El Departamento de Justicia de Delaware describe la coordinación de la protección electoral Con las elecciones generales de Delaware a una semana de distancia, la fiscal general Kathy Jennings le recuerda al público que el Departamento de Justicia de Delaware, las fuerzas del orden público estatales y locales y el Departamento de Elecciones harán cumplir […]

Defendant faces decades in prison Department of Justice prosecutors indicted a man Monday for robbing and brutally assaulting the owner of a Wilmington jewelry store in September 2022.  Calvin Ushery, Jr., 39, is charged with multiple felonies — including Assault 1st Degree — for the attack, which was caught on video. In the video, Ushery pistol-whips the victim […]

The Delaware Department of Agriculture (DDA) is warning anyone who purchased turtles, specifically the red-eared slider turtle, between August 2020 and January 2021 to take extra precautions to prevent illness.

The Delaware Hospital for the Chronically Ill (DHCI) in Smyrna is asking members of the community to sponsor a resident for the holidays. Since many residents have little family involvement or support, the nursing home relies on the generosity of community members including neighbors, local businesses, community organizations, and volunteers to help fulfill resident wishes at the holidays through the Adopt-A-Resident Program.

The greenhouse is operated by Bright Spot Urban Farm, a program operated by West End Neighborhood House in Wilmington. The Department of Health and Social Services has an agreement with West End to operate the greenhouse and gardens on the Herman Holloway Campus. Proceeds from the sale of the nearly 3,000 poinsettias grown this season will help support youth programs at West End.

DOVER, DE (Nov. 18, 2022) – The Delaware Division of Public Health (DPH) reports that the statewide 7-day average of new positive COVID-19 cases has decreased for the fourth consecutive month. Hospitalizations and deaths related to COVID-19 have remained low over the same time period. Average new positive cases are lowest in Kent County, with Sussex County only slightly higher. However, […]

DOVER, DE (Jan. 13, 2023) – The Delaware Division of Public Health (DPH) is seeing an increase in post-holiday COVID-19 cases and hospitalizations, though the increase is not nearly as high as the 2022 post-holiday surge. Still, DPH encourages individuals to take specific action steps to stay healthy and prevent the spread of the virus, such as staying home when sick, testing […]

SMYRNA (October 16, 2023) – The Delaware Hospital for the Chronically Ill (DHCI) in Smyrna is asking members of the community to sponsor a resident for the holidays. DHCI is a licensed Skilled Nursing Facility, operated by the Delaware Division of Services for Aging and Adults with Physical Disabilities, dedicated to comprehensive nursing home services […]

DOVER, Del. (Dec. 11, 2023) – The Delaware Division of Public Health (DPH) takes the safety and well-being of all Delawareans seriously. With COVID-19, flu and RSV all prevalent this time of year, DPH is actively educating residents about how to mitigate exposure and transmission of these respiratory viruses. Keeping in the spirit of the holiday season, […]

The new SAS Certified Specialist: Statistics for Machine Learning credential is designed to help you showcase your expertise and commitment to staying ahead in the industry.

Earn this SAS certification to validate your skills and training in machine learning was published on SAS Users.

The Results are in for the July 2, 2021, Statewide Checkpoint Activation FOR IMMEDIATE RELEASE Media Contact: Cynthia Cavett, Cynthia.Cavett@delaware.gov DOVER, Del. (July 6, 2021) — Delaware law enforcement officers statewide arrested six individuals for Driving Under the Influence (DUI) of alcohol, drugs, or a combination of alcohol and drugs at sobriety checkpoints on July […]

As the 4th of July holiday weekend approaches, the Delaware Department of Transportation (DelDOT) advises motorist to expect heavy traffic volumes on roads throughout the state. AAA Mid-Atlantic is forecasting more than 116,000 Delawareans will travel at least 50 miles during the holiday weekend. In addition, DelDOT reminds motorists that there will be many pedestrians […]

The annual Safe Family Holiday campaign seeks to prevent the holidays from “getting ugly” by helping Delawareans avoid dangerous driver, passenger, and pedestrian behaviors. DOVER, Del. (Nov. 17, 2022) — Starting on Nov. 18, the Delaware Office of Highway Safety (OHS) will begin its annual holiday safety campaign, designed to reduce crashes, injuries, and deaths […]

As the Memorial Day weekend approaches, DelDOT is reminding the public to expect crowded roads as AAA projects more than 42 million people nationally will travel 50 miles or more from home this holiday weekend. “Thousands of people will be visiting Delaware’s beaches and parks or traveling to see family and friends and we encourage […]

The Office of the Marijuana Commissioner (OMC) is pleased to announce the launch of the Social Equity Eligibility Validation Application and Disproportionately Impacted Areas (DIA) Map OMC is responsible for implementing the Marijuana Control Act in Delaware, which includes a Social Equity License program. Individuals interested in applying for a social equity license must first […]

The Delaware Department of Natural Resources and Environmental Control reminds those who plan to drive-on surf fish at one of the seven Delaware State Parks multi-use beaches that reservations are required during summer weekends and holidays. Drive-on surf fishing reservations for Thursday, July 4, open Thursday, June 27, at 11 a.m. Drive-on reservations for each weekend open weekly beginning Tuesdays for the upcoming Saturday and Wednesdays for the upcoming Sunday, and are available until sold out for that weekend.

Read the in depth Review of Wings Glide Audio Video. Know detailed info about Wings Glide configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Hi，

Can you tell me which setting is causing this?

In the general edit. I try slide via to other position. but the slide is wrong.

in the cm，i set pad-pad connect is all allowed，and i turn off via to pad spacing in the same net spacing. only turn on via to via spacing in the same net spacing，set to via to via spacing =0.

default the via is closer to the pad edge, I think the correct location is show in the pic2.

The Roku Ultra LT streaming device is $34 at Walmart, down from the list price of $79.99. That's a 57% discount.

Mashable's shopping experts are tracking major retailers' 2024 Black Friday sales. Some of the best deals have already landed at Walmart, Best Buy, and Target.

Japan braced for a feared rebound in coronavirus cases as the highways and airports filled with travelers at the start of New Year’s holidays yesterday.

TOUR products for Thailand with departure dates during the National Day holiday plus the Mid-Autumn festival have mostly sold out, major Chinese travel operators say, attributing the boom to a temporary

Yaounde, Cameroon — Workers have recovered 12 bodies following landslides that engulfed a road in the west of Cameroon, a regional official said Saturday, adding there is no hope of finding survivors.   State television CRTV reported the comments by the governor of Ouest region, Augustine Awa Fonka.   "In our opinion, there is no longer any possibility of finding survivors," he told the station.  Only 12 bodies had been recovered from the site of the disaster, the last of them on Saturday morning, he said.   Dozens more people are still missing, and the search for bodies is still continuing, he added.   Two landslides hit the Dschang cliff road Tuesday — the second as emergency workers were using heavy machinery to try to clear the road.   Vehicles hit included three coaches with around 20 seats each, five six-seater vehicles, and several motorbikes said Awa Fonka in an earlier statement.   Cameroon's roads are notoriously dangerous, with almost 3,000 deaths each year in accidents, or more than 10 deaths per 100,000 inhabitants, according to the latest figures from the World Health Organization, published in 2023.    In early September, a tractor-trailer carrying passengers plunged off a cliff road into a ravine near the town of Dschang, killing eight people and injuring 62 others, including eight children. 

The recent summit underscored Hong Kong's position as a "super-connector" and "super value adder," solidifying its status as a premier regional business hub and a vital link to the global market, that could support the eight major steps announced by President Xi Jinping last year to enhance the high-quality development of the Belt and Road Initiative (BRI).

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Khalid al-Asaad, an 83-year-old caretaker of antiquities in Syria, was beheaded by ISIS, but did not receive the same attention as a slain lion.

MANILA, Philippines – The Bureau of Internal Revenue (BIR) will closely monitor the tax compliance of online marketplaces and online sellers during the holiday season, Commissioner Romeo Lumagui Jr. has said. In a statement Wednesday, Lumagui warned that online businesses violating tax laws would be blocked. Section 115 of the National Internal Revenue Code, as […]...

Keep on reading: BIR to monitor online sellers' tax compliance during holiday season

We can’t stir ordinary solids, but one research team now claims to have stirred an extraordinary quantum “supersolid”, generating tiny vortices

Seismologists were mystified by a strange signal that persisted for nine days in 2023 – now its source has been identified as a standing wave caused by a landslide in Greenland

A stellar cast play leaders of G7 countries facing an existential crisis in Rumours, a smart film about communication, diplomatic nonsense and not coping, says Simon Ings

Title: Survivors' Plasma Still a Solid Option for Treating COVID-19, Experts Say
Category: Health News
Created: 8/26/2020 12:00:00 AM
Last Editorial Review: 8/26/2020 12:00:00 AM

Title: Nerve Block Plus Lidocaine Clears Psoriasis in Small Study
Category: Health News
Created: 8/15/2022 12:00:00 AM
Last Editorial Review: 8/16/2022 12:00:00 AM

A prefilled syringe (PFS) should be able to be adequately and consistently extruded during injection for optimal safe drug delivery and accurate dosing. To facilitate appropriate break-loose and gliding forces (BLGFs) required during injection, certain primary packaging materials (PPMs) such as the syringe barrel and plunger are usually coated with silicone oil, which acts as a lubricant. Due to its direct contact with drug, silicone oil can increase the number of particles in the syringe, which could lead to adverse interactions. Compliance with regulatory-defined silicone oil quantities in certain drug products, such as ophthalmics, presents a trade-off with the necessity for desirable low and consistent BLGF. In addition to its siliconization, the dimensional accuracy of the PPM has an important role in controlling the BLGF. The dimensions of the PPM are individualized depending on the product and its design and have certain tolerances that must be met during manufacturing. Most studies on ophthalmics focused on the adverse interactions between silicone oil and the drug. To the authors' knowledge, there have been no public studies so far that have investigated the impact of the dimensional variability of the PPM on the BLGF in ophthalmic PFSs. In this study, we applied advanced optical shaft and tactile measuring technologies to investigate this impact. The syringes investigated were first sampled during aseptic production and tested for the BLGF. Subsequently, defined dimensions of the PPM were measured individually. The results showed that the dimensional variability of the PPM can have a negative impact on the BLGF, despite their conformity to specifications, which indicates that the currently available market quality of PPMs is improvable for critical drug products such as ophthalmics. This study could serve as an approach to define product-specific requirements for primary packaging combinations and thus appropriate specifications based on data during the development stage of drug products.

For clean-room technologies such as isolators and restricted access barrier systems (RABS), decontamination using hydrogen peroxide (H₂O₂) is increasingly attractive to fulfill regulatory requirements. Several approaches are currently used, ranging from manual wipe disinfection to vapor phase hydrogen peroxide (VPHP) or automated nebulization sanitization. Although the residual airborne H₂O₂ concentration can be easily monitored, detection of trace H₂O₂ residues in filled products is rather challenging. To simulate the filling process in a specific clean room, technical runs with water for injection (WfI) are popular. Thus, the ability to detect traces of H₂O₂ in water is an important prerequisite to ensure a safe and reliable use of H₂O₂ for isolator or clean room decontamination. The objective of this study was to provide a validated quantitative, fluorometric Amplex UltraRed assay, which satisfies the analytical target profile of quantifying H₂O₂ in WfI at low nanomolar to low micromolar concentrations (ppb range) with high accuracy and high precision. The Amplex UltraRed technology provides a solid basis for this purpose; however, no commercial assay kit that fulfills these requirements is available. Therefore, a customized Amplex UltraRed assay was developed, optimized, and validated. This approach resulted in an assay that is capable of quantifying H₂O₂ in WfI selectively, sensitively, accurately, precisely, and robustly. This assay is used in process development and qualification approaches using WfI in H₂O₂-decontaminated clean rooms and isolators.

Neural reflexes occupy a central role in physiological homeostasis. The vagus nerve is a major conduit for transmitting afferent and efferent signals in homeostatic reflex arcs between the body and the brain. Recent advances in neuroscience, immunology, and physiology have revealed important vagus nerve mechanisms in suppressing inflammation and treating rheumatoid arthritis and other autoimmune conditions. Numerous clinical trials indicate that there is significant benefit to vagus nerve stimulation therapy. Although many questions are still unanswered, it will be important, even necessary, to pursue answers that will be useful in guiding interventions to modulate immunological and physiological homeostasis.

Internal ribosomal entry sites (IRESs) recruit the ribosome to promote translation, typically in an m7G cap-independent manner. Although IRESs are well-documented in viral genomes, they have also been reported in mammalian transcriptomes, where they have been proposed to mediate cap-independent translation of mRNAs. However, subsequent studies have challenged the idea of these "cellular" IRESs. Current methods for screening and discovering IRES activity rely on a bicistronic reporter assay, which is prone to producing false positive signals if the putative IRES sequence has a cryptic promoter or cryptic splicing sites. Here, we report an assay for screening IRES activity using a genetically encoded circular RNA comprising a split nanoluciferase (nLuc) reporter. The circular split nLuc reporter is less susceptible to the various sources of false positives that adversely affect the bicistronic IRES reporter assay and provides a streamlined method for screening IRES activity. Using the circular split nLuc reporter, we find that nine reported cellular IRESs have minimal IRES activity. Overall, the circular split nLuc reporter offers a simplified approach for identifying and validating IRESs and exhibits reduced propensity for producing the types of false positives that can occur with the bicistronic reporter assay.