The pandemic has impacted us in many ways, but despite these challenges, our commitment to our community and you is stronger than ever.

Life as we knew it will definitely change after this, as firms realise that people can work from home, saving them money, the air is better without traffic and pollution and more and more courses and meetings take place online.

“Outbreaks have sparked riots and propelled public-health innovations, prefigured revolutions and redrawn maps.” – The New Yorker, April 2020 “Nothing will be the same.”  That’s the overwhelming takeaway I’ve heard from dozens of conversations I’ve had with C-suite leaders, physicians, policy experts and media professionals these past few weeks.  When it comes to the business … Continue reading "An Open Letter To American Corporations: It’s Good Business (and Smart Marketing) To Support Quality Journalism"

1 September 2016 , Volume 92, Number 5

In our computational study, we use molecular simulations to substantiate a hypothetical mechanism for glycosidic bond cleavage in the presence of a single catalytic acid at the active site of the mutant D10N HiCel45A. In addition to discussing this plausible mechanism from the context of structurally related MltA lytic transglycosylase and subfamily C GH45s, we also suggest the implications of the plausible mechanism for our current understanding of the action of expansins and lytic transglycosylases. As correctly pointed out by Professor Cosgrove (1), there is large body of evidence, a significant portion of which was regrettably not discussed in our paper, that suggests that expansins are incapable of lytic action on polysaccharide substrates. Whereas these insights do not change the results or the conclusions of our article, we would like to thank Professor Cosgrove for these additional insights. In particular, our main point with respect to expansins is that our results suggest the possibility that expansins are capable of nonhydrolytic lytic activity. Our intention was not to suggest this was the mechanism of expansins, but that it should be considered based on our results and the similarity of the active sites.The molecular mechanisms of how expansins enable cell wall expansion remains to be fully understood. Whereas our proposed mechanism resulting in the formation of the 1,6-anhdro product might be found in expansins and might contribute to the mode of action of expansins, we would like to emphasize that the intent of this study was only to suggest this as a...

From their simulations of endoglucanase Cel45A, Bharadwaj et al. (1) propose that structurally related expansins and MltA may cut glycan backbones without generating reducing ends. This is tenable for MltA, a peptidoglycan lytic transglycosylase whose action produces nonreducing 1,6-anhydro products, but is untenable for expansins.Expansins loosen plant cell walls and induce wall expansion. Contrary to the assertion by Bharadwaj et al., the conclusion that expansins are not lytic is not merely based on lack of new reducing ends but is supported by multiple (negative) tests for polysaccharide cleavage that do not rely on detection of reducing ends. At least eight studies with three divergent groups of expansins document this point. For instance, α-expansin did not reduce the viscosity of various wall polysaccharide solutions, an endolytic assay that does not rely on measuring reducing ends (e.g. see Ref. 2 and other studies).Walls treated with α-expansin did not release saccharide fragments, measured by pulsed amperometric detection, which can detect nonreducing saccharides (3).In the case of β-expansins, protein treatments did not cleave the backbones of a wide range of dye-coupled cross-linked wall polysaccharides; nor did they cleave backbones of polysaccharides extracted from plant cell walls, measured by gel permeation chromatography (4).For five microbial expansins, tests with a range of dye-coupled cross-linked polysaccharides likewise did not detect lytic activity (e.g. see Ref. 5). Thus, extensive published evidence argues against lytic action by expansins, as proposed by Bharadwaj (1), and attempts to identify 1,6-anhydro products seem unlikely to succeed.

Dear Shareholders, As Chairwoman of the Supervisory Board, I am contacting you personally today in advance of the Annual General Meeting to ask for your continued trust and support.

1 February 2008 , Number 5

In many countries (including the UK and Australia) it is still common practice for hospital doctors to write letters to patients’ general practitioners (GPs) following outpatient consultations, and for patients to receive copies of these letters. However, Hugh Rayner, consultant nephrologist, and Peter Rees, former Chair of the Academy of...

THE EDITOR, Madam: The devastating news of Jodian Fearon’s death has resulted in public outrage and concern. The controversy and seemingly negligent actions of the hospitals involved have left many Jamaicans anxious about our health system and...

The Editor, Madam: Today, as we celebrate Teachers’ Day, I pause in reflection, looking back at some of the educators who have deeply impacted me. Let me start with the principal of my primary school. She was a God-fearing woman, but I suppose,...

THE EDITOR, Madam: THE JAMAICAN economy has been underperforming for the last 40 years, during which economic growth averaged approximately one per cent per annum. One of the main reasons for this poor performance is the non-competitive nature of...

THE EDITOR, Madam: The Jamaican Government and local private-sector power brokers are still way behind and woefully lacking in investing, financially and otherwise, in Jamaica’s number one most powerful, most famous, most influential, and most...

THE EDITOR, Madam: With most things grinding to a halt worldwide, this pandemic has proven to be as much of an economic crisis as it is a health one. Many sectors have changed their day-to-day operations, with some allowing for greater flexibility...

You have mail! Inoreader now allows you to subscribe to Email Newsletters just as regular RSS feeds. By creating a…

SOCIETY FOR JUDGMENT AND DECISION MAKING NEWSLETTER The quarterly Society for Judgment and Decision Making newsletter is available for download from the SJDM site: http://sjdm.org/newsletters/ It features announcements, conferences, jobs, and the 2019 Conference program. See y’all in Montreal (nobody ever says that but the 2019 SJDM meeting will take place in Montreal, November 15-18, […]

The post SJDM Newsletter is ready for download appeared first on Decision Science News.

Fidelity is often seen as a bad word in school, but it doesn't have to be that way. In this guest blog by George Toman, the concept of fidelity is explained and defended.

Early Modern Letters Online is a combined finding aid and editorial interface for basic descriptions of early modern correspondence: a collaboratively populated union catalogue of sixteenth, seventeenth, and eighteenth-century letters.

London : S. Highley, 1848.

London : J. & A. Churchill, [1874]

London : Hurst, Chance, 1831.

Oxford : printed by W. Baxter, 1843.

When it comes to education, the 49th state faces its own challenges, some of which are unique to Alaska and some that it shares with other rural states. This series explores how cultural and geographic barriers, teacher shortages, historical developments, and more have shaped schooling in Alaska.

[London] (at the Historic Gallery, 87 Pall Mall) : Pub.d by Mr Stone.

Bruxelles (rue de l'Industrie) : Félix Callewaert père, éditeur, 1875.

[Manchester] : [James Mudd], [between 1800 and 1899]

[The Netherlands] : [publisher not identified], [1688]

[New York, N.Y.] : [The Foundation] [195-?]-1970.

South East Family History Group (S.A.) -- Periodicals.