoprotein (Env) spike on the surface of human immunodeficiency virus type 1 (HIV-1) mediates the entry of the virus into host cells and is also the target for antibodies. During virus entry, Env needs to change shape. Env flexibility also contributes to the ability of HIV-1 to evade the host immune response; many shapes of Env raise antibodies that cannot recognize the functional Env and therefore do not block virus infection. We found that an HIV-1 entry inhibitor, BMS-806, stabilizes the functional shape of Env. We developed new variants of BMS-806 that stabilize Env in its natural state for long periods of time. The availability of such long-acting stabilizers of Env shape will allow the natural Env conformation to be characterized and tested for efficacy as a vaccine.

In obsessive–compulsive disorder (OCD), functional behaviors such as checking that a door is locked become dysfunctional, maladaptive, and debilitating. However, it is currently unknown how aversive and appetitive motivations interact to produce functional and dysfunctional behavior in OCD. Here we show a double dissociation in the effects of anxiogenic cues and sensitivity to rewarding stimuli on the propensity to develop functional and dysfunctional checking behavior in a rodent analog of OCD, the observing response task (ORT). While anxiogenic manipulations of perceived threat (presentation of threat-associated contextual cues) and actual threat (punishment of incorrect responding on the ORT) enhanced functional checking, dysfunctional checking was unaffected. In contrast, rats that had previously been identified as "sign-trackers" on an autoshaping task—and therefore were highly sensitive to the incentive salience of appetitive environmental cues—selectively showed elevated levels of dysfunctional checking under a range of conditions, but particularly so under conditions of uncertainty. These data indicate that functional and dysfunctional checking are dissociable and supported by aversive and appetitive motivational processes, respectively. While functional checking is modulated by perceived and actual threat, dysfunctional checking recruits appetitive motivational processes, possibly akin to the "incentive habits" that contribute to drug-seeking in addiction.

npj Microgravity, Published online: 08 April 2020; doi:10.1038/s41526-020-0101-4

Imagine a bucket of greenhouse gases that's almost full.

One year saving for airline would be just 5 per cent of ex-fuel operating costs

The EU is culpably complacent about the challenges of the digital age

Oxford : Oxford University Press, 2019.

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