We're happy to have guest blogger Thorsten Dworzak, Principal Consultant at Verilab GmbH, describe how he added Specman/e syntax to Sublime Text 3:

According to the 2018 StackOverflow Developer Survey, the popularity of development environments (IDEs, Text Editors) among software developers shows the following ranking:

1. Visual Studio Code 34.9%
2. Visual Studio 34.3%
3. Notepad++ 34.2%
4. Sublime Text 28.9%
5. Vim 25.8%
6. IntelliJ 24.9%
7. Android Studio 19.3%
8. (DVT) Eclipse 18.9%
9. …

15. Emacs 4.1%

Of these, only Vim, (DVT) Eclipse, and Emacs support editing in e-language (at least, last time I checked). Kate, which comes with KDE and also has a Specman mode, is not on this list.

I started using Sublime Text 3 some time ago. It offers packages that support a number of programming languages.

Though there is an e-language syntax available from Tsvi Mostovicz, it is unfinished work, and there are many syntactic constructs are missing. So, I created a fork of his project and finished it (it will eventually be merged back here).

It is a never-ending task because my code base for testing is limited and e is still undergoing development. The project is available through ST3's Package Control and you can contribute to it via Github.

I am eagerly waiting for your pull requests and/or comments and contributions!

I am trying to understand why axlDBTextBlockCompact(nil) on my test case says it can compact the text blocks down to 38, whereas I find only a total of 26 unique text block references in axlDBGetDesign()->text, axlDBGetDesign()->symbols and axlDBGetDesign()->symdefs. Where else are text blocks used besides these three?

Snare for Apache provides a remote distribution facility for Apache Web server logs. It is known to run on most Unix variations, including Linux, Solaris, AIX, Tru64, and Irix. Snare for Apache can be used to send data to either a remote or local SYSLOG server, or the Snare Server for centralized collection, analysis, and archival.

This Metasploit module exploits a stack buffer overflow vulnerability in the handling of the TextBytesAtom records by Microsoft PowerPoint Viewer. According to Microsoft, the PowerPoint Viewer distributed with Office 2003 SP3 and earlier, as well as Office 2004 for Mac, are vulnerable. NOTE: The vulnerable code path is not reachable on versions of Windows prior to Windows Vista.

Vopium for Android and iPhone leaks various data such as your password by passing it in the clear.

A new textbook on offshore renewable energy has been released by M. Reza Hashemi with the University of Rhode Island, in collaboration with Simon Neill with Bangor University in Wales, the United Kingdom.

Ashtead Plant Hire Company Limited v Granton Central Developments Limited [2019] CSOH 7 This case involves a landlord and tenant dispute over the proper construction of the rent review provisions in a lease of commercial premises.  The parties ...

Introduction In a recent judgment on an application to vary consent orders relating to the establishment of a confidentiality ring (Bombardier Transportation UK Limited v Merseytravel [2017] EWHC 726 (TCC)), the court decided that despite some conce...

The European Data Protection Board (EDPB) has published a set of guidelines (in draft) for public consultation. These will be absolutely key to providers of online services, such as social media, e-commerce, internet search engines, communication an...

What you need to know UK regulatory guidance has been updated to explain what ‘manifestly unfounded’ and ‘excessive’ means in relation to the individual rights of data subjects under GDPR. This includes but is not limited to ...

ONLINE HIGH-LEVEL DIALOGUE Moderated by Jorge Ramos (journalist & author, Univision)

 
4 May 2020, 17:00-18:15 CET (GMT+2) / 11:00am-12:15pm EDT

 
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The post Press Freedom and Tackling Disinformation in the COVID-19 context appeared first on Inter Press Service.

Title: No Safe Way to Text and Drive for Teens
Category: Health News
Created: 4/29/2012 11:00:00 AM
Last Editorial Review: 4/30/2012 12:00:00 AM

Title: Smartphone App Blocks Teens From Texting, Phoning While Driving
Category: Health News
Created: 4/27/2015 12:00:00 AM
Last Editorial Review: 4/28/2015 12:00:00 AM

In order to facilitate text and data mining for articles in the Open Access Subset, we are now providing plain text files for those articles on our FTP site. These files contain the full text of the article, extracted either from the XML source files, or (for those articles that don't have XML) the PDF files. Users are directly and solely responsible for compliance with copyright restrictions and are expected to adhere to the terms and conditions defined by the copyright holder (see the PMC Copyright Notice).

These text files are bundled in gzipped archives. Note that these files are quite large (each greater than one gigabyte). They are available for download as:

• ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/articles.txt.0-9A-B.tar.gz
• ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/articles.txt.C-H.tar.gz
• ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/articles.txt.I-N.tar.gz
• ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/articles.txt.O-Z.tar.gz

These files are updated every week, on Saturday.

For more information, see the Bulk Packages of OA Articles section of our FTP Service page.

NIH-supported scientists have made over 300,000 author manuscripts available in PMC. Now NIH is making these papers accessible to the public in a format that will allow robust text analyses.

You can download the PMC collection of NIH-supported author manuscripts as a package in either XML or plain-text format at ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/manuscript/. The collection encompasses all NIH manuscripts posted to PMC that were published in July 2008 or later. While the public can access the manuscripts’ full text and accompanying figures, tables, and multimedia via the PMC website, the newly available XML and plain-text files include full text only. In addition to text mining, the files may be used consistent with the principles of fair use under copyright law.

Please note that these author manuscript files are not part of the PMC Open Access Subset.

The NIH Office of Extramural Research developed this resource to increase the impact of NIH funding. Through this collection, scientists will be able to analyze these manuscripts, further apply NIH research findings, and generate new discoveries.

For more information, please visit the PMC author manuscript collection webpage.

PMC has reorganized its FTP Service site for users interested in accessing the Text Mining Collections, which include the original Open Access (OA) Subset. New top-level FTP directories help users quickly locate the content available for bulk download that best suits their research needs. These directories include:

• oa_package - article packages for individual OA articles
• oa_pdf – individual PDFs for OA articles
• oa_bulk – bulk packages of text from OA articles
• manuscript – author manuscripts collected under a funding agency’s public access policy
• historical_ocr – select OCR texts from the PMC Back Issue Digitization project

To make it easier for users to identify and comply with the different licenses that apply to OA articles, new file lists have been created and the file lists for individual OA articles now include a “license-type” field for each article. Similarly, the bulk packages of OA article text have been divided into two sets. One set comprises articles that may be used for commercial purposes (the Commercial Use Collection); the other contains articles that can be used only for non-commercial purposes. See the Open Access Subset page for details.

To allow regular users to transition to the new arrangement, the previous arrangement of files and directories will be maintained in parallel for at least four weeks (i.e., until the end of August 2016).

There is a need to develop novel approaches to improve the balance between efficacy and toxicity for transcription factor–targeted therapies. In this study, we exploit context-dependent differences in RNA polymerase II processivity as an approach to improve the activity and limit the toxicity of the EWS-FLI1–targeted small molecule, mithramycin, for Ewing sarcoma. The clinical activity of mithramycin for Ewing sarcoma is limited by off-target liver toxicity that restricts the serum concentration to levels insufficient to inhibit EWS-FLI1. In this study, we perform an siRNA screen of the druggable genome followed by a matrix drug screen to identify mithramycin potentiators and a synergistic "class" effect with cyclin-dependent kinase 9 (CDK9) inhibitors. These CDK9 inhibitors enhanced the mithramycin-mediated suppression of the EWS-FLI1 transcriptional program leading to a shift in the IC₅₀ and striking regressions of Ewing sarcoma xenografts. To determine whether these compounds may also be liver protective, we performed a qPCR screen of all known liver toxicity genes in HepG2 cells to identify mithramycin-driven transcriptional changes that contribute to the liver toxicity. Mithramycin induces expression of the BTG2 gene in HepG2 but not Ewing sarcoma cells, which leads to a liver-specific accumulation of reactive oxygen species (ROS). siRNA silencing of BTG2 rescues the induction of ROS and the cytotoxicity of mithramycin in these cells. Furthermore, CDK9 inhibition blocked the induction of BTG2 to limit cytotoxicity in HepG2, but not Ewing sarcoma cells. These studies provide the basis for a synergistic and less toxic EWS-FLI1–targeted combination therapy for Ewing sarcoma.

ABSTRACT

Microbes affect vertebrates on timescales from daily to evolutionary, and the cumulative effect of these interactions is immense. However, how microbiomes compare across (host) species is poorly understood, as most studies focus on relatively few species. A recent mBio article by S. J. Song, J. G. Sanders, F. Delsuc, J. Metcalf, et al. (mBio 11:e02901-19, 2019, https://doi.org/10.1128/mBio.02901-19) expands our collective understanding of the vertebrate microbiome by analyzing ~900 species. They demonstrate that patterns within mammals contrast with those within birds. Their results suggest many hypotheses about the role of host ecology and evolution on microbiome variation. Bats, the only volant mammals, appear to contradict many of the general mammal microbiome trends, in some ways resembling birds. What role has powered flight, and the evolution thereof, played in microbiome structure and function? Comparative methods, mechanistic hypotheses, and theory will elucidate this exciting question (and others) that we can ask using Song, Sanders et al.’s data and results.

ABSTRACT

Pseudomonas aeruginosa is an opportunistic human pathogen, particularly noted for causing infections in the lungs of people with cystic fibrosis (CF). Previous studies have shown that the gene expression profile of P. aeruginosa appears to converge toward a common metabolic program as the organism adapts to the CF airway environment. However, we still have only a limited understanding of how these transcriptional changes impact metabolic flux at the systems level. To address this, we analyzed the transcriptome, proteome, and fluxome of P. aeruginosa grown on glycerol or acetate. These carbon sources were chosen because they are the primary breakdown products of an airway surfactant, phosphatidylcholine, which is known to be a major carbon source for P. aeruginosa in CF airways. We show that the fluxes of carbon throughout central metabolism are radically different among carbon sources. For example, the newly recognized "EDEMP cycle" (which incorporates elements of the Entner-Doudoroff [ED] pathway, the Embden-Meyerhof-Parnas [EMP] pathway, and the pentose phosphate [PP] pathway) plays an important role in supplying NADPH during growth on glycerol. In contrast, the EDEMP cycle is attenuated during growth on acetate, and instead, NADPH is primarily supplied by the reaction catalyzed by isocitrate dehydrogenase(s). Perhaps more importantly, our proteomic and transcriptomic analyses revealed a global remodeling of gene expression during growth on the different carbon sources, with unanticipated impacts on aerobic denitrification, electron transport chain architecture, and the redox economy of the cell. Collectively, these data highlight the remarkable metabolic plasticity of P. aeruginosa; that plasticity allows the organism to seamlessly segue between different carbon sources, maximizing the energetic yield from each.

IMPORTANCE Pseudomonas aeruginosa is an opportunistic human pathogen that is well known for causing infections in the airways of people with cystic fibrosis. Although it is clear that P. aeruginosa is metabolically well adapted to life in the CF lung, little is currently known about how the organism metabolizes the nutrients available in the airways. In this work, we used a combination of gene expression and isotope tracer ("fluxomic") analyses to find out exactly where the input carbon goes during growth on two CF-relevant carbon sources, acetate and glycerol (derived from the breakdown of lung surfactant). We found that carbon is routed ("fluxed") through very different pathways during growth on these substrates and that this is accompanied by an unexpected remodeling of the cell’s electron transfer pathways. Having access to this "blueprint" is important because the metabolism of P. aeruginosa is increasingly being recognized as a target for the development of much-needed antimicrobial agents.

A soundtrack to Nile Koetting’s 2016 installation of the same name at Maison Hermès, Tokyo. Following recommendations from the Amazon algorithm, artist Nile Koetting purchased a selection of devices, including a wireless LAN system, a Dyson humidifier, an air purifier, an aroma diffuser, a 5.1ch home theater speaker, a line array speaker system, and a […]

The post Nozomu Matsumoto turns punk lyrics into text-to-speech ambient on <em>Sustainable Hours</em> appeared first on FACT Magazine.

Lab-grown ‘meat’ often uses gelatin produced in slaughterhouses to give artificial beef a meat-like texture – but substituting soya protein can achieve that without killing animals

Loni SDM clarified that four employees have tested positive for coronavirus and not all of them, as claimed.

How African researchers are using the continent's languages to help spur innovation in Artificial Intelligence.

I am not that kind of person and have made it clear I don’t want to hear from him. What more can I do?

Before the lockdown, I had a boyfriend with whom I had been for 16 months. He said he wanted to experiment sexually with another couple, which I found shocking. I am not that kind of person, so I broke up with him. Despite the breakup, he is still constantly texting me, even though I stopped texting him a while back and made it clear I don’t want to see him. The situation hurts me so much, and any help you could offer would be much appreciated.

Joining another couple for erotic fun is not uncommon; many people enjoy it. In fact, there are many communities of people who regularly participate in this sexual style. But it is not for everyone, and jealousies and insecurities can arise no matter how sexually open a person is. “Swinging” is advanced sexual play that requires a couple to be well bonded and requires each partner to be psychologically stable as well as sexually mature.

Southampton manager Ralph Hasenhuttl has revealed that Sir Alex Ferguson sent him a text message after watching Saints get hammered 9-0 by Leicester City.

Bell Helicopter Textron Inc. has agreed to pay the United States an additional $3,718,770, bringing the total paid to resolve civil claims arising from the company’s cost charging practices on some of its contracts with the government to $16,570,018.