DOVER, DE (Dec. 10, 2021) – The Delaware Division of Public Health (DPH) is providing an update on the most recent statistics related to coronavirus disease 2019 (COVID-19) in Delaware, as of 6 p.m. Thursday, Dec. 9, 2021.  Total positive cases since March 11, 2020: 159,399 7-day average of new positive cases: 603.9, a significant increase from […]

DOVER, DE (Dec. 31, 2021) – The Delaware Division of Public Health (DPH) is providing an update on the most recent statistics related to coronavirus disease 2019 (COVID-19) in Delaware, as of 6 p.m. Thursday, Dec. 30, 2021. DPH reported the highest number of new positive daily cases since the start of the pandemic with […]

Please note, this press release was updated on Jan. 10, 2022, to correct an error in the total breakthrough cases, and to incorporate additional data points that were not immediately available at the time of the initial release.  DOVER, DE (Jan. 7, 2022) – The Delaware Division of Public Health (DPH) is providing an update […]

DOVER, DE (Jan. 14, 2022) – The Delaware Division of Public Health (DPH) is providing an update on the most recent statistics related to coronavirus disease 2019 (COVID-19) in Delaware, as of Thursday, Jan 13, 2021. DPH reported the highest number of new positive daily cases since the start of the pandemic with 4,771 positive […]

DOVER, DE (Jan. 28, 2022) – The Delaware Division of Public Health (DPH) is providing an update on the most recent statistics related to coronavirus disease 2019 (COVID-19) in Delaware, as of Thursday, Jan 27, 2022. DPH reports a 57 percent decrease in the seven-day average of new positive cases reported since the peak of the surge […]

DOVER, DE (February 18, 2022) – The Delaware Division of Public Health (DPH) is providing an update on the most recent statistics related to coronavirus disease 2019 (COVID-19) in Delaware, as of Thursday, Feb 17, 2022. COVID-19 Cases and Hospitalizations:  Total positive cases since March 11, 2020: 254,719 7-day average of new positive cases: 232.6, a decrease […]

DOVER, DE (February 25, 2022) – The Delaware Division of Public Health (DPH) is providing an update on the most recent statistics related to coronavirus disease 2019 (COVID-19) in Delaware as of Thursday, Feb 24, 2022. COVID-19 Cases and Hospitalizations:  Total positive cases since March 11, 2020: 256,337  7-day average of new positive cases: 127, a decrease […]

DOVER, DE (March 4, 2022) – With new positive cases and hospitalizations continuing to decline in Delaware, mask mandates for schools and state buildings were lifted earlier this week across the state, consistent with updated guidance from the Centers for Disease Control and Prevention (CDC). The CDC guidance is based on county or community levels of spread and the level […]

DOVER, DE (April 22, 2022) – The Delaware Division of Public Health (DPH) is providing an update on case and vaccination data since the last COVID-19 update released on March 25, 2022.  While Delaware is experiencing a rise in COVID-19 cases and hospitalizations, both remain significantly lower than during the winter surge. Deaths are also low […]

DOVER, DE (September 16, 2022) – The Delaware Division of Public Health (DPH) is pleased to share declines in hospitalizations, test positivity rates and the 7-day average of new positive COVID-19 cases continued for the second month in a row.  Deaths also remain low. However, COVID-19 is still circulating in the community, and at higher levels […]

While the hustle and bustle of summer may be over, Fall is the perfect time to get out and visit Delaware farmers’ markets and on-farm markets to access fresh fruits and vegetables. Many of these venues will be open until right before Thanksgiving; however, the Delaware Department of Agriculture (DDA) reminds seniors and WIC participants with Farmers’ Market Nutrition Program vouchers to spend these by October 31.

DOVER, DE (20 de Diciembre de 2022) – La División de Salud Pública de Delaware (DPH) anuncia cambios en el acceso a las pruebas de COVID-19 en Delaware. Según las necesidades operativas, el valioso socio de DPH Curative, decidió no renovar su contrato de pruebas con el estado cuando finalice en las siguientes dos semanas. […]

DOVER, DE (Jan. 13, 2023) – The Delaware Division of Public Health (DPH) is seeing an increase in post-holiday COVID-19 cases and hospitalizations, though the increase is not nearly as high as the 2022 post-holiday surge. Still, DPH encourages individuals to take specific action steps to stay healthy and prevent the spread of the virus, such as staying home when sick, testing […]

DPH Sees Decrease in Cases and Hospitalizations Since Last Month, but Increase in Deaths. DPH Encourages Public to Get Updated Boosters         DOVER, DE (FEB. 10, 2023) – The Delaware Division of Public Health (DPH) saw a 28% decrease in COVID-19 cases and 29% decrease in hospitalizations in the last month and is encouraging residents to continue to remain current on their vaccinations by getting the updated COVID-19 bivalent booster.   Still, Delawareans, many with underlying health conditions, are dying from COVID-19. In the […]

This phenomenon has been in the news recently, so I've updated this article that I originally published in 2017. The paper currency in circulation in the US is mostly $100 bills. And not just by a little bit -- these account for 34% of the notes by denomination and nearly [...]

The post Visualized: US Currency in circulation, past and present appeared first on The SAS Dummy.

The Delaware Department of Transportation (DelDOT) in collaboration with the Delaware Department of Safety and Homeland Security (DSHS), Delaware Office of Highway Safety (OHS), Delaware State Police (DSP), Federal Highway Administration (FHA), and the National Highway Traffic Safety Administration (NHTSA) after coordinating with stakeholders, advocacy groups and the public recently unveiled the Delaware 2021-2025 Strategic […]

A fund created to help strengthen neighborhoods throughout Delaware hit hardest by the 2008 financial crisis is now up and running.

Filings and affordability standard reporting reviewed by Department, consumers continue to benefit from increased competition, Inflation Reduction Act, and 1332 Reinsurance Waiver After welcoming new entrants for two consecutive years, the Delaware Health Insurance Marketplace is experiencing stability in carriers, plans, and rates for the 2025 plan year. Consumers will choose from 45 plans offered […]

Delaware Attorney General Kathy Jennings, alongside a bipartisan coalition of thirty state attorneys general, announced today the completion of the $1.37 billion settlement agreement with Kroger, addressing the grocery chain’s role in the opioid crisis. Delaware will receive over $2.7 million for opioid abatement, all of which will be overseen by the Prescription Opioids Settlement Distribution Commission. Payments are […]

Everything happens somewhere, and much of our customer data includes location information. Websites include x, y coordinates in semi-structured click streams, and the mobile apps your prospects depend on frequently support device location to provide a personalized, targeted experience. As my SAS peer Robby Powell said: "Human brains are hardwired [...]

SAS Customer Intelligence 360: Data visualization, location analytics and geospatial insights was published on Customer Intelligence Blog.

A common way to visualize the sample correlations between many numeric variables is to display a heat map that shows the Pearson correlation for each pair of variables, as shown in the image to the right. The correlation is a number in the range [-1, 1], where -1 indicated perfect [...]

The post The correlogram: Visualize correlations by fitting angles appeared first on The DO Loop.

With containers, you can build once, run anywhere – no worries about underlying dependencies.

The post How containers have moved us to next-gen virtualization appeared first on The Data Roundtable.

Hello everyone. In recent days, I'm having a weird problem with sound output on my Windows 10 PC. In fact, I can't control the loudness of it. So is there any possibility of PCB of sound card being damaged?

This blog describes how to efficiently use Virtuoso Visualization and Analysis XL.(read more)

A new AI-powered, imaging-based technology that creates accurate three-dimensional models of tumors, veins and other soft tissue offers a promising new method to help surgeons operate on, and better treat, breast cancers. The technology, from Illinois-based startup SimBioSys, converts routine black-and-white MRI images into spatially accurate, volumetric images of a patient’s breasts. It then illuminates Read Article

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Under Article 8 of Law No. 80, which governs the construction and restoration of churches in Egypt, the government continues to support religious institutions by aligning them with legal standards.

About 50 settlers gathered to attack the IDF soldiers, injuring one soldier who was taken to hospital with head injuries.

[UNHCR] UNHCR, the UN Refugee Agency has just concluded a three-day event, hosting partners and Governments from the East and Horn of Africa, Great Lakes Region and Yemen, to review strategies for comprehensive solutions to the ongoing displacement crisis in Somalia. The meeting brought together representatives from Uganda, Yemen, Djibouti, Ethiopia and Kenya, as well as the regional body, Intergovernmental Authority on Development (IGAD) and provided a platform for sharing insights and aligning efforts among

The Government of Bangladesh (GOB) has recently launched the Bangladesh Climate and Development Partnership to drive climate actions at scale and with urgency. The BCDP is an example of country-led climate platform established to scale up implementation of climate actions and is being recognized as an important modality by the global community to deliver climate actions at scale.

Some lizards dive into streams to escape predators, and a specialised bubble-breathing technique enables them to stay submerged for up to 18 minutes

Title: Hospitals Must Report COVID-19 Data or Be Penalized
Category: Health News
Created: 8/28/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM

Title: Jesse Jackson, Wife Hospitalized With COVID
Category: Health News
Created: 8/24/2021 12:00:00 AM
Last Editorial Review: 8/24/2021 12:00:00 AM

Title: Fatal ODs From Illicit Tranquilizers Jumped 6-Fold During Pandemic
Category: Health News
Created: 8/26/2021 12:00:00 AM
Last Editorial Review: 8/27/2021 12:00:00 AM

Title: Even Chores, Socializing Might Lower Your Odds for Dementia
Category: Health News
Created: 7/28/2022 12:00:00 AM
Last Editorial Review: 7/29/2022 12:00:00 AM

Most studies of genome organization have focused on intrachromosomal (cis) contacts because they harbor key features such as DNA loops and topologically associating domains. Interchromosomal (trans) contacts have received much less attention, and tools for interrogating potential biologically relevant trans structures are lacking. Here, we develop a computational framework that uses Hi-C data to identify sets of loci that jointly interact in trans. This method, trans-C, initiates probabilistic random walks with restarts from a set of seed loci to traverse an input Hi-C contact network, thereby identifying sets of trans-contacting loci. We validate trans-C in three increasingly complex models of established trans contacts: the Plasmodium falciparum var genes, the mouse olfactory receptor "Greek islands," and the human RBM20 cardiac splicing factory. We then apply trans-C to systematically test the hypothesis that genes coregulated by the same trans-acting element (i.e., a transcription or splicing factor) colocalize in three dimensions to form "RNA factories" that maximize the efficiency and accuracy of RNA biogenesis. We find that many loci with multiple binding sites of the same DNA-binding proteins interact with one another in trans, especially those bound by factors with intrinsically disordered domains. Similarly, clustered binding of a subset of RNA-binding proteins correlates with trans interaction of the encoding loci. We observe that these trans-interacting loci are close to nuclear speckles. These findings support the existence of trans-interacting chromatin domains (TIDs) driven by RNA biogenesis. Trans-C provides an efficient computational framework for studying these and other types of trans interactions, empowering studies of a poorly understood aspect of genome architecture.

Introduction:

High-quality primary care can reduce avoidable emergency department visits and emergency hospitalizations. The availability of electronic medical record (EMR) data and capacities for data storage and processing have created opportunities for predictive analytics. This systematic review examines studies which predict emergency department visits, hospitalizations, and mortality using EMR data from primary care.

Purpose Low-income children experience disproportionately high rates of dental caries and challenges in accessing dental care compared to their higher-income peers. The purpose of this scoping review was to examine the prevalence of dental caries and dental service utilization among Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) enrolled children.Methods The literature search and review were conducted between September 2023 and February 2024. The review followed the PRISMA-ScR reporting guidelines and included three databases: PubMed, CINAHL, and Dentistry & Oral Sciences Source. The study focused on children aged one to five participating in WIC within the United States (US) and aimed to determine the prevalence of dental service utilization and dental caries in the targeted population.Results This review includes twelve articles that are quantitative observational studies conducted from February 2001 to February 2023. Most of the studies were conducted in WIC programs in the Southern and Midwest regions of the US. Dental caries rates decreased by 61.8% from 2004 to 2016, with the highest prevalence in 2004, and the lowest prevalence in 2016. Dental service utilization among WIC children increased by 56.9% from 1992 to 2020.Conclusion There has been an increase in dental service utilization among WIC-enrolled children, with an overall decrease in dental caries over the last two decades. However, the prevalence of dental caries remains disproportionately high for children enrolled in WIC when compared to non-participants. To develop effective dental interventions for children enrolled in WIC, it is fundamental to identify the unique determinants of dental caries in this population.

The SARS-CoV-2 frameshifting element (FSE) has been intensely studied and explored as a therapeutic target for coronavirus diseases, including COVID-19. Besides the intriguing virology, this small RNA is known to adopt many length-dependent conformations, as verified by multiple experimental and computational approaches. However, the role these alternative conformations play in the frameshifting mechanism and how to quantify this structural abundance has been an ongoing challenge. Here, we show by DMS and dual-luciferase functional assays that previously predicted FSE mutants (using the RAG graph theory approach) suppress structural transitions and abolish frameshifting. Furthermore, correlated mutation analysis of DMS data by three programs (DREEM, DRACO, and DANCE-MaP) reveals important differences in their estimation of specific RNA conformations, suggesting caution in the interpretation of such complex conformational landscapes. Overall, the abolished frameshifting in three different mutants confirms that all alternative conformations play a role in the pathways of ribosomal transition.

Protein abundance data of drug-metabolizing enzymes and transporters (DMETs) are useful for scaling in vitro and animal data to humans for accurate prediction and interpretation of drug clearance and toxicity. Targeted DMET proteomics that relies on synthetic stable isotope-labeled surrogate peptides as calibrators is routinely used for the quantification of selected proteins; however, the technique is limited to the quantification of a small number of proteins. Although the global proteomics-based total protein approach (TPA) is emerging as a better alternative for large-scale protein quantification, the conventional TPA does not consider differential sequence coverage by identifying unique peptides across proteins. Here, we optimized the TPA approach by correcting protein abundance data by the sequence coverage, which was applied to quantify 54 DMETs for characterization of 1) differential tissue DMET abundance in the human liver, kidney, and intestine, and 2) interindividual variability of DMET proteins in individual intestinal samples (n = 13). Uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7), microsomal glutathione S-transferases (MGST1, MGST2, and MGST3) carboxylesterase 2 (CES2), and multidrug resistance-associated protein 2 (MRP2) were expressed in all three tissues, whereas, as expected, four cytochrome P450s (CYP3A4, CYP3A5, CYP2C9, and CYP4F2), UGT1A1, UGT2B17, CES1, flavin-containing monooxygenase 5, MRP3, and P-glycoprotein were present in the liver and intestine. The top three DMET proteins in individual tissues were: CES1>CYP2E1>UGT2B7 (liver), CES2>UGT2B17>CYP3A4 (intestine), and MGST1>UGT1A6>MGST2 (kidney). CYP3A4, CYP3A5, UGT2B17, CES2, and MGST2 showed high interindividual variability in the intestine. These data are relevant for enhancing in vitro to in vivo extrapolation of drug absorption and disposition and can be used to enhance the accuracy of physiologically based pharmacokinetic prediction of systemic and tissue concentration of drugs.

ABSTRACTWe document the effort over the last 30 years to respond to the call by women advocates at the International Conference on Population and Development for more woman-initiated single or dual-purpose contraceptive methods by developing the Caya contoured diaphragm, an innovative diaphragm designed to meet the needs of women and their partners and expand options for nonhormonal barrier contraception. We describe the complex and interrelated set of activities undertaken to develop the product using a human-centered design process and how we are working to create a corollary sustainable market. This review includes the evidence generated around improved acceptability among couples in low- and middle-income countries and depicts challenges and practical actions on how to dispel misconceptions about diaphragm use. Importantly, we share programmatic lessons learned on increasing universal access to this new sexual and reproductive health technology. Following our new model for increasing access to new and underutilized methods, Caya is now registered and being marketed in nearly 40 countries worldwide.

This single-center, single-arm, phase II trial (ChiCTR2100050057) investigated the ability of ¹⁸F-labeled fibroblast activation protein inhibitor ([¹⁸F]AlF-NOTA-FAPI-04, denoted as ¹⁸F-FAPI) PET/CT to predict the response to neoadjuvant camrelizumab plus chemotherapy (nCC) in locally advanced esophageal squamous cell carcinoma (LA-ESCC). Methods: This study included 32 newly diagnosed LA-ESCC participants who underwent ¹⁸F-FAPI PET/CT at baseline, of whom 23 also underwent scanning after 2 cycles of nCC. The participants underwent surgery after 2 cycles of nCC. Recorded PET parameters included maximum, peak, and mean SUVs and tumor-to-background ratios (TBRs), metabolic tumor volume, and total lesion FAP expression. PET parameters were compared between patient groups with good and poor pathologic responses, and the predictive performance for treatment response was analyzed. Results: The good and poor response groups each included 16 participants (16/32, 50.0%). On ¹⁸F-FAPI PET/CT, the posttreatment SUVs were significantly lower in good responders than in poor responders, whereas the changes in SUVs with treatment were significantly higher (all P < 0.05). SUV_max (area under the curve [AUC], 0.87; P = 0.0026), SUV_peak (AUC, 0.89; P = 0.0017), SUV_mean (AUC, 0.88; P = 0.0021), TBR_max (AUC, 0.86; P = 0.0031), and TBR_mean (AUC, 0.88; P = 0.0021) after nCC were significant predictors of pathologic response to nCC, with sensitivities of 63.64%–81.82% and specificities of 83.33%–100%. Changes in SUV_max (AUC, 0.81; P = 0.0116), SUV_peak (AUC, 0.82; P = 0.0097), SUV_mean (AUC, 0.81; P = 0.0116), and TBR_mean (AUC, 0.74; P = 0.0489) also were significant predictors of the pathologic response to nCC, with sensitivities and specificities in similar ranges. Conclusion: ¹⁸F-FAPI PET/CT parameters after treatment and their changes from baseline can predict the pathologic response to nCC in LA-ESCC participants.

Jay-yi Nah is an underwater archaeological site dating to the Early Classic Maya period (250-600 CE) that focused on salt production for local use or perhaps local production for down-the-line trading.

The post Earliest-Known Maya Salt Works Discovered in Belize appeared first on Sci.News: Breaking Science News.

It's a little rogue-lite, it's a bit '90s arcade, and it's surprisingly deep.