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Shetland Library and the National Library of Scotland have been praised for "providing optimist for the future."

The Elder Scrolls: Legends, the free-to-play card game set in Bethesda's fantasy world, has been removed from sale on Steam. Its servers will shut down for good on January 30th, 2025, after which it will no longer be playable. The closure comes five years after the game was last updated.

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The water column is hazy as an unusual remotely operated vehicle glides over the seafloor in search of a delicate tilt meter deployed three years ago off the west side of Vancouver Island. The sensor measures shaking and shifting in continental plates that will eventually unleash another of the region’s 9.0-scale earthquakes (the last was in 1700). Dwindling charge in the instruments’ loggers threatens the continuity of the data.

The 4-metric-ton, C$8-million (US $5.8-million) remotely operated vehicle (ROV) is 50 meters from its target when one of the seismic science platforms appears on its sonar imaging system, the platform’s hard edges crystallizing from the grainy background like a surgical implant jumping out of an ultrasound image. After easing the ROV to the platform, operators 2,575 meters up at the Pacific’s surface instruct its electromechanical arms and pincer hands to deftly unplug a data logger, then plug in a replacement with a fresh battery.

This mission, executed in early October, marked an exciting moment for Josh Tetarenko, director of ROV operations at North Vancouver-based Canpac Marine Services. Tetarenko is the lead designer behind the new science submersible and recently dubbed it Jenny in homage to Forrest Gump, because the fictional character named all of his boats Jenny. Swapping out the data loggers west of Vancouver Island’s Clayoquot Sound was part of a weeklong shakedown to test Jenny’s unique combination of dexterity, visualization chops, power, and pressure resistance.

Jenny is only the third science ROV designed for subsea work to a depth of 6,000 meters.

By all accounts Jenny sailed through. Tetarenko says the worst they saw was a leaky O-ring and the need to add some spring to a few bumpers. “Usually you see more things come up the first time you dive a vehicle to those depths,” says Tetarenko.

Jenny’s successful maiden cruise is just as important for Victoria, B.C.–based Ocean Networks Canada (ONC), which operates the NEPTUNE undersea observatory. The North-East Pacific Time-series Undersea Networked Experiments array boasts thousands of sensors and instruments, including deep-sea video cameras, seismometers, and robotic rovers sprawled across this corner of Pacific. Most of these are connected to shore via an 812-kilometer power and communications cable. Jenny was custom-designed to perform the annual maintenance and equipment swaps that have kept live data streaming from that cabled observatory nearly continuously for the past 15 years, despite trawler strikes, a fault on its backbone cable, and insults from corrosion, crushing pressures, and fouling.

NEPTUNE remains one of the world’s largest installations for oceanographic science despite a proliferation of such cabled observatories since it went live in 2009. ONC’s open data portal has over 37,000 registered users tapping over 1.5 petabytes of ocean data—information that’s growing in importance with the intensification of climate change and the collapse of marine ecosystems.

Over the course of Jenny’s maiden cruise, her operators swapped devices in and out at half a dozen ONC sites, including at several of NEPTUNE’s five nodes and at one of NEPTUNE’s smaller sister observatories closer to Vancouver.

Inside Jenny

ROV Jenny aboard the Valour, Canpac’s 50-meter offshore workhorse, ahead of October’s NEPTUNE observatory maintenance cruise.Ocean Networks Canada

What makes Jenny so special?

• Jenny is only the third science ROV designed for subsea work to a depth of 6,000 meters.
• Motion sensors actively adjust her 7,000-meter-long umbilical cable to counteract topside wave action that would otherwise yank the ROV around at depth and, in rough seas, could damage or snap the cable.
• Dual high-dexterity manipulator arms are controlled by topside operators via a pair of replica mini-manipulators that mirror the movements.
• Each arm is capable of picking up objects weighing about 275 kilograms, and the ROV itself can transport equipment weighing up to 3,000 kg.
• 11 high-resolution cameras deliver 4K video, supported by 300,000 lumens of lighting that can be tuned to deliver the soft red light needed to observe bioluminescence.
• Dual multibeam sonar systems maximize visibility in turbid water.

Meghan Paulson, ONC’s executive director for observatory operations, says the sonar imaging system will be particularly invaluable during dives to shallower sites where sediments stirred up by waves and weather can cut visibility from meters to centimeters. “It really reduces the risk of running into things accidentally,” says Paulson.

To experience the visibility conditions for yourself, check out recordings of the live video broadcast from the NEPTUNE maintenance cruise. Tetarenko says that next year they hope to broadcast not only the main camera feed but also one of the sonar images.

3D video could be next, according to Canpac ROV pilot and Jenny codesigner, James Barnett. He says they would need to boost the computing power installed topside, to process that “firehose of data,” but insists that real-time 3D is “definitely not impossible.” Tetarenko says the science ROV community is collaborating on software to help make that workable: “3D imagining is kind of the very latest thing that’s being tested on lots of ROV systems right now, but nobody’s really there yet.”

More Than Science

Expansion of the cabled observatory concept is the more certain technological legacy for ONC and NEPTUNE. In fact, the technology has evolved beyond just oceanography applications.

ONC tapped Alcatel Submarine Networks (ASN) to design and build the Neptune backbone and the French firm delivered a system that has reliably delivered multigigabit Ethernet plus 10 kilovolts of direct-current electricity to the deep sea. Today ASN deploys a second-generation subsea power and communications networking solution, developed with the Norwegian international energy company Equinor.

ASN’s “Direct Current/Fiber Optic” or DC/FO system provides the 100-km backbone for the ARCA subsea neutrino observatory near Sicily, in addition to providing control systems for a growing number of offshore oil and gas installations. The latter include projects led by Equinor and BP where DC/FO networks drive the subsea injection of captured carbon dioxide and monitor its storage below the seabed. Future oil and gas projects will increasingly rely on the cables’ power supply to replace the hydraulic lines that have traditionally been used to operate machinery on the seafloor, according to Ronan Michel, ASN’s product line manager for oil and gas solutions.

Michel says DC/FO incorporates important lessons learned from the Neptune installation. And the latter’s existence was a crucial prerequisite. “The DC/FO solution would probably not exist if Neptune Canada would not have been developed,” says Michel. “It probably gave confidence to Equinor that ASN was capable to develop subsea power and coms infrastructure.”

Depending on PC config you may see up to a 30fps uplift with anti-tamper tech ditched.

A woman's brain was scanned throughout her pregnancy, adding to the growing body of evidence that dramatic remodelling takes place in preparation for motherhood

An Ottawa high school principal has apologized for playing an Arabic song about peace during a Remembrance Day ceremony after facing swift backlash from critics calling it inappropriate and hurtful to members of the Jewish community.

1. Swiggy’s reclusive CEO Sriharsha Majety makes rare public appearance at IPO listing ceremony  Hindustan Times
2. Zomato gives ‘Jai and Veeru’ vibes with special meme for rival Swiggy on IPO day  Hindustan Times
3. JM Financial gives Swiggy its first 'buy' tag, sees 20% upside from IPO price  Moneycontrol
4. Swiggy IPO: 9 execs who will become richer by Rs 50 crore or more  The Times of India
5. ‘You and I…’: Zomato welcomes Swiggy on Dalal Street post stock market listing  India Today

Protect your dog from ticks with these easy steps for safe removal and prevention. Learn how to spot, remove, and keep ticks at bay.

Asahi Kasei Medical has launched the Planova FG1, a next-generation virus removal filter featuring higher flux for the manufacture of biotherapeutics, in October 2024.

The General Pharmaceutical Council has said most candidates living in countries with a two-hour or more time difference from the UK will be able to apply to sit the registration assessment at home.

Maybe those pesky sites are good for something after all. 

It's been six years since Pfizer boldly announced the launch of its "clinical trial in a box". The REMOTE trial was designed to be entirely online, and involved no research sites: study information and consent was delivered via the web, and medications and diaries were shipped directly to patients' homes.

Despite the initial fanfare, within a month REMOTE's registration on ClinicalTrials.gov was quietly reduced from 600 to 283. The smaller trial ended not with a bang but a whimper, having randomized only 18 patients in over a year of recruiting.

Still, the allure of direct to patient clinical trials remains strong, due to a confluence of two factors. First, a frenzy of interest in running "patient centric clinical trials". Sponsors are scrambling to show they are doing something – anything – to show they have shifted to a patient-centered mindset. We cannot seem to agree what this means (as a great illustration of this, a recent article in Forbes on "How Patients Are Changing Clinical Trials" contained no specific examples of actual trials that had been changed by patients), but running a trial that directly engages patients wherever they are seems like it could work.

The less-openly-discussed other factor leading to interest in these DIY trials is sponsors' continuing willingness to heap almost all of the blame for slow-moving studies onto their research sites. If it’s all the sites’ fault – the reasoning goes – then cutting them out of the process should result in trials that are both faster and cheaper. (There are reasons to be skeptical about this, as I have discussed in the past, but the desire to drop all those pesky sites is palpable.)

However, while a few proof-of-concept studies have been done, there really doesn't seem to have been another trial to attempt a full-blown direct-to-patient clinical trial. Other pilots have been more successful, but had fairly lightweight protocols. For all its problems, REMOTE was a seriously ambitious project that attempted to package a full-blown interventional clinical trial, not an observational study.

In this context, it's great to see published results of the TAPIR Trial in vasculitis, which as far as I can tell is the first real attempt to run a DIY trial of a similar magnitude to REMOTE.

TAPIR was actually two parallel trials, identical in every respect except for their sites: one trial used a traditional group of 8 sites, while the other was virtual and recruited patients from anywhere in the country. So this was a real-time, head-to-head assessment of site performance.

And the results after a full two years of active enrollment?

• Traditional sites: 49 enrolled
• Patient centric: 10 enrolled

The FDA has proposed removing oral phenylephrine from its guidelines for over-the-counter drugs due to inefficacy as a decongestant. Use of this ingredient in cold and allergy medicines grew after a federal law required that pseudoephedrine-containing products be kept behind pharmacy counters.

The post FDA Takes Step Toward Removal of Ineffective Decongestants From the Market appeared first on MedCity News.

Dec 21, 2023

Artificial intelligence is poised to remove human limitations inherent in many systems, including information and logistical bottlenecks in decision-making.

Preparations for a live screening of the Fight of the Century on a remote island in the Philippines

European Business Award Teaser 2015

HGTV Dream Home 90-second Tour

Ryan Lochte explains the feeling of Gentle Laser Hair Removal

Research conducted in Bangladesh could have dramatic implications both for poor households and the entire wastewater value chain.

The post Press Release: New “pay-monthly” poop removal system could revolutionize sanitation in developing world, says new study first appeared on International Water Management Institute (IWMI).

Extended lymph node removal during surgery for localized muscle-invasive medlinkbladder cancer/medlink does not improve patient survival(!--ref1--).

Doctors at King George's Medical University (KGMU) have successfully removed a massive four-kg fibroid (!--ref1--) tumor from the uterus of a 30-year-old woman.

The Uttar Pradesh health department has adopted YouTube as a platform for ongoing medical education and professional development of government doctors stationed in remote areas (!--ref1--).

A lawmaker revealed that only 12% of unsafe food imports have been removed from the market, according to government data. According to the data from

medlinkCancer/medlink-causing mutations in prostate cancer hyperactivate PI3K signaling, leading to cancer cell growth. PLEKHS1, a largely unknown

US President Joe Biden had a cancerous skin lesion removed from his chest, said White House physician Kevin O'Connor. O'Connor wrote on Friday in

Administering medlinkblood pressure/medlink medications to reduce systolic blood pressure readings may not be a safe or effective approach for medlinkacute

Varicose Vein Removal Now Easier and More Affordable Than Ever

In a major policy decision the Food and Drug Administration (FDA) of the USA has lifted the ban on gay and bisexual men

Remote echocardiograms using robot arm technology are as precise as in-person exams by cardiologists, according to new research to be presented at this

Doctors had successfully removed 156 kidney stones from a 50-year-old man at a Hyderabad hospital. Doctors at the Preeti Urology (and) Kidney Hospital,

About 206 kidney stones have been removed from a 56-year-old patient at Aware Gleneagles Global Hospital in Hyderabad, India. These stones caused

Accor and the Arora Group are proud to announce the groundbreaking of the highly anticipated Sofitel Dublin Airport, a new luxury hotel set to redefine the hospitality experience at Ireland’s main international gateway. The hotel will feature 412 elegantly designed rooms and suites, an all-day dining restaurant, a tea salon, and a sky bar located on the 11th floor, offering stunning views of the airport and beyond. This franchised development project features a new-build Sofitel hotel located at Dublin Airport, set to open by late 2026 as a full-service luxury hotel comprising approximately 412 guest rooms. The hotel will be directly linked to the airport’s Terminal 2, providing seamless connectivity for travellers. The developer for this project is the Arora Group, a significant franchise partner of Accor in the UK and the owner of both the Sofitel London Heathrow Airport and the Sofitel London Gatwick Airport. In 2018, Arora was awarded the opportunity to develop this over €100 mill...

Malaika Arora has penned down some big challenges for herself for the month of November. Let's take a look.

The personnel deputed for election duty were sent on Monday to 225 polling stations located in remote and inaccessible areas of five districts of the state -- West Singhbhum, Latehar, Lohardaga, Gumla and Garhwa.

Amsterdam-based Brineworks, a company specializing in seawater electrolysis technology, says its innovative method is expected to cost under $100 per ton of CO2 at scale.

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Bob Dole, a longtime Republican leader and senator for more than half a century, was honored at a ceremony in the Capitol Rotunda on Thursday. President Biden and leaders of Congress were among those paying tribute. Photo: Jonathan Ernst/Pool via AP

In recent weeks, some YouTube users have voiced concerns that the platform is making it more difficult to skip ads, with reports circulating about black rectangles obscuring the skip button. These claims surfaced on Reddit, and users reported a lack of

A monitor is an integral if not essential part of any desktop setup. And when it comes to PC monitors, few brands can hold a candle to BenQ. However, I have never really considered BenQ as an affordable option when it

Harriet Tubman honoured as a one-star general in a Veterans Day ceremony, recognising her contributions as a military leader and abolitionist.

Considering efforts by the government over two decades have not shown a significant impact, Tobacco has become an irremovable part of our society. What could the government do to save the legal age of smokers? 

Aam Aadmi Party (AAP) Supremo Arvind Kejriwal will relocate to a bungalow at 5, Ferozshah Road, Delhi, which is currently allotted to the party's Rajya Sabha MP Ashok Mittal, the party has conformed.