The mission will simulate life in an interplanetary habitat to tackle the challenges of a base station beyond the earth

12 March 2015 , Volume 91, Number 2

The digital divide has shifted.

Three new isotypic heteropolynuclear complexes, namely penta­aqua­carbonato­penta­kis­(glycinehydroxamato)nitrato­penta­copper(II)lanthanide(III) x-hydrate, [LnCu5(GlyHA)5(CO3)(NO3)(H2O)5]·xH2O (GlyHA2− is glycine­hydrox­amate, N-hy­droxy­glycinamidate or amino­aceto­hydroxamate, C2H4N2O22−), with lanthanide(III) (LnIII) = gadolinium (Gd, 1, x = 3.5), dysprosium (Dy, 2, x = 3.28) and holmium (Ho, 3, x = 3.445), within a 15-metallacrown-5 class were obtained on reaction of lanthanide(III) nitrate, copper(II) acetate and sodium glycinehydroxamate. Complexes 1–3 contain five copper(II) ions and five bridging GlyHA2− anions, forming a [CuGlyHA]5 metallamacrocyclic core. The LnIII ions are coordinated to the metallamacrocycle through five O-donor hydroxamates. The electroneutrality of complexes 1–3 is achieved by a bidentate carbonate anion coordinated to the LnIII ion and a monodentate nitrate anion coordinated apically to one of the copper(II) ions of the metallamacrocycle. The lattice parameters of complexes 1–3 are similar to those previously reported for an EuIII–CuII 15-metallacrown-5 complex with glycine­hydroxamate of proposed composition [EuCu5(GlyHA)5(OH)(NO3)2(H2O)4]·3.5H2O [Stemmler et al. (1999). Inorg. Chem. 38, 2807–2817]. High-quality X-ray data obtained for 1–3 have allowed a re-evaluation of the X-ray data solution proposed earlier for the EuCu5 complex and suggest that the formula is actually [EuCu5(GlyHA)5(CO3)(NO3)(H2O)5]·3.5H2O.

The title homoleptic Schiff base complexes, [M(C14H9Cl2N2O)2], for M = CoII, (I), and CuII, (II), present distinct coordination geometries despite the Schiff base dianion coordinating via the phenolato-O and imine-N atoms in each case. For (I), the coordination geometry is based on a trigonal bipyramid whereas for (II), a square-planar geometry is found (Cu site symmetry overline{1}). In the crystal of (I), discernible supra­molecular layers in the ac plane are sustained by chloro­benzene-C—H⋯O(coordinated), chloro­benzene-C—H⋯π(fused-benzene ring) as well as π(fused-benzene, chloro­benzene)–π(chloro­benzene) inter­actions [inter-centroid separations = 3.6460 (17) and 3.6580 (16) Å, respectively]. The layers inter-digitate along the b-axis direction and are linked by di­chloro­benzene-C—H⋯π(fused-benzene ring) and π–π inter­actions between fused-benzene rings and between chloro­benzene rings [inter-centroid separations = 3.6916 (16) and 3.7968 (19) Å, respectively] . Flat, supra­molecular layers are also found in the crystal of (II), being stabilized by π–π inter­actions formed between fused-benzene rings and between chloro­benzene rings [inter-centroid separations = 3.8889 (15) and 3.8889 (15) Å, respectively]; these stack parallel to [10overline{1}] without directional inter­actions between them. The analysis of the respective calculated Hirshfeld surfaces indicate diminished roles for H⋯H contacts [26.2% (I) and 30.5% (II)] owing to significant contributions by Cl⋯H/H⋯Cl contacts [25.8% (I) and 24.9% (II)]. Minor contributions by Cl⋯Cl [2.2%] and Cu⋯Cl [1.9%] contacts are indicated in the crystals of (I) and (II), respectively. The inter­action energies largely arise from dispersion terms; the aforementioned Cu⋯Cl contact in (II) gives rise to the most stabilizing inter­action in the crystal of (II).

Digitonin has long been used as a mild detergent for extracting proteins from membranes for structure and function studies. As supplied commercially, digitonin is inhomogeneous and requires lengthy pre-treatment for reliable downstream use. Glyco-diosgenin (GDN) is a recently introduced synthetic surfactant with features that mimic digitonin. It is available in homogeneously pure form. GDN is proving to be a useful detergent, particularly in the area of single-particle cryo-electron microscopic studies of membrane integral proteins. With a view to using it as a detergent for crystallization trials by the in meso or lipid cubic phase method, it was important to establish the carrying capacity of the cubic mesophase for GDN. This was quantified in the current study using small-angle X-ray scattering for mesophase identification and phase microstructure characterization as a function of temperature and GDN concentration. The data show that the lipid cubic phase formed by hydrated monoolein tolerates GDN to concentrations orders of magnitude in excess of those used for membrane protein studies. Thus, having GDN in a typical membrane protein preparation should not deter use of the in meso method for crystallogenesis.

Bisphenol A (BPA) is a chemical that is widespread in the environment. Researchers reviewed and critically discussed the sources and routes of human exposure to chlorinated derivatives (ClxBPA) and alternatives to BPA (BPF, BPS), as well as their metabolism, toxicity and concentrations in human tissues. The researchers suggest BPA alternatives and derivatives may have similar effects, and provide directions for future research.

Analog inputs and outputs to meet all machine control needs, from general purpose to high-speed synchronous control(NX-AD / DA)

Simultaneous sampling of 4 channels with sampling times down to 5 μs(NX-HAD[][][])

Analog input units for CK3M Controller(CK3W-AD[]100)

The SIRIUS missions are the latest spaceflight analogs NASA is utilizing to help us understand the risks of travel further into the solar system.

Using Webkit keyframes to produce an analogue clock. A small javascript routine is used to set the correct time on page entry.

The problem of sampling from the stationary distribution of a Markov chain finds widespread applications in a variety of fields. The time required for a Markov chain to converge to its stationary distribution is known as the classical mixing time. In this article, we deal with analog quantum algorithms for mixing. First, we provide an analog quantum algorithm that given a Markov chain, allows us to sample from its stationary distribution in a time that scales as the sum of the square root of the classical mixing time and the square root of the classical hitting time. Our algorithm makes use of the framework of interpolated quantum walks and relies on Hamiltonian evolution in conjunction with von Neumann measurements.

There also exists a different notion for quantum mixing: the problem of sampling from the limiting distribution of quantum walks, defined in a time-averaged sense. In this scenario, the quantum mixing time is defined as the time required to sample from a distribution that is close to this limiting distribution. Recently we provided an upper bound on the quantum mixing time for Erd"os-Renyi random graphs [Phys. Rev. Lett. 124, 050501 (2020)]. Here, we also extend and expand upon our findings therein. Namely, we provide an intuitive understanding of the state-of-the-art random matrix theory tools used to derive our results. In particular, for our analysis we require information about macroscopic, mesoscopic and microscopic statistics of eigenvalues of random matrices which we highlight here. Furthermore, we provide numerical simulations that corroborate our analytical findings and extend this notion of mixing from simple graphs to any ergodic, reversible, Markov chain.

The present invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

A system, method, and computer program product for containing analog verification IP for circuit simulation. Embodiments introduce analog verification units (“vunits”), and corresponding analog verification files to contain them. Vunits allow circuit design verification requirement specification via text file. No editing of netlist files containing design IP is required to implement static and dynamic circuit checks, PSL assertions, clock statements, or legacy assertions. Vunits reference a top-level circuit or subcircuits (by name or by specific instance), and the simulator automatically binds vunit contents appropriately during circuit hierarchy expansion. Vunits may be re-used for other design cells, and may be easily processed by text-based design tools. Vunits may be provided via vunit_include statements in a control netlist file, command line arguments, or by directly placing a vunit block into a netlist. Vunits may also contain instance statements to monitor or process signals, such as those needed by assertions.

An LCD is integrated with the cover glass of a wrist watch radio paging receiver which indicates the time data with a dial plate and hands, and a message is displayed on the cover glass by controlling this LCD. In this message display, the parts of the characters indicating the message are made transparent and the remaining parts intercept light. In this manner, message display is made possible by the difference in light transmissivity.

A cytosine analog, a method of preparation of a cytosine analog, a DNA methyltransferase 1 inhibitor, and a method for DNA methylation inhibition, is provided for the treatment of diseases associated with deviations from normal DNA methylation. The analog of cytosine may be comprised of 1, N4, 5 and 6-substituted derivatives of cytosine or 5,6-dihydrocytosine, wherein the analog can be described by the chemical formula where R1 is H, R3, R4, 2'-deoxyribosyl, R4 is alkyl or aryl, X is N or C, wherein if X in the analog of formula I is N, then R5 is no substituent and if X in the analog of formula I and/or II is C or if X in the analog of formula II is N, then R5 and R6 are independently alkyl, aryl, hydroxyalkyl, aminoalkyl, hydroxyl, carboxyl, amino group, alkoxyl, aryloxyl, aminoalkyl, aminoaryl, thio group, sulfonyl, sulfinyl or halogen.

The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediate.

The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediate.

Disclosed are methods of purifying (20R) and (20S) analogs of 2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 to obtain the (20R) and (20S) analogs in crystalline form. The method includes the steps of preparing a solvent of either diethyl ether or a mixture of 2-propanol and hexane, dissolving a product containing the (20R) and (20S) analog to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of crystals, and recovering the crystals.

The present invention provides novel 16,23-diene 25-oxime ether analogs of 1,25-dihydroxy vitamin D3, compositions comprising these compounds and methods of using these compounds as inhibitors of CYP24. In particular, the novel compound of the invention are useful for treating diseases which benefit from a modulation of the levels of 1,25-dihydroxy vitamin D3, for example, cell-proliferative disorders.

Several different pyrrolysine analogs are disclosed in this application. Those analogs have distinct chemical and biophysical properties. Some analogs are useful in chemical ligation applications. Methods of making and using are also disclosed.

This invention discloses N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs, and specifically N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-1α-hydroxyvitamin D3 and pharmaceutical uses therefor. This compound exhibits relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer.

This invention discloses 3-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D3 and (20R)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D3 as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to monocytes thus evidencing use as anti-cancer agents especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. These compounds also exhibit relatively high calcemic activity evidencing use in the treatment of bone diseases.

Tracers for imaging distribution of reactive oxygen species (ROS) are disclosed. The tracers include radiolabeled dihydroethidine (DHE) analogues. Further disclosed are uses of the compounds, including methods of imaging tissue distribution of ROS in vivo by positron emission tomography (PET). Methods of synthesizing the compounds are also disclosed.

The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.

To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I), wherein A is a metal chelator comprising at least one radionuclide metal, B is a spacer linked to N-terminal of C or a covalent bond and C is a bombesin analog peptide antagonist having a sequence as claimed, where further x is an integer from 1 to 3 and n is an integer from 1 to 6. [A-(B)n]x—C (I)

Disclosed is an apparatus for protecting an analog input module from overvoltage, the apparatus including an analog input module and a stabilization unit. The analog input module converts one of a plurality of positive/negative analog signals inputted from the outside thereof into a digital signal and insulates the converted digital signal. The stabilization unit supplies voltages of the positive/negative analog signals to the analog input module when the voltage levels of the plurality of positive/negative analog signals are higher than the levels of positive/negative operating voltages in the analog input module.

The present invention discloses a dual-channel analog door entry system and a method thereof. The dual-channel analog door entry system comprises two cables connected between the building gateway and the floor distributors, configured to transmit audio and/or video signals between the outdoor stations and indoor phones; the building gateway, configured to receive a call request from at least one of the outdoor stations, identify and assign an available cable as an intercom channel, send the call request to each of the floor distributors via the intercom channel, and switch the audio and/or video signals from the outdoor station to the available cable; at least one of floor distributors, configured to receive and forward the call request to a desired indoor phone, receive a call response from the desired indoor phone if the desired indoor phone is available, and switch the audio and/or video signals from the available cable to the desired indoor phone. The solutions of the present invention achieves great improvement on line busy probability for large buildings and communities; and the solution is smart and simple to implement with low additional cost for reconstruction.

The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention. It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.

An analog-to-digital converter can use a variable sampling rate. By using a variable sampling rate analog-to-digital converter and an anti-aliasing filter lower sampling rates, and accordingly, generally lower power consumption may be achieved. For example, a lower sampling rate can be used when it is determined that no undesirable signals are present and a higher sampling period can be used when an undesirable signal is present. Determining the presence of an undesired signal can be based on signal-to-noise ratio, over-sampling, bit error rate, using a detector, etc. An undesirable signal can be any signal that is close in frequency to a signal of interest or a signal farther away in frequency that has a relatively high amplitude. Sampling rate can be varied in a binary fashion, stepwise, continuously, etc.

An analog front-end circuit includes an analog processing circuit, an A/D converter, a target register in which a lower limit target value of an input image signal is set, and a calculation circuit. The analog processing circuit includes an offset control circuit which performs offset control based on an offset control value set in an offset control register. The calculation circuit monitors the A/D-converted value in a lower limit value output period when the A/D-converted value corresponding to a lower limit value of an input range is output from the A/D converter, and sets the offset control value that causes the A/D-converted value to become closer to the lower limit target value set in the target register in the offset control register.

An input buffer for an ADC is provided. The input buffer includes a receiving circuit and an impedance circuit. The receiving circuit is coupled between a power supply and a sample-and-hold circuit of the ADC, and receives an analog input signal and generating an analog signal. The impedance circuit is coupled to the receiving circuit, and selectively provides a variable impedance. When the sample-and-hold circuit of the ADC is operated in a first phase, the impedance circuit provides a small impedance, and when the sample-and-hold circuit of the ADC is operated in a second phase, the impedance circuit provides a large impedance.

A digital-to-analog converter (DAC) and a high-voltage tolerance circuit are provided. The DAC includes a high-voltage tolerance circuit. The high-voltage tolerance circuit is configured to generate a reference voltage, and select the reference voltage or a first power-source voltage to control the node voltage of each branch of an operational amplifier circuit of the high-voltage tolerance circuit according the logical signal level of an input signal.

An ultrasound device including an asynchronous successive approximation analog-to-digital converter and method are provided. The device includes at least one ultrasonic transducer, a plurality of asynchronous successive-approximation-register (SAR) analog-to-digital converters (ADC) coupled to the at least one ultrasonic transducer, at least one asynchronous SAR in the plurality having a sample and hold stage, a digital-to-analog converter (DAC), a comparator, and control circuitry, wherein a DAC update event following at least one bit conversion is synchronized to a corresponding DAC update event of at least one other ADC in the plurality of ADCs.

Methods and systems for time interleaved analog-to-digital converter timing mismatch calibration and compensation may include receiving an analog signal on a chip, converting the analog signal to a digital signal utilizing a time interleaved analog-to-digital-converter (ADC), and reducing a blocker signal that is generated by timing offsets in the time interleaved ADC by estimating complex coupling coefficients between a desired digital output signal and the blocker signal utilizing a decorrelation algorithm on frequencies within a desired frequency bandwidth. The decorrelation algorithm may comprise a symmetric adaptive decorrelation algorithm. The received analog signal may be generated by a calibration tone generator on the chip. An aliased signal may be summed with an output signal from a multiplier. The complex coupling coefficients may be determined utilizing the decorrelation algorithm on the summed signals. A multiplier may be configured to cancel the blocker signal utilizing the determined complex coupling coefficients.

Typically, complex systems require a separate and expensive equalizer at the output of an analog-to-digital converter (ADC). Rather than providing a separate equalizer, the effective Signal Transfer Function (STF) of a Multi-stAge noise SHaping (MASH) ADC can be modified by leveraging available digital filtering hardware necessary for quantization noise cancellation. The modification can involves adding calculations in the software previously provided for computing digital quantization noise cancellation filter coefficients, where the calculations are added to take into account equalization as well. As a result, the signal transfer function can be modified to meet ADC or system-level signal-chain specifications without additional equalization hardware. The method is especially attractive for high-speed applications where magnitude and phase responses are more challenging to meet.

An analog-to-digital converter (ADC) is a device that can include a reference shuffler and a loop filter. An ADC can achieve better performance with incremental adjustment of a pointer of the reference shuffler, changing coefficients of the loop filter, and storing calibration codes of the ADC in a non-volatile memory. By incrementally adjusting a pointer of the reference shuffler, a calibration can be performed more efficiently than with a random adjustment of the pointer. By temporarily changing the loop filter coefficients, a greater amount of activity can be introduced into the loop filter. This activity can allow the calibration to proceed more efficiently. By storing the calibration codes in a non-volatile memory, a search space for calibration codes can be reduced. Thus, a calibration can occur more quickly, and the calibration itself can be improved.

An analog to digital converter includes an error integration circuit configured to receive an input charge from a detector and to integrate a difference between the input charge and one or more feedback charge pulses to create an error voltage. A quantizer is in operable communication with the error integration circuit and is responsive to the created error voltage. An accumulator having a mantissa component and a radix component is in operable communication with the quantizer. A charge feedback device in operable communication with the quantizer and the radix component of the accumulator. The charge feedback device is configured to generate the one or more feedback charge pulses proportional to the radix component of the accumulator and an output of the quantizer. Digital focal plane read out integrated circuits including the analog to digital converter are also disclosed.

The disclosure relates to a circuit for stabilizing a digital-to-analog converter reference voltage. One example embodiment is a circuit for stabilizing a voltage on a reference node. The circuit includes a digital-to-analog converter that includes an array of capacitors and arranged for: receiving an input voltage via an input node, receiving a voltage via a reference node and a digital-to-analog code via a controller node, and outputting a digital-to-analog output voltage. The circuit also includes a capacitive network on the reference node comprising a fixed capacitor arranged to be pre-charged to an external reference voltage and a variable capacitor arranged to be pre-charged to an external auxiliary voltage. Further, the circuit includes a measurement block. In addition, the circuit includes a calibration block arranged for determining an updated setting of the variable capacitor based on the digital-to-analog code and the measured voltage on the reference node.