hy Respective Contributions of Glycemic Variability and Mean Daily Glucose as Predictors of Hypoglycemia in Type 1 Diabetes: Are They Equivalent? By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To evaluate the respective contributions of short-term glycemic variability and mean daily glucose (MDG) concentration to the risk of hypoglycemia in type 1 diabetes. RESEARCH DESIGN AND METHODS People with type 1 diabetes (n = 100) investigated at the University Hospital of Montpellier (France) underwent continuous glucose monitoring (CGM) on two consecutive days, providing a total of 200 24-h glycemic profiles. The following parameters were computed: MDG concentration, within-day glycemic variability (coefficient of variation for glucose [%CV]), and risk of hypoglycemia (presented as the percentage of time spent below three glycemic thresholds: 3.9, 3.45, and 3.0 mmol/L). RESULTS MDG was significantly higher, and %CV significantly lower (both P < 0.001), when comparing the 24-h glycemic profiles according to whether no time or a certain duration of time was spent below the thresholds. Univariate regression analyses showed that MDG and %CV were the two explanatory variables that entered the model with the outcome variable (time spent below the thresholds). The classification and regression tree procedure indicated that the predominant predictor for hypoglycemia was %CV when the threshold was 3.0 mmol/L. In people with mean glucose ≤7.8 mmol/L, the time spent below 3.0 mmol/L was shortest (P < 0.001) when %CV was below 34%. CONCLUSIONS In type 1 diabetes, short-term glycemic variability relative to mean glucose (i.e., %CV) explains more hypoglycemia than does mean glucose alone when the glucose threshold is 3.0 mmol/L. Minimizing the risk of hypoglycemia requires a %CV below 34%. Full Article
hy The Contemporary Prevalence of Diabetic Neuropathy in Type 1 Diabetes: Findings From the T1D Exchange By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To evaluate the contemporary prevalence of diabetic peripheral neuropathy (DPN) in participants with type 1 diabetes in the T1D Exchange Clinic Registry throughout the U.S. RESEARCH DESIGN AND METHODS DPN was assessed with the Michigan Neuropathy Screening Instrument Questionnaire (MNSIQ) in adults with ≥5 years of type 1 diabetes duration. A score of ≥4 defined DPN. Associations of demographic, clinical, and laboratory factors with DPN were assessed. RESULTS Among 5,936 T1D Exchange participants (mean ± SD age 39 ± 18 years, median type 1 diabetes duration 18 years [interquartile range 11, 31], 55% female, 88% non-Hispanic white, mean glycated hemoglobin [HbA1c] 8.1 ± 1.6% [65.3 ± 17.5 mmol/mol]), DPN prevalence was 11%. Compared with those without DPN, DPN participants were older, had higher HbA1c, had longer duration of diabetes, were more likely to be female, and were less likely to have a college education and private insurance (all P < 0.001). DPN participants also were more likely to have cardiovascular disease (CVD) (P < 0.001), worse CVD risk factors of smoking (P = 0.008), hypertriglyceridemia (P = 0.002), higher BMI (P = 0.009), retinopathy (P = 0.004), reduced estimated glomerular filtration rate (P = 0.02), and Charcot neuroarthropathy (P = 0.002). There were no differences in insulin pump or continuous glucose monitor use, although DPN participants were more likely to have had severe hypoglycemia (P = 0.04) and/or diabetic ketoacidosis (P < 0.001) in the past 3 months. CONCLUSIONS The prevalence of DPN in this national cohort with type 1 diabetes is lower than in prior published reports but is reflective of current clinical care practices. These data also highlight that nonglycemic risk factors, such as CVD risk factors, severe hypoglycemia, diabetic ketoacidosis, and lower socioeconomic status, may also play a role in DPN development. Full Article
hy February JADA examines connection between healthy eating habits, untreated caries By www.ada.org Published On :: Mon, 27 Jan 2020 08:00:00 -0600 Greater compliance with dietary guidelines may reduce the chance of untreated caries in adults, according to a study published in the February issue of The Journal of the American Dental Association. Full Article
hy American College of Emergency Physicians endorses ADA's antibiotics guideline By www.ada.org Published On :: Wed, 22 Apr 2020 14:18:00 -0500 The American College of Emergency Physicians has endorsed the American Dental Association's clinical practice guideline on the use of antibiotics for the management of pulpal- and periapical-related pain and swelling. Full Article
hy May JADA discusses calcium hydroxide overfill risk during root canals By www.ada.org Published On :: Wed, 22 Apr 2020 22:33:00 -0500 Overfill of medication or obturation materials in endodontic treatment can cause permanent neurologic injury, and there are steps clinicians can take to help prevent that, according to an article published in the May issue of The Journal of the American Dental Association. Full Article
hy Rapid Corneal Nerve Fiber Loss: A Marker of Diabetic Neuropathy Onset and Progression By care.diabetesjournals.org Published On :: 2020-03-05T08:52:34-08:00 OBJECTIVECorneal nerve fiber length (CNFL) represents a biomarker for diabetic distal symmetric polyneuropathy (DSP). We aimed to determine the reference distribution of annual CNFL change, the prevalence of abnormal change in diabetes, and its associated clinical variables.RESEARCH DESIGN AND METHODSWe examined 590 participants with diabetes [399 type 1 diabetes (T1D) and 191 type 2 diabetes (T2D)] and 204 control patients without diabetes with at least 1 year of follow-up and classified them according to rapid corneal nerve fiber loss (RCNFL) if CNFL change was below the fifth percentile of the control patients without diabetes.RESULTSControl patients without diabetes were 37.9 ± 19.8 years old, had median follow-up of three visits over 3.0 years, and mean annual change in CNFL was –0.1% (90% CI, –5.9 to 5.0%). RCNFL was defined by values exceeding the fifth percentile of 6% loss. Participants with T1D were 39.9 ± 18.7 years old, had median follow-up of three visits over 4.4 years, and mean annual change in CNFL was –0.8% (90% CI, –14.0 to 9.9%). Participants with T2D were 60.4 ± 8.2 years old, had median follow-up of three visits over 5.3 years, and mean annual change in CNFL was –0.2% (90% CI, –14.1 to 14.3%). RCNFL prevalence was 17% overall and was similar by diabetes type [64 T1D (16.0%), 37 T2D (19.4%), P = 0.31]. RNCFL was more common in those with baseline DSP (47% vs. 30% in those without baseline DSP, P = 0.001), which was associated with lower peroneal conduction velocity but not with baseline HbA1c or its change over follow-up.CONCLUSIONSAn abnormally rapid loss of CNFL of 6% per year or more occurs in 17% of diabetes patients. RCNFL may identify patients at highest risk for the development and progression of DSP. Full Article
hy 2017 American Academy of Pediatrics Clinical Practice Guideline: Impact on Prevalence of Arterial Hypertension in Children and Adolescents With Type 1 Diabetes By care.diabetesjournals.org Published On :: 2020-03-30T13:26:58-07:00 OBJECTIVEIn 2017, the American Academy of Pediatrics introduced a new guideline (2017 Clinical Practice Guideline of the American Academy of Pediatrics [AAP 2017]) to diagnose arterial hypertension (HTN) in children that included revised, lower normative blood pressure (BP) values and cut points for diagnosing high BP in adolescents. We studied the impact of the new AAP 2017 guideline on prevalence of HTN in children with type 1 diabetes mellitus (T1DM).RESEARCH DESIGN AND METHODSUp to September 2018, 1.4 million office BP measurements in 79,849 children and adolescents (aged 5–20 years) with T1DM have been documented in the DPV (Diabetes Prospective Follow-up) registry. BP values of the most recent year were aggregated, and BP values of 74,677 patients without antihypertensive medication were analyzed (median age 16 years and diabetes duration 5.3 years and 52.8% boys). BP values were classified according to AAP 2017 and the references of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) (2011) and the Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents (fourth report) (2004).RESULTSOf the patients, 44.1%, 29.5%, and 26.5% were hypertensive according to AAP 2017, KiGGS, and fourth report, respectively. Differences in prevalence of HTN were strongly age dependent: <10 years, AAP 2017 31.4%, KiGGS 30.7%, fourth report 19.6%; 10 to <15 years, AAP 2017 30.9%, KiGGS 31.2%, fourth report 22.4%; and ≥15 years, AAP 2017 53.2%, KiGGS 28.4%, fourth report 30.0%. Among teenagers ≥15 years, 59.1% of boys but only 46.3% of girls were classified as hypertensive by AAP 2017 but only 21.1%/26% of boys and 36.7%/34.4% of girls by KiGGS/fourth report, respectively.CONCLUSIONSClassification of BP as hypertension depends strongly on the normative data used. Use of AAP 2017 results in a significant increase in HTN in teenagers ≥15 years with T1DM, particularly in boys. AAP 2017 enhances the awareness of elevated BP in children, particularly in patients with increased risk for cardiovascular disease. Full Article
hy Use of Antihyperglycemic Medications in U.S. Adults: An Analysis of the National Health and Nutrition Examination Survey By care.diabetesjournals.org Published On :: 2020-03-31T07:14:53-07:00 OBJECTIVE1) To examine trends in the use of diabetes medications and 2) to determine whether physicians individualize diabetes treatment as recommended by the American Diabetes Association (ADA).RESEARCH DESIGN AND METHODSWe conducted a retrospective, cross-sectional analysis of 2003–2016 National Health and Nutrition Examination Survey (NHANES) data. We included people ≥18 years who had ever been told they had diabetes, had an HbA1C >6.4%, or had a fasting plasma glucose >125 mg/dL. Pregnant women, and those aged <20 years receiving only insulin were excluded. We assessed trends in use of ADA’s seven preferred classes from 2003–2004 to 2015–2016. We also examined use by hypoglycemia risk (sulfonylureas, insulin, and meglitinides), weight effect (sulfonylureas, thiazolidinediones [TZDs], insulin, and meglitinides), cardiovascular benefit (canagliflozin, empagliflozin, and liraglutide), and cost (brand-name medications and insulin analogs).RESULTSThe final sample included 6,323 patients. The proportion taking any medication increased from 58% in 2003–2004 to 67% in 2015–2016 (P < 0.001). Use of metformin and insulin analogs increased, while use of sulfonylureas, TZDs, and human insulin decreased. Following the 2012 ADA recommendation, the choice of drug did not vary significantly by older age, weight, or presence of cardiovascular disease. Patients with low HbA1C, or HbA1C <6%, and age ≥65 years were less likely to receive hypoglycemia-inducing medications, while older patients with comorbidities were more likely. Insurance, but not income, was associated with the use of higher-cost medications.CONCLUSIONSFollowing ADA recommendations, the use of metformin increased, but physicians generally did not individualize treatment according to patients’ characteristics. Substantial opportunities exist to improve pharmacologic management of diabetes. Full Article
hy Risk of Major Adverse Cardiovascular Events, Severe Hypoglycemia, and All-Cause Mortality for Widely Used Antihyperglycemic Dual and Triple Therapies for Type 2 Diabetes Management: A Cohort Study of All Danish Users By care.diabetesjournals.org Published On :: 2020-04-01T06:54:34-07:00 OBJECTIVEThe vast number of antihyperglycemic medications and growing amount of evidence make clinical decision making difficult. The aim of this study was to investigate the safety of antihyperglycemic dual and triple therapies for type 2 diabetes management with respect to major adverse cardiovascular events, severe hypoglycemia, and all-cause mortality in a real-life clinical setting.RESEARCH DESIGN AND METHODSCox regression models were constructed to analyze 20 years of data from the Danish National Patient Registry with respect to effect of the antihyperglycemic therapies on the three end points.RESULTSA total of 66,807 people with type 2 diabetes were treated with metformin (MET) including a combination of second- and third-line therapies. People on MET plus sulfonylurea (SU) had the highest risk of all end points, except for severe hypoglycemia, for which people on MET plus basal insulin (BASAL) had a higher risk. The lowest risk of major adverse cardiovascular events was seen for people on a regimen including a glucagon-like peptide 1 (GLP-1) receptor agonist. People treated with MET, GLP-1, and BASAL had a lower risk of all three end points than people treated with MET and BASAL, especially for severe hypoglycemia. The lowest risk of all three end points was, in general, seen for people treated with MET, sodium–glucose cotransporter 2 inhibitor, and GLP-1.CONCLUSIONSFindings from this study do not support SU as the second-line treatment choice for patients with type 2 diabetes. Moreover, the results indicate that adding a GLP-1 for people treated with MET and BASAL could be considered, especially if those people suffer from severe hypoglycemia. Full Article
hy Metabolic Factors, Lifestyle Habits, and Possible Polyneuropathy in Early Type 2 Diabetes: A Nationwide Study of 5,249 Patients in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Cohort By care.diabetesjournals.org Published On :: 2020-04-28T09:53:07-07:00 OBJECTIVETo investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes.RESEARCH DESIGN AND METHODSWe thoroughly characterized 6,726 patients with recently diagnosed diabetes. After a median of 2.8 years, we sent a detailed questionnaire on neuropathy, including the Michigan Neuropathy Screening Instrument questionnaire (MNSIq), to identify possible DPN (score ≥4) and the Douleur Neuropathique en 4 Questions (DN4) questionnaire for possible associated neuropathic pain (MNSIq ≥4 + pain in both feet + DN4 score ≥3).RESULTSAmong 5,249 patients with data on both DPN and pain, 17.9% (n = 938) had possible DPN, including 7.4% (n = 386) with possible neuropathic pain. In regression analyses, central obesity (waist circumference, waist-to-hip ratio, and waist-to-height ratio) was markedly associated with DPN. Other important metabolic factors associated with DPN included hypertriglyceridemia ≥1.7 mmol/L, adjusted prevalence ratio (aPR) 1.36 (95% CI 1.17; 1.59); decreased HDL cholesterol <1.0/1.2 mmol/L (male/female), aPR 1.35 (95% CI 1.12; 1.62); hs-CRP ≥3.0 mg/L, aPR 1.66 (95% CI 1.42; 1.94); C-peptide ≥1,550 pmol/L, aPR 1.72 (95% CI 1.43; 2.07); HbA1c ≥78 mmol/mol, aPR 1.42 (95% CI 1.06; 1.88); and antihypertensive drug use, aPR 1.34 (95% CI 1.16; 1.55). Smoking, aPR 1.50 (95% CI 1.24; 1.81), and lack of physical activity (0 vs. ≥3 days/week), aPR 1.61 (95% CI 1.39; 1.85), were also associated with DPN. Smoking, high alcohol intake, and failure to increase activity after diabetes diagnosis associated with neuropathic pain.CONCLUSIONSPossible DPN was associated with metabolic syndrome factors, insulin resistance, inflammation, and modifiable lifestyle habits in early type 2 diabetes. Full Article
hy Predicting the Risk of Inpatient Hypoglycemia With Machine Learning Using Electronic Health Records By care.diabetesjournals.org Published On :: 2020-04-29T13:46:01-07:00 OBJECTIVEWe analyzed data from inpatients with diabetes admitted to a large university hospital to predict the risk of hypoglycemia through the use of machine learning algorithms.RESEARCH DESIGN AND METHODSFour years of data were extracted from a hospital electronic health record system. This included laboratory and point-of-care blood glucose (BG) values to identify biochemical and clinically significant hypoglycemic episodes (BG ≤3.9 and ≤2.9 mmol/L, respectively). We used patient demographics, administered medications, vital signs, laboratory results, and procedures performed during the hospital stays to inform the model. Two iterations of the data set included the doses of insulin administered and the past history of inpatient hypoglycemia. Eighteen different prediction models were compared using the area under the receiver operating characteristic curve (AUROC) through a 10-fold cross validation.RESULTSWe analyzed data obtained from 17,658 inpatients with diabetes who underwent 32,758 admissions between July 2014 and August 2018. The predictive factors from the logistic regression model included people undergoing procedures, weight, type of diabetes, oxygen saturation level, use of medications (insulin, sulfonylurea, and metformin), and albumin levels. The machine learning model with the best performance was the XGBoost model (AUROC 0.96). This outperformed the logistic regression model, which had an AUROC of 0.75 for the estimation of the risk of clinically significant hypoglycemia.CONCLUSIONSAdvanced machine learning models are superior to logistic regression models in predicting the risk of hypoglycemia in inpatients with diabetes. Trials of such models should be conducted in real time to evaluate their utility to reduce inpatient hypoglycemia. Full Article
hy Why is My Child Defiant or Explosive? By schoolpsychologistfiles.blogspot.com Published On :: Fri, 24 Aug 2012 14:56:00 +0000 Dedicated to the lady at Walmart with the screaming kid and all of us "good parents" who have been that lady at Walmart.One of the most difficult behaviors for parents or teachers to address is explosive behavior, a child who has little control over emotions and "melts down" in the classroom or at home. It is frustrating, it is embarrassing, it is anxiety producing, it causes intense emotions in ourselves. Parents agonize over why it happens or what they did wrong? Often the parents are blamed or judged by bystanders in stores, family members, friends, or school staff. However, I have seen parents with a variety of parenting styles have kids with poor emotional control, including those who are strict, those who are quick to give in, those who spank, those who use time out, those who take away privileges, and a whole lot of parents who feel like they have tried everything. I know children with very little emotional control from homes that are falling apart, from homes that are loving and supportive, from poor families, from affluent families, from parents who have no clue how to parent, from parents with excellent skills, even from School Psychologists. This is not to say that parenting styles do not have a role in this, but there IS more to it. We have to stop judging each other and get to the root of the problem. What is the Root of the Problem?The problem, the reason some children "explode" or act out with little emotional control, is because he or she is lacking a skill. Emotional control is a skill. Most kids will learn this skill through consistent discipline strategies, but some do not. Another way to look at it.We don't tell our kids how to read and then expect them to do it. We show them step by step. Some kids will pick it up easy, others will need to be taught and retaught and retaught and will need extensive help in doing so. Do we blame ourselves? Do we look at our friends judgementally and think to ourselves "look at the book she is using, it's all wrong?" No, we assume the child has a problem learning to read and we find a way to teach him. WE HAVE TO START LOOKING AT BEHAVIOR IN THE SAME WAY. When a child is exploding, the first step should not be to label the child or blame the parent. Lets start looking for the skill that is lacking. When we find that skill, lets teach it.It's NOT always a control issue. Sometimes kids act out because they have not been taught to obey and respect authority, but sometimes they act out in spite of good training at home. The explosions lead to self esteem problems in the child and the child feeling like a "bad kid," which in turn makes explosions bigger and more frequent. Have you ever looked at a screaming child and demanded he control himself right now or "act your age." It's a common thing to do. Have you ever looked at a child with a Learning Disability and said "read on your grade level, now!" or "I have told you and told you how to read, why aren't you reading?" Of course you haven't. We work with the reader at his level and patiently try different strategies to improve reading. We can't demand them to be good readers and we can't demand that a child who does not have the skills to control his emotions "act his age." These explosive kids need skills and truth be told, we who work with these kids need skills. If you are a parent with a child who acts "out of control" stop blaming yourself. It isn't necessarily because you spanked or didn't spank or were too strict or too lenient. Your child is lacking the skills she needs to control her emotions. Also, realize you are going to need to learn new skills to help your child learn the lacking skills. You are no longer in the Parenting 101 class, you need to move on to the Advanced skill- teaching parenting class. The BEST book I have read on this topic is The Explosive Child by Ross Greene. He addresses the skills these children might be lacking and he has great strategies to address the issue. (see Amazon link below)If you are a teacher and have an "explosive child" in your class, rethink your perspective of the student. The child needs to learn skills, so lets focus on teaching the skills and being patient with the children who are slower to learn emotional control. We as school staff can not make excuses or blame the parents. We have to reach the child at her level. We teach a child to read at her level. We must teach a child to control emotions at her level as well. Challenge for EveryoneLet us stop labeling these kids with emotional skill deficits as "bad kids" and stop judging the parents. Let's be honest with ourselves and recognize we all have shortcomings and could use skills in certain areas. Maybe our kids need skills in emotional control, maybe we do, maybe we need skills in teaching emotional control, or maybe we need skills in some other area all together. Let's be patient with our children and our peers and ourselves. Let's stop criticizing ourselves and others and start learning and teaching new skills. We don't live in a world with bad kids, we live in a world will kids who need skills, so let's teach. Full Article Interventions
hy Ask Ariely: On Healthy Handshakes, Bus Behaviors, and Diet Defenses By danariely.com Published On :: Sat, 14 Mar 2020 11:30:57 +0000 Here’s my Q&A column from the WSJ this week — and if you have any questions for me, you can tweet them to @danariely with the hashtag #askariely, post a comment on my Ask Ariely Facebook page, or email them to AskAriely@wsj.com. ___________________________________________________ Dear Dan, I know that because of the... Full Article Ask Ariely Blog advice column ask ariely Behavioral Economics & Psychology dear dan wall street journal wsj
hy [ Religion & Spirituality ] Open Question : Christians, why do some people keep lying by saying trans been using other Gender's room for long time but that lie? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:15:22 +0000 i even got this from pro trans page that say they have laws banning men from women's room & trans aka GD was put into mad house, & even then there been alot of time where rapists &perverted freaks been using other Gender's bath room too doesn't make it right, they go to prison if they find out Full Article
hy [ Politics ] Open Question : Why are Democrats so fond of china? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:16:59 +0000 Full Article
hy [ Politics ] Open Question : Why do people in Chicago kill themselves for nothing? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:17:22 +0000 Full Article
hy [ Royalty ] Open Question : Why do males often name their male kids the same name, and a number, but females do not do the same for their daughters? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:17:29 +0000 (I am in the USA). There was 8 Henry s https://en.wikipedia.org/wiki/Henry_VIII_of_England Full Article
hy [ Politics ] Open Question : Why hasn't there ever been a great Democrat presidents' face on Mount Rushmore? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:20:24 +0000 Maybe because there's never been a great Democrat president? And never will be. They're all horrible. Full Article
hy [ Politics ] Open Question : Why are other countries like New Zealand and Australia destroying the virus while America is killing people off to restart the economy? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:22:00 +0000 Full Article
hy [ Politics ] Open Question : Why do so me people worship celebrities? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:22:09 +0000 Full Article
hy [ Religion & Spirituality ] Open Question : How come there are different writers attributed to the Gospel of Mark.... why would Mark need different people to write his Gospel.? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:24:57 +0000 Full Article
hy [ Law & Ethics ] Open Question : Why isn't COVID called the Wuhan Flu? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:25:06 +0000 Sounds better than some made up nonsense. Might as well have called it the rumoponosisack 77 syndrome H. Full Article
hy Why Women May Be More Susceptible to Mood Disorders By rss.sciam.com Published On :: Tue, 14 Apr 2020 10:45:00 GMT New research in mice suggests that a pregnancy hormone contributes to brain and behavioral changes caused by childhood adversity -- Read more on ScientificAmerican.com Full Article Mind Behavior & Society Mental Health
hy Why Exercise Is So Good For You By rss.sciam.com Published On :: Fri, 24 Apr 2020 23:23:00 GMT Health journalist Judy Foreman talks about her new book Exercise Is Medicine: How Physical Activity Boosts Health and Slows Aging. -- Read more on ScientificAmerican.com Full Article Health The Body Wellness Mind Mental Health The Sciences Biology
hy Why Torture Keeps Pace With Enlightenment By www.washingtonpost.com Published On :: Mon, 11 Jun 2007 00:00:00 EDT In the year 65, the Roman emperor Nero discovered that a group of nobles had hatched a conspiracy to kill him. The tyrant captured the suspects one by one and threatened them with torture; most confessed and implicated others. One of the conspirators, Epicharis, was publicly tortured -- her bones... Full Article Opinions Why Torture Keeps Pace With Enlightenment
hy Why We Don't Go for It By www.washingtonpost.com Published On :: Mon, 18 Jun 2007 00:00:00 EDT This year's National Basketball Association playoffs recently provided not one but two examples of a very interesting facet of human decision making. Even if you are not a sports fan, these moments tell you something about human nature. Full Article Opinions Why We Don't Go for It
hy Why Voters Play Follow-the-Leader By www.washingtonpost.com Published On :: Mon, 04 Feb 2008 00:00:00 EST What do you think is more dangerous? Terrorists getting their hands on a biological weapon that can be smuggled into the country or another hurricane like Katrina? Which is the smarter way to keep Social Security solvent? Raise the retirement age or raise taxes? How can the current economic crisi... Full Article Opinions Why Voters Play Follow-the-Leader
hy Why Being the GOP's No. 2 Isn't So Bad By www.washingtonpost.com Published On :: Mon, 18 Feb 2008 00:00:00 EST Through much of the Republican presidential primary, Sen. John McCain and former Massachusetts governor Mitt Romney could barely restrain their contempt for each other. During one Republican debate in New Hampshire in early January, McCain landed a zinger that summed up Romney's opportunistic... Full Article Opinions Why Being the GOP's No. 2 Isn't So Bad
hy Petroleum Feeds Patriarchy By www.washingtonpost.com Published On :: Mon, 10 Mar 2008 00:00:00 EDT Climate change. Pollution. Financial expense. Our gas-guzzling ways have long been associated with a variety of problems, but disturbing evidence now points to a new dimension of our love affair with petroleum: Oil consumption and high oil prices hurt the political, social and economic development... Full Article Opinions Petroleum Feeds Patriarchy
hy Why Fluff-Over-Substance Makes Perfect Evolutionary Sense By www.washingtonpost.com Published On :: Mon, 25 Aug 2008 00:00:00 EDT Consider these scenarios. Scandal A: A prominent politician gets caught sleeping with a campaign aide and plunges himself into an ugly paternity dispute -- all while his cancer-stricken wife is fighting for her life. Full Article Opinions Why Fluff-Over-Substance Makes Perfect Evolutionary Sense
hy Mass Suffering and Why We Look the Other Way By www.washingtonpost.com Published On :: Mon, 05 Jan 2009 00:00:00 EST When President-elect Barack Obama, an early opponent of the Iraq war, asked Sen. Hillary Rodham Clinton -- who helped to authorize the war -- to be his secretary of state, many liberals scratched their heads. Full Article Opinions Mass Suffering and Why We Look the Other Way
hy Why the Ideological Melting Pot Is Getting So Lumpy By www.washingtonpost.com Published On :: Mon, 19 Jan 2009 00:00:00 EST Americans like to live in diverse communities. At least, that's what they say. Full Article Opinions Why the Ideological Melting Pot Is Getting So Lumpy
hy Borderline Irrelevant: Why Reforming the Dublin Regulation Misses the Point By www.migrationpolicy.org Published On :: Fri, 26 Jan 2018 14:50:37 -0500 European policymakers are fixated on reform of the Dublin Regulation, the contentious rules that carve up responsibility for asylum claims between EU states. They see it not only as a long-term prophylactic against future fluctuations in irregular migration, but as a marker of the success or failure of solidarity in Europe overall. Yet rather than doggedly working to salvage Dublin, policymakers need to stop and consider why they regard it as so integral to European cooperation, as this commentary explores. Full Article
hy K-12 Instructional Models for English Learners: What They Are and Why They Matter By www.migrationpolicy.org Published On :: Wed, 27 Jun 2018 19:58:24 -0400 Marking the release of an MPI brief, experts on this webinar examine the key features of English Learner (EL) instructional models and discuss state- and district-level approaches to supporting schools in implementing effective EL program models, with a particular focus on what is being done in New York and Madison Wisconsin. Full Article
hy Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin [Computational Biology] By www.jbc.org Published On :: 2020-04-24T06:08:45-07:00 In Staphylococcus aureus–caused endocarditis, the pathogen secretes staphylocoagulase (SC), thereby activating human prothrombin (ProT) and evading immune clearance. A previous structural comparison of the SC(1–325) fragment bound to thrombin and its inactive precursor prethrombin 2 has indicated that SC activates ProT by inserting its N-terminal dipeptide Ile1-Val2 into the ProT Ile16 pocket, forming a salt bridge with ProT's Asp194, thereby stabilizing the active conformation. We hypothesized that these N-terminal SC residues modulate ProT binding and activation. Here, we generated labeled SC(1–246) as a probe for competitively defining the affinities of N-terminal SC(1–246) variants preselected by modeling. Using ProT(R155Q,R271Q,R284Q) (ProTQQQ), a variant refractory to prothrombinase- or thrombin-mediated cleavage, we observed variant affinities between ∼1 and 650 nm and activation potencies ranging from 1.8-fold that of WT SC(1–246) to complete loss of function. Substrate binding to ProTQQQ caused allosteric tightening of the affinity of most SC(1–246) variants, consistent with zymogen activation through occupation of the specificity pocket. Conservative changes at positions 1 and 2 were well-tolerated, with Val1-Val2, Ile1-Ala2, and Leu1-Val2 variants exhibiting ProTQQQ affinity and activation potency comparable with WT SC(1–246). Weaker binding variants typically had reduced activation rates, although at near-saturating ProTQQQ levels, several variants exhibited limiting rates similar to or higher than that of WT SC(1–246). The Ile16 pocket in ProTQQQ appears to favor nonpolar, nonaromatic residues at SC positions 1 and 2. Our results suggest that SC variants other than WT Ile1-Val2-Thr3 might emerge with similar ProT-activating efficiency. Full Article
hy The Story of Philosophy by Will Durant By brooklynbooktalk.blogspot.com Published On :: Tue, 09 Jul 2013 18:50:00 +0000 “And last are the few whose delight is in meditation and understanding; who yearn not for goods, nor for victory, but for knowledge; who leave both market and battlefield to lose themselves in the quiet clarity of secluded thought; whose will is a light rather than a fire, whose haven is not power but truth: these are the men of wisdom, who stand aside unused by the world.” ― Will Durant, The Story of PhilosophyConsidered one of the finest introductions to the lives and opinions of some of the world’s greatest Western philosophers, Will Durant’s The Story of Philosophy (1926), was such a huge success (it sold more than two million copies in less than three decades), that it gave him the necessary and sufficient leisure, for almost fifty years, to work on his critically acclaimed 11-volume series, The Story of Civilization. Given the contributions he had made for the writing of popular history and philosophy, and championing freedom and human rights, he was awarded the Pulitzer Prize in 1968 and the Presidential Medal of Freedom in 1977. Please join us at Brooklyn Book Talk, for a discussion on philosophy and philosophers such as Socrates, Plato, Aristotle, Bacon, Spinoza, Voltaire, Kant, Schopenhauer, Spencer, Nietzsche, Bergson, Croce, Russell, Santayana, James and Dewey, whose ideas have formed the enduring foundations of Western civilization. Philosophy, which has also been defined as “what we don’t know,” comes alive in the delightful prose and passion of Will Durant who towards the end of his life was humble enough to admit: “Sixty years ago I knew everything; now I know nothing; education is a progressive discovery of our own ignorance.” Full Article
hy The Patchy Landscape of State English Learner Policies under ESSA By www.migrationpolicy.org Published On :: Tue, 11 Feb 2020 10:14:34 -0500 All 50 states, the District of Columbia, and Puerto Rico have developed blueprints to meet their commitments under the Every Student Succeeds Act—including requirements that aim to raise the profile of English Learners (EL) in state accountability systems. This report breaks these plans down, comparing the significant diversity of approaches taken on everything from EL identification to tracking academic achievement. Full Article
hy Roasted Honey and Thyme Peaches By www.abc.net.au Published On :: Thu, 11 Feb 2016 13:19:00 +1100 Celebrate sweet, juicy peaches with this easy and delicious dessert. No ricotta? Serve peaches with vanilla ice cream and toasted almonds. Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690
hy Buckwheat polenta with roasted vegetables, blue cheese, pine nuts and thyme By www.abc.net.au Published On :: Mon, 09 May 2016 13:18:00 +0800 As the cold weather sets in, this nourishing winter dish is perfect to warm hands, feet and heart. The addition of buckwheat flour to polenta gives it a delicious smoky earth flavour and adds to the nutrition level of this dish. Rich in fibre and silica, gluten free buckwheat contain rutin, a bioflavonoid that is know to increase blood circulation and reduce high blood pressure. Perfect for winter! Full Article ABC Local southwestwa Lifestyle and Leisure:Recipes:Main Lifestyle and Leisure:Recipes:Mostly Vegetarian Health:Diet and Nutrition:Healthy recipes Australia:WA:Pemberton 6260
hy Autumn roasted vegetables with lemon thyme and a drizzle of macadamia honey By www.abc.net.au Published On :: Thu, 16 Mar 2017 13:45:00 +1100 Nothing beats beautifully roasted vegetables caramelized in their own sugar content to accompany a simple roast dinner or even on their own with a nice salad. The addition of perfumed lemon thyme and macadamia gives a nice touch. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
hy Reduction in Global Myocardial Glucose Metabolism in Subjects With 1-Hour Postload Hyperglycemia and Impaired Glucose Tolerance By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Impaired insulin-stimulated myocardial glucose uptake has occurred in patients with type 2 diabetes with or without coronary artery disease. Whether cardiac insulin resistance is present remains uncertain in subjects at risk for type 2 diabetes, such as individuals with impaired glucose tolerance (IGT) or those with normal glucose tolerance (NGT) and 1-h postload glucose ≥155 mg/dL during an oral glucose tolerance test (NGT 1-h high). This issue was examined in this study. RESEARCH DESIGN AND METHODS The myocardial metabolic rate of glucose (MRGlu) was measured by using dynamic 18F-fluorodeoxyglucose positron emission tomography combined with a euglycemic-hyperinsulinemic clamp in 30 volunteers without coronary artery disease. Three groups were studied: 1) those with 1-h postload glucose <155 mg/dL (NGT 1-h low) (n = 10), 2) those with NGT 1-h high (n = 10), 3) and those with IGT (n = 10). RESULTS After adjusting for age, sex, and BMI, both subjects with NGT 1-h high (23.7 ± 6.4 mmol/min/100 mg; P = 0.024) and those with IGT (16.4 ± 6.0 mmol/min/100 mg; P < 0.0001) exhibited a significant reduction in global myocardial MRGlu; this value was 32.8 ± 9.7 mmol/min/100 mg in subjects with NGT 1-h low. Univariate correlations showed that MRGlu was positively correlated with insulin-stimulated whole-body glucose disposal (r = 0.441; P = 0.019) and negatively correlated with 1-h (r = –0.422; P = 0.025) and 2-h (r = –0.374; P = 0.05) postload glucose levels, but not with fasting glucose. CONCLUSIONS This study shows that myocardial insulin resistance is an early defect that is already detectable in individuals with dysglycemic conditions associated with an increased risk of type 2 diabetes, such as IGT and NGT 1-h high. Full Article
hy Confirming the Bidirectional Nature of the Association Between Severe Hypoglycemic and Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE We sought to confirm a bidirectional association between severe hypoglycemic events (SHEs) and cardiovascular (CV) event risk and to characterize individuals at dual risk. RESEARCH DESIGN AND METHODS In a post hoc analysis of 14,752 Exenatide Study of Cardiovascular Event Lowering (EXSCEL) participants, we examined time-dependent associations between SHEs and subsequent major adverse cardiac events (CV death, nonfatal myocardial infarction [MI] or stroke), fatal/nonfatal MI, fatal/nonfatal stroke, hospitalization for acute coronary syndrome (hACS), hospitalization for heart failure (hHF), and all-cause mortality (ACM), as well as time-dependent associations between nonfatal CV events and subsequent SHEs. RESULTS SHEs were uncommon and not associated with once-weekly exenatide therapy (hazard ratio 1.13 [95% CI 0.94–1.36], P = 0.179). In fully adjusted models, SHEs were associated with an increased risk of subsequent ACM (1.83 [1.38–2.42], P < 0.001), CV death (1.60 [1.11–2.30], P = 0.012), and hHF (2.09 [1.37–3.17], P = 0.001), while nonfatal MI (2.02 [1.35–3.01], P = 0.001), nonfatal stroke (2.30 [1.25–4.23], P = 0.007), hACS (2.00 [1.39–2.90], P < 0.001), and hHF (3.24 [1.98–5.30], P < 0.001) were all associated with a subsequent increased risk of SHEs. The elevated bidirectional time-dependent hazards linking SHEs and a composite of all CV events were approximately constant over time, with those individuals at dual risk showing higher comorbidity scores compared with those without. CONCLUSIONS These findings, showing greater risk of SHEs after CV events as well as greater risk of CV events after SHEs, validate a bidirectional relationship between CV events and SHEs in patients with high comorbidity scores. Full Article
hy Algorhythms for Marketing Transformation By brandleadership.wordpress.com Published On :: Fri, 24 Jun 2016 17:24:16 +0000 We all understand that digital media, data, and analytics are driving transformations in society and business. Most marketers are now armed with case studies of what can be done differently, but many are still challenged with how to truly develop new ideas and execute new strategies to grow their business. Mitch Joel, President of Mirum […] Full Article Uncategorized
hy Interdisciplinary Team Care for Diabetic Patients by Primary Care Physicians, Advanced Practice Nurses, and Clinical Pharmacists By clinical.diabetesjournals.org Published On :: 2011-04-01 David WillensApr 1, 2011; 29:60-68Feature Articles Full Article
hy Management of Diabetic Peripheral Neuropathy By clinical.diabetesjournals.org Published On :: 2005-01-01 Andrew J.M. BoultonJan 1, 2005; 23:9-15Feature Articles Full Article
hy Helping Patients Make and Sustain Healthy Changes: A Brief Introduction to Motivational Interviewing in Clinical Diabetes Care By clinical.diabetesjournals.org Published On :: 2008-10-01 Michele HeislerOct 1, 2008; 26:161-165Practical Pointers Full Article
hy Hospital Management of Hyperglycemia By clinical.diabetesjournals.org Published On :: 2004-04-01 Kristen B. CampbellApr 1, 2004; 22:81-88Practical Pointers Full Article
hy Cardiac Manifestations of Congenital Generalized Lipodystrophy By clinical.diabetesjournals.org Published On :: 2016-10-01 Vani P. SanonOct 1, 2016; 34:181-186Feature Articles Full Article
hy Hypoglycemia in Type 1 and Type 2 Diabetes: Physiology, Pathophysiology, and Management By clinical.diabetesjournals.org Published On :: 2006-07-01 Vanessa J. BriscoeJul 1, 2006; 24:115-121Feature Articles Full Article
hy Amylin Replacement With Pramlintide in Type 1 and Type 2 Diabetes: A Physiological Approach to Overcome Barriers With Insulin Therapy By clinical.diabetesjournals.org Published On :: 2002-07-01 John B. BuseJul 1, 2002; 20:Feature Articles Full Article
