Background

Quality of life is impaired in patients with sarcoidosis. The King's Sarcoidosis Questionnaire (KSQ) is a brief questionnaire assessing health-related quality of life in patients with sarcoidosis, comprising subdomains of General Health Status (GHS), Lung, Medication, Skin and Eyes. The aim of this study was to enhance the validation of the KSQ, incorporating longitudinal validation and known-groups validity in a cohort with mild sarcoidosis.

The aim of this study was to validate a previously developed deep learning model in 5 independent clinical trials. The predictive performance of this model was compared with the international prognostic index (IPI) and 2 models incorporating radiomic PET/CT features (clinical PET and PET models). Methods: In total, 1,132 diffuse large B-cell lymphoma patients were included: 296 for training and 836 for external validation. The primary outcome was 2-y time to progression. The deep learning model was trained on maximum-intensity projections from PET/CT scans. The clinical PET model included metabolic tumor volume, maximum distance from the bulkiest lesion to another lesion, SUV_peak, age, and performance status. The PET model included metabolic tumor volume, maximum distance from the bulkiest lesion to another lesion, and SUV_peak. Model performance was assessed using the area under the curve (AUC) and Kaplan–Meier curves. Results: The IPI yielded an AUC of 0.60 on all external data. The deep learning model yielded a significantly higher AUC of 0.66 (P < 0.01). For each individual clinical trial, the model was consistently better than IPI. Radiomic model AUCs remained higher for all clinical trials. The deep learning and clinical PET models showed equivalent performance (AUC, 0.69; P > 0.05). The PET model yielded the highest AUC of all models (AUC, 0.71; P < 0.05). Conclusion: The deep learning model predicted outcome in all trials with a higher performance than IPI and better survival curve separation. This model can predict treatment outcome in diffuse large B-cell lymphoma without tumor delineation but at the cost of a lower prognostic performance than with radiomics.

Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using SUV ratios (SUVRs) for estimating synaptic density with [¹¹C]UCB-J PET. Methods: Participants included 31 older adults with AD and 16 with normal cognition. The distribution volume ratio (DVR) using simplified reference tissue model 2 was compared with SUVR at short scan windows using a whole-cerebellum reference region. Results: Synaptic density was reduced in AD participants using DVR or SUVR. SUVR using later scan windows (60–90 or 70–90 min) was minimally biased, with the strongest correlation with DVR. Effect sizes using SUVR at these late time windows were minimally reduced compared with effect sizes with DVR. Conclusion: A simplified tissue-to-reference method may be useful for multicenter and longitudinal studies seeking to measure synaptic density in AD.

The role of gastrin-releasing peptide receptor (GRPR) in various diseases, including cancer, has been extensively studied and has emerged as a promising therapeutic target. In this study, we successfully achieved the use of [²¹²Pb]Pb-DOTAM-GRPR1, comprising the α-particle generator, ²¹²Pb, combined with a GRPR-targeting peptide, GRPR1, in a prostate cancer model. Methods: Pharmacokinetics, toxicity, radiation dosimetry, and efficacy were assessed in GRPR-positive prostate tumor–bearing mice after intravenous administration of [²¹²Pb]Pb-DOTAM-GRPR1 (where DOTAM is 1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane). Results: Preclinical studies have shown tumor targeting of up to 5 percent injected dose per gram over 24 h, and optimization of the drug formulation and quantity has led to minimized oxidation and off-target binding, respectively. Particularly, an increase in peptide amount from 28 to 280 ng was shown to reduce off-target uptake, especially at the level of the pancreas, by about 30%. Furthermore, dosimetry studies confirmed the kidney as the dose-limiting organ, and toxicity studies revealed that a nontoxic dose of up to 1,665 kBq could be injected into mice. Efficacy studies indicated a median survival time of 9 wk in the control group, which received only a buffer solution, compared with 19 wk in the group that received 4 injections of 370 kBq at 3-wk intervals. Conclusion: Taken together, these combined data demonstrate the safety, tolerability, and efficacy of [²¹²Pb]Pb-DOTAM-GRPR1, thus warranting further exploration in clinical trials.

BACKGROUND AND PURPOSE:

Mechanical thrombectomy is a fundamental intervention for acute ischemic stroke treatment. While conventional techniques are effective, cyclic aspiration (CyA) shows potential for better recanalization rates. We aim to investigate factors affecting CyA and compare them with static aspiration (StA).

We'll have a review of Planet Coaster 2 soon, but I keep making Brendy do other tasks so he's not had enough time yet to ride the rails. That means it falls to me to at least let you know that Frontier's theme park builder is out now.

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Putting aside my natural annoyance at Metal Gear Solid Delta: Snake Eater for almost beating out the Twarhammer series in the headline real estate wars, I am more than a little excited to play. Some days, you simply must feast on a tree frog, and while we still don’t have a solid release date, that day doesn’t feel too far away. Good news for stealth fans, and perhaps gooder news for a dozen strapline writers sweating profusely, soiling themselves in anticipation of using “kept you waiting, huh?”.

Until then, I at least have a steady drip feed of new information to keep me sated, the latest of which is the substantial hint that there'll be some new dialogue in the game, as per the video below. Alongside that, the previously pseudonymous Suzetta Miñet - who was credited with voicing EVA in MGS3 and Peace Walker - has revealed herself to be Jodi Benson, the voice of Ariel in Disney’s The Little Mermaid. Cheers for the spot, Automaton West.

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The Euclid space telescope's massive “cosmic atlas” promises to shed light on fundamental questions in physics and cosmology

The storm decimated a region rich with dozens of species already struggling with habitat loss and disease

Can you get one speaker on Alexa, Google, and Apple's home apps all at once?

Whoopi Goldberg told her co-hosts Tuesday on ABC's "The View" that she agrees with Vice President Kamala Harris voters who want to avoid family members who voted for President-elect Donald Trump during the holidays.

The post Whoopi Goldberg Endorses Harris Voters Avoiding Holidays with Trump-Supporting Family — ‘It Might Not Be the Time to Gather’ appeared first on Breitbart.

A NEW image captured by NASA Hubble space telescope shows ‘doomed duo’ galaxies colliding and then trying to destroy one another.

The Arctic territory hopes that three new airports will pave the way for direct flights from the US and Europe.

Thousands of drivers on ride-hailing and food delivery app Bolt have won a legal claim to be classed as workers.

This paper begins with a look at both optimization modeling and discrete-event simulation modeling, and explores how they can most effectively work together to create additional analytic value. It then considers two examples of a combined optimization and simulation approach and discusses the resulting benefits.

Actor/comedian Rob Riggle announces his next breakfast move as the Holiday Inn Express brand�s Creative Director � BREAKFA-mojis!

Adding festive flair to your cocktail is an easy way to impress your holiday party guests.

Former star or ABC�s The Bachelorette Ali Fedotowsky and [ yellow tail ], America�s go-to holiday wine, team up to Spread Holiday Cheer in New York City to kick-off [yellow tail ] wine�s 12 Days of Giveaways. Starting Tuesday, Dec. 8, 2015, people can visit Facebook.com/yellowtail to find out more ways to win exciting prizes.

Enjoy the Road This Winter with Helpful Tips

Bad traffic, tired drivers and cranky kids; life makes holiday travel anything but a holiday. Watch what happens when Ziploc� takes over a tollbooth and surprises real holiday travelers with gifts.

With the support of mentor Orbi Rosario, Hannah Strope overcame financial and family instability to become the first in her family to graduate high school. She is currently a college student.

With a Keurig� in every room at Holiday Inn Express� hotels, smart travelers � like actor/comedian Rob Riggle � can get a great cup of coffee with just the push of a button.

When traveling, the hotel becomes Sword & Plough�s mobile office, and Holiday Inn� hotels have become an integral extension of their team while on the road.

Dale a Papá Regalos Que se Ajusten a su Personalidad

El avance de Habla Men

Holiday Pork Loin: Nothing says Christmas like a traditional recipe that brings the family closer with a flavor-filled celebration of aromas, textures, ingredients and, of course, pork. Ingredients: pork loin roast, oranges, garlic, chipotle chilies...

Exclusive sneak-peek of how Andrea gets her #BrilliantSmile holiday ready in Episode 7 of The Smile Show.

Government of IndiaMinistry of FinanceDepartment of RevenueCentral Board of Indirect Taxes and CustomsCustoms Policy Wing**** Room No. 252A, North Block, New Delh

Browse 2024’s most popular gift ideas with Google Shopping’s Holiday 100.

We speak with historian Robin D. G. Kelley about the roots of Donald Trump’s election victory and the decline of Democratic support among many of the party’s traditional constituencies. Kelley says he agrees with Vermont Senator Bernie Sanders, who said Democrats have “abandoned” working-class people. “There was really no program to focus on the actual suffering of working people across the board,” Kelley says of the Harris campaign. He says the highly individualistic, neoliberal culture of the United States makes it difficult to organize along class lines and reject the appeal of authoritarians like Trump. “Solidarity is what’s missing — the sense that we, as a class, have to protect each other.”

The Hon'ble Delhi High Court in the case of JV Creatives (P.) Ltd. v. Principal Additional Director General, DGGI, Gurugram Zonal Unit [W.P. (C) No. 10042 of 2024 dated July 23, 2024] dismissed the writ petition filed against the order of provisional attachment passed under Section 83 of the Central

For January, the most recent month for which data is available, the TCI came in at -1.71, a significant improvement over December’s -6.1 and November’s -7.94. That was preceded by October’s -11.25, its lowest level since the April 2020 all-time low, at -28.66. The September TCI reading came in at -2.35.

There's the potential for endless installments of "programmers not understanding how UUIDs work." Frankly, I think the fact that we represent them as human readable strings is part of the problem; sure, it's readable, but conceals the fact that it's just a large integer.

Which brings us to this snippet, from Capybara James.

    if (!StringUtils.hasLength(uuid) || uuid.length() != 36) {
        throw new RequestParameterNotFoundException(ErrorCodeCostants.UUID_MANDATORY_OR_FORMAT);
    }

StringUtils.hasLength comes from the Spring library, and it's a simple "is not null or empty" check. So- we're testing to see if a string is null or empty, or isn't exactly 36 characters long. That tells us the input is bad, so we throw a RequestParameterNotFoundException, along with an error code.

So, as already pointed out, a UUID is just a large integer that we render as a 36 character string, and there are better ways to validate a UUID. But this also will accept any 36 character string- as long as you've got 36 characters, we'll call it a UUID. "This is valid, really valid, dumbass" is now a valid UUID.

With that in mind, I also like the bonus of it not distinguishing between whether or not the input was missing or invalid, because that'll make it real easy for users to understand why their input is getting rejected.

This guest review is from Danielle Fritz. Danielle is a former librarian who has a special affection for children’s lit and books about the funeral industry. She first cut her criticism teeth as a fanfic writer. A resident of the upper midwest, she’s learned to love beer and tater tot casserole and tolerate long winters. Most nights will find her cuddled up with her pups and wearing out her wrists with yet another crochet project. … Continue reading Earls Trip by Jenny Holiday →

Artificial intelligence is being developed to help organise holidays, but is it any good?

Social media is helping travel agents to impress clients, and sometimes to scam them.

The OECD/G20 Inclusive Framework on BEPS has published the outcome of more reviews into territories' preferential tax regimes and on tax dispute resolution through the Mutual Agreement Procedure.

The OECD/G20 Inclusive Framework on BEPS has published the outcome of more reviews into territories' preferential tax regimes and on tax dispute resolution through the Mutual Agreement Procedure.

Chocolate prices soar as El Nino dries up major producers but is there more to the story?

The post When climate and cocoa collide   first appeared on International Water Management Institute (IWMI).

Adapting to more frequent climate disasters calls for enhanced planning and collaboration.

The post Extreme flooding and landslides worldwide highlight need for anticipatory action  first appeared on International Water Management Institute (IWMI).

Highlights: Many individuals are unaware that food safety is the most crucial factor to consider when preparin

Sunrise Senior Living Becomes an Authorized Validation Organization to Greatly Enhance Memory Care for More Than 10,000

Genoptix Reports Solid Results for the First Quarter 2010

First Validated iPhone Medical Application for Depression and Anxiety

The 100-key new-build hotel is set to open in 2028, bringing world-class hospitality to the city. IHG® Hotels & Resorts, one of the world’s leading hotel companies, has announced the signing of a management agreement with Peachery LLP to launch Holiday Inn Ujjain. Scheduled to open in 2028, the new property aligns with IHG’s strategic focus on expanding its footprint in high-growth secondary markets across India. A major Hindu pilgrimage center, Ujjain is renowned for hosting the Kumbh Mela, with the next event set for 2028. The city is also home to the famous Mahakaleshwar Jyotirlinga temple, one of the twelve Jyotirlingas shrines respected as sacred abodes of Shiva, making it a significant attraction for pilgrims. With over 70 years of trusted hospitality, Holiday Inn is set to launch in Ujjain and offer unique stay experiences tailored to both spiritual travellers and those celebrating weddings in the culturally rich city. Holiday Inn Ujjain will feature 100 well-appointed rooms, i...