sparks - A typeface for creating sparklines in text without code.

(United States Ninth Circuit) - Revived a textile company's copyright infringement claims accusing certain competitors of illegally copying its floral lace designs. Reversed dismissals.

(United States Ninth Circuit) - Held that a clothing manufacturer could not proceed with a copyright infringement lawsuit against a competitor that allegedly copied a fabric design because the copyright registration was invalid due to knowingly inaccurate paperwork. Affirmed summary judgment for the defendants.

(California Court of Appeal) - In an unfair competition suit arising out of claims by plaintiff, a large scale laundry business, against defendant, a new competitor in the laundry business and one of its own former employees, summary adjudication for defendant on all claims not arising under the Uniform Trade Secrets Act (UTSA), is: 1) reversed in part, where the trial court erred in concluding that the non-UTSA claims were preempted or displaced by UTSA because each cause of action has a basis independent of any misappropriation of a trade secret; and 2) otherwise affirmed.

Cleverly disguised WebCam Spam from MySafeStreams.com

(United States Ninth Circuit) - Revived a textile company's copyright infringement claims accusing certain competitors of illegally copying its floral lace designs. Reversed dismissals.

(United States Ninth Circuit) - Held that a clothing manufacturer could not proceed with a copyright infringement lawsuit against a competitor that allegedly copied a fabric design because the copyright registration was invalid due to knowingly inaccurate paperwork. Affirmed summary judgment for the defendants.

Shaq's son and Mamba were extremely close.

She got the message as her daughter looked over her shoulder

The message came after her comments on reopening businesses

Introducing two new free themes: Dara, a classic, elegant theme for businesses, and TextBook, geared to schools, colleges, and non-profits.

The border attribute of the style sheets can vary in color and width, but it was not expected to give it a texture. However, only a CSS rule is required to add this graphic effect... The principle is to assign a texture to the whole fieldset and insert into it another fieldset (for rounded edges) or a div, whose background is the same as that of the page

This technical appendix from the TRB Airport Cooperative Research Program, ACRP Web-Only Document 38: Technical Appendix to Air Demand in a Dynamic Competitive Context with the Automobile , supplements ACRP Research Report 204: Air Demand in a Dynamic Competitive Context with the Automobile with more detailed documentation of the research effort, including greater technical detail on the analytical models created for the research and their application.

Within the academic aviation world, good textbooks can be hard to come by. Not only do few aviation textbook publishers exist, but the aviation industry is constantly changing. The TRB Airport Cooperative Research Program's latest Impacts on Practice brief, ACRP in the Classroom: Reimagining the Textbook at the University of North Dakota Department of Aviation , details how Dr. Kim Kenville uses ACRP Research Report 16, Second Edition: Guidebook for Managing Small Airports , in her classes. “This publica...

The PHP development team announces the immediate availability of PHP 7.2.30. This is a security release.All PHP 7.2 users are encouraged to upgrade to this version.For source downloads of PHP 7.2.30 please visit our downloads page, Windows source and binaries can be found on windows.php.net/download/. The list of changes is recorded in the ChangeLog.

I’m reading a book! This is a big deal! I’ve always been an avid reader, but lately, all my “reading” …

We have a special episode for you today: a full episode of "Harry Potter and the Sacred Text," a podcast you should really check out. Melissa was a guest on one of their shows, and speaks about chance, J.K. Rowling, and the Harry Potter fandom. Then hang with Vanessa and Casper as they break down "The Dream" chapter from Goblet of Fire!

Thanks to our friends at HPatSS for the collaboration - and we can't wait to have them on PotterCast!

“While we did send you the text file two days late last Thursday, the rest of the schedule cannot be delayed by two days. Oh, by the way, here is a new version of the text file you will have to use instead.”

- Client, on Monday

Recent breakthroughs in scanning, image processing, and machine learning are helping researchers read historic documents once considered lost to time.

Ghosting gets a worse rep than it deserves, in my opinion. As both a former ghoster and a ghostee, I find it way more merciful than a text with stupid excuses.

If you run a WordPress website where you intend on adding eCommerce functionality at one stage or another, you cannot go past the free Stripe Payment Plugin. This plugin is designed to allow admin to sell either digital or tangible goods from their website through simple Stripe ‘Buy Now’ buttons. Just like PayPal, Stripe is […]

The post How to Make a Stripe Text Link Payment Button appeared first on Tips and Tricks HQ.

Blast from the Past: This blog entry was first issued on June 30, 2014 and was reissued on March 28, 2020. As I re-introduce this piece, we are sheltering in place as is so much of the world. That means schools are closed in many places and teachers and parents are concerned about what is being lost from children's education. As with many of you, I've been trying to help protect children's learning during these fraught times. Which brings us to today's blog entry, this one about how I taught my own children to read at home.

Teacher question: When working with state educational standards are the expectations for the student to be able to accomplish each of the standards with grade level text. Some of us believe that if a fourth-grade student can determine the main idea in a second-grade text that the student has mastered that standard. Please help us settle this argument. Shanahan's response:

Teacher question: I’m confused. I’ve worked with Lexiles for years and my district provided us with a chart showing the levels of books to use for each grade level. Then Common Core came along with a different chart that put different book levels with each grade level. I don’t live in a Common Core state, but I’m still not sure which chart to use. Can you help me? Shanahan's response:  It’s funny, but no one has ever asked me that before.

Teacher question: When working with state educational standards are the expectations for the student to be able to accomplish each of the standards with grade level text. Some of us believe that if a fourth-grade student can determine the main idea in a second-grade text that the student has mastered that standard. Please help us settle this argument. Shanahan's response:

Teacher question: I’m confused. I’ve worked with Lexiles for years and my district provided us with a chart showing the levels of books to use for each grade level. Then Common Core came along with a different chart that put different book levels with each grade level. I don’t live in a Common Core state, but I’m still not sure which chart to use. Can you help me? Shanahan's response:  It’s funny, but no one has ever asked me that before.

Invitation Only Research Event

Event participants

Rebecca Wolfe, Lecturer, Harris School for Public Policy and Associate, Pearson Institute for the Study and Resolution of Global Conflicts, University of Chicago
Tom Gillhespy, Principal Consultant, Itad
Shodmon Hojibekov, Chief Executive Officer, Aga Khan Agency for Habitat (Afghanistan)
Chair: Champa Patel, Director, Asia-Pacific Programme, Chatham House

Invitation Only Research Event

Event participants

Viacheslav Chirikba, de facto Minister of Foreign Affairs, Abkhazia

Invitation Only Research Event

Event participants

Rebecca Wolfe, Lecturer, Harris School for Public Policy and Associate, Pearson Institute for the Study and Resolution of Global Conflicts, University of Chicago
Tom Gillhespy, Principal Consultant, Itad
Shodmon Hojibekov, Chief Executive Officer, Aga Khan Agency for Habitat (Afghanistan)
Chair: Champa Patel, Director, Asia-Pacific Programme, Chatham House

Invitation Only Research Event

Event participants

Rebecca Wolfe, Lecturer, Harris School for Public Policy and Associate, Pearson Institute for the Study and Resolution of Global Conflicts, University of Chicago
Tom Gillhespy, Principal Consultant, Itad
Shodmon Hojibekov, Chief Executive Officer, Aga Khan Agency for Habitat (Afghanistan)
Chair: Champa Patel, Director, Asia-Pacific Programme, Chatham House

Korey Capozza
May 1, 2015; 28:83-91
Feature Articles

Bokai Song
Apr 28, 2020; 0:RA120.001981v1-mcp.RA120.001981
Research

The cyclic GMP-AMP synthase (cGAS) protein is a pattern-recognition receptor of the mammalian innate immune system that is recognized as a main cytosolic sensor of pathogenic or damaged DNA. cGAS DNA binding initiates catalytic production of the second messenger, cyclic GMP-AMP, which activates the STING-TBK1-IRF3 signaling axis to induce cytokine expression. Post-translational modification (PTM) has started to be recognized as a critical component of cGAS regulation, yet the extent of these modifications remains unclear. Here, we report the identification and functional analysis of cGAS phosphorylations and acetylations in several cell types under basal and immune-stimulated conditions. cGAS was enriched by immunoaffinity purification from human primary fibroblasts prior to and after infection with herpes simplex virus type 1 (HSV-1), as well as from immune-stimulated STING-HEK293T cells. Six phosphorylations and eight acetylations were detected, of which eight PTMs were not previously documented. PTMs were validated by parallel reaction monitoring (PRM) mass spectrometry in fibroblasts, HEK293T cells, and THP-1 macrophage-like cells. Primary sequence and structural analysis of cGAS highlighted a subset of PTM sites with elevated surface accessibility and high evolutionary sequence conservation. To assess the functional relevance of each PTM, we generated a series of single-point cGAS mutations. Stable cell lines were constructed to express cGAS with amino acid substitutions that prevented phosphorylation (Ser-to-Ala) and acetylation (Lys-to-Arg) or that mimicked the modification state (Ser-to-Asp and Lys-to-Gln). cGAS-dependent apoptotic and immune signaling activities were then assessed for each mutation. Our results show that acetyl-mimic mutations at Lys384 and Lys414 inhibit the ability of cGAS to induce apoptosis. In contrast, the Lys198 acetyl-mimic mutation increased cGAS-dependent interferon signaling when compared to the unmodified charge-mimic. Moreover, targeted PRM quantification showed that Lys198 acetylation is decreased upon infections with two herpesviruses—HSV-1 and human cytomegalovirus (HCMV), highlighting this residue as a regulatory point during virus infection.

T cells isolated from the pancreatic infiltrates of non-obese diabetic mice have been shown to recognize epitopes formed by the covalent cross-linking of proinsulin and secretory granule peptides. Formation of such hybrid insulin peptides (HIPs) was confirmed through mass spectrometry and responses to HIPs were observed among the islet-infiltrating T cells of pancreatic organ donors and in the peripheral blood of individuals with type 1 diabetes (T1D). However, questions remain about the prevalence of HIP-specific T cells in humans, the sequences they recognize, and their role in disease. We identified six novel HIPs that are recognized in the context of DRB1*04:01, discovered by utilizing a library of theoretical HIP sequences derived from insulin fragments covalently linked to one another or to fragments of secretory granule proteins or other islet-derived proteins. We demonstrate that T cells that recognize these HIPs are detectable in the peripheral blood of subjects with T1D and exhibit an effector memory phenotype. HIP-reactive T cell clones produced Th1-associated cytokines and proliferated in response to human islet preparations. These results support the relevance of HIPs in human disease, further establishing a novel post-translational modification that may contribute to the loss of peripheral tolerance in T1D.

Research Event

Event participants

Tom Butler, Chief Executive Officer, International Council for Mining and Metals (ICMM)
Evelyn Dietsche, Associate Fellow, Energy, Environment and Resources, Chatham House
Chair: Bernice Lee, Executive Director, Hoffman Centre, Chatham House 

Thailand has become a key destination for migrant workers, primarily from Myanmar, Cambodia, and Laos. Many lack authorization, however, and as their numbers have grown, so has the government's intent in regulating their movement—sometimes provoking unintended results. This article explores recent patterns in labor migration to Thailand and examines the likely impacts of a 2017 decree criminalizing illegal employment.

In advance of the December 2018 adoption of the Global Compact for Safe, Orderly, and Regular Migration and its commitment to facilitate the return, readmission, and reintegration of migrants, this webinar examines the policies, practices, and contextual factors that make compulsory returns such a difficult issue for international cooperation, and the programs that are being implemented to make reintegration of returnees sustainable.

A class action lawsuit alleging that a Florida dental practice sent unsolicited text messages in violation of the Telephone Consumer Protection Act was filed in the U.S. District Court for the Southern District of Florida Jan. 6.

Textron was awarded a $20.7 million contract modification Friday for work on the Navy's Unmanned Influence Sweep System and Unmanned Surface Vehicle program.

Gwyneth Paltrow, Ben Schwartz and other celebrities read text messages from their mothers on "Jimmy Kimmel Live" in honor of Mother's Day.

As long-simmering passions related to federal immigration policies have come to a full boil, less noted but no less important debates are taking place at state and local levels with regards to policies affecting immigrants and their children. As states are increasingly diverging in their responses, this report examines how some of the key policies and programs that support long-term integration success are faring in this volatile era.

What if we could help people in crisis anytime, anywhere with a simple text message? That's the idea behind Crisis Text Line, a free 24-hour service that connects people in need with trained, volunteer crisis counselors -- "strangers helping strangers around the world, like a giant global love machine," as cofounder and CEO Nancy Lublin puts it. Learn more about their big plans to expand to four new languages, providing a third of the globe with crucial, life-saving support. (This ambitious plan is a part of the Audacious Project, TED's initiative to inspire and fund global change.)