Their wonderful story is told in the Book of Daniel, in which the coming of Christ is prophesied and prefigured in several places. Large portions of the book are missing from the protestant Bible: make every effort to obtain and read the full version. The Song of the Three Youths in the Furnace have become the Seventh and Eight of the Old Testament Odes of the Matins Canon; the Odes are sung in full only in monasteries during Lent. The Three Youths' sojourn in the fiery furnace is prominent in Orthodox hymns and devotions, for their passage through the flames unharmed is a type of the holy Virgin's incorrupt birth-giving: receiving the divine Fire within her womb, she was not consumed but remained ever-virgin.   According to the Synaxarion, Daniel reposed in peace at the age of eighty, two years after the return of the Hebrew people from their captivity in Babylon. The Three Youths also reposed in peace. But St Cyril of Alexandria writes that all of them met a martyr's end, by beheading.   According to tradition these four were among the righteous dead who rose at Christ's Crucifixion and were seen by many (Matthew ch. 27).   The Three Holy Youths were named, in Hebrew, Hananiah, Azariah, and Mishael; the names given above are Greek renderings of the Hebrew names. Their captors also gave them Babylonian names, by which they are also called: Shadrach, Abed-nego, and Meshak, respectively. Daniel was given the Babylonian name Belteshazzar.

Modern historians often bring attention to the effects of secularization on the West. Once traditional Christianity ceased to influence Western culture, the experience of the kingdom of heaven naturally diminished, something the famous German sociologist Max Weber called the "disenchantment of the world." In this episode, Fr. John describes how the concept of the saeculum, a kind of neutral cultural space cut off from the life of the Church, first appeared, and how, with Petrarch, it became a haven for humanists fleeing the pessimism of the fourteenth century.

A hybrid network system for mitigating errors due to jamming attacks in cognitive radio networks (CRNs) is named LeNet deep stacked autoencoder (LDSAE) and is developed. In this exploration, the sensing stage and decision-making are considered. The sensing unit is composed of four steps. First, the detected signal is forwarded to filtering progression. Here, BPF is utilised to filter the detected signal. The filtered signal is squared in the second phase. Third, signal samples are combined and jamming attacks occur by including false energy levels. Last, the attack is maliciously affecting the FC decision in the fourth step. On the other hand, FC initiated the decision-making and also recognised jamming attacks that affect the link amidst PU and SN in decision-making stage and it is accomplished by employing LDSAE-based trust model where the proposed module differentiates the malicious and selfish users. The analytic measures of LDSAE gained 79.40%, 79.90%, and 78.40%.

Actor shared a clip on IG praising her fellow star

SSAE 18 is a set of audit standards established to provide a common framework for service organizations to report on their systems and controls for handling sensitive client data. Find out if your organization is required to comply.

Nawal Alsaeed, a successful entrepreneur, founded the modest clothing and uniform company Studyus Monday

La Luciérnaga se enciende para hablar de lo que sucede con los bienes incautado por la sociedad de activos especiales. Además, ¿Qué pasa con el precio del dólar? También, le contamos sobre el polémico discurso del presidente de El Salvador, Nayib Bukele.

Escuche el programa de este martes 25 de junio. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.

En Caracol Radio estuvo Mauricio Urquijo, director territorial occidente de la SAE

Formula SAE and Formula Student teams increasingly demand SolidWorks software for its ease of use and integrated design analysis

Admitting that they are "facing a tough time in the courts," Asif related that the LHC has asked for the evidence that the Home Department used to extend the detention. "There has never been a case against them," he noted, "and we have no criminal record of these gentlemen."

Saeed, Aisha, author

The Sindh government has assured the local Manghopir representatives that it will not establish any quarantine centre in Union Council 4, as keeping suspected patients of the coronavirus in the locality would be a risky proposition keeping in view the weak civic infrastructure of the area.The...

Recent geologic mapping of the Medusae Fossae Formation on Mars—an intensely eroded deposit near the northern edge of the cratered highlands—has revealed a wider distribution of its western component than was previously recognized.

The post New mapping of Mars shows Medusae Fossae Formation older than once thought appeared first on Smithsonian Insider.

Dr. Jamaluddin has been endorsed by Marquis Who's Who as a leader in the engineering industry

Mr. Saenz has been endorsed by Marquis Who's Who as a leader in the computer programming field

An area supervisor for Bento Sushi, Ms. Saengwong notably placed first in a chili chowder competition in 2019 and 2016

Saez Earns Months of Free Rent and $300 Gift Card for Racking Up the Most Referrals Who Leased Space at Salon and Spa Galleria

Saeed Maasarwe said his family is not motivated by revenge over the rape and murder of his daughter Aiia Maasarwe, as he remembered her as a positive woman who wanted to help everybody.

Aviation authorities ground an Australian-made aircraft that Swedish investigators believe may have broken up mid-flight in Sweden, leading to the deaths of nine people.

SUMOylation is a posttranslational modification (PTM) at a lysine residue and is crucial for the proper functions of many proteins, particularly of transcription factors, in various biological processes. Zinc finger homeobox 3 (ZFHX3), also known as AT motif-binding factor 1 (ATBF1), is a large transcription factor that is active in multiple pathological processes, including atrial fibrillation and carcinogenesis, and in circadian regulation and development. We have previously demonstrated that ZFHX3 is SUMOylated at three or more lysine residues. Here, we investigated which enzymes regulate ZFHX3 SUMOylation and whether SUMOylation modulates ZFHX3 stability and function. We found that SUMO1, SUMO2, and SUMO3 each are conjugated to ZFHX3. Multiple lysine residues in ZFHX3 were SUMOylated, but Lys-2806 was the major SUMOylation site, and we also found that it is highly conserved among ZFHX3 orthologs from different animal species. Using molecular analyses, we identified the enzymes that mediate ZFHX3 SUMOylation; these included SUMO1-activating enzyme subunit 1 (SAE1), an E1-activating enzyme; SUMO-conjugating enzyme UBC9 (UBC9), an E2-conjugating enzyme; and protein inhibitor of activated STAT2 (PIAS2), an E3 ligase. Multiple analyses established that both SUMO-specific peptidase 1 (SENP1) and SENP2 deSUMOylate ZFHX3. SUMOylation at Lys-2806 enhanced ZFHX3 stability by interfering with its ubiquitination and proteasomal degradation. Functionally, Lys-2806 SUMOylation enabled ZFHX3-mediated cell proliferation and xenograft tumor growth of the MDA-MB-231 breast cancer cell line. These findings reveal the enzymes involved in, and the functional consequences of, ZFHX3 SUMOylation, insights that may help shed light on ZFHX3's roles in various cellular and pathophysiological processes.

SUMOylation is a posttranslational modification (PTM) at a lysine residue and is crucial for the proper functions of many proteins, particularly of transcription factors, in various biological processes. Zinc finger homeobox 3 (ZFHX3), also known as AT motif-binding factor 1 (ATBF1), is a large transcription factor that is active in multiple pathological processes, including atrial fibrillation and carcinogenesis, and in circadian regulation and development. We have previously demonstrated that ZFHX3 is SUMOylated at three or more lysine residues. Here, we investigated which enzymes regulate ZFHX3 SUMOylation and whether SUMOylation modulates ZFHX3 stability and function. We found that SUMO1, SUMO2, and SUMO3 each are conjugated to ZFHX3. Multiple lysine residues in ZFHX3 were SUMOylated, but Lys-2806 was the major SUMOylation site, and we also found that it is highly conserved among ZFHX3 orthologs from different animal species. Using molecular analyses, we identified the enzymes that mediate ZFHX3 SUMOylation; these included SUMO1-activating enzyme subunit 1 (SAE1), an E1-activating enzyme; SUMO-conjugating enzyme UBC9 (UBC9), an E2-conjugating enzyme; and protein inhibitor of activated STAT2 (PIAS2), an E3 ligase. Multiple analyses established that both SUMO-specific peptidase 1 (SENP1) and SENP2 deSUMOylate ZFHX3. SUMOylation at Lys-2806 enhanced ZFHX3 stability by interfering with its ubiquitination and proteasomal degradation. Functionally, Lys-2806 SUMOylation enabled ZFHX3-mediated cell proliferation and xenograft tumor growth of the MDA-MB-231 breast cancer cell line. These findings reveal the enzymes involved in, and the functional consequences of, ZFHX3 SUMOylation, insights that may help shed light on ZFHX3's roles in various cellular and pathophysiological processes.

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SUMOylation is a posttranslational modification (PTM) at a lysine residue and is crucial for the proper functions of many proteins, particularly of transcription factors, in various biological processes. Zinc finger homeobox 3 (ZFHX3), also known as AT motif-binding factor 1 (ATBF1), is a large transcription factor that is active in multiple pathological processes, including atrial fibrillation and carcinogenesis, and in circadian regulation and development. We have previously demonstrated that ZFHX3 is SUMOylated at three or more lysine residues. Here, we investigated which enzymes regulate ZFHX3 SUMOylation and whether SUMOylation modulates ZFHX3 stability and function. We found that SUMO1, SUMO2, and SUMO3 each are conjugated to ZFHX3. Multiple lysine residues in ZFHX3 were SUMOylated, but Lys-2806 was the major SUMOylation site, and we also found that it is highly conserved among ZFHX3 orthologs from different animal species. Using molecular analyses, we identified the enzymes that mediate ZFHX3 SUMOylation; these included SUMO1-activating enzyme subunit 1 (SAE1), an E1-activating enzyme; SUMO-conjugating enzyme UBC9 (UBC9), an E2-conjugating enzyme; and protein inhibitor of activated STAT2 (PIAS2), an E3 ligase. Multiple analyses established that both SUMO-specific peptidase 1 (SENP1) and SENP2 deSUMOylate ZFHX3. SUMOylation at Lys-2806 enhanced ZFHX3 stability by interfering with its ubiquitination and proteasomal degradation. Functionally, Lys-2806 SUMOylation enabled ZFHX3-mediated cell proliferation and xenograft tumor growth of the MDA-MB-231 breast cancer cell line. These findings reveal the enzymes involved in, and the functional consequences of, ZFHX3 SUMOylation, insights that may help shed light on ZFHX3's roles in various cellular and pathophysiological processes.

The Verisae solution is the first web-enabled site and asset management software created to meet the unique needs of multi-site owners. We offer a powerful suite of web-based process management solutions for facilities, the assets in those facilities, and the people who manage them.

In their new book, The Triumph of Injustice: How the Rich Dodge Taxes and How to Make Them Pay, economists Emmanuel Saez and Gabriel Zucman challenge seemingly every fundamental element of conventional tax policy analysis. Given the attention the book has generated, it is worth stepping back and considering their sweeping critique of conventional wisdom.…

Bollywood actor Irrfan Khan's mother Saeda Begum passed away on Saturday morning. She was 95. Saeda Begum, who belongs to the Nawab family of Tonk, was unwell for a long time. She died due to natural causes. Begum resided in the Beniwal Kanta Krishna Colony in Jaipur.

Further details are awaited.

On the work front, the actor was last seen in Angrezi Medium. The film, which released on March 13, will be re-released after the country announced a shut down of movie theatres due to the coronavirus outbreak. Directed by Homi Adajania, Angrezi Medium revolves around a father-daughter relationship, played by Irrfan Khan and Radhika Madan. It also features Deepak Dobriyal, Ranvir Shorey, Dimple Kapadia and Kareena Kapoor Khan.

Angrezi Medium is a sequel to the 2017 hit film Hindi Medium, which starred Irrfan Khan and Saba Qamar in the lead roles. The movie also features Kareena Kapoor Khan, Radhika Madaan and Deepak Dobriyal in pivotal roles. The film has been produced by Dinesh Vijan.

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Former Pakistan off-spinner Saeed Ajmal is still not over the disappointment of missing Sachin Tendulkar's wicket in the lost 2011 World Cup semifinal against India and is now deriving solace from English umpire Ian Gould's recent assertion that the iconic batsman was indeed out. Tendulkar, who made crucial 85 runs in the semifinal at Mohali, was on 23 when Gould ruled him out LBW off Ajmal. But third umpire Billy Bowden, after a review, overturned the decision.

Gould, who served on the ICC's elite panel of umpires, recently said that he would stands by his decision of giving Tendulkar out. Recalling the incident, Ajmal, now 42, said, "It was straight in front and I was 100 percent sure he was out. Shahid Afridi, Kamran, Wahab and other players asked me was he (Tendulkar) out and I told them he is gone." He said he was heart-broken after the third umpire ruled Tendulkar not out. "I never got a chance to bowl to him in a Test so whenever I played against him in white ball cricket I always wanted to do my best. "More disappointing was that we lost the semifinal and it is obvious that Tendulkar's 85 runs made all the difference," he said on a television channel," he said.

"Even today, the third umpire's decision baffles me. Maybe luck was with him that day and he went on play such a crucial innings for his team," said Ajmal who played 35 Tests between 2009 and 2014, taking 178 wickets. He also took 183 wickets in 113 ODIs and 85 in 64 T20 Internationals. Ajmal said Gould was upset after his decision was overturned by the third umpire. The off-spinner's career, however, came to an unceremonious end after a tour of Bangladesh. His bowling action was reported in 2014 and he could not cope with the subsequent modification and retired in 2017.

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Calvin, who is the world's highest paid DJ, was 'really interested in Sophie and made a beeline for her as soon as he got inside', according to sources.

Sophie Kasaei, 28, stayed close to her roots as she attended the annual Video Music awards hosted by the television channel on Monday evening.

The star, 30, left little to the imagination as she joined Georgia Harrison, Ellie Brown and Joey Essex for the screening of the new series at London's Curzon in Soho on Tuesday.

The Geordie Shore girls were out in force on Saturday night as Chloe Ferry, Bethan Kershaw and Sophie Kasaei stepped out in Newcastle to celebrate a pal's birthday.

Geordie Shore bombshells Chloe Ferry and Sophie Kasaei ensured they pulled out all the stops as they supported their former co-star on Saturday night.