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A look at the potential impact of shutting down the Department of Education

NPR's Steve Inskeep asks the Brookings Institution's Jon Valant about President-elect Trump's campaign promise to close the Department of Education.




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Rare and complex NATO tank spotted and destroyed in Russia's Kursk region

A "rare and complex" British Challenger 2 tank that Ukraine received from the UK was spotted in the Kursk region of Russia. "The destruction of a heavy British Challenger 2 tank, a rather rare and complex tank to operate, by the marines of our 155th brigade indicates the concentration of enemy efforts," Two Majors Telegram channel said. The fact that such rare military hardware was transferred to the Russian region indicates the intention of the Armed Forces of Ukraine to use all opportunities to hold positions in the Kursk region, authors of the channel added.




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McMaster University Researchers Uncover Potential Treatment for Rare Genetic Disorders

In a groundbreaking study, researchers at McMaster University have identified a potential treatment for Sandhoff and Tay-Sachs diseases--two rare, often fatal lysosomal storage disorders that cause progressive damage to nerve cells in the brain and spinal cord. After years of investigating the diseases' underlying mechanisms, the research team has identified an existing FDA-approved drug that could significantly improve quality of life for affected patients and their families.




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Lean Hypotheses and Effectual Commitments: An Integrative Framework Delineating the Methods of Science and Entrepreneurship




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McMaster University Researchers Uncover Potential Treatment for Rare Genetic Disorders

In a groundbreaking study, researchers at McMaster University have identified a potential treatment for Sandhoff and Tay-Sachs diseases--two rare, often fatal lysosomal storage disorders that cause progressive damage to nerve cells in the brain and spinal cord. After years of investigating the diseases' underlying mechanisms, the research team has identified an existing FDA-approved drug that could significantly improve quality of life for affected patients and their families.




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Potential NFL stadium moves closer to going on Inglewood ballot this summer

A rendering of he new stadium and complex to be built near the Forum in Inglewood was released by the Hollywood Park Land Company, Kroenke Group and Stockbridge Capital Group earlier this month.; Credit: Courtesy Hollywood Park Land Company

Ben Bergman

A measure that would allow an 80,000-seat NFL-caliber stadium to be built in Inglewood could be on that city’s ballot by this summer after developers submitted almost three times as many signatures than needed for a voter initiative.

“22,216 signatures were submitted to the city clerk today,” said Gerard McCallum, project manager with the Hollywood Park Land Company. “It was unbelievable. The response was more than we could have ever anticipated.”

Normally, before construction can begin on any project there has to be an environmental review, but that can take a long time and time is something in short supply for St. Louis Rams Owner Stan Kroenke and his plan to move the team to L.A.

“We would be going through another three year project process, and the current construction wouldn’t allow that,” said McCallum, referring to the redevelopment of 238 acres of the old Hollywood Park site that was permitted in 2009.

“If we were going to make any modifications, it would have to be approved this year,” said McCallum.

To speed things up, developers decided to bring the stadium project directly to Inglewood voters, which required 8,000 signatures.

Once the signatures are verified, Inglewood’s City Council will consider the measure, then developers hope a special election would take place before the start of the next NFL season.

McCallum says construction would begin whether the Rams or any other team decides to move here, though on Monday Kroenke made another move suggesting a return of the NFL to Los Angeles could be closer than it has been at any point during the last two decades, though not until after the 2015 season. From The St Louis Post-Dispatch:

Rams management sent a letter to regional officials on Monday afternoon. The letter said the team was converting its 30-year lease to an “annual tenancy,” effective April 1 and, “in the absence of intervening events,” extending through March 31, 2016.

The notice, which has long been expected, does two things:

  • It allows owner Stan Kroenke to pull the team out of St. Louis as soon as 2016, because the Rams lease will now expire at the end of every season. The original lease was to expire in 2025.
  • It also legally binds the Rams to play at the Edward Jones Dome next fall — a point on which many here were uncertain.

This content is from Southern California Public Radio. View the original story at SCPR.org.




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Home Depot says malware affected 56M payment cards

File photo: Customers enter a Home Depot store on May 21, 2013 in El Cerrito, Calif.; Credit: Justin Sullivan/Getty Images

The Home Depot says it has eliminated malware from its U.S. and Canadian networks that affected 56 million unique payment cards between April and September.

The Atlanta-based home improvement retailer said Thursday it has also completed a "major" payment security project that provides enhanced encryption of customers' payment data in the company's U.S. stores.

Home Depot also is confirming its sales-growth estimates for the fiscal year and expects to earn $4.54 per share in fiscal 2014, up 2 cents from its prior guidance.




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Cool role spotlight: how this chef combines her passions for culinary arts and sales (November 14, 2024 12:00pm)

Event Begins: Thursday, November 14, 2024 12:00pm
Location:
Organized By: University Career Center


No career path is a straight line, sometimes you have to funnel your passions into new directions. On November 14 at 12:00PM PT joinus for a virtual session with Chef and Sales Manager Juliet Hope. During the event Juliet will share her insights into her role and career journey, including:
Pivoting your career to find the right path for you
What a day in the life of a Regional Sales Manager looks like
Tips for a successful career in the food industry
Hope to see you there! 




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USD/JPY enters into the pocket of space, potentially freeing up more gains

The dollar continues to push higher in the post-election period and in the case of USD/JPY, that momentum is helped by higher yields as well. The pair has been on a tear since October trading, racing up from 143.00 all the way to touching 156.00 earlier today. The break above 155.00 yesterday is a crucial one, signifying another breach of a key technical/psychological level.

When it comes to USD/JPY, there's always something about big figure levels. And this is arguably no exception.

With buyers clearing the key daily moving averages and 150.00 mark last month, the focus has been drawn on the 155.00 mark since. And inevitably with Trump winning the election, we've finally gotten there today.

And having done so, we're into a bit of a pocket of space with little to no technical resistance all the way to 160.00 potentially.

It doesn't mean we'll get there overnight but it does present an attractive level for buyers to take aim at. Nonetheless, the pace of any further gains will of course be another thing to be mindful of though.

That might invite scrutiny from Japan officials to verbally intervene. As for any real intervention threat, it's going to be tough to fight the underlying market momentum in play currently. So, I wouldn't imagine Tokyo trying that out - at least for the time being.

The bond market is once again going to be a key driver to be mindful of when it comes to USD/JPY. But for now, the overall dollar bullishness is also helping to underpin the pair rather strongly. That especially when the greenback is starting to creep up on some key technical levels in the bigger picture, as seen here with EUR/USD.

This article was written by Justin Low at www.forexlive.com.




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Spot Report by OSCE Special Monitoring Mission to Ukraine: SMM threatened at gunpoint near Lobacheve in Luhansk region

This report is for media and the general public.

At 10:10 on 2 August, an armed man at a known Ukrainian Armed Forces position wearing military-style clothing with no markings stopped two SMM vehicles in government-controlled areas travelling east on the road from Lopaskyne (government-controlled, 24km north-west of Luhansk) to Lobacheve (government-controlled, 17km north-west of Luhansk).  When one of the SMM monitors stepped out of the vehicle to speak with the man, the latter chambered a round into his submachine gun (AKSU-74) and after removing the weapon’s safety, pointed it at the SMM monitor and put his finger on the trigger. Speaking in Russian, the armed man told the SMM “Stop. You are not going anywhere”.

The SMM requested the armed man call his commander, which he did. Standing approximately two metres away, the man kept his gun pointed at the SMM monitor and spoke to someone in Russian on his handheld radio. Approximately five to seven minutes later, another man arrived at the scene carrying an assault rifle (AK-74) with a silencer. He was accompanied by three other armed men carrying assault rifles, some of whom appeared to be intoxicated, and appeared to be in a position of authority. Some of the men were dressed in military-style clothing. Using Russian and speaking in an aggressive manner, the man said that he and the other armed men present were members of the Ukrainian Armed Forces. The SMM monitor asked the man who appeared to be in charge to order the armed man to lower his weapon. He did so but the weapon was not made safe.

Speaking with the commander of the group, the SMM monitor tried to diffuse the situation by explaining the Mission’s mandate and after approximately fifteen minutes, the SMM was allowed to leave the area and proceed to Lobacheve to complete their tasks.

The SMM returned safely to its base at 16:00. The Joint Centre for Control and Co-ordination was informed.

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Spot Report by OSCE Special Monitoring Mission to Ukraine: Explosion in Luhansk city

This report is for media and the general public.

On 6 August at 07:51hrs the SMM heard an explosion approximately 3.9km east of its location in Luhansk city.

The SMM went to the site from where it had heard the explosion located at the intersection of Karpynsky and Vatutyn Street in Luhansk city, 500m north-east of SMM’s accommodation. The site was cordoned off, by so-called “LPR” “police” and the SMM could assess from a distance of approximately 15-30 meters, that an explosion had likely been caused by an improvised explosive device (assessed as approximately 1kg of high explosives) placed next to or in, a lamp post about two meters away from the vehicle, which was damaged and downed, at the side of the road. The SMM saw a black sport utility vehicle “Toyota Landcruiser Prado” severely damaged with windows shattered and front and side airbags deployed.

“LPR” “police” members at the site told the SMM that there were two casualties, without giving further details. Mr Vladislav Deynego, “LPR” member, told the SMM that Mr Plotnitsky was “in a bad condition and not able to receive visitors.”  At the time of writing, the SMM could not reach personnel at either of the two hospitals in Luhansk city for confirmation.

The SMM will continue following up to confirm the information, and observe further developments.

Related Stories




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Spot Report by OSCE Special Monitoring Mission to Ukraine: Explosion in Luhansk city

This report is for media and the general public.

On 6 August at 07:51hrs the SMM heard an explosion approximately 3.9km east of its location in Luhansk city.

The SMM went to the site from where it had heard the explosion located at the intersection of Karpynsky and Vatutyn Street in Luhansk city, 500m north-east of SMM’s accommodation. The site was cordoned off, by so-called “LPR” “police” and the SMM could assess from a distance of approximately 15-30 meters, that an explosion had likely been caused by an improvised explosive device (assessed as approximately 1kg of high explosives) placed next to or in, a lamp post about two meters away from the vehicle, which was damaged and downed, at the side of the road. The SMM saw a black sport utility vehicle “Toyota Landcruiser Prado” severely damaged with windows shattered and front and side airbags deployed.

“LPR” “police” members at the site told the SMM that there were two casualties, without giving further details. Mr Vladislav Deynego, “LPR” member, told the SMM that Mr Plotnitsky was “in a bad condition and not able to receive visitors.”  At the time of writing, the SMM could not reach personnel at either of the two hospitals in Luhansk city for confirmation.

The SMM will continue following up to confirm the information, and observe further developments.

Related Stories




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Harry Potter Filmed Two Different Versions Of A Key Scene For UK & US Audiences

Depending on which country you live in, the first Harry Potter movie features Harry, Ron, and Hermione talking about a different magical object.





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Here's How I Spot a Fake Malvertisement Every Time

These ads aren't selling anything; they're coming for your data instead.




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Get a tiny Crock-Pot perfect for warm meals on the go for just $30 at Amazon

As of Nov. 13, the Crock-Pot 20-ounce electric lunch box is available at Amazon for $29.99, a $15 discount.




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Bonk Coin Shows Positive Price Forecast: Potential Bullish Trend Ahead

Bonk coin continued its upsurge this week and reached $0.000034. It is the highest level in the past five months The victory of Donald Trump in the US Assembly election created a positive trend in the crypto market. All the cryptos including the meme coins benefited from this upsurge caused due to this positive trend. [...]




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New Product Spotlight: Aeriz, Copperstate Farms revisit the old while exploring the new

Award-winning cannabis cultivator Aeriz has debuted a carefully crafted lineup of four new cannabis strains…



  • News & Opinion/Cannabis

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Het succes van Spotify Wrapped verklaard: zo zit dat

Nu de kou z’n intrede maakt, beginnen mensen zich weer klaar te maken. Nee, niet voor kerst of het klagen over de (weer) te vroege intrede van de kruidnoten in de supermarkt. Men begint reikhalzend uit te kijken naar de lancering van de enige echte Spotify Wrapped. Wat is er gebeurd dat dit de tongen […]





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DENR Responds To Spotted Lanternfly

The Department of Environment and Natural Resources [DENR] responded to reports of ‘spotted lanternflies’ — an invasive insect species — discovered aboard two cruise ships, with DENR noting that “both ships fully cooperated with DENR’s protocols, ensuring the effective elimination of the invasive pest.” A Government spokesperson said, “On September 2, 2024, the Department of […]




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Улучшения и ограничения, которые появились в обновлении приложения Spotify: что нужно знать пользователю

Spotify представил обновление мобильного приложения, полностью переработав очередь песен и некоторые элементы управления. В этом обновлении появились как плюси, так и минусы.




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Filing: FTX co-founder Gary Wang, due for sentencing on Nov. 20, built “tools” to help the US government detect potential fraud in the stock and crypto markets






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Will $POPCAT’s Decline Lead to a Rebound, or Should Investors Look to $FLOCK for Potentially Bigger Gains?

At a time when Bitcoin has reached its all-time high and a meme coin rally is underway, Popcat (SOL) has… Continue reading Will $POPCAT’s Decline Lead to a Rebound, or Should Investors Look to $FLOCK for Potentially Bigger Gains?

The post Will $POPCAT’s Decline Lead to a Rebound, or Should Investors Look to $FLOCK for Potentially Bigger Gains? appeared first on ReadWrite.




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Potholes still hurting rural roads after £500m spend

Deteriorating conditions of rural roads are affecting journeys, a transport provider says.




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Potential Tropical Cyclone 19 forms, likely to become Tropical Storm Sara and may impact Florida




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Emu spotted three months after two giant birds escaped in S.C.

South Carolina residents reported sightings of an emu in Horry County, prompting the owner of the bird to share a pair of shocking revelations: there are actually two emus, and they've been on the loose since June.




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Competition heats up for potential sale of 7-Eleven chain

Canada-based Alimentation Couche-Tard isn't the only retail giant proposing to buy the 7-Eleven stores from its Japanese owner.




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Competition heats up for potential sale of 7-Eleven chain

Canada-based Alimentation Couche-Tard isn't the only retail giant proposing to buy the 7-Eleven stores from its Japanese owner.




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Ottawa businesses worry about potential postal disruption

Businesses in Ottawa are bracing for the prospect of a postal strike or lockout on the eve of the holiday shopping season.



  • News/Canada/Ottawa

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Nigeria’s $700bn mining potential draws global interest

Nigeria’s push to revamp its mining sector is generating heightened interest from global investors as President Bola Tinubu’s administration drives reforms to unlock an estimated $700 billion in untapped mineral resources, diplomatic sources said. Last week, Nigeria launched a four-day mining investment roadshow in South Africa, aiming to attract $500m in foreign investment for its


Read More




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Wind energy sector calls for urgent grid access reforms to unlock potential




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World Bank to help realise $60bn export potential

ISLAMABAD: The Ministry of Commerce and the World Bank have agreed to form a joint working group on trade to capitalise on the country’s true export potential.

The understanding was reached during a meeting of Commerce Minister Jam Kamal Khan with a team from the World Bank. Both sides agreed that the working group would meet periodically to advance the goal of realising Pakistan’s export potential of $60 billion.

An official announcement said both sides discussed Pakistan’s export reform agenda, focusing on strategies to enhance export competitiveness and streamline enabling policies.

The discussion also addressed how the World Bank can support these initiatives under the broader country programme.

Mr Kamal highlighted the whole-of-government approach to export enhancement, which promotes a unified policy framework to improve competitiveness and the Ease of Doing Business for exporters.

This strategy emphasises export-led growth by providing crucial enabling factors such as financing, liquidity support, reduced input costs, and regulatory facilitation to empower Pakistan’s export sector.

Published in Dawn, November 14th, 2024




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TikTok Virality Nets Joker 2 Survivor Lady Gaga a Spot in Wednesday



Mama Monster joining the cast of Netflix's Wednesday just makes sense.




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Mysterious Ultra-Massive Galaxies Spotted in Early Universe

Astronomers using the NASA/ESA/CSA James Webb Space Telescope have discovered three ultra-massive galaxies -- nearly as massive as our own Milky Way Galaxy -- already in place within the first billion years after the Big Bang.

The post Mysterious Ultra-Massive Galaxies Spotted in Early Universe appeared first on Sci.News: Breaking Science News.




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Decades after spotting a mysterious creature in the deep, researchers announce a new species

The mystery mollusc has been identified




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Spotify unveils a new payout model for creators with popular videos

Spotify is aiming to give YouTube some competition with its new partner program for video creators and content that goes viral. The music and podcast app announced a new “Partner Program” that monetizes audio and video beyond income from advertising starting on January 2, 2025.

The new monetization program pays Spotify creators in two ways. Creators can earn a share of ad revenue from their content on all platforms through its Partner Program. They can also earn money through monthly podcast subscriptions that “allow listeners to support creators directly in return for exclusive bonus content and perks.”

Both tiers also come with eligibility requirements. The Spotify Partner Program requires participants to host and upload their content through its Spotify for Creators platform, have streamed 10,000 hours and at least 2,000 unique views in a 30-day period and published at least 12 episodes. Subscriptions will be open to content creators who have at least two published episodes and at least 100 unique Spotify listeners in a 60-day period. The new programs will be available for subscribers in the US, UK, Canada and Australia next January.

Spotify has taken other steps to make its video and music content more accessible and mainstream. The music and video streamer integrated with TikTok and Instagram so users can post tracks on the social media sites.

This article originally appeared on Engadget at https://www.engadget.com/entertainment/music/spotify-unveils-a-new-payout-model-for-creators-with-popular-videos-221706698.html?src=rss




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Shaheen Afridi reclaims top spot in ODI bowlers rankings

Pakistan's premier fast bowler Shaheen Afridi has reclaimed the No.1 position in the ICC Men's ODI Bowler Rankings, a spot he initially held during last year's Cricket World Cup in India.




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Spotify teases a ‘super premium’ tier for superfans and upcoming video expansion in Q3 earnings call

Spotify CEO Daniel Ek has once again teased the company’s long-delayed HiFi or “super premium” tier, a higher-qualify subscription offering the streaming service first announced in 2021 and then failed to roll out. In the company’s third-quarter earnings call with investors on Wednesday, the exec suggested that such a product was still on the way, […]

© 2024 TechCrunch. All rights reserved. For personal use only.




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Bogdan Speteanu, Moov Leasing: “Utilizatorii pot închiria o mașină pe o perioadă medie, de la unu la cinci ani, și au posibilitatea de a o schimba în funcție de nevoile de moment”

Moov Leasing, un start-up românesc lansat de Bogdan Speteanu și Mircea Dihel, propune o schimbare radicală în leasingul auto, transformând experiența de utilizare a unei mașini într-una simplă și accesibilă, la fel ca utilizarea unui telefon mobil. După 20 de ani de experiență la BCR, timp în care a ocupat mai multe funcții de conducere, printre care și ...

The post Bogdan Speteanu, Moov Leasing: “Utilizatorii pot închiria o mașină pe o perioadă medie, de la unu la cinci ani, și au posibilitatea de a o schimba în funcție de nevoile de moment” appeared first on Forbes Romania.




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Development of a photoenzymatic one-pot hybrid system for the direct synthesis of 3,3-disubstituted indole-2-ketones from N-methyl indoles

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00371C, Research Article
Yao Yao, Yuan Yu, Ming-Liang Shi, Xin-Yue Fan, Ru-De Lin, Kun Li, Wen-Dian Li, Fei-Yan Tao, Na Wang
The effective combination of photocatalysis and enzyme catalysis has been widely utilized for the synthesis of high-value-added products.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Probing the potential of Al2CO/SiC heterostructures for visible light driven photocatalytic water splitting using first-principles strategies

J. Mater. Chem. A, 2024, Accepted Manuscript
DOI: 10.1039/D4TA00885E, Paper
Amina Shehbaz, Abdul Majid, Hira Batool, Mohammad Alkhedher, Sajjad Haider, Kamran Alam
Photocatalytic water splitting is a sustainable and eco-friendly method for renewable energy production. The fabrication of an efficient photocatalyst based on two-dimensional (2D) interfaces with suitable band offsets is at...
The content of this RSS Feed (c) The Royal Society of Chemistry




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The Role of Mn in Boosting Wide Potential Window on Solid Solution Derived Electrodes for Aqueous Supercapacitors

J. Mater. Chem. A, 2024, Accepted Manuscript
DOI: 10.1039/D4TA00979G, Paper
Ziying Shi, Enzuo Liu, Biao Chen, Junwei Sha, Lihua Qian, Zhijia Zhang, Xiaopeng Han, Wenbin Hu, Chunnian He, Naiqin Zhao, Jianli Kang
The interaction mechanism of the multi-element oxide electrodes remains a challenge, despite the fact that their synergy can not only improve the electronic structure, but also broaden the working potential...
The content of this RSS Feed (c) The Royal Society of Chemistry




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In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP

RSC Med. Chem., 2024, 15,3674-3694
DOI: 10.1039/D4MD00580E, Research Article
Jinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin Jin
Oridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction

RSC Med. Chem., 2024, 15,3652-3673
DOI: 10.1039/D4MD00425F, Review Article
Semim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra Borah
Metabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

RSC Med. Chem., 2024, 15,3817-3836
DOI: 10.1039/D4MD00477A, Research Article
Maha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa Matboli
ZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors

RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00610K, Research Article
Open Access
Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina Marzano
In this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....
The content of this RSS Feed (c) The Royal Society of Chemistry