McMillan, Peter -- Travel.

Wiesbaden : J.F. Bergmann, 1879.

Heidelberg : Winter, 1900.

London : A. and C. Black, 1913.

London : H. Kimpton, 1893.

Philadelphia, Pa. : Lippincott, 1896.

London : W. Swan Sonnenschein, 1884-1885.

London : Swan Sonnenschein, 1897.

But some Democrats say that could make the selection process more political.

Mississippi’s outdated textbooks teach an abbreviated version of civil rights, undermining the state’s new ‘innovative’ standards.

[London] : [Wellcome Trust], [2009]

Bertrand Clarke, Jennifer Clarke

Source: Statist. Surv., Volume 6, 1--73.

Abstract:
We review predictive techniques from several traditional branches of statistics. Starting with prediction based on the normal model and on the empirical distribution function, we proceed to techniques for various forms of regression and classification. Then, we turn to time series, longitudinal data, and survival analysis. Our focus throughout is on the mechanics of prediction more than on the properties of predictors.

The PFC, through its high degree of interconnectivity with cortical and subcortical brain areas, mediates cognitive and emotional processes in support of adaptive behaviors. This includes the formation of fear memories when the anticipation of threat demands learning about temporal or contextual cues, as in trace fear conditioning. In this variant of fear learning, the association of a cue and shock across an empty trace interval of several seconds requires sustained cue-elicited firing in the prelimbic cortex (PL). However, it is unknown how and when distinct PL afferents contribute to different associative components of memory. Among the prominent inputs to PL, the hippocampus shares with PL a role in both working memory and contextual processing. Here we tested the necessity of direct hippocampal input to the PL for the acquisition of trace-cued fear memory and the simultaneously acquired contextual fear association. Optogenetic silencing of ventral hippocampal (VH) terminals in the PL of adult male Long-Evans rats selectively during paired trials revealed that direct communication between the VH and PL during training is necessary for contextual fear memory, but not for trace-cued fear acquisition. The pattern of the contextual memory deficit and the disruption of local PL firing during optogenetic silencing of VH-PL suggest that the VH continuously updates the PL with the current contextual state of the animal, which, when disrupted during memory acquisition, is detrimental to the subsequent rapid retrieval of aversive contextual associations.

SIGNIFICANCE STATEMENT Learning to anticipate threat from available contextual and discrete cues is crucial for survival. The prelimbic cortex is required for forming fear memories when temporal or contextual complexity is involved, as in trace fear conditioning. However, the respective contribution of distinct prelimbic afferents to the temporal and contextual components of memory is not known. We report that direct input from the ventral hippocampus enables the formation of the contextual, but not trace-cued, fear memory necessary for the subsequent rapid expression of a fear response. This finding dissociates the contextual and working-memory contributions of prelimbic cortex to the formation of a fear memory and demonstrates the crucial role for hippocampal input in contextual fear learning.

Neonatal stroke is as frequent as stroke in the elderly, but many pathophysiological injury aspects are distinct in neonates, including immune signaling. While myeloid cells can traffic into the brain via multiple routes, the choroid plexus (CP) has been identified as a uniquely educated gate for immune cell traffic during health and disease. To understand the mechanisms of myeloid cell trafficking via the CP and their influence on neonatal stroke, we characterized the phenotypes of CP-infiltrating myeloid cells after transient middle cerebral artery occlusion (tMCAO) in neonatal mice of both sexes in relation to blood-brain barrier permeability, injury, microglial activation, and CX3CR1-CCR2 signaling, focusing on the dynamics early after reperfusion. We demonstrate rapid recruitment of multiple myeloid phenotypes in the CP ipsilateral to the injury, including inflammatory CD45⁺CD11b⁺Ly6c^highCD86⁺, beneficial CD45⁺CD11b⁺Ly6c^lowCD206⁺, and CD45⁺CD11b⁺Ly6c^lowLy6g^high cells, but only minor leukocyte infiltration into acutely ischemic-reperfused cortex and negligible vascular albumin leakage. We report that CX3CR1-CCR2-mediated myeloid cell recruitment contributes to stroke injury. Considering the complexity of inflammatory cascades triggered by stroke and a role for TLR2 in injury, we also used direct TLR2 stimulation as an independent injury model. TLR2 agonist rapidly recruited myeloid cells to the CP, increased leukocytosis in the CSF and blood, but infiltration into the cortex remained low over time. While the magnitude and the phenotypes of myeloid cells diverged between tMCAO and TLR2 stimulation, in both models, disruption of CX3CR1-CCR2 signaling attenuated both monocyte and neutrophil trafficking to the CP and cortex.

SIGNIFICANCE STATEMENT Stroke during the neonatal period leads to long-term disabilities. The mechanisms of ischemic injury and inflammatory response differ greatly between the immature and adult brain. We examined leukocyte trafficking via the choroid plexus (CP) following neonatal stroke in relation to blood-brain barrier integrity, injury, microglial activation, and signaling via CX3CR1 and CCR2 receptors, or following direct TLR2 stimulation. Ischemia-reperfusion triggered marked unilateral CX3CR1-CCR2 dependent accumulation of diverse leukocyte subpopulations in the CP without inducing extravascular albumin leakage or major leukocyte infiltration into the brain. Disrupted CX3CR1-CCR2 signaling was neuroprotective in part by attenuating monocyte and neutrophil trafficking. Understanding the migratory patterns of CP-infiltrating myeloid cells with intact and disrupted CX3CR1-CCR2 signaling could identify novel therapeutic targets to protect the neonatal brain.

Audible's new service is aimed at school-age children participating in distance learning but features selections likely to appeal to all

The post SOLIDWORKS Apps for Kids How-To: Edit Text and Its Color in Capture It appeared first on SOLIDWORKS Education Blog.

Distracted driving due to texting while driving (TWD) has emerged as an important teenage safety issue. Previous studies have shown that the self-reported prevalence of TWD among teenagers varies widely.

In 2011, 45% of US high school students aged ≥16 years reported TWD during the past 30 days. TWD was positively associated with other risky motor vehicle behaviors; this association strengthened as frequency of TWD increased. (Read the full article)

Influenza vaccine coverage is low, and young children in need of 2 doses in a given season are at particular risk, with less than half receiving both doses. Text message vaccine reminders increase receipt of first dose of influenza vaccine.

Little is known about what types of text message reminders are most effective, including embedding educational information. We demonstrate that text message reminders increase timely receipt of the second dose of influenza vaccine and embedding health literacy information improves effectiveness. (Read the full article)

Adolescent vaccination rates lag behind other childhood vaccines. Text messaging to improve uptake of adolescent vaccines has been shown to be effective in academic centers but has not been studied in other settings.

This study, done in 5 private and 2 safety-net practices, used a bidirectional text message as a behavioral prompt and showed text messaging was effective at increasing uptake of all adolescent vaccines. Costs were similar to other reminder/recall methods. (Read the full article)

Over one hundred languages should help make a few conversations easier to get through, but that's still well short of the hundreds of languages Gboard typing supports.

Most districts have the technology to support the basic digital textbooks of today, but not the interactive, multimedia-rich ones of the future.

A new study finds that materials often portray scientists as geniuses working alone—a framing that can make students think science isn't for them.

Shoba Sivaprasad Wadhia, Samuel Weiss Faculty Scholar and Clinical Professor of Law at Penn State Law in University Park, has written a chapter on immigration law in a new legal textbook covering issues surrounding the current global COVID-19 pandemic, published by Columbia Law School.

Cost of one SMS is around 12 paise, whereas a promotional e-mail could cost 2-4 paise. A retail brand organising a high intensity campaign for its seasonal sale could end up spending Rs 15-20 lakh to reach its consumers.

Kesavananda Bharati V. state of Kerala that outlined the basic structure doctrine of the constitution. The judgment was delivered by the largest SC bench so far i.e. 13 judges.

Regular expressions are a powerful method for finding specific patterns in text. The syntax of regular expressions is intimidating, but once you've solved a few pattern-recognition problems with regex, you'll never go back to your old methods.

The post Convert a text-based measurement to a number in SAS appeared first on The SAS Dummy.

I'm a big fan of the Import Data task in SAS Enterprise Guide, especially for its support of text-based files (CSV, tab delimited, fixed width, and more). There's no faster method for generating SAS code that reads your data exactly the way you need it. I use the tool so [...]

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  We are gearing up for two of the biggest shows of the year: Game Developers Conference (GDC) in San Francisco and Mobile World Conference (MWC) in Barcelona, Spain - both the week of March 2. Come loo...

  Rejoice Sublime Text* users, you can now automate Intel® XDK tasks directly from Sublime Text. With the new plugin for the Intel XDK, you can edit your code in Sublime Text and launch the editor,...

MEE Order 12 comes into force 1 January 2021

The first five books of the Murty Classical Library of India (MCLI), an initiative by the Harvard University...