The Toronto Maple Leafs have signed Finnish defenceman Mikko Lehtonen to a one-year, entry-level contract for the 2020-21 season, the club announced Monday.

Pittsburgh Penguins superstar Sidney Crosby is easing the burden for many Pennsylvania families struggling during the COVID-19 virus.

Maple Leafs defenceman Justin Holl is ready to go. He's just waiting for the green light. Holl has spent most of the COVID-19 pandemic that shut down the NHL, and much of North America, at home in Minnesota since the season was paused March 12.

The sport is considering radical rule changes as it tries to balance centuries of tradition with the modern need to move things along.

Team Homan's decision to part ways with Lisa Weagle dramatically changed the look of one of the country's top rinks and put the all-star lead at the top of curling's free agent list.

In the span of a few days, Canada's curling landscape has shifted dramatically. The country's past women's and men's Olympic teams and last year's women's world champion team have all split.

The province says no one has to tell others if they get COVID-19. The same goes for businesses or landlords, should employees or tenants get sick. But should you tell?

Curbside pickups offer a bit of hope after months of being shuttered by COVID-19, but while retailers are happy to start getting back to business some are raising questions of fairness and access to opportunity.

The COVID-19 pandemic may be keeping families physically distant, but that doesn't mean you can't show someone you care.

Flurries or rain showers are in the forecast for Hamilton on Friday, Environment Canada says.

Sofina Foods plants in Burlington and Mississauga have each had an employee test positive.

Hamilton Conservation Authority is re-opening the Hamilton-to-Branford Rail Trail, while the city announced the reopening of the Hamilton Waterfront Trail, between Confederation Park and the Burlington Lift Bridge.

McMaster University is planning for fewer international students, more deferred acceptance offers and online teaching for the thousands who are attending as the start of a new school year looms in the near future and in the middle of the COVID-19 pandemic.

The Xenopus oocyte is a unique model system, allowing both the study of complex biological processes within a cellular context through expression of exogenous mRNAs and proteins, and the study of the cell, molecular, and developmental biology of the oocyte itself. During oogenesis, Xenopus oocytes grow dramatically in size, with a mature oocyte having a diameter of ~1.3 mm, and become highly polarized, localizing many mRNAs and proteins. Thus, the mature oocyte is a repository of maternal mRNAs and proteins that will direct early embryogenesis prior to zygotic genome transcription. Importantly, the Xenopus oocyte also has the capacity to translate exogenous microinjected RNAs, which has enabled breakthroughs in a wide range of areas including cell biology, developmental biology, molecular biology, and physiology. This introduction outlines how Xenopus oocytes can be used to study a variety of important biological questions.

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One of the main mechanisms of azole resistance of Aspergillus fumigatus is thought to be a reduction in the drug’s affinity for the target molecule, Cyp51A, due to its amino acid mutation(s). It is known that the azole resistance pattern is closely related to the mutation site(s) of the molecule. In this study, we tried to develop a simple and rapid detection method for cyp51A mutations using the endonuclease Surveyor nuclease. The Surveyor nuclease assay was verified using several azole-resistant strains of A. fumigatus that possess point mutations in Cyp51A. For validation of the Surveyor nuclease assay, blind tests were conducted using 48 strains of A. fumigatus (17 azole-resistant and 31 azole-susceptible strains). The Surveyor nuclease assay could rapidly detect cyp51A mutations with one primer set. Also, all the tested strains harboring different cyp51A single point mutations could be clearly distinguished from the wild type. The Surveyor nuclease assay is a simple method that can detect cyp51A mutations rapidly.

Close to 300 series at various frequencies for 60 countries have been updated.

Banks globally entered the Covid-19 crisis with roughly US$ 5 trillion of capital above their Pillar 1 regulatory requirements. The amount of additional lending will depend on how hard banks' capital is hit by the crisis, on their willingness to use the buffers and on other policy support. In an adverse stress scenario such as the savings and loan crisis, banks' usable buffers would decline to US$ 800 billion, which could support US$ 5 trillion of additional loans (6% of total loans outstanding). Yet in a severely adverse scenario, similar to the Great Financial Crisis, the corresponding figures would be only US$ 270 billion and US$ 1 trillion (1.3% of total loans).

We document that corporate pension contributions respond to tax-based incentives using the 2017 Tax Cut & Jobs Act (TCJA) as a natural experiment. The TCJA cut the U.S. federal corporate tax rate, temporarily increasing contribution incentives for sponsors of defined-benefit retirement plans. We exploit cross-sectional variation in ex-ante exposure to these incentives.

Gold and silver prices often move in tandem, but the gap between them widened by 31% January through April in line with a trend that began nine years ago.

Bank for International Settlements BIS Working Papers by David Cook and Nikhil Patel

Bank for International Settlements BIS Working Papers by Claudio Borio, Marc Farag and Nikola Tarashev

Bank of England Working Papers by Aydan Dogan and Ida Hjortsoe

Bank of England Working Papers by Cristiano Cantore, Filippo Ferroni and Miguel León-Ledesma

Netherlands Bank DNB Occasional Studies by Peter Wierts and Harro Boven

European Central Bank Working Papers by Marien Ferdinandusse, Maximilian Freier and Annukka Ristiniemi

Central Bank of Chile Working Papers by Andrés Sagner

Frankly, Trump doesn’t give a damn.

Trump washes his hands of responsibility.

Anti-government ideology is crippling pandemic policy.